LOCUS       NM_024923               7206 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleoporin 210 (NUP210), mRNA.
ACCESSION   NM_024923
VERSION     NM_024923.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7206)
  AUTHORS   Li,M. and Zhao,H.
  TITLE     Bioinformatics analysis of the expression and clinical significance
            of the NUP210 Gene in acute myeloid leukaemia
  JOURNAL   Hematology 27 (1), 456-462 (2022)
   PUBMED   35413221
  REMARK    GeneRIF: Bioinformatics analysis of the expression and clinical
            significance of the NUP210 Gene in acute myeloid leukaemia.
REFERENCE   2  (bases 1 to 7206)
  AUTHORS   Kondo,H., Mishiro,K., Iwashima,Y., Qiu,Y., Kobayashi,A., Lim,K.,
            Domoto,T., Minamoto,T., Ogawa,K., Kunishima,M., Hazawa,M. and
            Wong,R.W.
  TITLE     Discovery of a Novel Aminocyclopropenone Compound That Inhibits
            BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal
            Cancer Growth
  JOURNAL   Cells 11 (3), 317 (2022)
   PUBMED   35159127
  REMARK    GeneRIF: Discovery of a Novel Aminocyclopropenone Compound That
            Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates
            Colorectal Cancer Growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7206)
  AUTHORS   Amin,R., Shukla,A., Zhu,J.J., Kim,S., Wang,P., Tian,S.Z.,
            Tran,A.D., Paul,D., Cappell,S.D., Burkett,S., Liu,H., Lee,M.P.,
            Kruhlak,M.J., Dwyer,J.E., Simpson,R.M., Hager,G.L., Ruan,Y. and
            Hunter,K.W.
  TITLE     Nuclear pore protein NUP210 depletion suppresses metastasis through
            heterochromatin-mediated disruption of tumor cell mechanical
            response
  JOURNAL   Nat Commun 12 (1), 7216 (2021)
   PUBMED   34903738
  REMARK    GeneRIF: Nuclear pore protein NUP210 depletion suppresses
            metastasis through heterochromatin-mediated disruption of tumor
            cell mechanical response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7206)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 7206)
  AUTHORS   Hong,S.H., Son,K.H., Ha,S.Y., Wee,T.I., Choi,S.K., Won,J.E.,
            Han,H.D., Ro,Y., Park,Y.M., Eun,J.W., Nam,S.W., Han,J.W., Kang,K.
            and You,J.S.
  TITLE     Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer
  JOURNAL   Cancer Res 81 (2), 356-370 (2021)
   PUBMED   33239431
  REMARK    GeneRIF: Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver
            Cancer.
REFERENCE   6  (bases 1 to 7206)
  AUTHORS   Bodoor,K., Shaikh,S., Enarson,P., Chowdhury,S., Salina,D.,
            Raharjo,W.H. and Burke,B.
  TITLE     Function and assembly of nuclear pore complex proteins
  JOURNAL   Biochem Cell Biol 77 (4), 321-329 (1999)
   PUBMED   10546895
  REMARK    Review article
REFERENCE   7  (bases 1 to 7206)
  AUTHORS   Favreau,C., Worman,H.J., Wozniak,R.W., Frappier,T. and
            Courvalin,J.C.
  TITLE     Cell cycle-dependent phosphorylation of nucleoporins and nuclear
            pore membrane protein Gp210
  JOURNAL   Biochemistry 35 (24), 8035-8044 (1996)
   PUBMED   8672508
REFERENCE   8  (bases 1 to 7206)
  AUTHORS   Nickowitz,R.E. and Worman,H.J.
  TITLE     Autoantibodies from patients with primary biliary cirrhosis
            recognize a restricted region within the cytoplasmic tail of
            nuclear pore membrane glycoprotein Gp210
  JOURNAL   J Exp Med 178 (6), 2237-2242 (1993)
   PUBMED   7504063
REFERENCE   9  (bases 1 to 7206)
  AUTHORS   Courvalin,J.C., Lassoued,K., Bartnik,E., Blobel,G. and Wozniak,R.W.
  TITLE     The 210-kD nuclear envelope polypeptide recognized by human
            autoantibodies in primary biliary cirrhosis is the major
            glycoprotein of the nuclear pore
  JOURNAL   J Clin Invest 86 (1), 279-285 (1990)
   PUBMED   2195063
REFERENCE   10 (bases 1 to 7206)
  AUTHORS   Greber,U.F., Senior,A. and Gerace,L.
