LOCUS       NM_005124               6026 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens nucleoporin 153 (NUP153), transcript variant 2, mRNA.
ACCESSION   NM_005124
VERSION     NM_005124.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6026)
  AUTHORS   Colussi,C., Bertozzi,A., Leone,L., Rinaudo,M., Sollazzo,R.,
            Conte,F., Paccosi,E., Nardella,L., Aceto,G., Li Puma,D.D.,
            Ripoli,C., Vita,M.G., Marra,C., D'Ascenzo,M. and Grassi,C.
  TITLE     Nucleoporin 153 deficiency in adult neural stem cells defines a
            pathological protein-network signature and defective neurogenesis
            in a mouse model of AD
  JOURNAL   Stem Cell Res Ther 15 (1), 275 (2024)
   PUBMED   39227892
  REMARK    GeneRIF: Nucleoporin 153 deficiency in adult neural stem cells
            defines a pathological protein-network signature and defective
            neurogenesis in a mouse model of AD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6026)
  AUTHORS   Schertzer,M., Jullien,L., Pinto,A.L., Calado,R.T., Revy,P. and
            Londono-Vallejo,A.
  TITLE     Human RTEL1 Interacts with KPNB1 (Importin beta) and NUP153 and
            Connects Nuclear Import to Nuclear Envelope Stability in S-Phase
  JOURNAL   Cells 12 (24), 2798 (2023)
   PUBMED   38132118
  REMARK    GeneRIF: Human RTEL1 Interacts with KPNB1 (Importin beta) and
            NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in
            S-Phase.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6026)
  AUTHORS   Gan,C., Zhou,K., Li,M., Shang,J., Liu,L. and Zhao,Q.
  TITLE     NUP153 promotes HCC cells proliferation via c-Myc-mediated
            downregulation of P15INK4b
  JOURNAL   Dig Liver Dis 54 (12), 1706-1715 (2022)
   PUBMED   35288064
  REMARK    GeneRIF: NUP153 promotes HCC cells proliferation via c-Myc-mediated
            downregulation of P15[INK4b].
REFERENCE   4  (bases 1 to 6026)
  AUTHORS   Li,S., Patel,J.S., Yang,J., Crabtree,A.M., Rubenstein,B.M.,
            Lund-Andersen,P.K., Ytreberg,F.M. and Rowley,P.A.
  TITLE     Defining the HIV Capsid Binding Site of Nucleoporin 153
  JOURNAL   mSphere 7 (5), e0031022 (2022)
   PUBMED   36040047
  REMARK    GeneRIF: Defining the HIV Capsid Binding Site of Nucleoporin 153.
REFERENCE   5  (bases 1 to 6026)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 6026)
  AUTHORS   Ullman,K.S., Shah,S., Powers,M.A. and Forbes,D.J.
  TITLE     The nucleoporin nup153 plays a critical role in multiple types of
            nuclear export
  JOURNAL   Mol Biol Cell 10 (3), 649-664 (1999)
   PUBMED   10069809
REFERENCE   7  (bases 1 to 6026)
  AUTHORS   Zolotukhin,A.S. and Felber,B.K.
  TITLE     Nucleoporins nup98 and nup214 participate in nuclear export of
            human immunodeficiency virus type 1 Rev
  JOURNAL   J Virol 73 (1), 120-127 (1999)
   PUBMED   9847314
REFERENCE   8  (bases 1 to 6026)
  AUTHORS   Moroianu,J., Blobel,G. and Radu,A.
  TITLE     RanGTP-mediated nuclear export of karyopherin alpha involves its
            interaction with the nucleoporin Nup153
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9699-9704 (1997)
   PUBMED   9275187
REFERENCE   9  (bases 1 to 6026)
  AUTHORS   Yaseen,N.R. and Blobel,G.
  TITLE     Cloning and characterization of human karyopherin beta3
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4451-4456 (1997)
   PUBMED   9114010
REFERENCE   10 (bases 1 to 6026)
  AUTHORS   McMorrow,I., Bastos,R., Horton,H. and Burke,B.
  TITLE     Sequence analysis of a cDNA encoding a human nuclear pore complex
            protein, hnup153
  JOURNAL   Biochim Biophys Acta 1217 (2), 219-223 (1994)
   PUBMED   8110839
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138724.12, AB210024.1,
            BC052965.1, AL597150.1 and AI948895.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005124.3.
