LOCUS       NM_020772              10877 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens nuclear FMR1 interacting protein 2 (NUFIP2), mRNA.
ACCESSION   NM_020772
VERSION     NM_020772.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10877)
  AUTHORS   Zou,Z., Wei,J., Chen,Y., Kang,Y., Shi,H., Yang,F., Shi,Z., Chen,S.,
            Zhou,Y., Sepich-Poore,C., Zhuang,X., Zhou,X., Jiang,H., Wen,Z.,
            Jin,P., Luo,C. and He,C.
  TITLE     FMRP phosphorylation modulates neuronal translation through YTHDF1
  JOURNAL   Mol Cell 83 (23), 4304-4317 (2023)
   PUBMED   37949069
  REMARK    GeneRIF: FMRP phosphorylation modulates neuronal translation
            through YTHDF1.
REFERENCE   2  (bases 1 to 10877)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   3  (bases 1 to 10877)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 10877)
  AUTHORS   Taha,M.S., Haghighi,F., Stefanski,A., Nakhaei-Rad,S., Kazemein
            Jasemi,N.S., Al Kabbani,M.A., Gorg,B., Fujii,M., Lang,P.A.,
            Haussinger,D., Piekorz,R.P., Stuhler,K. and Ahmadian,M.R.
  TITLE     Novel FMRP interaction networks linked to cellular stress
  JOURNAL   FEBS J 288 (3), 837-860 (2021)
   PUBMED   32525608
REFERENCE   5  (bases 1 to 10877)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 10877)
  AUTHORS   Ramos,A., Hollingworth,D., Adinolfi,S., Castets,M., Kelly,G.,
            Frenkiel,T.A., Bardoni,B. and Pastore,A.
  TITLE     The structure of the N-terminal domain of the fragile X mental
            retardation protein: a platform for protein-protein interaction
  JOURNAL   Structure 14 (1), 21-31 (2006)
   PUBMED   16407062
REFERENCE   7  (bases 1 to 10877)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 10877)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   9  (bases 1 to 10877)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   10 (bases 1 to 10877)
  AUTHORS   Bardoni,B., Castets,M., Huot,M.E., Schenck,A., Adinolfi,S.,
            Corbin,F., Pastore,A., Khandjian,E.W. and Mandel,J.L.
  TITLE     82-FIP, a novel FMRP (fragile X mental retardation protein)
            interacting protein, shows a cell cycle-dependent intracellular
            localization
  JOURNAL   Hum Mol Genet 12 (14), 1689-1698 (2003)
   PUBMED   12837692
  REMARK    GeneRIF: identification and characterization of FIP-82, a novel
            FMRP-interacting protein associated to polyribosomes as a component
            of mRNP complexes containing FMRP
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK293075.1, AB037742.1, AC005412.8 and BM969349.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020772.2.
            
            Sequence Note: This RefSeq was created from transcript and genomic
            sequence data to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.216214.1,
                                           SRR1660805.17924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225388.9/ ENSP00000225388.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2242              AK293075.1         1-2242
