LOCUS       NM_015231               5228 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens nucleoporin 160 (NUP160), transcript variant 1, mRNA.
ACCESSION   NM_015231 XM_113678
VERSION     NM_015231.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5228)
  AUTHORS   Han,Y., Sha,H., Yang,Y., Yu,Z., Zhou,L., Wang,Y., Yang,F., Qiu,L.,
            Zhang,Y. and Zhou,J.
  TITLE     Mutations in the NUP93, NUP107 and NUP160 genes cause
            steroid-resistant nephrotic syndrome in Chinese children
  JOURNAL   Ital J Pediatr 50 (1), 81 (2024)
   PUBMED   38650033
  REMARK    GeneRIF: Mutations in the NUP93, NUP107 and NUP160 genes cause
            steroid-resistant nephrotic syndrome in Chinese children.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5228)
  AUTHORS   Xie,J., Yuan,Y., Yao,G., Yu,W. and Zhu,Q.
  TITLE     Role and Mechanism of NUP160-regulated Autophagy in Pathogenesis of
            Diabetic Nephropathy
  JOURNAL   Iran J Kidney Dis 17 (6), 327-334 (2023)
   PUBMED   38043110
  REMARK    GeneRIF: Role and Mechanism of NUP160-regulated Autophagy in
            Pathogenesis of Diabetic Nephropathy.
REFERENCE   3  (bases 1 to 5228)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5228)
  AUTHORS   Braun,D.A., Lovric,S., Schapiro,D., Schneider,R., Marquez,J.,
            Asif,M., Hussain,M.S., Daga,A., Widmeier,E., Rao,J., Ashraf,S.,
            Tan,W., Lusk,C.P., Kolb,A., Jobst-Schwan,T., Schmidt,J.M.,
            Hoogstraten,C.A., Eddy,K., Kitzler,T.M., Shril,S., Moawia,A.,
            Schrage,K., Khayyat,A.I.A., Lawson,J.A., Gee,H.Y., Warejko,J.K.,
            Hermle,T., Majmundar,A.J., Hugo,H., Budde,B., Motameny,S.,
            Altmuller,J., Noegel,A.A., Fathy,H.M., Gale,D.P., Waseem,S.S.,
            Khan,A., Kerecuk,L., Hashmi,S., Mohebbi,N., Ettenger,R.,
            Serdaroglu,E., Alhasan,K.A., Hashem,M., Goncalves,S., Ariceta,G.,
            Ubetagoyena,M., Antonin,W., Baig,S.M., Alkuraya,F.S., Shen,Q.,
            Xu,H., Antignac,C., Lifton,R.P., Mane,S., Nurnberg,P., Khokha,M.K.
            and Hildebrandt,F.
  TITLE     Mutations in multiple components of the nuclear pore complex cause
            nephrotic syndrome
  JOURNAL   J Clin Invest 128 (10), 4313-4328 (2018)
   PUBMED   30179222
REFERENCE   5  (bases 1 to 5228)
  AUTHORS   Schwartz,T.U.
  TITLE     The Structure Inventory of the Nuclear Pore Complex
  JOURNAL   J Mol Biol 428 (10 Pt A), 1986-2000 (2016)
   PUBMED   27016207
  REMARK    Review article
REFERENCE   6  (bases 1 to 5228)
  AUTHORS   Loiodice,I., Alves,A., Rabut,G., Van Overbeek,M., Ellenberg,J.,
            Sibarita,J.B. and Doye,V.
  TITLE     The entire Nup107-160 complex, including three new members, is
            targeted as one entity to kinetochores in mitosis
  JOURNAL   Mol Biol Cell 15 (7), 3333-3344 (2004)
   PUBMED   15146057
REFERENCE   7  (bases 1 to 5228)
  AUTHORS   Le Rouzic,E., Mousnier,A., Rustum,C., Stutz,F., Hallberg,E.,
            Dargemont,C. and Benichou,S.
  TITLE     Docking of HIV-1 Vpr to the nuclear envelope is mediated by the
            interaction with the nucleoporin hCG1
  JOURNAL   J Biol Chem 277 (47), 45091-45098 (2002)
   PUBMED   12228227
REFERENCE   8  (bases 1 to 5228)
  AUTHORS   Vasu,S., Shah,S., Orjalo,A., Park,M., Fischer,W.H. and Forbes,D.J.
