LOCUS       NM_005085               7568 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleoporin 214 (NUP214), transcript variant 2, mRNA.
ACCESSION   NM_005085 NM_153642
VERSION     NM_005085.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7568)
  AUTHORS   Choi,Y.J., Min,Y.K., Lee,S.T., Choi,J.R. and Shin,S.
  TITLE     NUP214 Rearrangements in Leukemia Patients: A Case Series From a
            Single Institution
  JOURNAL   Ann Lab Med 44 (4), 335-342 (2024)
   PUBMED   38145892
  REMARK    GeneRIF: NUP214 Rearrangements in Leukemia Patients: A Case Series
            From a Single Institution.
REFERENCE   2  (bases 1 to 7568)
  AUTHORS   Wang,J., Zhan,Q.R., Lu,X.X., Zhang,L.J., Wang,X.X. and Zhang,H.Y.
  TITLE     The characteristics and prognostic significance of the
            SET-CAN/NUP214 fusion gene in hematological malignancies: A
            systematic review
  JOURNAL   Medicine (Baltimore) 101 (30), e29294 (2022)
   PUBMED   35905214
  REMARK    GeneRIF: The characteristics and prognostic significance of the
            SET-CAN/NUP214 fusion gene in hematological malignancies: A
            systematic review.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7568)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 7568)
  AUTHORS   Gao,M.G., Fu,Q., Qin,Y.Z., Chang,Y.J., Wang,Y., Yan,C.H., Xu,L.P.,
            Zhang,X.H., Huang,X.J. and Zhao,X.S.
  TITLE     [Prognostic significance of DEK-NUP214 fusion gene in patients with
            acute myeloid leukemia after allogeneic hematopoietic stem cell
            transplantation]
  JOURNAL   Zhonghua Nei Ke Za Zhi 60 (10), 868-874 (2021)
   PUBMED   34551474
  REMARK    GeneRIF: [Prognostic significance of DEK-NUP214 fusion gene in
            patients with acute myeloid leukemia after allogeneic hematopoietic
            stem cell transplantation].
REFERENCE   5  (bases 1 to 7568)
  AUTHORS   Zheng,Y.Z., Wen,J.J., Wang,L.Y., Zheng,H., Hua,X.L., Li,J. and
            Hu,J.D.
  TITLE     [SET-NUP214-positive pediatric acute myeloid leukemia: a report of
            two cases]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 42 (9), 769 (2021)
   PUBMED   34753234
  REMARK    GeneRIF: [SET-NUP214-positive pediatric acute myeloid leukemia: a
            report of two cases].
REFERENCE   6  (bases 1 to 7568)
  AUTHORS   Napetschnig,J., Blobel,G. and Hoelz,A.
  TITLE     Crystal structure of the N-terminal domain of the human
            protooncogene Nup214/CAN
  JOURNAL   Proc Natl Acad Sci U S A 104 (6), 1783-1788 (2007)
   PUBMED   17264208
  REMARK    GeneRIF: A mechanism is proposed by which the C-terminal peptide
            extension is involved in nuclear pore complex assembly.
REFERENCE   7  (bases 1 to 7568)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   8  (bases 1 to 7568)
  AUTHORS   Kraemer,D., Wozniak,R.W., Blobel,G. and Radu,A.
  TITLE     The human CAN protein, a putative oncogene product associated with
            myeloid leukemogenesis, is a nuclear pore complex protein that
            faces the cytoplasm
  JOURNAL   Proc Natl Acad Sci U S A 91 (4), 1519-1523 (1994)
   PUBMED   8108440
REFERENCE   9  (bases 1 to 7568)
  AUTHORS   von Lindern,M., Fornerod,M., van Baal,S., Jaegle,M., de Wit,T.,
            Buijs,A. and Grosveld,G.
  TITLE     The translocation (6;9), associated with a specific subtype of
            acute myeloid leukemia, results in the fusion of two genes, dek and
            can, and the expression of a chimeric, leukemia-specific dek-can
            mRNA
  JOURNAL   Mol Cell Biol 12 (4), 1687-1697 (1992)
   PUBMED   1549122
REFERENCE   10 (bases 1 to 7568)
  AUTHORS   von Lindern,M., Poustka,A., Lerach,H. and Grosveld,G.
  TITLE     The (6;9) chromosome translocation, associated with a specific
            subtype of acute nonlymphocytic leukemia, leads to aberrant
            transcription of a target gene on 9q34
  JOURNAL   Mol Cell Biol 10 (8), 4016-4026 (1990)
   PUBMED   2370860
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB062584.1, AB159230.1,
            BC045620.1 and BC105998.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_005085.3.