  TITLE     A major glycoprotein of the nuclear pore complex is a
            membrane-spanning polypeptide with a large lumenal domain and a
            small cytoplasmic tail
  JOURNAL   EMBO J 9 (5), 1495-1502 (1990)
   PUBMED   2184032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027124.5, HY177936.1,
            BC067089.1, AK074101.1, AB020713.1 and BM508095.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024923.3.
            
            Summary: The nuclear pore complex is a massive structure that
            extends across the nuclear envelope, forming a gateway that
            regulates the flow of macromolecules between the nucleus and the
            cytoplasm. Nucleoporins are the main components of the nuclear pore
            complex in eukaryotic cells. The protein encoded by this gene is a
            membrane-spanning glycoprotein that is a major component of the
            nuclear pore complex. Multiple pseudogenes related to this gene are
            located on chromosome 3. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000254508.7/ ENSP00000254508.5
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC027124.5         96633-96635         c
            4-85                HY177936.1         1-82
            86-2453             BC067089.1         1-2368
            2454-3143           AK074101.1         73-762
            3144-4428           AB020713.1         157-1441
            4429-5963           AK074101.1         2048-3582
            5964-6736           AB020713.1         2977-3749
            6737-7206           BM508095.1         15-484              c
FEATURES             Location/Qualifiers
     source          1..7206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..7206
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /note="nucleoporin 210"
                     /db_xref="GeneID:23225"
                     /db_xref="HGNC:HGNC:30052"
                     /db_xref="MIM:607703"
     exon            1..263
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..5760
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /note="nuclear pore membrane glycoprotein 210; nucleoporin
                     Nup210; nuclear pore protein gp210; pore membrane protein
                     of 210 kDa; nuclear envelope pore membrane protein POM
                     210; nucleoporin 210kDa"
                     /codon_start=1
                     /product="nuclear pore membrane glycoprotein 210
                     precursor"
                     /protein_id="NP_079199.2"
                     /db_xref="CCDS:CCDS33704.1"
                     /db_xref="GeneID:23225"
                     /db_xref="HGNC:HGNC:30052"
                     /db_xref="MIM:607703"
                     /translation="MAARGRGLLLLTLSVLLAAGPSAAAAKLNIPKVLLPFTRATRVN
                     FTLEASEGCYRWLSTRPEVASIEPLGLDEQQCSQKAVVQARLTQPARLTSIIFAEDIT
                     TGQVLRCDAIVDLIHDIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWT
                     IVKDSEADRFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKL
                     KARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLMVGTSIHYKVQKIRQGKITELSM
                     PSDQYELQLQNSIPGPEGDPARPVAVLAQDTSMVTALQLGQSSLVLGHRSIRMQGASR
                     LPNSTIYVVEPGYLGFTVHPGDRWVLETGRLYEITIEVFDKFSNKVYVSDNIRIETVL
                     PAEFFEVLSSSQNGSYHRIRALKRGQTAIDAALTSVVDQDGGVHILQVPVWNQQEVEI