  TITLE     Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA
            export
  JOURNAL   J Cell Biol 155 (3), 339-354 (2001)
   PUBMED   11684705
REFERENCE   9  (bases 1 to 5228)
  AUTHORS   Belgareh,N., Rabut,G., Bai,S.W., van Overbeek,M., Beaudouin,J.,
            Daigle,N., Zatsepina,O.V., Pasteau,F., Labas,V., Fromont-Racine,M.,
            Ellenberg,J. and Doye,V.
  TITLE     An evolutionarily conserved NPC subcomplex, which redistributes in
            part to kinetochores in mammalian cells
  JOURNAL   J Cell Biol 154 (6), 1147-1160 (2001)
   PUBMED   11564755
REFERENCE   10 (bases 1 to 5228)
  AUTHORS   Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A.
  TITLE     Nuclear import of hepatic glucokinase depends upon glucokinase
            regulatory protein, whereas export is due to a nuclear export
            signal sequence in glucokinase
  JOURNAL   J Biol Chem 274 (52), 37125-37130 (1999)
   PUBMED   10601273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023232.16 and AC021443.27.
            
            On May 26, 2021 this sequence version replaced NM_015231.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832029.1, AK304308.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378460.7/ ENSP00000367721.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC023232.16        187796-187927
            133-244             AC023232.16        188187-188298
            245-455             AC021443.27        192865-193075       c
            456-678             AC021443.27        192330-192552       c
            679-757             AC021443.27        190032-190110       c
            758-872             AC021443.27        189374-189488       c
            873-1031            AC021443.27        188138-188296       c
            1032-1109           AC021443.27        174574-174651       c
            1110-1207           AC021443.27        174211-174308       c
            1208-1292           AC021443.27        171861-171945       c
            1293-1361           AC021443.27        170543-170611       c
            1362-1445           AC021443.27        168433-168516       c
            1446-1616           AC021443.27        167966-168136       c
            1617-1716           AC021443.27        165803-165902       c
            1717-1882           AC021443.27        165369-165534       c
            1883-2010           AC021443.27        164789-164916       c
            2011-2171           AC021443.27        164551-164711       c
            2172-2305           AC021443.27        160883-161016       c
            2306-2376           AC021443.27        159557-159627       c
            2377-2536           AC021443.27        158640-158799       c
            2537-2606           AC021443.27        157036-157105       c
            2607-2705           AC021443.27        155925-156023       c
            2706-2825           AC021443.27        154298-154417       c
            2826-2921           AC021443.27        150855-150950       c
            2922-3016           AC021443.27        150655-150749       c
            3017-3113           AC021443.27        150465-150561       c
            3114-3219           AC021443.27        150266-150371       c
            3220-3380           AC021443.27        145273-145433       c
            3381-3441           AC021443.27        144417-144477       c
            3442-3552           AC021443.27        140988-141098       c
            3553-3676           AC021443.27        140669-140792       c
            3677-3778           AC021443.27        138940-139041       c
            3779-3920           AC021443.27        137409-137550       c
            3921-4046           AC021443.27        135560-135685       c
            4047-4151           AC021443.27        132830-132934       c
            4152-5228           AC021443.27        130605-131681       c
FEATURES             Location/Qualifiers
     source          1..5228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..5228
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /note="nucleoporin 160"
