LOCUS       NM_018230               5208 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens nucleoporin 133 (NUP133), mRNA.
ACCESSION   NM_018230
VERSION     NM_018230.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5208)
  AUTHORS   Wang,Q., Gu,R., Li,F.W., Gu,W.Y. and Zhang,J.J.
  TITLE     Steroid-resistant nephrotic syndrome caused by nuclear pore gene
            NUP133 variation
  JOURNAL   Clin Genet 104 (2), 272-274 (2023)
   PUBMED   37041680
  REMARK    GeneRIF: Steroid-resistant nephrotic syndrome caused by nuclear
            pore gene NUP133 variation.
REFERENCE   2  (bases 1 to 5208)
  AUTHORS   Rogg,M., Maier,J.I., Ehle,M., Sammarco,A., Schilling,O., Werner,M.
            and Schell,C.
  TITLE     NUP133 Controls Nuclear Pore Assembly, Transcriptome Composition,
            and Cytoskeleton Regulation in Podocytes
  JOURNAL   Cells 11 (8), 1259 (2022)
   PUBMED   35455939
  REMARK    GeneRIF: NUP133 Controls Nuclear Pore Assembly, Transcriptome
            Composition, and Cytoskeleton Regulation in Podocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5208)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5208)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   5  (bases 1 to 5208)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5208)
  AUTHORS   Le Rouzic,E., Mousnier,A., Rustum,C., Stutz,F., Hallberg,E.,
            Dargemont,C. and Benichou,S.
  TITLE     Docking of HIV-1 Vpr to the nuclear envelope is mediated by the
            interaction with the nucleoporin hCG1
  JOURNAL   J Biol Chem 277 (47), 45091-45098 (2002)
   PUBMED   12228227
REFERENCE   7  (bases 1 to 5208)
  AUTHORS   Belgareh,N., Rabut,G., Bai,S.W., van Overbeek,M., Beaudouin,J.,
            Daigle,N., Zatsepina,O.V., Pasteau,F., Labas,V., Fromont-Racine,M.,
            Ellenberg,J. and Doye,V.
  TITLE     An evolutionarily conserved NPC subcomplex, which redistributes in
            part to kinetochores in mammalian cells
  JOURNAL   J Cell Biol 154 (6), 1147-1160 (2001)
   PUBMED   11564755
REFERENCE   8  (bases 1 to 5208)
  AUTHORS   Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A.
  TITLE     Nuclear import of hepatic glucokinase depends upon glucokinase
            regulatory protein, whereas export is due to a nuclear export
            signal sequence in glucokinase
  JOURNAL   J Biol Chem 274 (52), 37125-37130 (1999)
   PUBMED   10601273
REFERENCE   9  (bases 1 to 5208)
  AUTHORS   Stoffler,D., Fahrenkrog,B. and Aebi,U.
  TITLE     The nuclear pore complex: from molecular architecture to functional
            dynamics
  JOURNAL   Curr Opin Cell Biol 11 (3), 391-401 (1999)
   PUBMED   10395558
  REMARK    Review article
REFERENCE   10 (bases 1 to 5208)
  AUTHORS   Bodoor,K., Shaikh,S., Enarson,P., Chowdhury,S., Salina,D.,
            Raharjo,W.H. and Burke,B.
  TITLE     Function and assembly of nuclear pore complex proteins
  JOURNAL   Biochem Cell Biol 77 (4), 321-329 (1999)
   PUBMED   10546895
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121990.34, AL139252.8 and
            AL160004.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_018230.2.
