LOCUS       NM_001010906            3952 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens nuclear GTPase, germinal center associated (NUGGC),
            mRNA.
ACCESSION   NM_001010906 XM_372035 XM_939772
VERSION     NM_001010906.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3952)
  AUTHORS   Richter,K., Burch,L., Chao,F., Henke,D., Jiang,C., Daly,J.,
            Zhao,M.L., Kissling,G. and Diaz,M.
  TITLE     Altered pattern of immunoglobulin hypermutation in mice deficient
            in Slip-GC protein
  JOURNAL   J Biol Chem 287 (38), 31856-31865 (2012)
   PUBMED   22833677
REFERENCE   2  (bases 1 to 3952)
  AUTHORS   Perroud,N., Uher,R., Ng,M.Y., Guipponi,M., Hauser,J.,
            Henigsberg,N., Maier,W., Mors,O., Gennarelli,M., Rietschel,M.,
            Souery,D., Dernovsek,M.Z., Stamp,A.S., Lathrop,M., Farmer,A.,
            Breen,G., Aitchison,K.J., Lewis,C.M., Craig,I.W. and McGuffin,P.
  TITLE     Genome-wide association study of increasing suicidal ideation
            during antidepressant treatment in the GENDEP project
  JOURNAL   Pharmacogenomics J 12 (1), 68-77 (2012)
   PUBMED   20877300
REFERENCE   3  (bases 1 to 3952)
  AUTHORS   Richter,K., Brar,S., Ray,M., Pisitkun,P., Bolland,S., Verkoczy,L.
            and Diaz,M.
  TITLE     Speckled-like pattern in the germinal center (SLIP-GC), a nuclear
            GTPase expressed in activation-induced deaminase-expressing
            lymphomas and germinal center B cells
  JOURNAL   J Biol Chem 284 (44), 30652-30661 (2009)
   PUBMED   19734146
  REMARK    GeneRIF: SLIP-GC is a replication-related protein in germinal
            center B cells whose reduction is toxic to cells through an
            AICDA-dependent mechanism.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019031.7, AB075870.1, BU429067.1, CF137482.1, AC091573.8,
            AA482187.1, AK129923.1 and AA768146.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010906.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138522.605664.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413272.7/ ENSP00000408697.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC019031.7         89485-89549
            66-109              AB075870.1         1-44
            110-204             BU429067.1         37-131
            205-356             CF137482.1         126-277
            357-1190            AB075870.1         293-1126
            1191-1191           AC091573.8         47182-47182         c
            1192-1628           AB075870.1         1128-1564
            1629-2037           AA482187.1         20-428
            2038-2591           AB075870.1         1974-2527
            2592-2606           AK129923.1         629-643
            2607-3754           AC091573.8         8804-9951           c
            3755-3952           AA768146.1         26-223              c
FEATURES             Location/Qualifiers
     source          1..3952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..3952
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /note="nuclear GTPase, germinal center associated"
                     /db_xref="GeneID:389643"
                     /db_xref="HGNC:HGNC:33550"
                     /db_xref="MIM:619088"
     exon            1..162
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            163..251
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2599
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /note="GTPase SLIP-GC; speckled-like pattern in the
                     germinal center"
                     /codon_start=1
                     /product="nuclear GTPase SLIP-GC"
                     /protein_id="NP_001010906.1"
                     /db_xref="CCDS:CCDS47833.1"
                     /db_xref="GeneID:389643"
