LOCUS       NM_020401               6213 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleoporin 107 (NUP107), transcript variant 1, mRNA.
ACCESSION   NM_020401
VERSION     NM_020401.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6213)
  AUTHORS   Han,Y., Sha,H., Yang,Y., Yu,Z., Zhou,L., Wang,Y., Yang,F., Qiu,L.,
            Zhang,Y. and Zhou,J.
  TITLE     Mutations in the NUP93, NUP107 and NUP160 genes cause
            steroid-resistant nephrotic syndrome in Chinese children
  JOURNAL   Ital J Pediatr 50 (1), 81 (2024)
   PUBMED   38650033
  REMARK    GeneRIF: Mutations in the NUP93, NUP107 and NUP160 genes cause
            steroid-resistant nephrotic syndrome in Chinese children.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6213)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6213)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6213)
  AUTHORS   Braun,D.A., Lovric,S., Schapiro,D., Schneider,R., Marquez,J.,
            Asif,M., Hussain,M.S., Daga,A., Widmeier,E., Rao,J., Ashraf,S.,
            Tan,W., Lusk,C.P., Kolb,A., Jobst-Schwan,T., Schmidt,J.M.,
            Hoogstraten,C.A., Eddy,K., Kitzler,T.M., Shril,S., Moawia,A.,
            Schrage,K., Khayyat,A.I.A., Lawson,J.A., Gee,H.Y., Warejko,J.K.,
            Hermle,T., Majmundar,A.J., Hugo,H., Budde,B., Motameny,S.,
            Altmuller,J., Noegel,A.A., Fathy,H.M., Gale,D.P., Waseem,S.S.,
            Khan,A., Kerecuk,L., Hashmi,S., Mohebbi,N., Ettenger,R.,
            Serdaroglu,E., Alhasan,K.A., Hashem,M., Goncalves,S., Ariceta,G.,
            Ubetagoyena,M., Antonin,W., Baig,S.M., Alkuraya,F.S., Shen,Q.,
            Xu,H., Antignac,C., Lifton,R.P., Mane,S., Nurnberg,P., Khokha,M.K.
            and Hildebrandt,F.
  TITLE     Mutations in multiple components of the nuclear pore complex cause
            nephrotic syndrome
  JOURNAL   J Clin Invest 128 (10), 4313-4328 (2018)
   PUBMED   30179222
REFERENCE   5  (bases 1 to 6213)
  AUTHORS   Ren,Y., Diao,F., Katari,S., Yatsenko,S., Jiang,H.,
            Wood-Trageser,M.A. and Rajkovic,A.
  TITLE     Functional study of a novel missense single-nucleotide variant of
            NUP107 in two daughters of Mexican origin with premature ovarian
            insufficiency
  JOURNAL   Mol Genet Genomic Med 6 (2), 276-281 (2018)
   PUBMED   29363275
  REMARK    GeneRIF: Whole exome sequencing identified a novel and rare
            missense variant in the NUP107 gene (c.1063C>T, p.R355C) in both
            sisters with HH.
REFERENCE   6  (bases 1 to 6213)
  AUTHORS   Le Rouzic,E., Mousnier,A., Rustum,C., Stutz,F., Hallberg,E.,
            Dargemont,C. and Benichou,S.
  TITLE     Docking of HIV-1 Vpr to the nuclear envelope is mediated by the
            interaction with the nucleoporin hCG1
  JOURNAL   J Biol Chem 277 (47), 45091-45098 (2002)
   PUBMED   12228227
REFERENCE   7  (bases 1 to 6213)
  AUTHORS   Vasu,S., Shah,S., Orjalo,A., Park,M., Fischer,W.H. and Forbes,D.J.
  TITLE     Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA
            export
  JOURNAL   J Cell Biol 155 (3), 339-354 (2001)
   PUBMED   11684705
REFERENCE   8  (bases 1 to 6213)
  AUTHORS   Belgareh,N., Rabut,G., Bai,S.W., van Overbeek,M., Beaudouin,J.,
            Daigle,N., Zatsepina,O.V., Pasteau,F., Labas,V., Fromont-Racine,M.,
            Ellenberg,J. and Doye,V.