            
            Summary: The nuclear envelope creates distinct nuclear and
            cytoplasmic compartments in eukaryotic cells. It consists of two
            concentric membranes perforated by nuclear pores, large protein
            complexes that form aqueous channels to regulate the flow of
            macromolecules between the nucleus and the cytoplasm. These
            complexes are composed of at least 100 different polypeptide
            subunits, many of which belong to the nucleoporin family. The
            nucleoporin protein encoded by this gene displays evolutionarily
            conserved interactions with other nucleoporins. This protein, which
            localizes to both sides of the nuclear pore complex at interphase,
            remains associated with the complex during mitosis and is targeted
            at early stages to the reforming nuclear envelope. This protein
            also localizes to kinetochores of mitotic cells. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001676.1, BC020107.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261396.6/ ENSP00000261396.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AL121990.34        22083-22356         c
            275-393             AL121990.34        20055-20173         c
            394-497             AL121990.34        16014-16117         c
            498-605             AL121990.34        14771-14878         c
            606-740             AL121990.34        13699-13833         c
            741-911             AL121990.34        12151-12321         c
            912-1067            AL121990.34        9907-10062          c
            1068-1138           AL121990.34        9510-9580           c
            1139-1286           AL121990.34        3970-4117           c
            1287-1434           AL139252.8         24550-24697         c
            1435-1592           AL139252.8         23455-23612         c
            1593-1684           AL139252.8         21138-21229         c
            1685-1848           AL139252.8         14681-14844         c
            1849-1943           AL139252.8         12722-12816         c
            1944-2168           AL139252.8         7664-7888           c
            2169-2291           AL139252.8         3718-3840           c
            2292-2391           AL139252.8         2504-2603           c
            2392-2643           AL160004.18        85881-86132         c
            2644-2777           AL160004.18        84800-84933         c
            2778-2936           AL160004.18        81868-82026         c
            2937-3072           AL160004.18        79418-79553         c
            3073-3191           AL160004.18        73782-73900         c
            3192-3272           AL160004.18        71782-71862         c
            3273-3337           AL160004.18        70383-70447         c
            3338-3426           AL160004.18        66171-66259         c
            3427-5208           AL160004.18        61516-63297         c
FEATURES             Location/Qualifiers
     source          1..5208
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..5208
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="nucleoporin 133"
                     /db_xref="GeneID:55746"
                     /db_xref="HGNC:HGNC:18016"
                     /db_xref="MIM:607613"
     exon            1..274
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..3563
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="nucleoporin Nup133; 133 kDa nucleoporin;
                     nucleoporin 133kD; nucleoporin 133kDa"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup133"