            
            Summary: Nuclear pore complexes regulate the transport of
            macromolecules between the nucleus and cytoplasm. They are composed
            of at least 100 different polypeptide subunits, many of which
            belong to the nucleoporin family. Nucleoporins are glycoproteins
            found in nuclear pores and contain characteristic pentapeptide
            XFXFG repeats as well as O-linked N-acetylglucosamine residues
            oriented towards the cytoplasm. The protein encoded by this gene
            has three distinct domains: a N-terminal region containing a pore
            targeting and an RNA-binding domain domain, a central region
            containing multiple zinc finger motifs, and a C-terminal region
            containing multiple XFXFG repeats. Alternative splicing results in
            multiple transcript variants of this gene. [provided by RefSeq, May
            2013].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. It encodes
            isoform 2 which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052965.1, SRR11853560.24314.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262077.3/ ENSP00000262077.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL138724.12        9532-9622           c
            92-806              AB210024.1         1-715
            807-1678            BC052965.1         335-1206
            1679-2258           AB210024.1         1588-2167
            2259-3351           BC052965.1         1787-2879
            3352-3352           AL597150.1         220-220
            3353-5800           BC052965.1         2881-5328
            5801-6026           AI948895.1         5-230               c
FEATURES             Location/Qualifiers
     source          1..6026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..6026
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /note="nucleoporin 153"
                     /db_xref="GeneID:9972"
                     /db_xref="HGNC:HGNC:8062"
                     /db_xref="MIM:603948"
     exon            1..649
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     CDS             539..4966
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear pore complex protein hnup153; nucleoporin Nup153;
                     153 kDa nucleoporin; nucleoporin 153kD; nucleoporin
                     153kDa"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup153 isoform 2"
                     /protein_id="NP_005115.2"
                     /db_xref="CCDS:CCDS4541.1"
                     /db_xref="GeneID:9972"
                     /db_xref="HGNC:HGNC:8062"
                     /db_xref="MIM:603948"
                     /translation="MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVT
                     ESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPENKEDHLVYADEESSNITDGRIT
                     PEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGS
                     SGFSLVKEIKDSTSQHDDDNISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSL
                     SQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGAAAAVRQS
                     KLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSIVSS
                     PLNSPLDRSGIDITDFQAKREKVDSQYPPVQRLMTPKPVSIATNRSVYFKPSLTPSGE
                     FRKTNQRIDNKCSTGYEKNMTPGQNREQRESGFSYPNFSLPAANGLSSGVGGGGGKMR
                     RERTRFVASKPLEEEEMEVPVLPKISLPITSSSLPTFNFSSPEITTSSPSPINSSQAL
