LOCUS       XM_047427004            7337 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens nuclear mitotic apparatus protein 1
            (NUMA1), transcript variant X22, mRNA.
ACCESSION   XM_047427004
VERSION     XM_047427004.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000011.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
     gene            1..7337
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /note="nuclear mitotic apparatus protein 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 116 ESTs, 1017 long SRA reads, 5 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 42 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4926"
                     /db_xref="HGNC:HGNC:8059"
                     /db_xref="MIM:164009"
     CDS             315..6674
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /codon_start=1
                     /product="nuclear mitotic apparatus protein 1 isoform X2"
                     /protein_id="XP_047282960.1"
                     /db_xref="GeneID:4926"
                     /db_xref="HGNC:HGNC:8059"
                     /db_xref="MIM:164009"
                     /translation="MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIH
                     GTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLL
                     LYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTC
                     SSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRR
                     LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK
                     ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL
                     QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE
                     HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKL
                     LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT
                     TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ
                     LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL
                     QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS
                     EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK
                     AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT
                     AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV
                     AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK
                     EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER
                     EAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL
                     EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVK
                     QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL
                     ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK
                     AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKS
                     QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE
                     RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE
                     KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ
                     LSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV
                     QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLADSDQASK
                     VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK
                     KQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRS
                     LEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITRH
                     KALMTIIPDLSPNNPLSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPA
                     RSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYST
                     RSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAP
                     PGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDE
                     EMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPR
                     PMTPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASK
                     KALSKASPNTRSGTRRSPRIATTTASAATAAAIGATPRAKGKAKH"
ORIGIN      
        1 aattgtgcgc tcacagcgct ggcgcgagcc cacgaagagg tacgattccg gagaatcgcg
       61 aggcagagcg ggagcgcgca gccaggtgga aactaattct aagccagact gctggagatc
      121 accctgttct agtgtgtgga ggcttccacc aggaggaaac tgcagctgag gagccattgc
      181 agtcccatct ccagaagacc cccagaaaga gttggaagag ttcttcaggc tgtggcagcc
      241 actgcccacc aacacaccca aatcaatcaa gatgaatccc aggcgcattg gagtgactgt
      301 ctggcatcac caagatgaca ctccacgcca cccggggggc tgcactcctc tcttgggtga
      361 acagtctaca cgtggctgac cctgtggagg ctgtgctgca gctccaggac tgcagcatct
      421 tcatcaagat cattgacaga atccatggca ctgaagaggg acagcaaatc ttgaagcagc
      481 cggtgtcaga gagactggac tttgtgtgca gttttctgca gaaaaatcga aaacatccct
      541 cttccccaga atgcctggta tctgcacaga aggtgctaga gggatcagag ctggaactgg
      601 cgaagatgac catgctgctc ttataccact ctaccatgag ctccaaaagt cccagggact
      661 gggaacagtt tgaatataaa attcaggctg agttggctgt cattcttaaa tttgtgctgg
      721 accatgagga cgggctaaac cttaatgagg acctagagaa cttcctacag aaagctcctg
      781 tgccttctac ctgttctagc acattccctg aagagctctc cccacctagc caccaggcca
      841 agagggagat tcgcttccta gagctacaga aggttgcctc ctcttccagt gggaacaact
      901 ttctctcagg ttctccagct tctcccatgg gtgatatcct gcagacccca cagttccaga
      961 tgagacggct gaagaagcag cttgctgatg agagaagtaa tagggatgag ctggagctgg
     1021 agctagctga gaaccgcaag ctcctcaccg agaaggatgc acagatagcc atgatgcagc
     1081 agcgcattga ccgcctagcc ctgctgaatg agaagcaggc ggccagccca ctggagccca
     1141 aggagcttga ggagctgcgt gacaagaatg agagccttac catgcggctg catgaaaccc
     1201 tgaagcagtg ccaggacctg aagacagaga agagccagat ggatcgcaaa atcaaccagc
     1261 tttcggagga gaatggagac ctttccttta agctgcggga gtttgccagt catctgcagc
     1321 agctacagga tgccctcaat gagctgacgg aggagcacag caaggccact caggagtggc
     1381 tagagaagca ggcccagctg gagaaggagc tcagcgcagc cctgcaggac aagaaatgcc
     1441 ttgaagagaa gaacgaaatc cttcagggaa aactttcaca gctggaagaa cacttgtccc
     1501 agctgcagga taacccaccc caggagaagg gcgaggtgct gggtgatgtc ttgcagctgg
     1561 aaaccttgaa gcaagaggca gccactcttg ctgcaaacaa cacacagctc caagccaggg
     1621 tagagatgct ggagactgag cgaggccagc aggaagccaa gctgcttgct gagcggggcc
     1681 acttcgaaga agaaaagcag cagctgtcta gcctgatcac tgacctgcag agctccatct
     1741 ccaacctcag ccaggccaag gaagagctgg agcaggcctc ccaggctcat ggggcccggt
     1801 tgactgccca ggtggcctct ctgacctctg agctcaccac actcaatgcc accatccagc
     1861 aacaggatca agaactggct ggcctgaagc agcaggccaa agagaagcag gcccagctag
     1921 cacagaccct ccaacagcaa gaacaggcct cccagggcct ccgccaccag gtggagcagc
     1981 taagcagtag cctgaagcag aaggagcagc agttgaagga ggtagcggag aagcaggagg
     2041 caactaggca ggaccatgcc cagcaactgg ccactgctgc agaggagcga gaggcctcct