                     /db_xref="GeneID:23279"
                     /db_xref="HGNC:HGNC:18017"
                     /db_xref="MIM:607614"
     exon            1..132
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..4241
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear pore complex protein Nup160; nucleoporin Nup160;
                     160 kDa nucleoporin; nucleoporin 160kD; nucleoporin
                     160kDa"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup160 isoform 1"
                     /protein_id="NP_056046.2"
                     /db_xref="CCDS:CCDS31484.2"
                     /db_xref="GeneID:23279"
                     /db_xref="HGNC:HGNC:18017"
                     /db_xref="MIM:607614"
                     /translation="MAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVK
                     YSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLDINLLNNAIRLKFQNCS
                     VLPGGVYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVDSQMQSIFTDIGKVD
                     FTDPCNYQLIPAVPGISPNSTASTAWLSSDGEALFALPCASGGIFVLKLPPYDIPGMV
                     SVVELKQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIFALCQDHKLRM
                     WSYKEQMCLMVADMLEYVPVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYMHAPKRGQF
                     CIFQLVSTESNRYSLDHISSLFTSQETLIDFALTSTDIWALWHDAENQTVVKYINFEH
                     NVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFCRGTE
                     RNLDLSWSELKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQEAL
                     SHPLALHLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDDVDIA
                     RDVICLIKCLRLIEESVTVDMSVIMEMSCYNLQSPEKAAEQILEDMITIDVENVMEDI
                     CSKLQEIRNPIHAIGLLIREMDYETEVEMEKGFNPAQPLNIRMNLTQLYGSNTAGYIV
                     CRGVHKIASTRFLICRDLLILQQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYY
                     LIKWGSECLATDVPLDTLESNLQHLSVLELTDSGALMANRFVSSPQTIVELFFQEVAR
                     KHIISHLFSQPKAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCLFLECLMGNCQYVQ
                     LQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEGQKALECFCQAASEVGKEEFLDRLIR
                     SEDGEIVSTPRLQYYDKVLRLLDVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFK
                     HHLDLGHNSQAYEALTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVG
                     IIESRARAVDLMTHNYYELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQG
                     NCYLAALNCLRLIRPEYAWIVQPVSGAVYDRPGASPKRNHDGECTAAPTNRQIEILEL
                     EDLEKECSLARIRLTLAQHDPSAVAVAGSSSAEEMVTLLVQAGLFDTAISLCQTFKLP
                     LTPVFEGLAFKCIKLQFGGEAAQAEAWAWLAANQLSSVITTKESSATDEAWRLLSTYL
                     ERYKVQNNLYHHCVINKLLSHGVPLPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLV
                     SEYVDAVLGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALGENSANSHNIALSQKI
                     LDKLEDYQQKVDKATRDLLYRRTL"
     exon            133..244
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            245..455
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            456..678
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            679..757
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            758..872
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1031
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1109
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1207
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1292
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1361
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1445
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1616
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1716
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1882
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2010
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2171
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2305
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2376