            2243-5088           AB037742.1         2213-5058
            5089-10318          AC005412.8         82346-87575
            10319-10877         BM969349.1         21-579              c
FEATURES             Location/Qualifiers
     source          1..10877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..10877
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /note="nuclear FMR1 interacting protein 2"
                     /db_xref="GeneID:57532"
                     /db_xref="HGNC:HGNC:17634"
                     /db_xref="MIM:609356"
     exon            1..366
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2177
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /note="82-kD FMRP Interacting Protein;
                     proliferation-inducing gene 1; FMRP-interacting protein 2;
                     82 kDa FMRP-interacting protein; cell
                     proliferation-inducing gene 1 protein; NUFIP2, FMR1
                     interacting protein 2"
                     /codon_start=1
                     /product="FMR1-interacting protein NUFIP2"
                     /protein_id="NP_065823.1"
                     /db_xref="CCDS:CCDS32600.1"
                     /db_xref="GeneID:57532"
                     /db_xref="HGNC:HGNC:17634"
                     /db_xref="MIM:609356"
                     /translation="MEEKPGQPQPQHHHSHHHPHHHPQQQQQQPHHHHHYYFYNHSHN
                     HHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHTLQQHQETPKKKTGYGELNGNAG
                     EREISLKNLSSDEATNPISRVLNGNQQVVDTSLKQTVKANTFGKAGIKTKNFIQKNSM
                     DKKNGKSYENKSGENQSVDKSDTIPIPNGVVTNNSGYITNGYMGKGADNDGSGSESGY
                     TTPKKRKARRNSAKGCENLNIVQDKIMQQETSVPTLKQGLETFKPDYSEQKGNRVDGS
                     KPIWKYETGPGGTSRGKPAVGDMLRKSSDSKPGVSSKKFDDRPKGKHASAVASKEDSW
                     TLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKTIQNSSVSPTSSSSSSSSTGETQT
                     QSSSRLSQVPMSALKSVTSANFSNGPVLAGTDGNVYPPGGQPLLTTAANTLTPISSGT
                     DSVLQDMSLTSAAVEQIKTSLFIYPSNMQTMLLSTAQVDLPSQTDQQNLGDIFQNQWG
                     LSFINEPSAGPETVTGKSSEHKVMEVTFQGEYPATLVSQGAEIIPSGTEHPVFPKAYE
                     LEKRTSPQVLGSILKSGTTSESGALSLEPSHIGDLQKADTSSQGALVFLSKDYEIESQ
                     NPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRAAIVYHTKEMESIWNLQKQDPKR
                     IITYNEAMDSPDQ"
     exon            367..2091
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2124
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..10877
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9531..9536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /note="hexamer: AATAAA"
     polyA_site      9553
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /note="major polyA site"
     regulatory      10857..10862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
                     /note="hexamer: AATAAA"
     polyA_site      10877
                     /gene="NUFIP2"
                     /gene_synonym="182-FIP; 82-FIP; FIP-82; NUFP2; PIG1"