     2101 taagggagcg ggatgcggct ctcaagcagc tggaggcact ggagaaggag aaggctgcca
     2161 agctggagat tctgcagcag caacttcagg tggctaatga agcccgggac agtgcccaga
     2221 cctcagtgac acaggcccag cgggagaagg cagagctgag ccggaaggtg gaggaactcc
     2281 aggcctgtgt tgagacagcc cgccaggaac agcatgaggc ccaggcccag gttgcagagc
     2341 tagagttgca gctgcggtct gagcagcaaa aagcaactga gaaagaaagg gtggcccagg
     2401 agaaggacca gctccaggag cagctccagg ccctcaaaga gtccttgaag gtcaccaagg
     2461 gcagccttga agaggagaag cgcagggctg cagatgccct ggaagagcag cagcgttgta
     2521 tctctgagct gaaggcagag acccgaagcc tggtggagca gcataagcgg gaacgaaagg
     2581 agctggaaga agagagggct gggcgcaagg ggctggaggc tcgattacag cagcttgggg
     2641 aggcccatca ggctgagact gaagtcctgc ggcgggagct ggcagaggcc atggctgccc
     2701 agcacacagc tgagagtgag tgtgagcagc tcgtcaaaga agtagctgcc tggcgtgagc
     2761 ggtatgagga tagccagcaa gaggaggcac agtatggcgc catgttccag gaacagctga
     2821 tgactttgaa ggaggaatgt gagaaggccc gccaggagct gcaggaggca aaggagaagg
     2881 tggcaggcat agaatcccac agcgagctcc agataagccg gcagcagaac gaactagctg
     2941 agctccatgc caacctggcc agagcactcc agcaggtcca agagaaggaa gtcagggccc
     3001 agaagcttgc agatgacctc tccactctgc aggaaaagat ggctgccacc agcaaagagg
     3061 tggcccgctt ggagaccttg gtgcgcaagg caggtgagca gcaggaaaca gcctcccggg
     3121 agttagtcaa ggagcctgcg agggcaggag acagacagcc cgagtggctg gaagagcaac
     3181 agggacgcca gttctgcagc acacaggcag cgctgcaggc tatggagcgg gaggcagagc
     3241 agatgggcaa tgagctggaa cggctgcggg ccgcgctgat ggagagccag gggcagcagc
     3301 aggaggagcg tgggcagcag gaaagggagg tggcgcggct gacccaggag cggggccgtg
     3361 cccaggctga ccttgccctg gagaaggcgg ccagagcaga gcttgagatg cggctgcaga
     3421 acgccctcaa cgagcagcgt gtggagttcg ctaccctgca agaggcactg gctcatgccc
     3481 tgacggaaaa ggaaggcaag gaccaggagt tggccaagct tcgtggtctg gaggcagccc
     3541 agataaaaga gctggaggaa cttcggcaaa ccgtgaagca actgaaggaa cagctggcta
     3601 agaaagaaaa ggagcacgca tctggctcag gagcccaatc tgaggctgct ggcaggacag
     3661 agccaacagg ccccaagctg gaggcactgc gggcagaggt gagcaagctg gaacagcaat
     3721 gccagaagca gcaggagcag gctgacagcc tggaacgcag cctcgaggct gagcgggcct
     3781 cccgggctga gcgggacagt gctctggaga ctctgcaggg ccagttagag gagaaggccc
     3841 aggagctagg gcacagtcag agtgccttag cctcggccca acgggagttg gctgccttcc
     3901 gcaccaaggt acaagaccac agcaaggctg aagatgagtg gaaggcccag gtggcccggg
     3961 gccggcaaga ggctgagagg aaaaatagcc tcatcagcag cttggaggag gaggtgtcca
     4021 tcctgaatcg ccaggtcctg gagaaggagg gggagagcaa ggagttgaag cggctggtga
     4081 tggccgagtc agagaagagc cagaagctgg aggagaggct gcgcctgctg caggcagaga
     4141 cagccagcaa cagtgccaga gctgcagaac gcagctctgc tctgcgggag gaggtgcaga
     4201 gcctccggga ggaggctgag aaacagcggg tggcttcaga gaacctgcgg caggagctga
     4261 cctcacaggc tgagcgtgcg gaggagctgg gccaagaatt gaaggcgtgg caggagaagt
     4321 tcttccagaa agagcaggcc ctctccaccc tgcagctcga gcacaccagc acacaggccc
     4381 tggtgagtga gctgctgcca gctaagcacc tctgccagca gctgcaggcc gagcaggccg
     4441 ctgccgagaa acgccaccgt gaggagctgg agcagagcaa gcaggccgct gggggactgc
     4501 gggcagagct gctgcgggcc cagcgggagc ttggggagct gattcctctg cggcagaagg
     4561 tggcagagca ggagcgaaca gctcagcagc tgcgggcaga gaaggccagc tatgcagagc
     4621 agctgagcat gctgaagaag gcgcatggcc tgctggcaga ggagaaccgg gggctgggtg
