LOCUS       NM_004756               3561 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NUMB like endocytic adaptor protein (NUMBL),
            transcript variant 1, mRNA.
ACCESSION   NM_004756
VERSION     NM_004756.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3561)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   2  (bases 1 to 3561)
  AUTHORS   Xin,Y., Shang,X., Sun,X., Xu,G., Liu,Y. and Liu,Y.
  TITLE     SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer
            malignant progression via the FUS RNA binding protein (FUS)/NUMB
            like endocytic adaptor protein (Numbl) axis
  JOURNAL   Bioengineered 13 (5), 12572-12582 (2022)
   PUBMED   35599603
  REMARK    GeneRIF: SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer
            malignant progression via the FUS RNA binding protein (FUS)/NUMB
            like endocytic adaptor protein (Numbl) axis.
REFERENCE   3  (bases 1 to 3561)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3561)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3561)
  AUTHORS   Hirai,M., Arita,Y., McGlade,C.J., Lee,K.F., Chen,J. and Evans,S.M.
  TITLE     Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by
            targeting ERBB2 for degradation
  JOURNAL   J Clin Invest 127 (2), 569-582 (2017)
   PUBMED   28067668
  REMARK    GeneRIF: investigations revealed that NUMB and NUMBL interacted
            with small GTPase Rab7 to transition ERBB2 from early to late
            endosome for degradation.
REFERENCE   6  (bases 1 to 3561)
  AUTHORS   Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
            Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Binding specificity and in vivo targets of the EH domain, a novel
            protein-protein interaction module
  JOURNAL   Genes Dev 11 (17), 2239-2249 (1997)
   PUBMED   9303539
REFERENCE   7  (bases 1 to 3561)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
REFERENCE   8  (bases 1 to 3561)
  AUTHORS   Zhong,W., Jiang,M.M., Weinmaster,G., Jan,L.Y. and Jan,Y.N.
  TITLE     Differential expression of mammalian Numb, Numblike and Notch1
            suggests distinct roles during mouse cortical neurogenesis
  JOURNAL   Development 124 (10), 1887-1897 (1997)
   PUBMED   9169836
REFERENCE   9  (bases 1 to 3561)
  AUTHORS   Zhong,W., Feder,J.N., Jiang,M.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Asymmetric localization of a mammalian numb homolog during mouse
            cortical neurogenesis
  JOURNAL   Neuron 17 (1), 43-53 (1996)
   PUBMED   8755477
REFERENCE   10 (bases 1 to 3561)
  AUTHORS   Wong,W.T., Schumacher,C., Salcini,A.E., Romano,A., Castagnino,P.,
            Pelicci,P.G. and Di Fiore,P.P.
  TITLE     A protein-binding domain, EH, identified in the receptor tyrosine
            kinase substrate Eps15 and conserved in evolution
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9530-9534 (1995)
   PUBMED   7568168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010412.9 and AK289398.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004756.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF015041.2, SRR3476690.920880.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252891.8/ ENSP00000252891.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC010412.9         111339-111339       c
            2-1472              AK289398.1         1-1471
            1473-3561           AC010412.9         86593-88681         c
FEATURES             Location/Qualifiers
     source          1..3561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3561
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /note="NUMB like endocytic adaptor protein"
                     /db_xref="GeneID:9253"
                     /db_xref="HGNC:HGNC:8061"
                     /db_xref="MIM:604018"
     exon            1..192
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1998
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /note="isoform a is encoded by transcript variant 1; numb
                     homolog-like; numb-like protein; numb-related protein"
                     /codon_start=1
                     /product="numb-like protein isoform a"
                     /protein_id="NP_004747.1"
                     /db_xref="CCDS:CCDS12561.1"
                     /db_xref="GeneID:9253"
                     /db_xref="HGNC:HGNC:8061"
                     /db_xref="MIM:604018"
                     /translation="MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNK
                     LRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDA
                     VKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYI
                     CRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTS
                     FAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGE
                     AGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTL
                     QRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWG
                     EPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASV
                     APVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVV
                     GITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEP
                     APAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL"
     exon            193..277
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     exon            278..417
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     exon            418..492
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     exon            493..567
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     exon            568..708