                     HIPITLYPSILTFPWQPKTGAYQYTIRAHGGSGNFSWSSSSHLVATVTVKGVMTTGSD
                     IGFSVIQAHDVQNPLHFGEMKVYVIEPHSMEFAPCQVEARVGQALELPLRISGLMPGG
                     ASEVVTLSDCSHFDLAVEVENQGVFQPLPGRLPPGSEHCSGIRVKAEAQGSTTLLVSY
                     RHGHVHLSAKITIAAYLPLKAVDPSSVALVTLGSSKEMLFEGGPRPWILEPSKFFQNV
                     TAEDTDSIGLALFAPHSSRNYQQHWILVTCQALGEQVIALSVGNKPSLTNPFPAVEPA
                     VVKFVCAPPSRLTLAPVYTSPQLDMSCPLLQQNKQVVPVSSHRNPRLDLAAYDQEGRR
                     FDNFSSLSIQWESTRPVLASIEPELPMQLVSQDDESGQKKLHGLQAILVHEASGTTAI
                     TATATGYQESHLSSARTKQPHDPLVPLSASIELILVEDVRVSPEEVTIYNHPGIQAEL
                     RIREGSGYFFLNTSTADVVKVAYQEARGVAMVHPLLPGSSTIMIHDLCLVFPAPAKAV
                     VYVSDIQELYIRVVDKVEIGKTVKAYVRVLDLHKKPFLAKYFPFMDLKLRAASPIITL
                     VALDEALDNYTITFLIRGVAIGQTSLTASVTNKAGQRINSAPQQIEVFPPFRLMPRKV
                     TLLIGATMQVTSEGGPQPQSNILFSISNESVALVSAAGLVQGLAIGNGTVSGLVQAVD
                     AETGKVVIISQDLVQVEVLLLRAVRIRAPIMRMRTGTQMPIYVTGITNHQNPFSFGNA
                     VPGLTFHWSVTKRDVLDLRGRHHEASIRLPSQYNFAMNVLGRVKGRTGLRVVVKAVDP
                     TSGQLYGLARELSDEIQVQVFEKLQLLNPEIEAEQILMSPNSYIKLQTNRDGAASLSY
                     RVLDGPEKVPVVHVDEKGFLASGSMIGTSTIEVIAQEPFGANQTIIVAVKVSPVSYLR
                     VSMSPVLHTQNKEALVAVPLGMTVTFTVHFHDNSGDVFHAHSSVLNFATNRDDFVQIG
                     KGPTNNTCVVRTVSVGLTLLRVWDAEHPGLSDFMPLPVLQAISPELSGAMVVGDVLCL
                     ATVLTSLEGLSGTWSSSANSILHIDPKTGVAVARAVGSVTVYYEVAGHLRTYKEVVVS
                     VPQRIMARHLHPIQTSFQEATASKVIVAVGDRSSNLRGECTPTQREVIQALHPETLIS
                     CQSQFKPAVFDFPSQDVFTVEPQFDTALGQYFCSITMHRLTDKQRKHLSMKKTALVVS
                     ASLSSSHFSTEQVGAEVPFSPGLFADQAEILLSNHYTSSEIRVFGAPEVLENLEVKSG
                     SPAVLAFAKEKSFGWPSFITYTVGVLDPAAGSQGPLSTTLTFSSPVTNQAIAIPVTVA
                     FVVDRRGPGPYGASLFQHFLDSYQVMFFTLFALLAGTAVMIIAYHTVCTPRDLAVPAA
                     LTPRASPGHSPHYFAASSPTSPNALPPARKASPPSGLWSPAYASH"
     exon            264..400
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            401..532
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            533..629
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            630..780
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            781..913
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1072
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1141
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1248
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1389
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1527
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1683
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1882
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2028
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2250
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2424
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2617
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2724
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2829
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2931
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3060
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3188
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3324
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3387
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3567
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3648