                     /protein_id="NP_060700.2"
                     /db_xref="CCDS:CCDS1579.1"
                     /db_xref="GeneID:55746"
                     /db_xref="HGNC:HGNC:18016"
                     /db_xref="MIM:607613"
                     /translation="MFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVS
                     SPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEVD
                     DQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSY
                     SSPSGEAHSTQAVAVMVATREGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGG
                     SFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGILSPSSDLTLSS
                     VLWDRERSSFYSLTSSNISKWELDDSSEKHAYSWDINRALKENITDAIWGSESNYEAI
                     KEGVNIRYLDLKQNCDGLVILAAAWHSADNPCLIYYSLITIEDNGCQMSDAVTVEVTQ
                     YNPPFQSEDLILCQLTVPNFSNQTAYLYNESAVYVCSTGTGKFSLPQEKIVFNAQGDS
                     VLGAGACGGVPIIFSRNSGLVSITSRENVSILAEDLEGSLASSVAGPNSESMIFETTT
                     KNETIAQEDKIKLLKAAFLQYCRKDLGHAQMVVDELFSSHSDLDSDSELDRAVTQISV
                     DLMDDYPASDPRWAESVPEEAPGFSNTSLIILHQLEDKMKAHSFLMDFIHQVGLFGRL
                     GSFPVRGTPMATRLLLCEHAEKLSAAIVLKNHHSRLSDLVNTAILIALNKREYEIPSN
                     LTPADVFFREVSQVDTICECLLEHEEQVLRDAPMDSIEWAEVVINVNNILKDMLQAAS
                     HYRQNRNSLYRREESLEKEPEYVPWTATSGPGGIRTVIIRQHEIVLKVAYPQADSNLR
                     NIVTEQLVALIDCFLDGYVSQLKSVDKSSNRERYDNLEMEYLQKRSDLLSPLLSLGQY
                     LWAASLAEKYCDFDILVQMCEQTDNQSRLQRYMTQFADQNFSDFLFRWYLEKGKRGKL
                     LSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHATLLGLANMETRYFAKKKTLLG
                     LSKLAALASDFSEDMLQEKIEEMAEQERFLLHQETLPEQLLAEKQLNLSAMPVLTAPQ
                     LIGLYICEENRRANEYDFKKALDLLEYIDEEEDININDLKLEILCKALQRDNWSSSDG
                     KDDPIEVSKDSIFVKILQKLLKDGIQLSEYLPEVKDLLQADQLGSLKSNPYFEFVLKA
                     NYEYYVQGQI"
     exon            275..393
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            394..497
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            498..605
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            606..740
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            741..911
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1067
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1138
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1286
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1434
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1592
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1684
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1848
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1943
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2168
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2291
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2391
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2643
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2777
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2936
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3072
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3191
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3272
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3337
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3426
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..5208
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="hexamer: TATAAA"
     polyA_site      3727
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="major polyA site"
     regulatory      4147..4152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="hexamer: AATAAA"