  TITLE     An evolutionarily conserved NPC subcomplex, which redistributes in
            part to kinetochores in mammalian cells
  JOURNAL   J Cell Biol 154 (6), 1147-1160 (2001)
   PUBMED   11564755
REFERENCE   9  (bases 1 to 6213)
  AUTHORS   Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A.
  TITLE     Nuclear import of hepatic glucokinase depends upon glucokinase
            regulatory protein, whereas export is due to a nuclear export
            signal sequence in glucokinase
  JOURNAL   J Biol Chem 274 (52), 37125-37130 (1999)
   PUBMED   10601273
REFERENCE   10 (bases 1 to 6213)
  AUTHORS   Bastos,R., Ribas de Pouplana,L., Enarson,M., Bodoor,K. and Burke,B.
  TITLE     Nup84, a novel nucleoporin that is associated with CAN/Nup214 on
            the cytoplasmic face of the nuclear pore complex
  JOURNAL   J Cell Biol 137 (5), 989-1000 (1997)
   PUBMED   9166401
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ295745.1, AC124890.8 and
            BE326877.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020401.3.
            
            Summary: This gene encodes a member of the nucleoporin family. The
            protein is localized to the nuclear rim and is an essential
            component of the nuclear pore complex (NPC). All molecules entering
            or leaving the nucleus either diffuse through or are actively
            transported by the NPC. Alternate transcriptional splice variants
            of this gene have been observed but have not been thoroughly
            characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.92806.1,
                                           SRR1803617.198004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229179.9/ ENSP00000229179.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3092              AJ295745.1         28-3119
            3093-5736           AC124890.8         56027-58670
            5737-6213           BE326877.1         6-482               c
FEATURES             Location/Qualifiers
     source          1..6213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..6213
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /note="nucleoporin 107"
                     /db_xref="GeneID:57122"
                     /db_xref="HGNC:HGNC:29914"
                     /db_xref="MIM:607617"
     exon            1..96
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..2866
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear pore complex protein Nup107; nucleoporin 107kDa"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup107 isoform 1"
                     /protein_id="NP_065134.1"
                     /db_xref="CCDS:CCDS8985.1"
                     /db_xref="GeneID:57122"
                     /db_xref="HGNC:HGNC:29914"
                     /db_xref="MIM:607617"
                     /translation="MDRSGFGEISSPVIREAEVTRTARKQSAQKRVLLQASQDENFGN
                     TTPRNQVIPRTPSSFRQPFTPTSRSLLRQPDISCILGTGGKSPRLTQSSGFFGNLSMV
                     TNLDDSNWAAAFSSQRSGLFTNTEPHSITEDVTISAVMLREDDPGEAASMSMFSDFLQ
                     SFLKHSSSTVFDLVEEYENICGSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVT
                     WRLLASLYRDRIQSALEEESVFAVTAVNASEKTVVEALFQRDSLVRQSQLVVDWLESI
                     AKDEIGEFSDNIEFYAKSVYWENTLHTLKQRQLTSYVGSVRPLVTELDPDAPIRQKMP
                     LDDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGG
                     TELEPVEGNPYRRIWKISCWRMAEDELFNRYERAIYAALSGNLKQLLPVCDTWEDTVW
                     AYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEEN
                     QEHYHIVQKFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKE
                     EVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQYALFLESVTEFEQRHHCLEL
                     AKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDP
                     AQRAEALKQGNAIMRKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAED
                     DNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKVAHEHKEKKYEMD
                     FGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPM
                     LCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLDQ
                     GLDPLGYEIQL"
     exon            97..188
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            189..275
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            276..391
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            392..536
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            537..640
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            641..768
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            769..817
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            818..889
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            890..978
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1057
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1171
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1262
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1339
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1399
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1545
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1594
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1664
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1783
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1822
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1973
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2086
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2189
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2350
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2476
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2590
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2758
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..6213
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3052..3057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /note="hexamer: AATAAA"
     regulatory      3069..3074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /note="hexamer: ATTAAA"
     polyA_site      3075
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
     polyA_site      3092
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /note="major polyA site"
     regulatory      4354..4359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /note="hexamer: AACAAA"
     polyA_site      4374
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
     regulatory      6195..6200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
                     /note="hexamer: AATAAA"
     polyA_site      6213
                     /gene="NUP107"
                     /gene_synonym="GAMOS7; NPHS11; NUP84; ODG6"
ORIGIN      
        1 gaagggcttg cttccggaga gcgggaaggc taaaacgcgg tagctaaact gcagccaact
       61 ttggttgtgt gtggaaaagg ctttagccat ggacaggagt ggctttggag agatatcatc
      121 ccctgtaatc cgggaggcag aggtgacacg gactgcacgg aaacagagtg ctcagaaaag
      181 agttttactt caggcatctc aagatgaaaa ttttggtaat actacaccaa gaaaccaggt
      241 tatccctcga actcctagct catttcgaca gccttttacc ccaacaagcc gaagcttact
      301 aaggcagcca gatatttcct gcattcttgg aacaggaggg aagtcgcccc gacttacgca
      361 gtcttcaggg ttctttggaa atctctccat ggttactaat ctggatgaca gtaactgggc
