LOCUS       NM_006185               7198 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens nuclear mitotic apparatus protein 1 (NUMA1),
            transcript variant 1, mRNA.
ACCESSION   NM_006185
VERSION     NM_006185.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7198)
  AUTHORS   van Toorn,M., Gooch,A., Boerner,S. and Kiyomitsu,T.
  TITLE     NuMA deficiency causes micronuclei via checkpoint-insensitive
            k-fiber minus-end detachment from mitotic spindle poles
  JOURNAL   Curr Biol 33 (3), 572-580 (2023)
   PUBMED   36626904
  REMARK    GeneRIF: NuMA deficiency causes micronuclei via
            checkpoint-insensitive k-fiber minus-end detachment from mitotic
            spindle poles.
REFERENCE   2  (bases 1 to 7198)
  AUTHORS   Risteski,P., Bozan,D., Jagric,M., Bosilj,A., Pavin,N. and
            Tolic,I.M.
  TITLE     Length-dependent poleward flux of sister kinetochore fibers
            promotes chromosome alignment
  JOURNAL   Cell Rep 40 (5), 111169 (2022)
   PUBMED   35926461
  REMARK    GeneRIF: Length-dependent poleward flux of sister kinetochore
            fibers promotes chromosome alignment.
REFERENCE   3  (bases 1 to 7198)
  AUTHORS   Radulescu,A.E. and Cleveland,D.W.
  TITLE     NuMA after 30 years: the matrix revisited
  JOURNAL   Trends Cell Biol 20 (4), 214-222 (2010)
   PUBMED   20137953
  REMARK    Review article
REFERENCE   4  (bases 1 to 7198)
  AUTHORS   Compton,D.A. and Luo,C.
  TITLE     Mutation of the predicted p34cdc2 phosphorylation sites in NuMA
            impair the assembly of the mitotic spindle and block mitosis
  JOURNAL   J Cell Sci 108 (Pt 2), 621-633 (1995)
   PUBMED   7769006
REFERENCE   5  (bases 1 to 7198)
  AUTHORS   Tang,T.K., Tang,C.J., Chao,Y.J. and Wu,C.W.
  TITLE     Nuclear mitotic apparatus protein (NuMA): spindle association,
            nuclear targeting and differential subcellular localization of
            various NuMA isoforms
  JOURNAL   J Cell Sci 107 (Pt 6), 1389-1402 (1994)
   PUBMED   7962183
REFERENCE   6  (bases 1 to 7198)
  AUTHORS   Maekawa,T. and Kuriyama,R.
  TITLE     Primary structure and microtubule-interacting domain of the SP-H
            antigen: a mitotic MAP located at the spindle pole and
            characterized as a homologous protein to NuMA
  JOURNAL   J Cell Sci 105 (Pt 2), 589-600 (1993)
   PUBMED   8408288
REFERENCE   7  (bases 1 to 7198)
  AUTHORS   Tang,T.K., Tang,C.J., Chen,Y.L. and Wu,C.W.
  TITLE     Nuclear proteins of the bovine esophageal epithelium. II. The NuMA
            gene gives rise to multiple mRNAs and gene products reactive with
            monoclonal antibody W1
  JOURNAL   J Cell Sci 104 (Pt 2), 249-260 (1993)
   PUBMED   8505359
REFERENCE   8  (bases 1 to 7198)
  AUTHORS   Compton,D.A., Szilak,I. and Cleveland,D.W.
  TITLE     Primary structure of NuMA, an intranuclear protein that defines a
            novel pathway for segregation of proteins at mitosis
  JOURNAL   J Cell Biol 116 (6), 1395-1408 (1992)
   PUBMED   1541636
REFERENCE   9  (bases 1 to 7198)
  AUTHORS   Yang,C.H., Lambie,E.J. and Snyder,M.
  TITLE     NuMA: an unusually long coiled-coil related protein in the
            mammalian nucleus
  JOURNAL   J Cell Biol 116 (6), 1303-1317 (1992)
   PUBMED   1541630
REFERENCE   10 (bases 1 to 7198)
  AUTHORS   Lydersen,B.K. and Pettijohn,D.E.