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3780
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3939
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4031
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4206
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            4207..4382
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            4383..4603
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            4604..4740
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            4741..4864
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..5011
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5262
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            5263..5479
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            5480..5575
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            5576..5659
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     exon            5660..7206
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7182..7187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /note="hexamer: AATAAA"
     polyA_site      7206
                     /gene="NUP210"
                     /gene_synonym="GP210; POM210"
                     /note="major polyA site"
ORIGIN      
        1 acctgctggc ctggcgcgcg cgcgggcggg agcggagggc aacggggcgg cgcgggcggc
       61 cgggcgcagg gtcgcgggag gtgacgcgcg gcgaggatgg cggcgcgggg ccgggggctg
      121 ctgctgctga cgctgtcggt gctgttggcg gcgggcccct ccgccgctgc ggccaagctc
      181 aacatcccca aagtgctgct gcccttcacg cgggccacgc gcgttaactt cacgctggag
      241 gcctcggagg gctgctaccg ctggttgtcc acccggccgg aggtggccag catcgagccg
      301 ctgggcctgg acgagcagca gtgctcccag aaggcagtgg tgcaggcccg cctgacccag
      361 cctgcccgcc tcaccagcat catcttcgca gaggacatca ccacaggcca ggtcctgcgc
      421 tgtgatgcca ttgtggacct catccatgac atccagatcg tctccaccac ccgcgagctc
      481 tacctggagg actcccccct ggagctgaag atccaggccc tggactccga agggaacacc
      541 ttcagcactc tggctggact ggtcttcgag tggacgattg tgaaggactc cgaggcggac
      601 aggttctcag actcccacaa tgcgctgcga atcctcactt tcttggagtc tacgtacatc
      661 cctccttctt acatctcaga gatggagaag gctgccaagc aaggggacac catcctggtg
      721 tctgggatga agaccgggag ctccaagctc aaggctcgca tccaggaggc tgtctacaag
      781 aatgtacgcc ctgcagaagt caggctgctg attttggaaa acatccttct gaacccggcc
      841 tatgacgtct acctgatggt gggaacctcc attcactaca aggtgcagaa gatcaggcaa
      901 gggaaaatta cagaactctc catgccttcc gatcagtacg agttgcagct tcagaacagc
      961 atcccgggcc ccgaaggaga cccagcccgg ccggtggctg tcttggccca ggacacgtcg
     1021 atggtcactg cactgcagct gggacagagc agcctcgtcc ttggccacag gagtattcgc
     1081 atgcaaggtg cttctaggtt acccaacagc actatctacg tggtcgaacc tggataccta
     1141 gggttcactg ttcaccctgg tgacaggtgg gtgctggaga ccggccgcct gtatgaaatc
     1201 accatcgaag tttttgacaa gttcagcaac aaggtctatg tatctgacaa catccgaatt
     1261 gaaactgtgc ttcctgctga gttcttcgag gtgctctcgt cctcccagaa tgggtcatac
     1321 catcgcatca gggcactaaa gaggggacag acggccattg acgcggccct cacctctgtg
     1381 gtggaccagg atggaggggt ccacatacta caggtgcctg tgtggaacca gcaggaggtg
     1441 gaaattcaca tcccgatcac cctgtatccc agcatcttga catttccgtg gcaaccaaag
     1501 acgggcgcct atcagtacac aataagggcc cacggtggca gtgggaactt cagctggtct
     1561 tcgtcaagcc acctggttgc cacagttact gtcaagggcg tgatgaccac aggcagtgac
     1621 atcgggttca gtgtgatcca ggcacatgat gtgcagaacc cactccattt cggtgagatg
     1681 aaggtgtatg tgatcgagcc ccacagcatg gagtttgccc cgtgccaggt ggaggcacgt