      421 agctgcattt tcatcacagc gttccgggct gttcacaaac acagagcccc acagtataac
      481 agaagatgta actatcagtg ctgttatgtt acgtgaggat gatcctggag aagctgcatc
      541 catgagtatg ttttctgatt tcctgcagtc ttttctgaag cactcttcga gtacagtttt
      601 tgatcttgtg gaagagtatg aaaacatctg tggtagtcag gtgaatatac tgagtaaaat
      661 agtgagtcga gcaacacctg gacttcaaaa attttcaaaa acagccagta tgctctggct
      721 tcttcaacag gagatggtca catggaggct gctggcttct ttgtatagag acagaataca
      781 gtctgcatta gaagaggaaa gtgtattcgc agttactgct gttaatgcca gtgaaaaaac
      841 agttgtggaa gcgttatttc agagggattc acttgttcga caaagtcagc tggtggtaga
      901 ttggttagag agtattgcca aagatgaaat tggagaattt tctgataata ttgagtttta
      961 tgcaaaatca gtatattggg aaaatactct gcatacctta aaacaacggc agctgacttc
     1021 ttacgttgga agtgttcgtc cgcttgtcac tgaattggac cctgatgctc ccataagaca
     1081 gaaaatgccc cttgatgatc tggatagaga agatgaagtt agattactca aatatctctt
     1141 tactctaatc cgtgctggaa tgacagaaga ggcacaacga ctctgtaaac gctgtggtca
     1201 agcatggaga gctgcaacac ttgaaggctg gaaactgtac catgacccta atgttaatgg
     1261 aggaacagaa ttagaacctg ttgaagggaa tccatataga cgcatttgga aaataagttg
     1321 ctggagaatg gcagaagatg agctttttaa tagatacgag agagcaattt atgcagcttt
     1381 aagtgggaat cttaagcagc tgcttcctgt ctgtgacacc tgggaagaca cagtttgggc
     1441 ctacttccgg gtgatggtgg acagtctggt agaacaggag atccagacat cagtagcaac
     1501 tctggatgaa actgaagaac tccctagaga atatctggga gcaaactgga cgttagaaaa
     1561 ggtttttgag gaacttcaag ctactgacaa aaagagagtt ctggaagaga atcaagaaca
     1621 ttatcatata gttcaaaagt ttcttatcct gggagacatt gatggtttga tggatgagtt
     1681 tagcaaatgg ctttccaaaa gcagaaacaa tctacctgga cacctgcttc gctttatgac
     1741 tcaccttatt ttgtttttcc gtactctggg actacagacc aaggaggaag tttctattga
     1801 agttttaaag acatacatac agcttttaat aagagagaaa catacaaatc ttatagcatt
     1861 ttatacctgt catttgcctc aagacctagc tgttgcccag tatgcattat ttttggaaag
     1921 tgttacagaa tttgaacagc gccaccattg cctggagttg gctaaagaag cagatttgga
     1981 tgttgcaaca ataacaaaaa ctgtagttga gaatattcga aagaaagata atggtgaatt
     2041 tagtcatcat gacctggccc cagccctaga tactggcact actgaggagg atcgtttaaa
     2101 aattgatgta attgactggt tggtatttga cccagcgcag agggcagaag cactgaaaca
     2161 aggcaatgca attatgagaa aattcttggc atcaaaaaag cacgaagctg caaaagaagt
     2221 atttgtgaaa attcctcagg attctatagc agaaatctat aatcagtgcg aggaacaagg
     2281 aatggaaagt ccacttcctg ctgaagatga taatgctatc cgagaacatt tgtgcatcag
     2341 agcttatttg gaagcccatg aaacctttaa tgagtggttt aagcatatga attcagttcc
     2401 acaaaaacct gctttgatac ctcaaccaac ttttactgag aaagtggctc atgaacacaa
     2461 agaaaagaaa tatgaaatgg attttggtat ttggaaaggg catttggatg ccctaactgc
     2521 tgatgtgaag gagaaaatgt ataacgtctt gttgtttgtt gatggagggt ggatggtgga
     2581 tgttagagag gatgccaaag aagaccatga aagaacacat caaatggtct tactgagaaa
     2641 gctttgtctg ccaatgttgt gttttctgct tcatacgata ttgcacagta ctggtcagta
     2701 tcaggaatgc ctacagttag cagatatggt atcctctgag cgccacaaac tgtacctggt
     2761 attttctaag gaagagctaa ggaagttgct gcagaagctc agagagtcct ctctaatgct
     2821 cctagaccag ggacttgacc cattagggta tgaaattcag ttatagttta atctttgtaa
     2881 tctcactaat tttcatgata aatgaagttt ttaataaaat atacttgtta ttagtaattt
     2941 tttcttttgc attaccatgt aaaatttaga catttgaatt ttgtactttt cagaatatta
     3001 tcgtgacact ttcaacatgt agggatatca gcgtttctct gtgtgcttgt taataaaact
     3061 atataaaaat taaaattttc tgtttttaca aattccaggg ttgtctcttt ttcatgtaat
     3121 aagaaaatta aattttctgt tctagttttt tctgtaatca taagcattct gatattttaa
     3181 aatcataaag atgatggaaa gtagatttat ttttaagcca ggtacgtaat tttttattta
     3241 tcataaaatt tagtattttt gaatattaaa attaagaaga tgactataac aagaattttt
     3301 ctaacataac atgctattat tattttagtt attttgaaga catttctagt ttaactttca