                     TNKVQMTSPSSTGSPMFKFSSPIVKSTEANVLPPSSIGFTFSVPVAKTAELSGSSSTL
                     EPIISSSAHHVTTVNSTNCKKTPPEDCEGPFRPAEILKEGSVLDILKSPGFASPKIDS
                     VAAQPTATSPVVYTRPAISSFSSSGIGFGESLKAGSSWQCDTCLLQNKVTDNKCIACQ
                     AAKLSPRDTAKQTGIETPNKSGKTTLSASGTGFGDKFKPVIGTWDCDTCLVQNKPEAI
                     KCVACETPKPGTCVKRALTLTVVSESAETMTASSSSCTVTTGTLGFGDKFKRPIGSWE
                     CSVCCVSNNAEDNKCVSCMSEKPGSSVPASSSSTVPVSLPSGGSLGLEKFKKPEGSWD
                     CELCLVQNKADSTKCLACESAKPGTKSGFKGFDTSSSSSNSAASSSFKFGVSSSSSGP
                     SQTLTSTGNFKFGDQGGFKIGVSSDSGSINPMSEGFKFSKPIGDFKFGVSSESKPEEV
                     KKDSKNDNFKFGLSSGLSNPVSLTPFQFGVSNLGQEEKKEELPKSSSAGFSFGTGVIN
                     STPAPANTIVTSENKSSFNLGTIETKSASVAPFTCKTSEAKKEEMPATKGGFSFGNVE
                     PASLPSASVFVLGRTEEKQQEPVTSTSLVFGKKADNEEPKCQPVFSFGNSEQTKDENS
                     SKSTFSFSMTKPSEKESEQPAKATFAFGAQTSTTADQGAAKPVFSFLNNSSSSSSTPA
                     TSAGGGIFGSSTSSSNPPVATFVFGQSSNPVSSSAFGNTAESSTSQSLLFSQDSKLAT
                     TSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFG
                     ANQTPTFGQSQGASQPNPPGFGSISSSTALFPTGSQPAPPTFGTVSSSSQPPVFGQQP
                     SQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGF
                     PFNQSPAAFTVGSNGKNVFSSSGTSFSGRKIKTAVRRRK"
     exon            650..872
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1121
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1261
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1390
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1507
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1552
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1606
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1753
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1806
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1933
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2071
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2170
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2258
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2384
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..3002
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3197
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..4082
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            4083..4439
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4712
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            4713..4881
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..6026
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6008..6013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /note="hexamer: AATAAA"
     polyA_site      6026
                     /gene="NUP153"
                     /gene_synonym="HNUP153; N153"
                     /note="major polyA site"
ORIGIN      
        1 attctggctc gcgaccgcgg cagccgcctt agcaggggta ataggcgcaa cggcggcgga
       61 ggctgcaggg acgacgacga cgacggcggc ggggcgggcg ctgtgcgcac aggggagggg
      121 taggcgggcg tcgccagcgg cttcaactgc ggcagctacg gctagggcga cggaagaact
      181 cccaccagtc ggcggtcgag ttaggcctca gcaccgcggg gaactgttcg tgctgtcctc
      241 tgcgggagat ctccatagag accgtgacac acacagaggc gggggtccgc agaggcggcc
      301 ggaccggagc ctcctcggcc tctgcggccg ccaccccctt ccccgctgcc agcactcacc
      361 ctctctccgc tcctgctcgc aacctcgcgg ttcctggggt gcttgtgccc actgtgtgga
      421 cagcgcgggc ggacttttgg gccggggccg ggcggcgggg gaggctctct aaggcctccg
      481 cctctgcctc tcccgccccc ttacccgccc cggagcggga agcggcggag gctccgccat