            
            Summary: The nuclear pore complex is a massive structure that
            extends across the nuclear envelope, forming a gateway that
            regulates the flow of macromolecules between the nucleus and the
            cytoplasm. Nucleoporins are the main components of the nuclear pore
            complex in eukaryotic cells. This gene is a member of the
            FG-repeat-containing nucleoporins. The protein encoded by this gene
            is localized to the cytoplasmic face of the nuclear pore complex
            where it is required for proper cell cycle progression and
            nucleocytoplasmic transport. The 3' portion of this gene forms a
            fusion gene with the DEK gene on chromosome 6 in a t(6,9)
            translocation associated with acute myeloid leukemia and
            myelodysplastic syndrome. Alternative splicing of this gene results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X64228.1, SRR1803612.247797.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359428.10/ ENSP00000352400.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               DB062584.1         28-143
            117-2002            AB159230.1         1-1886
            2003-5733           BC045620.1         1972-5702
            5734-7568           BC105998.1         5704-7538
FEATURES             Location/Qualifiers
     source          1..7568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.13"
     gene            1..7568
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /note="nucleoporin 214"
                     /db_xref="GeneID:8021"
                     /db_xref="HGNC:HGNC:8064"
                     /db_xref="MIM:114350"
     exon            1..164
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..6392
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /note="isoform 2 is encoded by transcript variant 2; CAN
                     protein, putative oncogene; nuclear pore complex protein
                     Nup214; nucleoporin 214kDa"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup214 isoform 2"
                     /protein_id="NP_005076.3"
                     /db_xref="CCDS:CCDS6940.1"
                     /db_xref="GeneID:8021"
                     /db_xref="HGNC:HGNC:8064"
                     /db_xref="MIM:114350"
                     /translation="MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAV
                     SNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSC
                     DNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPT
                     VPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQ
                     YLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALL
                     PKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQSD
                     QINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLL
                     STDGVLCPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDAS
                     AAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYSSGSDS
                     SKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVS
                     APNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPL
                     SHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
                     SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKML
                     RTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLL
                     YKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERET
                     LFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLE
                     SLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAF
                     LSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLP
                     HAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISA
                     PQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYS
                     TAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTP
                     SASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSK
                     PSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGEL
                     LFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPP
                     VLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGK
                     TSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTE
                     EATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSG
                     TAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVE
                     TSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAP
                     SATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTF
                     GQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSF
                     SFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGF
                     GSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANK
                     NPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQG
                     FGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGT
                     AAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFS
                     FGSNNSSVQGFGGWRS"
     exon            165..360
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            361..512
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            513..711
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            712..782
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            783..846
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            847..950
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1057
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1124
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1251
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1413
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1888
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2064
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2159
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2246
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2396
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2555
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2659
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2842
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2928
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3012
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3276
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3438
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3538
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3614
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3693
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3778
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3840
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..5640
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            5641..5711
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            5712..5868
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            5869..6021
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            6022..6193
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            6194..6333
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            6334..6358
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     exon            6359..7568
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6587..6592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /note="hexamer: ATTAAA"
     polyA_site      6609
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /note="major polyA site"
     regulatory      7545..7550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
                     /note="hexamer: AATAAA"
     polyA_site      7568
                     /gene="NUP214"
                     /gene_synonym="CAIN; CAN; IIAE9"
ORIGIN      
        1 gaggtcaact gcgcgccgct ggcgctgagg ggaggaagtt tgctgtcgag cggcctgggt
       61 tccgtgggca aggccgtggg aggcagcgtt ggctgcttcg acacactgag ggcggcgcga
      121 tgggagacga gatggatgcc atgattcccg agcgggagat gaaggatttt cagtttagag
      181 cgctaaagaa ggtgagaatc tttgactccc ctgaggaatt gcccaaggaa cgctcgagtc
      241 tgcttgctgt gtccaacaaa tatggtctgg tcttcgctgg tggagccagt ggcttgcaga
      301 tttttcctac taaaaatctt cttattcaaa ataaacccgg agatgatccc aacaaaatag
      361 ttgataaagt ccaaggcttg ctagttccta tgaaattccc aatccatcac ctggccttga
      421 gctgtgataa cctcacactc tctgcgtgca tgatgtccag tgaatatggt tccattattg
      481 ctttttttga tgttcgcaca ttctcaaatg aggctaaaca gcaaaaacgc ccatttgcct
      541 atcataagct tttgaaagat gcaggaggca tggtgattga tatgaagtgg aaccccactg
      601 tcccctccat ggtggcagtt tgtctggctg atggtagtat tgctgtcctg caagtcacgg