     regulatory      4161..4166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="hexamer: AATGAA"
     polyA_site      4170
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="major polyA site"
     polyA_site      4180
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
     regulatory      4453..4458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="hexamer: AATAAA"
     polyA_site      4478
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
     regulatory      5185..5190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
                     /note="hexamer: AGTAAA"
     polyA_site      5208
                     /gene="NUP133"
                     /gene_synonym="GAMOS8; hNUP133; NPHS18"
ORIGIN      
        1 ctcttccctt aggtgtttaa gttccgcgcg caggccaggc tgcaacctga cggccagatc
       61 cctcgctgtc ctagtcgctg ctccttggag tcatgttccc agccgcccct tctccgcgga
      121 ccccgggtac cgggtcccga aggggcccgc tggccggact cgggcccggc tccacgcccc
      181 ggacggctag caggaagggt ctgcccctgg ggtctgcagt cagctcccca gtgctcttct
      241 cgccggtcgg ccggcgtagc tcgctaagct cgcggggaac accaacacga atgttcccac
      301 accactccat aactgagtct gtgaactatg atgtgaaaac gtttggatct tctcttcctg
      361 ttaaagtcat ggaagcccta acattggctg aagtcgatga ccagctgacc attaacatag
      421 atgaaggtgg atgggcttgt ctggtgtgca aagagaagct cattatttgg aagattgctc
      481 tgtcacctat tactaagtta tccgtttgca aagaacttca gctgccacct agtgatttcc
      541 actggagtgc cgacttagtg gctctttctt actcttctcc ctcaggtgaa gcacattcta
      601 ctcaggctgt tgctgtcatg gttgccacca gagaaggatc tatccgctat tggccaagcc
      661 ttgctggtga agatacctac acagaggctt ttgtagattc gggaggtgat aagacttaca
      721 gtttcctaac agcagtgcag ggaggaagtt ttattttgtc ttcatcagga agccaactaa
      781 ttcggttgat acctgagagc tcaggaaaga ttcatcagca tatcctgcct caggggcaag
      841 gcatgctttc aggaattggt cgaaaagttt cttctctttt tggaatttta tctcctagta
      901 gtgatctcac actttcaagt gttctctggg atagagagag atcaagcttt tatagcctga
      961 cgagttcaaa catcagtaaa tgggaattag atgattcttc agaaaagcat gcatacagtt
     1021 gggatataaa tagagccctg aaggaaaaca ttaccgatgc tatttgggga tctgaaagta
     1081 actatgaagc tattaaagaa ggagtcaaca ttcgatattt ggacttgaag caaaactgtg
     1141 atgggctggt gattttggca gcagcatggc actcagcaga caatccatgt ctcatctatt
     1201 actctctgat aacaatagaa gataatggtt gccaaatgtc agatgcagtt actgtagaag
     1261 tcactcaata taatccacct tttcagtctg aagacctgat tttgtgtcag ttgacggtcc
     1321 caaacttttc aaaccagact gcctatctgt ataacgaaag tgctgtctat gtgtgctcca
     1381 caggaactgg gaaattttct cttccccagg agaaaattgt ctttaatgca caaggagata
     1441 gtgttttagg tgctggtgcc tgtggtggtg ttcctatcat tttttctaga aacagtggac
     1501 tggtgtctat tacttcaagg gaaaatgtgt ctatattggc agaagacttg gaagggtctt
     1561 tagcatcttc agttgctgga ccaaacagtg agagtatgat ttttgagacc actacaaaga
     1621 atgaaactat agcccaggaa gataaaatca agttgctgaa agctgccttt ctgcaatact
     1681 gcagaaaaga tttaggtcat gctcaaatgg tggttgatga gctcttttcc tctcactctg
     1741 atttggattc tgattctgaa ctagacaggg cagttaccca aatcagtgta gacctgatgg
     1801 atgactaccc agcatctgac ccacggtggg ctgagtctgt ccctgaggaa gcacctgggt
     1861 tcagcaatac gtcactgatt atccttcacc agctagaaga caagatgaaa gctcactctt
     1921 ttcttatgga ctttattcat caagttggct tatttggacg tctaggcagt tttccagtta
     1981 gagggacacc gatggccact cgactgttgc tctgtgagca tgccgaaaag ctgtcagccg
     2041 ccattgttct caagaaccac cactcccggc tttctgacct tgtcaacaca gccatattga
     2101 ttgctttgaa caagagggag tatgaaatcc catccaacct gactcctgca gatgtctttt
     2161 tcagggaggt atcccaagta gataccatct gtgagtgctt actggagcat gaggagcaag
     2221 tcttgaggga tgcacctatg gattccattg aatgggctga agtggtgatc aatgtgaaca