  TITLE     Human-specific nuclear protein that associates with the polar
            region of the mitotic apparatus: distribution in a human/hamster
            hybrid cell
  JOURNAL   Cell 22 (2 Pt 2), 489-499 (1980)
   PUBMED   7004645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG771637.1, BC027493.1,
            AB210007.1, BG754891.1 and BC004165.2.
            
            On Nov 30, 2019 this sequence version replaced NM_006185.3.
            
            Summary: This gene encodes a large protein that forms a structural
            component of the nuclear matrix. The encoded protein interacts with
            microtubules and plays a role in the formation and organization of
            the mitotic spindle during cell division. Chromosomal translocation
            of this gene with the RARA (retinoic acid receptor, alpha) gene on
            chromosome 17 have been detected in patients with acute
            promyelocytic leukemia. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB210007.1, Z11583.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393695.8/ ENSP00000377298.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BG771637.1         156-203
            49-2247             BC027493.1         1-2199
            2248-6579           AB210007.1         2200-6531
            6580-7129           BG754891.1         57-606
            7130-7198           BC004165.2         3707-3775
FEATURES             Location/Qualifiers
     source          1..7198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..7198
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /note="nuclear mitotic apparatus protein 1"
                     /db_xref="GeneID:4926"
                     /db_xref="HGNC:HGNC:8059"
                     /db_xref="MIM:164009"
     exon            1..85
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            86..155
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            156..229
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..6535
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrophilin stabilizes mitotic spindle in mitotic cells;
                     structural nuclear protein; SP-H antigen; nuclear matrix
                     protein-22"
                     /codon_start=1
                     /product="nuclear mitotic apparatus protein 1 isoform 1"
                     /protein_id="NP_006176.2"
                     /db_xref="CCDS:CCDS31633.1"
                     /db_xref="GeneID:4926"
                     /db_xref="HGNC:HGNC:8059"
                     /db_xref="MIM:164009"
                     /translation="MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIH
                     GTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLL
                     LYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTC
                     SSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRR
                     LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK
                     ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL
                     QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE
                     HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKL
                     LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT
                     TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ
                     LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL
                     QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS
                     EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK
                     AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT
                     AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV
                     AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK
                     EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER
                     EAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL
                     EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVK
                     QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL
                     ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK
                     AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKS
                     QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE
                     RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE
                     KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ
                     LSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV
                     QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVE
                     ELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY
                     KLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKE
                     AEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLD
                     LSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQA
                     PLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAP
                     ASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRN
                     SFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKT
                     GDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTP
                     RDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALS
                     KASPNTRSGTRRSPRIATTTASAATAAAIGATPRAKGKAKH"
     exon            230..315
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            316..395
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            396..478
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            479..559
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            560..647
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            648..771
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            772..929
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1047
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1165
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1306
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1429
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..4795
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4837
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..4906
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4907..5026
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5245
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5246..5403
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5404..5650
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5651..5879
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            5880..6016
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            6017..6193
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            6194..6310
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            6311..6523
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     exon            6524..7198
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7174..7179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /note="hexamer: AATAAA"
     polyA_site      7198
                     /gene="NUMA1"
                     /gene_synonym="NMP-22; NUMA"
                     /note="major polyA site"
ORIGIN      
        1 aattgtgcgc tcacagcgct ggcgcgagcc cacgaagagg tacgattccg gagaatcgcg
       61 aggcagagcg ggagcgcgca gccaggtgga aactaattct aagccagact gctggagatc
      121 accctgttct agtgtgtgga ggcttccacc aggaggcgca ttggagtgac tgtctggcat
      181 caccaagatg acactccacg ccacccgggg ggctgcactc ctctcttggg tgaacagtct
      241 acacgtggct gaccctgtgg aggctgtgct gcagctccag gactgcagca tcttcatcaa
      301 gatcattgac agaatccatg gcactgaaga gggacagcaa atcttgaagc agccggtgtc
      361 agagagactg gactttgtgt gcagttttct gcagaaaaat cgaaaacatc cctcttcccc
      421 agaatgcctg gtatctgcac agaaggtgct agagggatca gagctggaac tggcgaagat
      481 gaccatgctg ctcttatacc actctaccat gagctccaaa agtcccaggg actgggaaca
      541 gtttgaatat aaaattcagg ctgagttggc tgtcattctt aaatttgtgc tggaccatga
      601 ggacgggcta aaccttaatg aggacctaga gaacttccta cagaaagctc ctgtgccttc
      661 tacctgttct agcacattcc ctgaagagct ctccccacct agccaccagg ccaagaggga