     1741 gtgggccagg ccctggagct gcccctgagg atcagtggcc tcatgcccgg cggggccagt
     1801 gaggtggtca ccttgagcga ctgctcccac tttgacttgg ctgtcgaggt ggagaaccag
     1861 ggtgtgttcc agccactccc agggaggctg ccgccaggct ctgagcactg cagcggcatc
     1921 cgggtaaagg ccgaggccca gggctctacc acgcttcttg tgagctacag acacggccac
     1981 gtccacctga gtgccaagat caccattgct gcctacctgc ccctcaaggc tgtggatccc
     2041 tcctctgttg ccttggtaac cctgggctcc tcaaaggaga tgctgtttga aggaggtccc
     2101 agaccttgga tcctcgagcc gtccaaattc ttccagaacg tcaccgctga ggacactgac
     2161 agcatcggcc tggctctctt tgccccccat tcctcccgga attatcagca acactggatc
     2221 cttgtgacct gtcaggcctt gggtgagcag gtcatcgccc tgtcggtggg gaacaagccc
     2281 agcctcacca acccctttcc tgcggtggag cctgccgtgg tgaagttcgt ctgcgcccca
     2341 ccgtccaggc tcaccctcgc gcctgtctac accagccccc agctggacat gtcctgtccg
     2401 ctgctgcagc agaacaagca ggtggtccca gtgtccagcc accgcaaccc ccggctggac
     2461 ctggctgctt acgaccagga gggccgccgg ttcgacaact tcagctctct gagcatccag
     2521 tgggagtcca ccaggccagt gttggccagc atcgagcctg agctgcccat gcagctggtg
     2581 tcccaggacg atgagagtgg ccaaaagaag ctgcacggtt tgcaggccat tttggttcac
     2641 gaggcatcag gaaccacagc catcactgcc actgccactg gctaccagga gtcccacctc
     2701 agctctgcca gaacaaagca gccgcatgac cctctggtgc ctctgtcggc ctccatagag
     2761 ctcatcctgg tggaggacgt gagggtgagc ccagaagagg tgaccatcta caaccaccct
     2821 ggcatccagg cagagctccg catcagggaa ggctcaggtt acttcttcct caacaccagc
     2881 accgcagatg ttgtcaaggt ggcctaccag gaggccaggg gtgtcgccat ggtgcaccct
     2941 ttgctcccgg gctcatccac catcatgatc catgacttgt gcctcgtctt cccggcccca
     3001 gccaaggctg tcgtttacgt gtcggacatt caggagctgt acatccgtgt ggttgacaag
     3061 gtggagattg ggaagacagt gaaggcatac gtccgcgtgc tggacttgca caagaagccc
     3121 ttccttgcca aatacttccc ctttatggac ctgaagctcc gagcagcctc cccgatcatt
     3181 acattggtgg cccttgatga agcccttgac aactacacca tcacattcct catccgcggt
     3241 gtggccatcg gccagaccag tctaactgca agtgtgacca ataaagctgg acagagaatc
     3301 aactcagccc cacaacagat tgaagtcttt cccccgttca ggctgatgcc caggaaggtg
     3361 acactgctta tcggggccac gatgcaggtc acctccgagg gcggccccca gcctcagtcc
     3421 aacatccttt tctccatcag caatgagagc gttgcgctgg tgagcgctgc tgggctggta
     3481 cagggcctcg ccatcgggaa cggcactgtg tctgggctcg tgcaggcagt ggatgcagag
     3541 accggcaagg tggtcatcat ctctcaggac ctcgtgcagg tggaggtgct gctgctaagg
     3601 gccgtgagga tccgcgcccc catcatgcgg atgaggacgg gcacccagat gcccatctat
     3661 gtcaccggca tcaccaacca ccagaaccct ttctcctttg gcaatgccgt gccaggcctg
     3721 accttccact ggtctgtcac caagcgggac gtcctggacc tccgagggcg gcaccacgag
     3781 gcgtcgatcc gactcccgtc acagtacaac tttgccatga acgtgctcgg ccgggtaaaa
     3841 ggccggaccg ggctgagggt ggtggtcaag gctgtggacc ccacatcggg gcagctgtat
     3901 ggcctggcca gagaactctc ggatgagatc caagtccagg tgtttgagaa gctgcagctg
     3961 ctcaaccctg aaatagaagc agaacaaata ttaatgtcgc ccaactcata tataaagctg
     4021 cagacaaaca gggatggtgc agcctctctg agctaccgcg tcctggatgg acccgaaaag
     4081 gttccagttg tgcatgttga tgagaaaggc tttctagcat cagggtctat gatcgggaca
     4141 tccaccatcg aagtgattgc acaagagccc tttggggcca accaaaccat cattgttgct
     4201 gtaaaggtat cccctgtttc ctacctgagg gtttccatga gccctgtcct gcacacccag
     4261 aacaaggagg ccctggtggc cgtgcctttg ggaatgaccg tgaccttcac tgtccacttc
     4321 cacgacaact ctggagatgt cttccatgct cacagttcgg tcctcaactt tgccactaac
     4381 agagacgact ttgtgcagat cgggaagggc cccaccaaca acacctgcgt tgtccgcaca
     4441 gtcagcgtgg gcctgacact gctccgtgtg tgggacgcag agcacccggg cctctcggac