     2281 atattctcaa ggatatgctg caggctgcta gtcattatcg ccaaaataga aactctttgt
     2341 atagaagaga agaatcacta gaaaaagaac ctgaatatgt tccatggacg gcaacaagtg
     2401 gtcctggtgg catccgaacg gtaataatac gccagcatga gattgtcctg aaggtggctt
     2461 atccacaggc agacagcaac ctccgaaaca tcgtgaccga gcagctggta gccctgatcg
     2521 attgcttcct ggatggttat gtttctcagc ttaagtctgt ggataaatcc agtaatcggg
     2581 aaagatatga caatctggag atggaatacc tacagaaaag atcagatctc ttatctcctc
     2641 ttctttcact aggccagtac ctgtgggctg cttctctagc agagaaatac tgtgactttg
     2701 atatattggt acaaatgtgt gagcagactg acaaccagag ccgactccag cgctacatga
     2761 cccagtttgc tgatcagaat ttttcagact ttctcttccg ttggtatctg gagaaaggaa
     2821 agcgaggcaa attattatct cagcccattt ctcagcatgg acagttggca aattttttgc
     2881 aagctcatga acatctcagc tggttacatg aaattaatag ccaagaatta gaaaaggctc
     2941 atgcaacact tctgggtttg gcaaatatgg aaactcgtta ctttgcaaag aagaaaaccc
     3001 ttcttggctt gagtaaattg gctgcattag cttcagactt ttcagaggat atgctacaag
     3061 aaaaaattga agaaatggct gagcaggagc gctttctact gcatcaggag accctacctg
     3121 aacagctgct ggcggagaaa cagctaaatc tcagtgcgat gccagtattg actgcaccac
     3181 aactcattgg tctatatatc tgtgaagaaa atagaagagc taatgaatat gatttcaaga
     3241 aagctttgga cttgttggaa tatattgatg aggaagaaga tataaatata aatgatctaa
     3301 aactggaaat cctttgcaaa gctcttcaga gagataactg gtccagttct gatggcaaag
     3361 atgatccaat tgaagtatct aaagacagta tatttgtgaa gatcttacag aaacttttaa
     3421 aagatggcat tcagctcagt gagtacttac cggaggtgaa agacctgcta caagcggatc
     3481 agcttggaag cttaaagtcc aatccttact tcgagtttgt tttgaaagca aattatgaat
     3541 attatgttca gggacaaata taactttttc taaaaatggc cattgtttat gaaatctgta
     3601 taagtgtgtc cttatacaaa ttttaggcca taaacaagtg taagtttgta caatttcata
     3661 acatgtatag ctgagttttt atactttata tgtaggaagc taatataaaa tagttatgta
     3721 actgtgattt tggttttcag ttatgtgact tgttttttcc acctgaaatg tgtcagttgt
     3781 tgttcctgta ctcggtgccc tttcttttta ctctcacgtg gtcccaggtt ctggagttct
     3841 tgtcctggtt ctagctgctc acatgtacaa atcacttcta ggcctcagtt tctgcgacta
     3901 tgaaaattac tagattgcac tagcttgtct ctaaaattgc tgtgactcca gatactttgc
     3961 actgaagaga atctagggtg tttgatatct gtttcagtta gggctaatgg gaaatgtcta
     4021 gtaagataaa tgtcaacttt tgctgactta ttatgagatg aaaaaccaaa ggagagtggg
     4081 cctaactcat gtgagcttga taactgatga actcattggg agcattttaa acttttctac
     4141 ataaataata aatgagcact aatgaaagta ttttagtgaa tgaaacgttt atgtggtttt
     4201 ctaacctatc tagaaattac tgttgatgtt tagttctaat ctttcagtgt ggggattcag
     4261 ccagcctcat gtattttcag aatgactcat gaatctttac cacagtctgc ctagctagtc
     4321 aaaagcatga atgatactag aaaccattat aggttttcct aatatggcaa ttgatgtgac
     4381 tgaaaggtac tgtactctca gagctttgtc ctgaccagtg tcatcactca ctcaatgttt
     4441 atctgggttt taaataaagg ccagaggttg gacagggagt tgctggcatg tccgcggctt
     4501 ggcccagtag aatgcccact aaccatcttg ctccagcagc tgaaaaggtc agaagttaaa
     4561 catggtgaag agtccggttc ctggattcac agagcccagc atcaggccgt ctcccccgca
     4621 ggctgcaagg ccagcccttg agtatgtttg gaagagcagg ttaatggagc tgtttgtaaa
     4681 tcaaagggaa gaaattagca gcctgttctt tttctctttg cagcttgtat gttaggacag
     4741 cattagggtc tgggttagga acatgttgga aggtactaag agaagttagg aagagcagct
     4801 tgtcagatgg ccagtaagaa accgctgagt acttgtatcg taagatgagg ctttgctttt
     4861 acgtggaggt cagctgtcag tgttcacgtc tcacctgtag gaccctgtcg ggtgataatg
     4921 tgctgcgaga cacacaggct cccatctccc tcccgtgctg ctgcaaacct ggtgatccct
     4981 ggtgtatggg acagtaccgc aggaaagccc atctgatcat gccccagaac ccactgatcg
     5041 cgtggacgta gaacgactgc tcttaccgtg tgaagtagag tcatcctgtt caagggaaga
     5101 aaaagctccc tcttttaatc ctgtttctct ctaagttagt agctattaca cccaaatggt
     5161 tgagttttta aaaattattt taacagtaaa aatgaaatta agacctag
//