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2536
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2606
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2705
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2825
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2921
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3016
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3113
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3219
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3380
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3441
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3552
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3676
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3778
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3920
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..4046
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4151
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..5228
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5093..5098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /note="hexamer: ATTAAA"
     polyA_site      5116
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /note="major polyA site"
     regulatory      5208..5213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /note="hexamer: ATTATA"
     polyA_site      5228
                     /gene="NUP160"
                     /gene_synonym="NPHS19"
                     /note="major polyA site"
ORIGIN      
        1 gttccgttgg gcgtcgcggc gacggcggga agatggcggc ggcgggagcc ctggaacgga
       61 gcttcgtgga gctaagcgga gctgagcgcg aaaggccgag gcactttcgg gaattcacag
      121 tctgcagcat tgggactgca aatgccgtgg ctggcgccgt aaaatacagt gaaagcgcgg
      181 gaggctttta ctacgtggag agtggcaagt tgttctccgt aaccagaaac aggttcattc
      241 attggaagac ctctggagat acattggagc tgatggagga gtcactggac ataaatctgt
      301 tgaataatgc cattcgccta aaattccaaa attgcagtgt tttacctgga ggggtttatg
      361 tctctgagac tcagaatcgt gtgataatct tgatgttaac caatcaaaca gtgcacaggt
      421 tacttttacc acacccctcc cggatgtata ggagtgagtt ggtagttgac agtcagatgc
      481 agtcaatatt cactgacatt ggaaaagttg atttcacaga tccttgcaac tatcagttaa
      541 ttccagcagt acctggaata tctcctaatt ccaccgcctc tacagcctgg ctcagcagtg
      601 atggggaggc cctgtttgcc ttaccatgtg cttctggggg aatctttgtt cttaagctac
      661 ctccttatga catacctggt atggtgtcag tcgtggaact gaaacagagt tcagtaatgc
      721 aacgattgct tacaggctgg atgccaacag ctatcagggg tgaccagtcg ccttcagatc
      781 gtcccctcag tcttgctgtt cattgtgtgg agcatgatgc cttcatcttt gctttgtgtc
      841 aggatcataa actacgaatg tggtcttaca aggagcaaat gtgcctaatg gtagctgaca
      901 tgctggagta tgtccctgtg aagaaagacc ttcggcttac tgctggaact ggacacaaat
      961 tacggcttgc ttattccccc accatgggac tctacctggg gatatacatg catgcaccaa
     1021 aacgaggaca gttctgcatt ttccagttgg tgagcactga gagtaatcgc tatagtctcg
     1081 atcatatttc ttcactgttc acttctcagg agacactgat tgactttgcc ttaacttcca
     1141 cggatatctg ggccctgtgg catgatgctg agaaccaaac agtagtgaaa tacatcaact
     1201 ttgaacataa tgttgcaggt cagtggaatc cagtttttat gcagcctctg ccagaggaag
     1261 agattgtcat cagagatgat caagacccca gagagatgta tctgcaaagt ctttttacac
     1321 caggacaatt cacaaatgaa gctttatgta aggctttaca gattttctgc cgaggaactg
     1381 agaggaattt ggatctttcc tggagtgaac tgaagaaaga agttacttta gctgttgaaa
     1441 atgagcttca aggaagtgta acagagtatg aattctccca ggaggagttt cgaaatttac
     1501 aacaagaatt ctggtgcaag ttctatgcct gttgtcttca gtatcaagaa gccctctctc
     1561 accctcttgc cctacatttg aatccacaca caaacatggt gtgcctgctg aaaaaagggt
     1621 acctgtcttt ccttattccc tcatccttag tggatcattt gtatctcctg ccttatgaga
     1681 accttttgac agaagatgag acaaccatat ctgatgatgt ggacatcgct cgggatgtca
     1741 tatgtcttat aaaatgcctc cggctgattg aagagtcagt aactgtggat atgtcagtta
     1801 taatggaaat gagttgttat aacctacagt ctccggaaaa ggctgcagag cagattctgg
     1861 aagatatgat cactattgat gtagaaaatg tgatggagga tatttgtagt aaactgcaag
     1921 agattaggaa cccaatccat gcaattggac tacttatacg ggaaatggat tatgaaacag
     1981 aagtggaaat ggaaaaggga ttcaatccag ctcagccttt gaatattcga atgaatctta