     4681 agcgggccaa ccttggccgg cagtttctgg aagtggagtt ggaccaggcc cgggagaagt
     4741 atgtccaaga gttggcagcc gtacgtgctg atgctgagac ccgtctggct gaggtgcagc
     4801 gagaagcaca gagcactgcc cgggagctgg aggtgatgac tgccaagtat gagggtgcca
     4861 aggtcaaggt cctggaggag aggcagcggt tccaggaaga gaggcagaaa ctcactgccc
     4921 aggtggaaga actgagtaag aaactggctg actctgacca agccagcaag gtgcagcagc
     4981 agaagctgaa ggctgtccag gctcagggag gcgagagcca gcaggaggcc cagcgcctcc
     5041 aggcccagct gaatgaactg caagcccagt tgagccagaa ggagcaggca gctgagcact
     5101 ataagctgca gatggagaaa gccaaaacac attatgatgc caagaagcag cagaaccaag
     5161 agctgcagga gcagctgcgg agcctggagc agctgcagaa ggaaaacaaa gagctgcgag
     5221 ctgaagctga acggctgggc catgagctac agcaggctgg gctgaagacc aaggaggctg
     5281 aacagacctg ccgccacctt actgcccagg tgcgcagcct ggaggcacag gttgcccatg
     5341 cagaccagca gcttcgagac ctgggcaaat tccaggtggc aactgatgct ttaaagagcc
     5401 gtgagcccca ggctaagccc cagctggact tgagtattga cagcctggat ctgagctgcg
     5461 aggaggggac cccactcagt atcaccagac ataaagcact catgacaatt atacctgatt
     5521 tgtcccccaa caaccctctg agcaagctgc ctcgtaccca gccagacggc accagcgtcc
     5581 ctggagaacc agcctcacct atctcccagc gcctgccccc caaggtagaa tccctggaga
     5641 gtctctactt cactcccatc cctgctcgga gtcaggcccc cctggagagc agcctggact
     5701 ccctgggaga cgtcttcctg gactcgggtc gtaagacccg ctccgctcgt cggcgcacca
     5761 cgcagatcat caacatcacc atgaccaaga agctagatgt ggaagagcca gacagcgcca
     5821 actcatcgtt ctacagcacg cggtctgctc ctgcttccca ggctagcctg cgagccacct
     5881 cctctactca gtctctagct cgcctgggtt ctcccgatta tggcaactca gccctgctca
     5941 gcttgcctgg ctaccgcccc accactcgca gttctgctcg tcgttcccag gccggggtgt
     6001 ccagtggggc ccctccagga aggaacagct tctacatggg cacttgccag gatgagcctg
     6061 agcagctgga tgactggaac cgcattgcag agctgcagca gcgcaatcga gtgtgccccc
     6121 cacatctgaa gacctgctat cccctggagt ccaggccttc cctgagcctg ggcaccatca
     6181 cagatgagga gatgaaaact ggagaccccc aagagaccct gcgccgagcc agcatgcagc
     6241 caatccagat agccgagggc actggcatca ccacccggca gcagcgcaaa cgggtctccc
     6301 tagagcccca ccagggccct ggaactcctg agtctaagaa ggccaccagc tgtttcccac
     6361 gccccatgac tccccgagac cgacatgaag ggcgcaaaca gagcactact gaggcccaga
     6421 agaaagcagc tccagcttct actaaacagg ctgaccggcg ccagtcgatg gccttcagca
     6481 tcctcaacac acccaagaag ctagggaaca gccttctgcg gcggggagcc tcaaagaagg
     6541 ccctgtccaa ggcttccccc aacactcgca gtggaacccg ccgttctccg cgcattgcca
     6601 ccaccacagc cagcgccgcc actgctgccg ccattggtgc cacccctcga gccaagggca
     6661 aggcaaagca ctaaagggcc agtaccagtg agtggcccca cctgtgtccc cgatgctgac
     6721 ctcacctggt cctccgccta ctgtccctct cagtgccttc tctcagctcc caggccaaca
     6781 gtagccaaac ccctagagac agtgatgcct gcccgcaccc tggcctggtc cctggtcctt
     6841 cactggcgcc ttctcggagc tggcccaggg ggcctggagc atggacagtg tgggcgctct
     6901 ccctaccttg cctccttttt tcttaaagca aagtcacttc tccatcacaa ccagatttga
     6961 ggctggtttt gatggctggg tccttgggcc tggccagtct tcctcttagc ctctggatct
     7021 agaagggacc ataagaggag taggccctgg ttcctgctgt cctggtggct gggcccagca
     7081 ggggccctca ctcttgaagt ccaggactgg gtctgacctg gtgggagcac ctgccagagg
     7141 atgctctttc ccaggacgga tgggccctat gtctcaggag tggggttggg ggacagcctt
     7201 cagcagcagc tcacacccta ccttccccag acttgcactg gggtgggatt tggagtgatg
     7261 ggaaggtttt taagggccgg ggatggatct tttctaaatg ttattacttg taaataaagt
     7321 ctatttttct cccgtga
//