      661 aaacagtgaa agtatgtgca actcttcctt ccacggtagc agtaacctct gtgtgctgga
      721 gccccaaagg aaagcagctg gcagtgggaa aacagaatgg aactgtggtc cagtatcttc
      781 ctactttgca ggaaaaaaaa gtcattcctt gtcctccgtt ttatgagtca gatcatcctg
      841 tcagagttct ggatgtgctg tggattggta cctacgtctt cgccatagtg tatgctgctg
      901 cagatgggac cctggaaacg tctccagatg tggtgatggc tctactaccg aaaaaagaag
      961 aaaagcaccc agagatattt gtgaacttta tggagccctg ttatggcagc tgcacggaga
     1021 gacagcatca ttactacctc agttacattg aggaatggga tttagtgctg gcagcatctg
     1081 cggcttcaac agaagttagt atccttgctc gacaaagtga tcagattaat tgggaatctt
     1141 ggctactgga ggattctagt cgagctgaat tgcctgtgac agacaagagt gatgactcct
     1201 tgcccatggg agttgtcgta gactatacaa accaagtgga aatcaccatc agtgatgaaa
     1261 agactcttcc tcctgctcca gttctcatgt tactttcaac agatggtgtg ctttgtccat
     1321 tttatatgat taatcaaaat cctggggtta agtctctcat caaaacacca gagcgacttt
     1381 cattagaagg agagcgacag cccaagtcac caggaagtac tcccactacc ccaacctcct
     1441 ctcaagcccc acagaaactg gatgcttctg cagctgcagc ccctgcctct ctgccacctt
     1501 catcacctgc tgctcccatt gccacttttt ctttgcttcc tgctggtgga gcccccactg
     1561 tgttctcctt tggttcttca tctttgaagt catctgctac ggtcactggg gagccccctt
     1621 catattccag tggctccgac agctccaaag cagccccagg ccctggccca tcaaccttct
     1681 cttttgttcc cccttctaaa gcctccctag cccccacccc tgcagcgtct cctgtggctc
     1741 catcagctgc ttcattctcc tttggatcat ctggttttaa gcctaccctg gaaagcacac
     1801 cagtgccaag tgtgtctgct ccaaatatag caatgaagcc ctccttccca ccctcaacct
     1861 ctgctgtcaa agtcaacctt agtgaaaagt ttactgctgc agctacctct actcctgtta
     1921 gtagctccca gagcgcaccc ccgatgtcgc cattctcttc tgcctccaag ccagctgctt
     1981 ctggaccact cagccacccc acacctctct cagcaccacc tagttccgtg ccattgaagt
     2041 cctcagtctt gccctcacca tcaggacgat ctgctcaggg cagttcaagc ccagtgccct
     2101 caatggtaca gaaatcaccc aggataaccc ctccagcggc aaagccaggc tctccccagg
     2161 caaagtcact tcagcctgct gttgcagaaa agcagggaca tcagtggaaa gattcagatc
     2221 ctgtaatggc tggaattggg gaggagattg cacactttca gaaggagttg gaagagttaa
     2281 aagcccgaac ttccaaagcc tgtttccaag tgggcacttc tgaggagatg aagatgctgc
     2341 gaacagaatc agatgacttg catacctttc ttttggagat taaagagacc acagagtcgc
     2401 ttcatggaga tataagtagc ctgaaaacaa ctttacttga gggctttgct ggtgttgagg
     2461 aagccagaga acaaaatgaa agaaatcgtg actctggtta tctgcatttg ctttataaaa
     2521 gaccactgga tcccaagagt gaagctcagc ttcaggaaat tcggcgcctt catcagtatg
     2581 tgaaatttgc tgtccaagat gtgaatgatg ttctagactt ggagtgggat cagcatctgg
     2641 aacaaaagaa aaaacaaagg cacctgcttg tgccagagcg agagacactg tttaacaccc
     2701 tagccaacaa tcgggaaatc atcaaccaac agaggaagag gctgaatcac ctggtggata
     2761 gtcttcagca gctccgcctt tacaaacaga cttccctgtg gagcctgtcc tcggctgttc
     2821 cttcccagag cagcattcac agttttgaca gtgacctgga aagcctgtgc aatgctttgt
     2881 tgaaaaccac catagaatct cacaccaaat ccttgcccaa agtaccagcc aaactgtccc
     2941 ccatgaaaca ggcacaactg agaaacttct tggccaagag gaagacccca ccagtgagat
     3001 ccactgctcc agccagcctg tctcgatcag cctttctgtc tcagagatat tatgaagact
     3061 tggatgaagt cagctcaacg tcatctgtct cccagtctct ggagagtgaa gatgcacgga
     3121 cgtcctgtaa agatgacgag gcagtggttc aggcccctcg gcacgccccc gtggttcgca
     3181 ctccttccat ccagcccagt ctcttgcccc atgcagcacc ttttgctaaa tctcacctgg
     3241 ttcatggttc ttcacctggt gtgatgggaa cttcagtggc tacatctgct agcaaaatta
     3301 ttcctcaagg ggccgatagc acaatgcttg ccacgaaaac cgtgaaacat ggtgcaccta
     3361 gtccttccca ccccatctca gccccgcagg cagctgccgc agcagcactc aggcggcaga
     3421 tggccagtca ggcaccagct gtaaacactt tgactgaatc aacgttgaag aatgtccctc
     3481 aagtggtaaa tgtgcaggaa ttgaagaata accctgcaac cccttctaca gccatgggtt
     3541 cttcagtgcc ctactccaca gccaaaacac ctcacccagt gttgacccca gtggctgcta
     3601 accaagccaa gcaggggtct ctaataaatt cccttaagcc atctgggcct acaccagcat
     3661 ccggtcagtt atcatctggt gacaaagctt cagggacagc caagatagaa acagctgtga
     3721 cttcaacccc atctgcttct gggcagttca gcaagccttt ctcattttct ccatcaggga
     3781 ctggctttaa ttttgggata atcacaccaa caccgtcttc taatttcact gctgcacaag
     3841 gggcaacacc ctccactaaa gagtcaagcc agccggacgc attctcatct ggtgggggaa
     3901 gcaaaccttc ttatgaggcc attcctgaaa gctcacctcc ctcaggaatc acatccgcat
     3961 caaacaccac cccaggagaa cctgccgcat ctagcagcag acctgtggca ccttctggaa
     4021 ctgctctttc caccacctct agtaagctgg aaaccccacc gtccaagctg ggagagcttc