                     /db_xref="HGNC:HGNC:33550"
                     /db_xref="MIM:619088"
                     /translation="MAETKDVFGQEPHPVEDDLYKERTRKRRKSDRDQRFRAFPSMEQ
                     SALKEYEKLESRTRRVLSNTYQKLIQSVFLDDSIPNGVKYLINRLLALIEKPTVDPIY
                     IALFGSTGAGKSSLINAIIQQAMFLPVSGESICTSCIVQVSSGCCVQYEAKIHLLSDQ
                     EWREELKNLTKLLHRTEELSREEADAWNRDEAVEEATWKLQMIYGNGAESKNYEELLR
                     AKPKRKIPTSRVITLKAEEAEELSIKLDPYIRTQRRDWDGEAAEMRIWPLIKHVEVTL
                     PKSDLIPEGVVLVDIPGTGDFNSKRDEMWKKTIDKCSVIWVISDIERVSGGQAHEDLL
                     NESIKACQRGFCRDVALVVTKMDKLHLPEYLRERKAGNQAIQSQREAVLERNEMIKLQ
                     RTRILKEKLKRKLPADFKVLEASDLVYTVSAQEYWQQALLTEEETEIPKLREYIRKSL
                     LDKKKRTVTKYVTEAFGLLLLTDSFNSTQNLPNEHLHMSVLRRFAEEKVELLEKAIAQ
                     CFACMEQPLQEGVRTARTSYRCILRACLVRSKGNQGFHQTLKAVCLKNGIYASRTLAR
                     IDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALMPHIDAFKQSLQEKMTEIGIRSGWK
                     YDSCKKNFLIQEISAILGGLEDHILRRKRRIYESLTASVQSDLKLCYEEAAQITGKKA
                     CERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTGIVEKVKGSITTMLALASSQG
                     DGLYKELADVGSEYKEMEKLHRSLREVAENARLRKGMQEFLLRASPSKAGPPGTSL"
     exon            252..356
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            357..465
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            466..688
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            689..919
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1129
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1305
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1324
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1414
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1520
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1654
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1819
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1977
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2116
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2225
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2362
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2453
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..3952
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3931..3936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /note="hexamer: AATAAA"
     polyA_site      3952
                     /gene="NUGGC"
                     /gene_synonym="C8orf80; HMFN0672; SLIP-GC; SLIPGC"
                     /note="major polyA site"
ORIGIN      
        1 acttctgctg tgtaaacgtg gctttgtgat tgtggcccaa agggctacgt accccagctg
       61 gttccaaata cctgaaccaa ggagaagctg ccaccatctc ctctgtggac tcctgtaacc
      121 aaaccagaac tttttttttt tttttctgtt cagtgacatc tggctggttc tcctgaactg
      181 agaagagcag gagttcacgt aacaaggaat ggcagaaacg aaggatgttt ttggccagga
      241 accgcatcca gttgaagatg atttatataa agaacgaacg agaaaaagaa ggaaatcaga
      301 tcgagaccag cggttccgag catttccctc catggagcag agtgctctta aggaatatga
      361 aaaattggaa tcacggacca gaagggtttt gagcaacact tatcagaaac ttattcagtc
      421 tgtcttcctg gatgacagca tccctaatgg agtcaagtat ctcataaata ggcttcttgc
      481 cttgattgaa aagccgacag tggacccaat ctacattgca ttatttggaa gcactggggc
      541 tgggaagagc tccctgatca atgccatcat ccagcaagca atgtttctac cagtgtctgg
      601 agaaagcata tgtacttcct gcattgtaca agtgagctct ggctgctgtg tgcagtatga
      661 ggccaaaatc caccttctgt ctgaccagga gtggagggag gagctgaaga acctgaccaa
      721 actcctgcat aggacggagg agctgagcag agaagaggca gatgcgtgga acagggatga
      781 ggcagtggag gaagccacct ggaagctaca aatgatttat ggaaatgggg cagagagtaa
      841 gaactatgag gagttactga gggcgaagcc caaaaggaag atccccacct ccagagtcat
      901 caccctcaag gcggaagagg cagaagagct gtccatcaag ctggacccct acatccgcac