ORIGIN      
        1 agatatactg agtgagccct gagaagcagt ctcagatcct gacggtgcag cagcccgcag
       61 cctcagccag ggagtcccag ccgctttcaa tggaggagaa gcccggccag ccacagcctc
      121 agcaccatca cagccaccac catccgcacc atcaccctca gcagcagcag cagcagccgc
      181 accaccacca ccattattat ttctacaacc acagccacaa ccaccaccac caccatcatc
      241 accagcagcc tcaccaatac ctgcagcatg gagccgaggg cagccccaag gcccagccaa
      301 agccgctgaa acatgagcag aaacacaccc tccagcagca ccaggaaacg ccgaagaaga
      361 aaacaggcta tggtgaacta aacggtaatg ctggagaaag agaaatatct ttaaagaacc
      421 tgagttctga tgaagccacc aaccctattt ccagggtcct caatggcaac cagcaagttg
      481 tagacactag cctgaagcag actgtaaagg ccaacacctt tgggaaagca ggaattaaaa
      541 ccaagaattt cattcagaaa aacagtatgg acaaaaagaa tgggaagtct tatgaaaata
      601 aatctggaga gaatcagtct gtagataagt ctgatactat accaattcca aatggtgtgg
      661 taacaaataa ttctggttat attactaatg gttatatggg taaaggagca gataatgatg
      721 gtagtggatc tgagagcgga tatacaactc ctaaaaaaag gaaagctagg cgcaatagtg
      781 ccaagggttg tgaaaacctt aatatagtgc aggacaaaat aatgcaacaa gagaccagtg
      841 tcccaacctt aaaacaggga cttgaaactt tcaagcctga ctatagtgaa caaaagggaa
      901 atcgagtaga tggttcgaag cccatttgga agtatgaaac tgggcctgga ggaacaagtc
      961 gaggaaaacc tgctgtgggt gatatgcttc ggaaaagctc agatagtaaa cctggtgtga
     1021 gcagcaaaaa gtttgatgat cggcccaaag gaaagcatgc ttcagctgtt gcctccaaag
     1081 aggactcgtg gaccctattt aaaccacccc cagtttttcc agtggacaat agcagtgcta
     1141 aaatagttcc taaaataagt tatgcaagca aagttaagga aaacctcaac aaaactatac
     1201 agaactcttc tgtgtcacca acttcatctt catcatcttc atcatctacc ggggaaactc
     1261 agacccaatc atcaagtcgc ttatcccagg tccctatgtc agcgctgaaa tctgttactt
     1321 ctgccaactt ttctaatggg cctgttttag cagggactga tggaaatgtt tatcctccag
     1381 ggggtcagcc actgctaact actgctgcta atactctaac acccatctct tctgggacag
     1441 attcagttct ccaggacatg agtctaactt cagcagctgt tgaacaaatt aagactagcc
     1501 tttttatcta tccttcaaat atgcaaacta tgctgttgag cacagcacaa gtggatctgc
     1561 cctctcagac agatcagcaa aacctggggg atatcttcca gaatcagtgg ggtttatcat
     1621 ttataaatga gcccagtgct ggccctgaga ctgttactgg gaagtcatca gagcataaag
     1681 tgatggaggt gacatttcaa ggagaatatc ctgctacttt ggtttcacag ggtgctgaaa
     1741 taattccctc aggaactgag catcctgtgt ttcccaaggc ttacgagctg gagaaacgga
     1801 ctagtcctca agttctgggt agcattctaa aatctgggac tactagtgag agtggagcct
     1861 tatccttgga acccagtcat ataggtgacc tgcagaaagc agacaccagt agtcaaggtg
     1921 ctttagtgtt tctctcaaag gactacgaga tagaaagtca aaatcctctg gcctctccta
     1981 cgaacacttt gttaggctct gccaaagaac agagatacca gagaggccta gaaaggaatg
     2041 atagctgggg ttcttttgac ctgagggctg ctattgtata tcacactaaa gaaatggaat
     2101 ctatttggaa tttgcagaag caagatccca aaaggataat cacttacaat gaagccatgg
     2161 atagtccaga tcaatgaagg accagactgc ctattcgtaa cctttctgca gcattagagc
     2221 catcgttcat gggggacaca aggcttttat gctcctagat cttcaacgca gcagaggaac
     2281 cataagtaga atcacaggat aatatataca aatatatata tatacatata tatatatata
     2341 gttatttaaa aaaggcaact gaaagtaatt agacttctta aggaatcaaa tttatttcaa