      541 ggcctcggga gccggaggag tcggaggggg cggtggcggc aagatccgga cgcggcgttg
      601 ccaccagggg ccaattaagc cttaccagca ggggcgacaa cagcatcagg gcattcttag
      661 cagggttaca gaatctgtta agaatattgt gccagggtgg ctacaaagat acttcaacaa
      721 gaatgaagat gtatgcagct gttcaacaga cacaagcgag gttccacgct ggccagaaaa
      781 taaagaggac catctggtat atgccgatga ggagagctct aatattactg atgggagaat
      841 cacacctgag ccagcagtca gtaatacaga agaaccttca acaactagta ctgcttcaaa
      901 ttatccagat gtgttaacaa ggccttctct tcatcggagc catctgaatt tttccatgtt
      961 ggaatcccct gcattacact gtcagccatc tacatcctcg gcattcccaa ttggcagttc
     1021 gggattttcc cttgtaaagg aaattaaaga ttctacctct cagcatgatg atgataacat
     1081 ctcaactacc agtggttttt cttcaagagc ttctgataaa gatataactg tttcaaagaa
     1141 cacttcattg ccacctctgt ggtccccaga agctgaacgt tctcactcac tctcacagca
     1201 cactgccacc agctcaaaaa aaccagcatt caacttgtct gcctttggaa cactttcccc
     1261 ttcacttggg aattcttcaa tccttaaaac cagtcagctt ggagattctc ctttttatcc
     1321 tggaaaaaca acatacggtg gggcagcagc tgctgtaaga cagtctaaac tacgaaatac
     1381 accttatcag gcaccagtta gaagacaaat gaaagctaag caactcagtg cacaatctta
     1441 cggtgtgacc agttcaacag ctcggcgaat attgcagtct ttagagaaga tgtcaagccc
     1501 tttagcggat gcaaaaagaa ttccatccat tgtttcttct cctctgaatt ctcctcttga
     1561 taggagtggg atagatatca cagattttca ggccaaaaga gaaaaggtgg attctcaata
     1621 tcctcctgtt cagagactta tgaccccaaa gccagtttcc atagcaacaa atcgaagtgt
     1681 ttattttaaa ccatctctga ctccttctgg tgaattcagg aagactaatc aaagaataga
     1741 taacaagtgc agtactggat atgaaaaaaa tatgacaccc ggacaaaata gagaacaacg
     1801 agaaagtggc ttttcatatc caaatttcag tttgcctgca gccaatggtt tatcttctgg
     1861 agtaggtggt ggaggtggca agatgagacg agaaagaaca cgctttgttg cttctaaacc
     1921 tctggaggag gaggaaatgg aagttccagt attaccgaaa atctctctac cgatcaccag
     1981 ttcttcactg cctaccttta attttagttc ccctgagatc acaacttcct ctccatcacc
     2041 catcaattcg tctcaagcat taacaaacaa ggtacaaatg acctctccga gcagcactgg
     2101 cagtcccatg tttaaatttt catctccaat cgtaaaatct actgaggcaa atgtactacc
     2161 tccatcatct attggattta catttagtgt gcctgttgca aaaacagcag aactttctgg
     2221 ttctagtagt actttagaac caattataag tagttcagct catcatgtca ctacagtgaa
     2281 cagtacaaat tgtaagaaga caccacctga agattgtgag ggtcctttta gacctgcaga
     2341 aatcctgaaa gaaggaagtg ttctagatat tctgaaaagc cctggtttcg catcgccgaa
     2401 gatagattct gttgctgctc agcccaccgc aacaagccca gtagtttata caagaccagc
     2461 aataagtagc ttttcttcta gtggaattgg gtttggggag agtttaaaag ctgggtcatc
     2521 atggcagtgt gatacatgtc tactccagaa caaagttaca gacaacaaat gcatagcctg
     2581 tcaagcagca aaattgtcac ccagagatac tgctaaacag actggaattg aaacaccaaa
     2641 taaaagtggc aaaacaactc tttctgcatc agggacaggc tttggagaca aatttaaacc
     2701 agtgataggc acttgggatt gtgatacctg tttagtgcaa aataaacctg aagcaataaa
     2761 atgtgtagcc tgtgaaacac cgaaacctgg aacttgtgtg aagcgagccc ttacattgac
     2821 agtggtttcg gaaagtgctg agactatgac tgcttcatct tccagctgca ctgtaaccac
     2881 tggtacctta ggatttggag ataaattcaa aaggcccatt ggatcttggg agtgttcagt
     2941 atgctgtgtt tctaataatg cagaagacaa taagtgtgtg tcctgtatgt ctgagaaacc
     3001 aggaagttca gtacctgctt caagtagcag cactgtacct gtctctctgc cttctggagg
     3061 ctctctagga ttggaaaagt tcaagaaacc cgagggaagc tgggactgtg aattgtgcct
     3121 agtgcagaat aaggcagact ctaccaaatg tttggcatgt gaaagtgcaa agccaggcac
     3181 aaaatctggg tttaaaggct ttgacacatc ttcctcatct tcgaactcag cagcctcctc
     3241 atccttcaaa tttggtgtct catcatcctc ttctgggcct tctcagactt taacaagcac