      961 acagaggaga gattgggatg gagaggccgc tgagatgcgc atctggccct tgatcaaaca
     1021 tgtggaagtg acacttccca aatccgacct gatcccagaa ggggtcgtgc tggtggacat
     1081 cccaggcaca ggcgacttca acagcaagag ggacgagatg tggaaaaaga ccattgacaa
     1141 gtgctcagtg atctgggtga tcagcgacat agagcgagtt tctggggggc aagcccacga
     1201 agaccttctg aatgagagca tcaaagcctg ccagcggggc ttctgtaggg acgtggccct
     1261 ggtggtcacc aagatggaca aactccactt gccagaatac ctaagggaaa gaaaggcagg
     1321 aaatcaagct attcagagtc agcgagaggc tgttttagaa agaaatgaaa tgataaaact
     1381 acaaaggact agaattctca aggaaaaact gaagagaaaa ctgccagctg acttcaaggt
     1441 tctggaagcc tcagatctgg tgtatacagt cagcgcccag gagtactggc agcaggctct
     1501 cctcaccgag gaggaaacgg aaatccctaa gttaagagaa tacatcagga agagcctctt
     1561 ggacaagaag aagaggacag tgaccaagta tgtgactgaa gcctttggcc tgttgctcct
     1621 cacagatagt ttcaactcca cgcaaaacct gccgaatgaa cacttgcaca tgagtgtcct
     1681 gcggagattt gcggaagaga aggttgagct gctggagaag gccatcgcac agtgcttcgc
     1741 ctgcatggag cagcctctgc aagaaggggt caggaccgcc aggacttctt accgctgcat
     1801 cctcagagca tgcttggtga ggagtaaagg aaaccaaggt tttcatcaga ccctgaaagc
     1861 tgtttgcctg aaaaatggca tctatgcctc caggactctg gcgagaattg atctaaatga
     1921 agccctcact cagcccgtct atgaccagat cgaccctgtt tttggaagca tttttaggac
     1981 ggggaagccc actggttcag ctctgatgcc tcacatagat gcttttaagc agtccctgca
     2041 ggagaaaatg acagaaattg ggataagaag tggctggaaa tatgatagct gcaaaaaaaa
     2101 tttcctgatc caggagataa gtgccatcct cgggggcctg gaggaccaca tcctcagaag
     2161 gaagaggagg atctacgagt ccctcactgc ctctgtccag agtgacctga agctctgtta
     2221 cgaagaggca gctcagatca cgggcaaaaa agcgtgtgag cggatgaaag atgccatcag
     2281 aagaggagtg gaccggcagg tggctgaggg catgtttgaa agggcccagg aaaggatgca
     2341 gcaccagttt cagcagctga agactggaat cgtggagaag gtgaagggca gcatcaccac
     2401 tatgctggcc cttgcttcgt cccaggggga tggcctctac aaggagcttg cagatgtcgg
     2461 gagtgaatac aaggagatgg agaagctgca cagaagcctg agggaggtcg cggagaatgc
     2521 acggctgagg aagggcatgc aagaattcct cctaagggca tcccccagca aggctggccc
     2581 ccccgggaca tcactgtaac tcctggggct tagtcccaat ggatgaaaaa tcagcccaga
     2641 gccagagaat tagaattact ttttttgttc ttaagagaca agatctatct acctctgttg
     2701 cccaggctgg agtgcagtgg caccatcaca gctcactgca gcctcgaact cctaggctca
     2761 agcgatcctc cagcctcagc ctccagagca gctggggcta caggtacagg ccaccacacc
     2821 tgggtaattt tttttttttt ttttttgaga cagagtctcg ctgtgtcacc caggctggaa
     2881 tgcagtggtg caatctcggc tcactgcaac ctccacctcc tgggttcaag aaattctctg
     2941 cctcagcctc ccaagtagct gggattatag gcgactgcca ccacacccgg ttaattttta
     3001 tatttttagt agagacgggg tttcatcatc ttggccaggc tggtcctgaa ctcctgacct
     3061 cgtgatccac ccatctctgc ctcccaaagt gctgggatta cgggcatgag ccaccgtgcc
     3121 cggcccatac ctgggtaatt ttttaatttt ttgtggagat ggcatcttgc tctgttgccc
     3181 agggtggtct caaactcctg gcctcaagtg attctctccc acctcagtct cttgtgctag
     3241 gattgcaggc atgagccatt gtgcctggct cagaattctt tctgttttgt gaaatctaat
     3301 agaggacatt tctcaactat ttggactttg catgcaatat aaaactagta tgtttactgc
     3361 attttatttt atagccccaa agagtcatct tcaataccta atggagttct aaagctttag
     3421 ggcaagaaac ttttgcttcc gcaaaaacat ctaaacatcg ctgggcatgg tggctcactc
     3481 ccgtaatccc agcactttgg gaggctgagg cgggcggatc atgaggtcag gagattgaga
     3541 ccatcctggc taacacagtg aaaccccatc tctactaaaa atacaaaaaa ttagccaggc
     3601 gtggtagcat gtgcctatag tcccagctac ttgggaggct gaggcaggag aatcgcttga
     3661 acccaggagg cataggttgc agtgagccaa ggtcgcgcca ctgcactcca gcctggacga
     3721 cggagtgaga ctatgtctca aaaaaaaaaa aaaaaaaaga aaaagaaaaa aatatatata
     3781 tatacacaca cacacccata cataaaaaaa cttaaacatt atagaaaaaa cattgcacga
     3841 tataaaacaa gccataaaaa gaaattcatc cttcaataaa gaaaaatatc taaacgttga
     3901 aaaacttaag tattatggaa aacattgcaa aataaagctt ttaggaatcc aa
//