     2401 gagactacac atggttattt aatctccggt actgaatagg ttttttttct tctgttagtt
     2461 tttgttttta agtgtgaatg caagtgatta atgaatacag acttaacaag tgtggttcta
     2521 aagttcctgc tgtcatcaac ttgggcaaca aatgacccac tggaaaggca aatccactta
     2581 aaagatctct gtatcttgtt ctgtgactga agtgatacac taatcacggg gaacccagaa
     2641 tgattcaaca ttttcccccc actcctccct tgatcttttt ggttttactt taattaagcc
     2701 ctgcgagaat gctggataaa tgccttgaag ttagcagggt gtattttttt agcgaatatg
     2761 atttgcatgt cttgccagga gttaagcggc ctctggggtg ttggggaaat actttatttc
     2821 tttccattta ttttttgtgg ggcggggata ggggagggca ttgaagttct acaattctgg
     2881 aatagttagt tgatggtaca tagttaactt ggcttcggtt acatattgga ctttaacaac
     2941 tgaagaatct atgcgtgtca tttaaagaaa agttgcagaa caagcaattg gcttagatat
     3001 acaatctgga aaaatattcc tgtgcccata ttttaatgta attgtataac tgggagcaaa
     3061 aatatattct gcttttcaac tgtaggtgct ccagacttgc tctccgtcac taacactaaa
     3121 tgtgctgttt tccttgtttt tcatcaaaca tttaagacaa acttagacct ttctgtaaat
     3181 tatcttttaa tttctcagca aaatctaaaa ggggaagaaa aaagtccatg aaaactaaaa
     3241 cttttcatgt ttttagccag tgagaagata ataaaccctg actgtagaag gtgtgttttc
     3301 atgcaaacta tacttctgag cttgttagct tctaattata tcttaataaa tatattttat
     3361 tactagagca agatgggttt ttaaggaaaa taatgtgaaa ttctggaaat tttctttggg
     3421 gcagagaaga gcattagccc tgtcttatca ttacattgcc atcctgttgc actgcagctt
     3481 gtgtatagca tgctaaaata aatttttgtg tgtgtgtgca gaaattaagg gtccaattga
     3541 gattgggtga tgttagtaac ataataacaa gttgtctggc ctgacacagc atcacatcac
     3601 acacacagaa attagtatat ccatgtatgt caaatacagg ttaaaatatc agggcattta
     3661 tataaagagt tgtagtcttc tgataaaagt agactggatc ccctggggta tttggggaga
     3721 aagtaactac tttggctcta cccctagaaa tgtccagttt tgagtgactg tagtatggat
     3781 gggttttctt gttttgttga ttatttgagg cttttaaaac aagtagttca tgaaagaagc
     3841 tgttggactc aacatagagt agagtaacta tctttttagt ctggatttct gccctgctta
     3901 gattttaaaa gtataagcat ggattgccaa ttccacttga tgtaaacaaa actttttttt
     3961 atacataata tatatatata tatataaaat aacttattgt atcagtccag gttcagaaac
     4021 ttgtggtagg ccagttccag atagtttcat ttcacctgta aactgtatca ctttgactga
     4081 tattgtaatt ttcaaatgta taatatgttt acagatgtgc cctgcattta gtctgccttg
     4141 ttcctatttt gatttttgtt gagtctcctg cctgcttgcc aaaagctagg atgcttcagg
     4201 cccatgtaca attgaaagca gaggcatcct tgagctttaa agcattgaac aaactggaaa
     4261 atgcaacata ccacataact gaagtgaaaa aagtctgtgt ttttgtgttt ttttaaataa
     4321 aaattttcaa aaagttaaaa aaaaagacat ataaggttga ttaaagggaa aaaaggctcc
     4381 agtttgtttt acaggtttta aagttctgct gtgtgttcaa ttgccttgtg taaccacttg
     4441 tcgccttagg gccagattcc cctctctagt cccctttttt aaatgtccat tttgcttgcc
     4501 tggaatttta aagttcttcc gtctcacaac tcacaagaaa ctttctgggt ttgtgacata
     4561 cagaggttga attgagtata tatttgaaaa ggaaaaaaca aaaaacaaac ccagacccca
     4621 cctgaattgg gctttttaac ttagaagcaa cacttgatta aacatcttta gaaagctatt
     4681 gcttttctaa tttccttcca tatccctcag gcctcagtgt tcagagaagc caaaaagaat
     4741 gtatcacttc tctgtctgtc caaaggtttt tgagagtctc acttctaaat gaaacaatgc