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     exon            709..898
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1204
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1327
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..3561
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2758..2763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /note="hexamer: AATAAA"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /note="hexamer: AATATA"
     polyA_site      2780
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /note="major polyA site"
     polyA_site      2792
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
     polyA_site      2828
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
     regulatory      3530..3535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
                     /note="hexamer: TATAAA"
     polyA_site      3561
                     /gene="NUMBL"
                     /gene_synonym="CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR;
                     TNRC23"
ORIGIN      
        1 aatcctcccg ggagccgagg aggctcgcgc gcgtgcatcc cgcaccatcc cccggccccg
       61 ggccctggcc ggcgtcagac cgagctgccg ccgccaccac cgcagcagca gcagtcgggg
      121 agccaggccc agccagggcc gcgggaggcg ggggcgcccg ggccctggat gtcccgcagc
      181 gcggcggcca gcggcggacc ccggaggcct gagcggcacc tgcccccagc cccctgtggg
      241 gccccggggc ccccagaaac ctgcaggacg gagccagacg gggcgggcac catgaacaag
      301 ttacggcaga gcctgcggcg gaggaagcca gcctacgtgc ccgaggcgtc gcgcccgcac
      361 cagtggcagg cagacgagga cgcggtgcgg aagggcacgt gcagcttccc ggtcaggtac
      421 ctgggtcacg tggaggtaga ggagtcccgg ggaatgcacg tgtgtgaaga tgcggtgaag
      481 aagctgaagg cgatgggccg aaagtccgtg aagtctgtcc tgtgggtgtc agccgatggg
      541 ctccgagtgg tggacgacaa aaccaaggat cttctggtcg accagaccat cgaaaaggtc
      601 tccttttgtg ctcctgaccg caacctggac aaggctttct cctatatctg tcgtgacggg
      661 actacccgcc gctggatctg ccactgtttt ctggcactga aggactccgg cgagaggctg
      721 agccacgctg tgggctgtgc ttttgccgcc tgcctggagc gaaaacagcg acgggagaag
      781 gaatgtgggg tcacggccgc cttcgatgcc agccgcacca gcttcgcccg cgagggctcc
      841 ttccgcctgt ctgggggtgg gcggcctgct gagcgagagg ccccggacaa gaagaaagca
      901 gaggcagcag ctgcccccac tgtggctcct ggccctgccc agcctgggca cgtgtccccg
      961 acaccagcca ccacatcccc tggtgagaag ggtgaggcag gcacccctgt ggctgcaggc
     1021 accactgcgg ccgccatccc ccggcgccat gcacccctgg agcagctggt tcgccagggc
     1081 tccttccgtg ggttcccagc actcagccag aagaactcgc ctttcaaacg gcagctgagc
     1141 ctacggctga atgagctgcc atccacgctg cagcgccgca ctgacttcca ggtgaagggc
     1201 acagtgcctg agatggagcc tcctggtgcc ggcgacagtg acagcatcaa cgctctgtgc
     1261 acacagatca gttcatcttt tgccagtgct ggagcgccag caccagggcc accacctgcc
     1321 acaacaggga cttctgcctg gggtgagccc tccgtgcccc ctgcagctgc cttccagcct
     1381 gggcacaagc ggacaccttc agaggctgag cgatggctgg aggaggtgtc acaggtggcc
     1441 aaggcccagc agcagcagca gcagcaacag caacagcagc agcagcagca gcagcaacag
     1501 cagcaagcag cctcagtggc cccagtgccc accatgcctc ctgccctgca gcctttcccc
     1561 gcccccgtgg ggccctttga cgctgcacct gcccaagtgg ccgtgttcct gccaccccca
     1621 cacatgcagc ccccttttgt gcccgcctac ccgggcttgg gctacccacc gatgccccgg
     1681 gtgcccgtgg tgggcatcac accctcacag atggtggcaa acgccttctg ctcagccgcc
     1741 cagctccagc ctcagcctgc cactctgctt gggaaagctg gggccttccc gccccctgcc
     1801 atacccagtg cccctgggag ccaggcccgc cctcgcccca atggggcccc ctggccccct
     1861 gagccagcgc ctgccccagc tccagagttg gacccctttg aggcccagtg ggcggcatta
     1921 gaaggcaaag ccactgtaga gaaaccctcc aacccctttt ctggcgacct gcaaaagaca
     1981 ttcgagattg aactgtagcc cgagccgccc cacccactcc atcatctcca ggtgccccac
     2041 gcctgggggt ggaggcacaa cctctcccct aaccctgctc cctggggctg cgcccctcaa
     2101 caccctctca acacccccct ccctcaacca ccccgacaac cactacagaa ccaacattgt
     2161 gacgcccagg ttgcaacagg atggaattca gggacggacc cagcctggct aagggaacca
     2221 tttcactgcc ggacttaggc tggcaatgcc cccttcccca accccagaca caggggttgg
     2281 ccacaatccc actgaatgcc cttggttcac actccatttc ccagtttctg ttgaccccca
     2341 ccttccagtg ttggacagga tggagggggg acacttgctt aggggctctc ctgggcccca
     2401 caccagtgcc caccccaaat ctggtcgtct cctcccccca tgcacagcac aagctaaggg
     2461 ctgccctctg cccacacgct gcgttcactg ccaatgctgt actcacctcc atcaccctcc
     2521 aactttgggg cccatgtctt ccttgggcca aggtctcatg ggggctaggg ccaagttggg
     2581 ggcccaggag gcggggaggg aggaggagga gaagatgcgc agttacctca tgtcggtgcc
     2641 cgctggggag gggtccggga agaaggggaa ggggtgcctg gcgggtactt ttctatcttt
     2701 tatttccaga ttttttttgt atctaaactt gaagatttgt attatacaag gacagccaat
     2761 aaaggaagaa tataatggtg cccctcggga aacgagggtg tgtgtagggc gctggtgagg
     2821 ccctagaacc tttcctcctg agtcatggac tgaaacagag tcagaaggat gtccctgagt
     2881 gataacctct gagtcatagc gtggtaacag gtaccactga ctcagcacct gccaggcggg
     2941 tattaaagga gccaaaatta atcaccccat ttctattcct tacagagtta gaatcaagga
     3001 ataaaaaaca aatattatga actgctggct gggcacagtg gctcacgcct gtaatcccag
     3061 cactttggga ggtcgaggca ggcagatcac ttaaggtcag gagttcgaga ccagcctggc
     3121 cgccatggag aaacccagtc tctaccaaaa attcaaaaat tagccgggcg tggtggcagg
     3181 cgcctgtaat tccaggaggc tgaggcacaa gaatcgcttg aacccaggca gcagaggttg
     3241 cagtgacctg aggtcacacc attgcactcc tgcctgggca acagaatgag actctgtctc
     3301 aaaaaaaaaa aacaaaaaaa aaaaaactac ttctaattag ctcaatatta atattttaac
     3361 aagttgggtt ggtaacagta tatctttgcc catgctggca aattcttgtt ttgtcagcat
     3421 tttccataac tctggccaaa gtgtcacctg atgtggcaac gttttacagt cttgctattg
     3481 tttcttgagt cctttaatct ataagatgta tttttaaaaa tatataacat ataaattttg
     3541 tttcgttata gctctttaaa a
//