     3301 tggaaatttt aaatttggag atcagggagg attcaaaata ggtgtgtcat ccgattctgg
     3361 gtctataaac cccatgagtg aaggctttaa attttctaaa ccaataggag attttaaatt
     3421 tggagtttca tctgaatcta agcccgaaga agttaaaaaa gatagtaaga atgataattt
     3481 taagtttgga ctttcttctg gtttaagcaa cccagtttct ttaactccat ttcaatttgg
     3541 ggtatctaat cttggacagg aagaaaagaa agaggaactg cccaaatctt cctctgcagg
     3601 ttttagcttt ggtacaggtg ttattaactc cacccctgct cctgctaaca ccatagtgac
     3661 ctctgagaac aagagcagct tcaaccttgg aaccatagaa accaagagtg cttcagtggc
     3721 tcctttcaca tgtaagacat cagaagctaa aaaagaagaa atgcctgcca ccaaaggagg
     3781 attctctttt ggcaacgtgg agcctgcctc tctgccatct gcctcagtgt ttgttttggg
     3841 aaggacagaa gagaaacagc aagagcctgt cacttctact tccctagttt ttgggaagaa
     3901 agctgacaat gaagagccaa agtgtcaacc agtgttttcc tttgggaatt cagagcaaac
     3961 caaagatgag aattcttcaa agtccacatt tagttttagt atgacaaaac catctgagaa
     4021 ggaatctgaa cagccagcaa aagccacttt tgcctttgga gctcaaacta gtactacagc
     4081 tgatcaaggt gcagcaaagc cagtttttag tttcttgaac aacagttcct ctagttcaag
     4141 tacaccagcc acttctgctg gtggtggcat atttggtagt tccacctctt cctccaatcc
     4201 acctgtggct acctttgtgt ttggacagtc cagcaatcct gtgagcagct ctgcctttgg
     4261 taacactgct gaatccagca cctctcagtc tttgctattt tctcaagata gcaaactagc
     4321 aaccacatcc agcacaggta cagctgtcac cccatttgtc tttggtccag gagccagcag
     4381 taataatact accacctctg gtttcggctt tggagccaca accacatcta gctctgcagg
     4441 atcctccttt gtatttggaa ctggaccctc agcaccatct gccagtccag catttggtgc
     4501 taaccagacc ccaacatttg gacaaagtca aggtgccagc cagcccaatc ccccaggctt
     4561 tggatctata tcatcttcca cagcattatt tcccactggt tctcagcctg caccacctac
     4621 ttttgggaca gtgtcaagca gtagccagcc ccctgtgttt ggacagcaac ctagtcagtc
     4681 tgcatttggc tctggaacaa ctcctaattc tagttcggct ttccagtttg gcagcagcac
     4741 tacaaatttc aacttcacaa acaacagtcc atcaggagtg ttcacatttg gtgcaaattc
     4801 tagcacacct gcagcctcag cccagccttc aggctcgggg ggctttccat ttaaccagtc
     4861 tccagcagca tttacagtgg ggtcaaatgg gaaaaatgtg ttctcttctt ctggaacttc
     4921 attctctggt cgcaagataa agactgctgt tagacgcagg aaataaaggt cacattggtg
     4981 ttgtactcaa ttttaacaac agctggtgcc ctgctttcag atactggatt gtactttgtg
     5041 ctggggttat ctgaagtcag atctgcctaa ggacttcttt aattttggaa ttttcctcct
     5101 ttctctttcg ttacagaagc cccaccctgc ctcacccacc cttttttaaa taaataaata
     5161 gctagactgg tgactgattc ttcagcaaaa atattttatg atccagcaga ttattcactg
     5221 atttgacata gtctggctgt acccaggaat ggagcctgca cggtgaatgg ctttgtatag
     5281 aacctctttg tctacaccat tatgtgcgct gataagcgtt catggaacgc gttgaaattg
     5341 taattatatc tgaggaattc tgtatagatt agaattctgt atagattaga gagtgttgaa
     5401 acggatgatt tctatgctga gtttgtgctg gtgtatgtgt gaagtgagtg agttgggtgt
     5461 attgtgcgct aaacttttct gatagaggaa gcctgattaa agaatggtcc gtgctaagga
     5521 cttgttagat ctagttcact ctccatttaa taattatatg ctatttctat attttcattc
     5581 tcctatcacc tgtcttgcct ttttcattat tttattatga aacttgtgta aatacaattt
     5641 tgtttctgta ctttttggca taacataaat ctgtgaactt gaaatttgaa ttttgtgtta
     5701 gagatttttt tgttgtttgt ttagtcttgt ctcagatttt attatgtaaa tcccattatt
     5761 caaagttgcc taaatccatt tggaaatctt taaaaaaaaa attggggatt cttaaagttg
     5821 aatttattgg cttttctgat ccagttttgt ttggaccaaa aaccagtatt gtacaaagta
     5881 ttaagcatat atttttatat ttactaaaat ggactgtggt gactttggat aataaggaaa
     5941 agtttaatat taaagccatg tttattacag tataattaac atgttaaacc atgggataaa
     6001 tgccatcaat aaaaaattat gacata
//