      721 gattcgcttc ctagagctac agaaggttgc ctcctcttcc agtgggaaca actttctctc
      781 aggttctcca gcttctccca tgggtgatat cctgcagacc ccacagttcc agatgagacg
      841 gctgaagaag cagcttgctg atgagagaag taatagggat gagctggagc tggagctagc
      901 tgagaaccgc aagctcctca ccgagaagga tgcacagata gccatgatgc agcagcgcat
      961 tgaccgccta gccctgctga atgagaagca ggcggccagc ccactggagc ccaaggagct
     1021 tgaggagctg cgtgacaaga atgagagcct taccatgcgg ctgcatgaaa ccctgaagca
     1081 gtgccaggac ctgaagacag agaagagcca gatggatcgc aaaatcaacc agctttcgga
     1141 ggagaatgga gacctttcct ttaagctgcg ggagtttgcc agtcatctgc agcagctaca
     1201 ggatgccctc aatgagctga cggaggagca cagcaaggcc actcaggagt ggctagagaa
     1261 gcaggcccag ctggagaagg agctcagcgc agccctgcag gacaagaaat gccttgaaga
     1321 gaagaacgaa atccttcagg gaaaactttc acagctggaa gaacacttgt cccagctgca
     1381 ggataaccca ccccaggaga agggcgaggt gctgggtgat gtcttgcagc tggaaacctt
     1441 gaagcaagag gcagccactc ttgctgcaaa caacacacag ctccaagcca gggtagagat
     1501 gctggagact gagcgaggcc agcaggaagc caagctgctt gctgagcggg gccacttcga
     1561 agaagaaaag cagcagctgt ctagcctgat cactgacctg cagagctcca tctccaacct
     1621 cagccaggcc aaggaagagc tggagcaggc ctcccaggct catggggccc ggttgactgc
     1681 ccaggtggcc tctctgacct ctgagctcac cacactcaat gccaccatcc agcaacagga
     1741 tcaagaactg gctggcctga agcagcaggc caaagagaag caggcccagc tagcacagac
     1801 cctccaacag caagaacagg cctcccaggg cctccgccac caggtggagc agctaagcag
     1861 tagcctgaag cagaaggagc agcagttgaa ggaggtagcg gagaagcagg aggcaactag
     1921 gcaggaccat gcccagcaac tggccactgc tgcagaggag cgagaggcct ccttaaggga
     1981 gcgggatgcg gctctcaagc agctggaggc actggagaag gagaaggctg ccaagctgga
     2041 gattctgcag cagcaacttc aggtggctaa tgaagcccgg gacagtgccc agacctcagt
     2101 gacacaggcc cagcgggaga aggcagagct gagccggaag gtggaggaac tccaggcctg
     2161 tgttgagaca gcccgccagg aacagcatga ggcccaggcc caggttgcag agctagagtt
     2221 gcagctgcgg tctgagcagc aaaaagcaac tgagaaagaa agggtggccc aggagaagga
     2281 ccagctccag gagcagctcc aggccctcaa agagtccttg aaggtcacca agggcagcct
     2341 tgaagaggag aagcgcaggg ctgcagatgc cctggaagag cagcagcgtt gtatctctga
     2401 gctgaaggca gagacccgaa gcctggtgga gcagcataag cgggaacgaa aggagctgga
     2461 agaagagagg gctgggcgca aggggctgga ggctcgatta cagcagcttg gggaggccca
     2521 tcaggctgag actgaagtcc tgcggcggga gctggcagag gccatggctg cccagcacac
     2581 agctgagagt gagtgtgagc agctcgtcaa agaagtagct gcctggcgtg agcggtatga
     2641 ggatagccag caagaggagg cacagtatgg cgccatgttc caggaacagc tgatgacttt
     2701 gaaggaggaa tgtgagaagg cccgccagga gctgcaggag gcaaaggaga aggtggcagg
     2761 catagaatcc cacagcgagc tccagataag ccggcagcag aacgaactag ctgagctcca
     2821 tgccaacctg gccagagcac tccagcaggt ccaagagaag gaagtcaggg cccagaagct
     2881 tgcagatgac ctctccactc tgcaggaaaa gatggctgcc accagcaaag aggtggcccg
     2941 cttggagacc ttggtgcgca aggcaggtga gcagcaggaa acagcctccc gggagttagt
     3001 caaggagcct gcgagggcag gagacagaca gcccgagtgg ctggaagagc aacagggacg
     3061 ccagttctgc agcacacagg cagcgctgca ggctatggag cgggaggcag agcagatggg
     3121 caatgagctg gaacggctgc gggccgcgct gatggagagc caggggcagc agcaggagga
     3181 gcgtgggcag caggaaaggg aggtggcgcg gctgacccag gagcggggcc gtgcccaggc
     3241 tgaccttgcc ctggagaagg cggccagagc agagcttgag atgcggctgc agaacgccct
     3301 caacgagcag cgtgtggagt tcgctaccct gcaagaggca ctggctcatg ccctgacgga
     3361 aaaggaaggc aaggaccagg agttggccaa gcttcgtggt ctggaggcag cccagataaa
     3421 agagctggag gaacttcggc aaaccgtgaa gcaactgaag gaacagctgg ctaagaaaga
     3481 aaaggagcac gcatctggct caggagccca atctgaggct gctggcagga cagagccaac
     3541 aggccccaag ctggaggcac tgcgggcaga ggtgagcaag ctggaacagc aatgccagaa
     3601 gcagcaggag caggctgaca gcctggaacg cagcctcgag gctgagcggg cctcccgggc
     3661 tgagcgggac agtgctctgg agactctgca gggccagtta gaggagaagg cccaggagct
     3721 agggcacagt cagagtgcct tagcctcggc ccaacgggag ttggctgcct tccgcaccaa
     3781 ggtacaagac cacagcaagg ctgaagatga gtggaaggcc caggtggccc ggggccggca
     3841 agaggctgag aggaaaaata gcctcatcag cagcttggag gaggaggtgt ccatcctgaa
     3901 tcgccaggtc ctggagaagg agggggagag caaggagttg aagcggctgg tgatggccga