     3361 tttagcaaac ttcctatcaa aataagagca tataaagact tagcgtagta cctggcacac
     3421 agtaagcact gaatatattg gagattacag atcccgctct tctaataggg gaaataccat
     3481 aagtacattt aaaaggtgtc atttaaaaat acaagtagtg gctgggtgca gtggctcacg
     3541 tctgtaaccc cagcacttcg ggaggccgag gcaggtggat cacctgtcgt caggagtttg
     3601 agaccagcct ggccaacatg gtgaaaccct gtctctacta aaaaaataca aaaattagcc
     3661 gggcatggtg gcaggtgcct gtaatcccag ctactcaggg gaggctgagg catgagaatc
     3721 tcttgaacct ggaaggcaga ggttgcagtg agccgagatc acgccactgc actccagcct
     3781 tggggacaga gcgagacact gtctccaaaa aaagaaagaa ttacaagtag tctgagcagg
     3841 aagaacctct ctccagctga aaagactctc aggaagtagt attggtttgg ggtttgagta
     3901 atgcactgaa tttgcaaagg caaagagtga cacaagaagg atgaggctct atagattaag
     3961 aaatcagtat gagcaagaaa tgataaatgc tgggcattat tatgaaccaa caaatacacc
     4021 aaataggcta gagtgtaggg cttataaaca ggagacaact aaaagaatgt gattctaata
     4081 gaaaacagta attccccaaa cttgctaatc atctaaggaa tttcttgaat atgtatttat
     4141 agatgccacc cctagagaca gctggcttgg gaagcctgag atgggatcat agaatttgat
     4201 cagttctata ttatgtgctt tttttgtttt atttctctaa agaattcatc ttgtcttcct
     4261 gttttcttta ttcttactaa tatgcaaatg atttttacag ctcatgcagt cctgtaatca
     4321 tgattattgc tatgctactt tgcaaaaaat aaaaacaaaa aattcatacc aaaacaaata
     4381 cagactagat ttggggtggg gaggggaaat aagtgagtct taaaagtagt tttgttactt
     4441 gcaacaaact gtatatatag aaactttgta caacccaggg tgactatttc caaagactgt
     4501 tacctatttg ttgaacaaca gtgggaaaac tacttagcct aaatgaggag gaggaatatt
     4561 gtatgcttcc atcgtaaccg tatgtgggta aatggacaag gtctgtcatc tatttaggaa
     4621 cttgttttgc atgtccccca ctctgtattt gtcttttgtt gtgccttgtt ttttgaatgt
     4681 cctttaaaaa acacagcaca gaaacccact aaggttgtgg aattacaaaa ttccttcaac
     4741 cttagactct taattaggat gccctcaaat ggacttgttt ttaattttta tttatttatt
     4801 tatttttgag acatggtctt gctctgtctc ccaggccgga gtgcagtggc atgatatctc
     4861 actgcaaacc tccgcctcct gggttcaagc gattctcctg cctcagcctc cctagtagct
     4921 gggattacag gcgcctgcca ccacgcctgg ctaatttttg tatttttagt agagacgggg
     4981 ttttgccatg ttggccaggc tggtctcaaa ctcttgacct caagtgatcc actcgcctcg
     5041 atctctcaaa gtgctgggat tacaggcata agccactgca cccagccaat tggactcctt
     5101 tgagtcctta gggagtcaat gtgtgtgttg ctgcttattt aaatacagtt cagttggagc
     5161 cccaagagtg ccaatgtgct cctcacaatt cccaaatgcc tctcttcctg aacaccagaa
     5221 gtggtgggca cctgagtggg aaatttcagg caacttaatt tagttcctca gtgcctactc
     5281 ttgaagaact gggttttcat tctagagagg aaactcaggg aagggcgtgt tgcctatcac
     5341 aggttcgcat actaagtttt aaaaactttt cttggtgtga cttatgccaa ggaattatga
     5401 agactttttc cttgagcatt gcatgaaggc tacaaagttg gaacaggcat gtcctgggtg
     5461 tgaaagtttt aatttcccta cctcatttat ttatttaatt tagagatggg ggtctcacta
     5521 tgttgcccat cccggcttcc aactcctggg ctcaagcaat cctcccacgt cagtctctca
     5581 aatagctggg actacaggcc cacgccacca tgccctactt cctcatttat tttaaatttt
     5641 ttgtaccaca gtctctcttt ttaattttat gactgctgaa ttaatcctag actctgtctt
     5701 aaaactaaga attgatgtat tggcaggaac agctggacat tcaagatgtt tttgtgattc
     5761 cttttttaaa aatctccttt tgtacctgta atatctacaa tatataatct ttctttatcg
     5821 acttaaggag gaaggagaaa ggaagaacct gacttctgtg tgaaggacct tactgtcgat
     5881 caagactgtt actcaaagtt ctatctctta gtcattgcac ctgacctgat ccaaaacata
     5941 tatatatatt tgtatgcacc cctagagaca gctgtatata tatacggttt tgccaggttg
     6001 tacgtttttt tctcgagttg taagtgaaca cagtagcact cgtttacatt gtcaagggga
     6061 catctttaga gaacacattt tctcactgtt gagctaataa tgctttgtga atgtatgatc
     6121 taaggagaaa cccttgtagt tatacccgat gatgctgtct gttggaaagt aaattttgaa
     6181 tgtctttttc caaaaataaa aaataaaaac atg
//