     4081 tgtttccaag ttctttggct ggagagactc tgggaagttt ttcaggactg cgggttggcc
     4141 aagcagatga ttctacaaaa ccaaccaata aggcttcatc cacaagccta actagtaccc
     4201 agccaaccaa gacgtcaggc gtgccctcag ggtttaattt tactgccccc ccggtgttag
     4261 ggaagcacac ggagccccct gtgacatcct ctgcaaccac cacctcagta gcaccaccag
     4321 cagccaccag cacttcctca actgccgttt ttggcagtct gccagtcacc agtgcaggat
     4381 cctctggggt catcagtttt ggtgggacat ctctaagtgc tggcaagact agtttttcat
     4441 ttggaagcca acagaccaat agcacagtgc ccccatctgc cccaccacca actacagctg
     4501 ccactcccct tccaacatca ttccccacat tgtcatttgg tagcctcctg agttcagcaa
     4561 ctaccccctc cctgcctatg tccgctggca gaagcacaga agaggccact tcatcagctt
     4621 tgcctgagaa gccaggtgac agtgaggtct cagcatcagc agcctcactt ctagaggagc
     4681 aacagtcagc ccagcttccc caggctcctc cgcaaacttc tgactctgtt aaaaaagaac
     4741 ctgttcttgc ccagcctgca gtcagcaact ctggcactgc agcatctagt actagtcttg
     4801 tagcactttc tgcagaggct accccagcca ccacgggggt ccctgatgcc aggacggagg
     4861 cagtaccacc tgcttcctcc ttttctgtgc ctgggcagac tgctgtcaca gcagctgcta
     4921 tctcaagtgc aggccctgtg gccgtcgaaa catcaagtac ccccatagcc tccagcacca
     4981 cgtccattgt tgctcccggc ccatctgcag aggcagcagc atttggtacc gtcacttctg
     5041 gctcatccgt ctttgctcag cctcctgctg ccagttctag ctcagctttc aaccagctca
     5101 ccaacaacac agccactgcc ccctctgcca cgcccgtgtt tgggcaagtg gcagccagca
     5161 ccgcaccaag tctgtttggg cagcagactg gtagcacagc cagcacagca gctgccacac
     5221 cacaggtcag cagctcaggg tttagcagcc cagcttttgg taccacagcc ccaggggtct
     5281 ttggacagac aaccttcggg caggcctcag tctttgggca gtcggcgagc agtgctgcaa
     5341 gtgtcttttc cttcagtcag cctgggttca gttccgtgcc tgccttcggt cagcctgctt
     5401 cctccactcc cacatccacc agtggaagtg tctttggtgc cgcctcaagt accagtagct
     5461 ccagttcctt ctcatttgga cagtcttctc ccaacacagg aggggggctg tttggccaaa
     5521 gcaacgctcc tgcttttggg cagagtcctg gctttggaca gggaggctct gtctttggtg
     5581 gtacctcagc tgccaccaca acagcagcaa cctctgggtt cagcttttgc caagcttcag
     5641 gttttgggtc tagtaatact ggttctgtgt ttggtcaagc agccagtact ggtggaatag
     5701 tctttggcca gcaatcatcc tcttccagtg gtagcgtgtt tgggtctgga aacactggaa
     5761 gagggggagg tttcttcagt ggccttggag gaaaacccag tcaggatgca gccaacaaaa
     5821 acccattcag ctcggccagt gggggctttg gatccacagc tacctcaaat acctctaacc
     5881 tatttggaaa cagtggggcc aagacatttg gtggatttgc cagctcgtcg tttggagagc
     5941 agaaacccac tggcactttc agctctggag gaggaagtgt ggcatcccaa ggctttgggt
     6001 tttcctctcc aaacaaaaca ggtggcttcg gtgctgctcc agtgtttggc agccctccta
     6061 cttttggggg atcccctggg tttggagggg tgccagcatt cggttcagcc ccagccttta
     6121 caagccctct gggctcgacg ggaggcaaag tgttcggaga gggcactgca gctgccagcg
     6181 caggaggatt cgggtttggg agcagcagca acaccacatc cttcggcacg ctcgcgagtc
     6241 agaatgcccc cactttcgga tcactgtccc aacagacttc tggttttggg acccagagta
     6301 gcggattctc tggttttgga tcaggcacag gagggttcag ctttgggtca aataactcgt
     6361 ctgtccaggg ttttggtggc tggcgaagct gagggcgtgt cagcaggcct ttcgatccct
     6421 gggaccaacc gcatcctcag cttcttcccc gagaaatgct ggagcaggct gttcagaccg
     6481 acgttgccat caaaacacat acacccagaa agaaacaaca gaaaccaaaa ctcacaaggc
     6541 gcatgattac ttgttttata tttcatgttg ggttttccct cccactatta aacagtctgt
     6601 ttccgtacag aacgtatgtg ggttttttca gatcacagcc aagaagattg ccccgtttct
     6661 gtggctctga gaagccagca gagcctccat cagccagaac actgtgtctt caaggatggc
     6721 atcagaagtc accagcgtcg ggtgttgata aacagcatcg aatgtgccgt ggtctcactt
     6781 ggacctagcg ccctccacat agggaagagg ttgaatgctg gtgggtcatc tttttgaggc
     6841 tgaaacttgg ttatctcctc tccttgttct tttagccatt gtgtatcagg accatccaag
     6901 gacgcactct gcgattgagt ggaggcagag gaagccactc atgccagcag cagttgagtt
     6961 tcagaagcag ccatagcgct tttcagtaca gtacaatagt agccagcgtg aggcaggaca
     7021 gtgctgcgcc ttagccggcc ttggctctca tctccatgtg gctcttgggt gccatgtgtc
     7081 ctactccaga gaggaggggg ccggtcactt gagaagacag cctttatatt ctgtatgtgg
     7141 cagtgacatt ggtagccaca cctacccagt gtctactaac cacagtgcag atagcccttg
     7201 ggtagaccca ggaagtgtga agacagacac tgctgttgcc agacaacact agcagaacga
     7261 tgctggattt gacaacagtg tttgctagga cggcccagag ctcatcactg cagttttatt
     7321 agagtgcttc tttatcttta atgcagtatc tttgaggcct gtaacatcct agatagttgc
     7381 catcaaacaa ggaccgtctc gcattgaaaa cagatgtaag aatttctctt tcaggcccag
     7441 aatctgacag tgctttggct tgggtcatga gcagcgggga gttgggaaga gatttttttt
     7501 tttagagttt tacatattgg caggttgtat ttttttaatg ttttaataaa agtttgacat
     7561 gacattaa
//