     3961 gtcagagaag agccagaagc tggaggagag gctgcgcctg ctgcaggcag agacagccag
     4021 caacagtgcc agagctgcag aacgcagctc tgctctgcgg gaggaggtgc agagcctccg
     4081 ggaggaggct gagaaacagc gggtggcttc agagaacctg cggcaggagc tgacctcaca
     4141 ggctgagcgt gcggaggagc tgggccaaga attgaaggcg tggcaggaga agttcttcca
     4201 gaaagagcag gccctctcca ccctgcagct cgagcacacc agcacacagg ccctggtgag
     4261 tgagctgctg ccagctaagc acctctgcca gcagctgcag gccgagcagg ccgctgccga
     4321 gaaacgccac cgtgaggagc tggagcagag caagcaggcc gctgggggac tgcgggcaga
     4381 gctgctgcgg gcccagcggg agcttgggga gctgattcct ctgcggcaga aggtggcaga
     4441 gcaggagcga acagctcagc agctgcgggc agagaaggcc agctatgcag agcagctgag
     4501 catgctgaag aaggcgcatg gcctgctggc agaggagaac cgggggctgg gtgagcgggc
     4561 caaccttggc cggcagtttc tggaagtgga gttggaccag gcccgggaga agtatgtcca
     4621 agagttggca gccgtacgtg ctgatgctga gacccgtctg gctgaggtgc agcgagaagc
     4681 acagagcact gcccgggagc tggaggtgat gactgccaag tatgagggtg ccaaggtcaa
     4741 ggtcctggag gagaggcagc ggttccagga agagaggcag aaactcactg cccaggtgga
     4801 gcagctagag gtatttcaga gagagcaaac taagcaggtg gaagaactga gtaagaaact
     4861 ggctgactct gaccaagcca gcaaggtgca gcagcagaag ctgaaggctg tccaggctca
     4921 gggaggcgag agccagcagg aggcccagcg cctccaggcc cagctgaatg aactgcaagc
     4981 ccagttgagc cagaaggagc aggcagctga gcactataag ctgcagatgg agaaagccaa
     5041 aacacattat gatgccaaga agcagcagaa ccaagagctg caggagcagc tgcggagcct
     5101 ggagcagctg cagaaggaaa acaaagagct gcgagctgaa gctgaacggc tgggccatga
     5161 gctacagcag gctgggctga agaccaagga ggctgaacag acctgccgcc accttactgc
     5221 ccaggtgcgc agcctggagg cacaggttgc ccatgcagac cagcagcttc gagacctggg
     5281 caaattccag gtggcaactg atgctttaaa gagccgtgag ccccaggcta agccccagct
     5341 ggacttgagt attgacagcc tggatctgag ctgcgaggag gggaccccac tcagtatcac
     5401 cagcaagctg cctcgtaccc agccagacgg caccagcgtc cctggagaac cagcctcacc
     5461 tatctcccag cgcctgcccc ccaaggtaga atccctggag agtctctact tcactcccat
     5521 ccctgctcgg agtcaggccc ccctggagag cagcctggac tccctgggag acgtcttcct
     5581 ggactcgggt cgtaagaccc gctccgctcg tcggcgcacc acgcagatca tcaacatcac
     5641 catgaccaag aagctagatg tggaagagcc agacagcgcc aactcatcgt tctacagcac
     5701 gcggtctgct cctgcttccc aggctagcct gcgagccacc tcctctactc agtctctagc
     5761 tcgcctgggt tctcccgatt atggcaactc agccctgctc agcttgcctg gctaccgccc
     5821 caccactcgc agttctgctc gtcgttccca ggccggggtg tccagtgggg cccctccagg
     5881 aaggaacagc ttctacatgg gcacttgcca ggatgagcct gagcagctgg atgactggaa
     5941 ccgcattgca gagctgcagc agcgcaatcg agtgtgcccc ccacatctga agacctgcta
     6001 tcccctggag tccaggcctt ccctgagcct gggcaccatc acagatgagg agatgaaaac
     6061 tggagacccc caagagaccc tgcgccgagc cagcatgcag ccaatccaga tagccgaggg
     6121 cactggcatc accacccggc agcagcgcaa acgggtctcc ctagagcccc accagggccc
     6181 tggaactcct gagtctaaga aggccaccag ctgtttccca cgccccatga ctccccgaga
     6241 ccgacatgaa gggcgcaaac agagcactac tgaggcccag aagaaagcag ctccagcttc
     6301 tactaaacag gctgaccggc gccagtcgat ggccttcagc atcctcaaca cacccaagaa
     6361 gctagggaac agccttctgc ggcggggagc ctcaaagaag gccctgtcca aggcttcccc
     6421 caacactcgc agtggaaccc gccgttctcc gcgcattgcc accaccacag ccagcgccgc
     6481 cactgctgcc gccattggtg ccacccctcg agccaagggc aaggcaaagc actaaagggc
     6541 cagtaccagt gagtggcccc acctgtgtcc ccgatgctga cctcacctgg tcctccgcct
     6601 actgtccctc tcagtgcctt ctctcagctc ccaggccaac agtagccaaa cccctagaga
     6661 cagtgatgcc tgcccgcacc ctggcctggt ccctggtcct tcactggcgc cttctcggag
     6721 ctggcccagg gggcctggag catggacagt gtgggcgctc tccctacctt gcctcctttt
     6781 ttcttaaagc aaagtcactt ctccatcaca accagatttg aggctggttt tgatggctgg
     6841 gtccttgggc ctggccagtc ttcctcttag cctctggatc tagaagggac cataagagga
     6901 gtaggccctg gttcctgctg tcctggtggc tgggcccagc aggggccctc actcttgaag
     6961 tccaggactg ggtctgacct ggtgggagca cctgccagag gatgctcttt cccaggacgg
     7021 atgggcccta tgtctcagga gtggggttgg gggacagcct tcagcagcag ctcacaccct
     7081 accttcccca gacttgcact ggggtgggat ttggagtgat gggaaggttt ttaagggccg
     7141 gggatggatc ttttctaaat gttattactt gtaaataaag tctatttttc tcccgtga
//