     4801 aacatttcac tttgatttct ccactgaaat ttccttgatt atatggttag aggtatgtag
     4861 ttaggaatgt ctgttaactt tctgagaacc ctagtgcccc atcatattaa ctgtcagtat
     4921 tttgggggca ttaggttaat agacttaatt gcctaggtac aagcaggact ttgggacaaa
     4981 tctctttgtg ctgtttggta acacttaact ctatttgttg caatctttct ccttaggtcc
     5041 tcacacaatt ccttacagag cacttattaa aaaaaaatct taagagttga tctgttttct
     5101 gattattttg tgtaagcttc taaacaaact tcagctgtga ttaatttagc acatttaaat
     5161 aacgtgttat tgtttggtat aaagaatttt ccttcaactc agagtattag tactgtagca
     5221 taaaccaaat acagtctaga ggggattttt aacatccctc cattataaag actgaaaaag
     5281 gggtgtgtgt gtgtgtgtgt gtttatgtat gtatgtatgt gtgtgtgagg aaaagatgga
     5341 gatattaaaa attagtaaat gaatgtgtat aagacattag tattcagaga atgaacttgt
     5401 atttattttg tgccatttgt tttcattaca cagaaaaaag tcaggtggtt taaatcctta
     5461 aaagggtagt attgaaaaat ggcactaaga atgaaattat gacctatttt tttaatagct
     5521 atgaagatac taattatggg tgaagatttc tttttaaatc tgttttgatt attgtaggct
     5581 tctgtgtcac ataccactct tgtaggtgtc ctcaataatc cccttttccc acaaaataca
     5641 cagggtgtat tatctttctc tttattcacc cccactttgc tgaactgaag ttaattacat
     5701 agcctttctt ctaacctcct tagtaatgaa ccttcacata aagtgtattt acagcgtctg
     5761 tggtagccag cccttcctcc tctactttct aggaggggat agccaataac taggaattta
     5821 atgacagatt tttttttctt tgaaataaat ggccagagtt tctccatttt agaattttgt
     5881 tgtcctcctt aatcatctgc ttacctagtc attactcaat ctgcagaaac ttcataaagg
     5941 aaaagtgctg cattgttttt acaaataaca gtttgtaggg aaaatatgac aaacctcaac
     6001 tatgggagtt gtccacaata caaaattttg aaaaaacatt acatagtgat aatatcatac
     6061 ttggttgtta ggcttgttgc ttccccacat cagaggcatc taatgattta tcttttgtaa
     6121 ttgctgtgaa cttttttaaa taagccattt agtgtgaaat tgtcatgtat caaatggcta
     6181 ttggaaatgg actttactca attttaattc cactgtaaat aaggacggag tcattcctac
     6241 aaggctctct tcagagaaat agattaaaag tccaatttcc aggtattatt agtatagtta
     6301 tgccgctggg ccacatcctc aacaacagct gatccctctt gtataaatat gttaactgtg
     6361 cagaacagtt atgttatggg acaaatataa tggtcattat ggtcagattg gttgatgcca
     6421 caccagtcaa ggtagagtct gatagggcag tatcttaata accctaccca tgacttaact
     6481 gttggatttg aaaggaaaac gtaggatttg ctcttgtccc cttacccgcc acaaaatttt
     6541 gataatttgt ttaaaaggga gaggcagagg aaaagactag aagcataaat agctgcttta
     6601 ggtttgccag aggcacatag cttaacatta gttcttaata tcgatgttat ttttactaat
     6661 gtaattaatc aacagagcac caagattctt tcatggtgaa aagggtgggc ttctgttttg
     6721 gtatcttaaa atgtttcttt taaaatatac atcacctgtg tgagaaccag gaccacctgg
     6781 gagagtgatg aatcattggc tccactcaaa agcattgctt tactgagttt taaatttcac
     6841 actgttttgc cgctcaagaa aggtcttaaa gtagttaaag gatgccagca atagtgcgaa
     6901 tagaattttc ggttgtctgc ataataaaaa cacccattgc agcatgattg gtatgttgct
     6961 cttgcattat tgggaatggt aaatcagtta tgggctagaa actatggaat ggccgtcctc
     7021 atatgtgatg ggattgctga ttcagacttc cctattttcc atacaatttt gttatgtgca
     7081 gagttctaaa gccattttat aatactgcag tatccccccc ccccccacct tttttttttt
     7141 gagacggact gtctgttgcc caggctggag tacagtggcg caatcttggc tcactgcaac