     4501 ttcatgcccc tgcctgtcct acaggccatc tccccagagc tgtctggggc catggtggtg
     4561 ggggacgtgc tctgtctggc cactgttctg accagcctgg aaggcctctc aggaacctgg
     4621 agctcctcgg ccaacagcat cctccacatc gaccccaaga cgggtgtggc tgtggcccgg
     4681 gccgtgggat ccgtgacggt ttactatgag gtcgctgggc acctgaggac ctacaaggag
     4741 gtggtggtca gcgtccctca gaggatcatg gcccgtcacc tccaccccat ccagaccagc
     4801 ttccaggagg ctacagcctc caaagtgatt gttgccgtgg gagacagaag ctctaacctg
     4861 agaggcgagt gcacccccac ccagagggaa gtcatccagg ccttgcaccc agagaccctc
     4921 atcagctgcc agtcccagtt caagccggcc gtctttgatt tcccatctca agatgtgttc
     4981 accgtggagc cacagtttga cactgctctc ggccagtact tctgctcaat cacaatgcac
     5041 aggctgacgg acaagcagcg gaagcacctg agcatgaaga agacagctct ggtggtcagt
     5101 gcctccctct ccagcagcca cttctccaca gagcaggtgg gggccgaggt gcccttcagc
     5161 ccaggtctct tcgccgacca ggctgaaatc cttttgagca accactacac cagttccgag
     5221 atcagggtct ttggtgcccc ggaggttctg gagaacttgg aggtgaaatc cgggtccccg
     5281 gccgtgctgg cattcgcaaa ggagaagtct tttgggtggc ccagcttcat cacatacacg
     5341 gtcggcgtct tggaccccgc ggctggcagc caagggcctc tgtccactac cctgaccttc
     5401 tccagccccg tgaccaacca agccattgcc atcccagtga cagtggcttt tgtggtggat
     5461 cgccgtgggc ccggtcctta tggagccagc ctcttccagc acttcctgga ttcctaccag
     5521 gtcatgttct tcacgctctt cgccctgttg gctgggacag cggtcatgat catagcctac
     5581 cacactgtct gcacgccccg ggatcttgct gtgcctgcag ccctcacgcc tcgagccagc
     5641 cctggacaca gcccccacta tttcgctgcc tcatcaccca catctcccaa tgcattgcct
     5701 cctgctcgca aagccagccc tccctcaggg ctgtggagcc cagcctatgc ctcccactag
     5761 gccgcgtgaa ggttcccgga ggatgggtct cagccgagcc tcgtgcaccc ccaagatgga
     5821 acatccctgc tgcattcaca ctggaacaag cccctccaga tgagtgcccc ggccccaggc
     5881 cagcttcact gccgtctctt cacacagagc tgtagtttcg gctctgccca ttagctcatt
     5941 ttatgtagga gttttaaatg tgtgtttttt tcctttcaag tcttacaaag ctaagacttt
     6001 ttggctcatt cctttttgca tggttgtcta gggtttctgg acaatgtgct gttgcatttt
     6061 tattttccta gccttgctaa aatctttccc ttctcaagac tttgagcagt tagaagtgct
     6121 ctttagaagt tgtctgtggg tgatgttact gtagtggtct cagggaaagg attgtccagt
     6181 tactttaggg ggtttttggt ggggtttttc cccctgtgaa aacttacttt gcccctagtc
     6241 tggctgctgc taggacttct gaggagcaat gggacatgag tgtccctgta tctgcgccac
     6301 tgccgcaagg gaagcctcag gaaccagcac ctggaggcca ggatagccaa gccctgggtg
     6361 agcgagaggc tggagaacac aggagctcac ccagggctgc tgcccaacca tgggccactg
     6421 tgaacagact tcagtcctct gtttttgttt cataagccgt tgagacatct gatggacttg
     6481 gcttaggccc tgctgggaca tcccacgtgt gatccctttc actccatcag gacaccagga
     6541 ctgtccttag gaaaatgtcc ttgagatggc agcaggagtc atattttctg tgtgtgtgtt
     6601 tcggaaagcc gctgtgtcct gcctcagcac aaagacccag tgtcatttgc tcctcctgtt
     6661 cctgtgccac tccagaacct cagcagatct gagccaccgc ctgccagtgt gagaggcggc
     6721 cactttcatg gcagctcatc aggcgcaggg ccccagacag cttcccagca ggccctagag
     6781 cccggcctgg gccaatgatg gagggcggcc gccagcccag ggcctgccca tccagaaggg
     6841 actccccagg gcctggggga ggagaccctt ggaaaagtcc tctcttccca gctcctgatt
     6901 ctggatctga gattctcaga tcacaggccc ctgtgctcca ggccgaggct gggctaccct
     6961 cagggagatc cagagactca tgcccatggc catccatgcg tggacgctgt gtggagagtc
     7021 caggatgacg ggatcccgca caagctccct tcagtccttc agggctgggc catgtggttg
     7081 atttttctaa agctggagaa aggaagaatt gtgccttgca tattacttga gcttaaactg
     7141 acaacctgga tgtaaatagg agcctttcta ctggtttatt taataaagtt ctatgtgatt
     7201 ttttaa
//