     2041 cccagctcta tggtagtaac acagcagggt atattgtgtg cagaggggtg cataaaatcg
     2101 ccagtactcg tttcctgatc tgcagagatc ttttgatctt acagcagctg ttaatgaggc
     2161 ttggagatgc tgtgatttgg ggaactggtc agctctttca agctcagcaa gacctactac
     2221 atcgaacagc tcccctactc ttatcttatt acctcattaa atggggaagt gagtgcttgg
     2281 caactgatgt tccacttgac acactggagt ctaatctcca acacttatca gtactggaat
     2341 taacagactc tggtgcttta atggcaaata ggtttgtatc tagtcctcag actattgtgg
     2401 agttattctt ccaagaagtt gcaagaaaac acattatatc tcacctcttc tctcagccaa
     2461 aggcacctct gagccaaact ggattgaatt ggcctgaaat gattactgca attaccagtt
     2521 atttattgca gcttttatgg cctagcaatc ctggttgtct ctttctagaa tgtttgatgg
     2581 gaaattgcca atatgtacaa ttgcaggatt atattcaact gctacatccc tggtgtcaag
     2641 tcaatgttgg ttcctgtcga tttatgctgg gaaggtgtta cctagttaca ggagaaggac
     2701 agaaggctct ggaatgtttt tgtcaggcag catctgaagt aggcaaagag gaattcttgg
     2761 atcgcttgat tcgctcagag gatggggaga tcgtgtctac ccccaggctg cagtattatg
     2821 acaaggtttt acgactacta gatgtcattg gtttgcctga actggttatt cagttggcta
     2881 catcagccat aactgaagca ggtgatgact ggaaaagtca ggctactcta aggacatgta
     2941 ttttcaaaca tcatttggat ttgggtcaca atagccaagc atatgaagcc ttaacccaaa
     3001 ttcctgattc cagcaggcaa ttagattgtt tacggcagtt ggtggtagtt ctttgtgaac
     3061 gctcacagct acaggatctt gtagagtttc cctatgtgaa tctgcataat gaggttgtgg
     3121 gaataattga gtcacgtgct agagctgtgg accttatgac tcacaattac tatgaacttc
     3181 tgtatgcctt tcacatctat cgccacaatt accgcaaggc tggcacagtg atgtttgagt
     3241 atggaatgcg gcttggcaga gaagttcgaa ctctccgggg acttgagaaa caaggcaact
     3301 gttatctggc tgctctcaat tgtttacgac ttattcgtcc agaatatgcg tggattgtgc
     3361 agccagtgtc tggtgcagtg tatgatcgcc ctggagcatc ccctaagagg aatcatgatg
     3421 gagaatgcac agctgccccc acaaatcgac aaattgaaat cctggaactg gaagatctgg
     3481 agaaagagtg ttccttggct cgcatccgcc tcactttggc tcagcatgat ccatcagcgg
     3541 ttgcagttgc tggaagttca tcagcagagg aaatggtcac tctcttggtt caggcgggcc
     3601 tctttgacac tgccatatca ctctgtcaga cttttaagct tcccttaacg ccagtctttg
     3661 aagggcttgc cttcaaatgc atcaaattgc aatttggagg agaggcagca caagcagaag
     3721 cctgggcctg gctagcagcc aatcagctct catctgtcat cactactaag gagtctagtg
     3781 ctacagatga agcatggcga ctattatcca cttacctgga gaggtacaaa gtccagaata
     3841 acttgtatca ccactgtgta atcaacaagc tcttgtctca tggagtgcct ctgcctaatt
     3901 ggcttataaa cagttacaag aaggttgatg ctgctgaatt gcttcgttta tacttaaact
     3961 atgacctttt agaagaagct gtggatttgg tgtcagaata tgtggatgct gtattgggaa
     4021 aaggacatca atacttcgga attgagtttc cactgtccgc aacagcccca atggtgtggc
     4081 ttccatactc ctctattgat cagcttctcc aagctctggg agagaacagt gccaacagtc
     4141 acaacatcgc actgtcccag aaaatacttg acaaattgga ggactaccag caaaaagttg
     4201 ataaggcaac acgggattta ttatatcgtc ggaccttgtg atttggattg tcacctagcc
     4261 tttgtaaccg cttggtgcct cttaggactt aagactaccc tacaggaacc ctgtactcaa
     4321 ggccgatttt tgtaactgta aatgatgtgt acaacattca agtctgcatt ctgcacaaga
     4381 taggagggcg gaagagtcag aggaccctgt gcttgctggt ggtgctaaca caatttctgg
     4441 tgttcaacct tggtctcaaa tagctgcttt tgtatatgat tcacgagctt ttttagagtt
     4501 tatatttttt taaactaccg aagacattca ttatctgcaa attaagactc accttcactt
     4561 tccaaaatag ctgagggttg ttggcttgtt gtagctgacc accaaaagca gtcactgcaa
     4621 atcttttaat tcttccctat caccttttgt attttaatgc aattattttg gtccagaact
     4681 gacctgtatt ttctgtattg tacacaaaag ctaataattt tgtgtacttt ttatttattt
     4741 tggaggtttt atatgatctt caattgagta ttaaataatt tgcctagatt aagcctaaaa
     4801 tgatgaccag ctaattaaag aagatatttt gaatctggtt ctgagctaaa gttgagtaaa
     4861 ttcttagcta agaaaaaatt ggaaatccat catctatatt agcaacagat tctcagagta
     4921 aattgttaac ttctatgatt tatgataatc aagctggact tgatcataca agttagtctc
     4981 ataatgtatt ggaccaaaat gtaaacttca ttggtcagat ttagaagcat tcatgctcac
     5041 aagttttggg aaagtgaaaa ataataaaat catcttggat tttattctgt atattaaaat
     5101 ttatctttta aggaaacaat ctgtatacta cttgcttgta tagccttttg acccttcttg
     5161 agtttttcag aagcctttaa tttttatact ttcaatacca tatttacatt atatacttta
     5221 attaacaa
//