     7201 ctccacctcc ctggttcaag caattcccct gcctcagcct cccatgtagc tgggattacg
     7261 ggcgcacacc accacacctg gctaatttgt attcttagta gagacggggt ttcaccatgt
     7321 tgaccagact ggtctcgaac tcctgacctc aggcaatctg cccgcctcag cctcccaaag
     7381 tgctggaatt acaggtgtga gccaccgtgc ccggccaagt atctcttttc tacagcctta
     7441 ttaaactaac tacaaacatt tattttccaa tttagtttta ctttcagtgc atatcaaagt
     7501 tgttgtactc ttcagaccaa caaattaact tgagggcaaa ttacatagct ttccatgtac
     7561 ccttttttcc tcaggtgcta atcaaaggct ctgaaaatgg atactgcttt agtgatgtct
     7621 gctttattct taaaatgctt atttcttttg ctagatgtaa agatttggtg ttaacaaaag
     7681 tggttttaat atgtaaatat gaatgaatgc ctttagttta ccctgtttgt ctattattaa
     7741 tctgttttca tttatccttc atagaggagg atcctttcat gatcttgaat acatttcatt
     7801 agatattgtt gcattttaag aatgaaaata caactgtttt ctgtcttaga ttaatcctgc
     7861 tgctatgaga aactgaaaat caagaatgtg atgcactttt tacattacta tataccatac
     7921 atataccata ggttgctttg atacctttcc tgtagcacag ccactaacaa gagtgaatga
     7981 attataaaat tctttttggg agggaatcaa tacaagtaac taattcttag ctgatattgt
     8041 cctatgaagg acaataactt aggaatataa gaattctgtt aatagtacac tttttggcct
     8101 taaatgtctt ctactactga aaatagttta aatcttagct ttgtttctat tattccctct
     8161 ctctgcctca gaaagaggaa ttgggaagaa tggcttaaag gacgtggtgt cattgatttg
     8221 ttgctgatct tttagaaaac atttgtctat gtaagctggg gacttatttt ttgtttgtat
     8281 atagagggga aatagtgctg ccctgaacca atcagattta gtttaaatca aatcaatcaa
     8341 aactccagct gtttctcttg tctttttact tagcaaagga aaactttagt gaatgctact
     8401 tgacaagaag aaaagtcatt tctcaagcac atacccaaac ttgaaggtga ttgaacccaa
     8461 aataatgggt gggaaacacc aaatgaggtg gaggaatgag aaagatgtgt gggccaaagc
     8521 tatctggtta tattttgatg ttgccaatat cgcaaagcca aaattttaat ttgcttattt
     8581 aatatatttg ttggccagag atctattttt atatcaatgt gccttgcatg tatattaaaa
     8641 aaaaaaaatt ggaaacgcca tgtagtaatg cctgagatag tcgatggttc ttaccacctc
     8701 actaattttt atgcagtatg aaatgctcat tctattgccc aactggtgct ctctgtttaa
     8761 agttacagat cttgcgaaac tggaactatt ttataagctg gggaagtgat ttactttttt
     8821 tgttgtatct tttttgttct tagtctgtta gtggctgtcc tgtagtggga aatagtaaaa
     8881 ggattcttca ctcccttctc ccctcagcac cttcttcaag taaacatttc ttgtgtgctt
     8941 tgaaaaaagt ttcagcttgc tgtctctttt agtgttttaa agaagtgtta tacaaagcat
     9001 tgtttgcaaa atatagggag ataatggagt ccactttaat ttggaattct gtgtgagcta
     9061 tgatccaagt tatcagctct ttccaacttt aaaaattttg ttaaaagcac cttgcttaga
     9121 aaattttaaa tatttatgtc tgcaacaatt gtctcaaaat aataaactgt gcaattcttg
     9181 tcattaaaaa aaaaaaagat ctgaattttc cctaatgtga cttgttagtt tctctctgta
     9241 tttcctgcca gtgtaaatgt gaaagctttg cttgcattac gttttagaaa tgcattttgc
     9301 acactcgaat tttgccgaag ctccgtgaaa aggttagatc taagtagatg aataaagcta
     9361 tgcacatgtt ttgaaagttt aatttgtgtg tcattaccaa aagtgaccga tttgtcctta
     9421 ctactttgct gttgttagct ttaccatctt tggaaacttg gctcaaagtt acatagttct
     9481 gggctagctc atcagtggaa ctaggagaga ggaaaactgg cacctatttt aataaagttc
     9541 aatttaaacg agagcttgac ttgtatctat taaagagctt ttcttgaaac agggcagttt
     9601 tatcagcttt acaaatcatt ggatgctctt ccttagtaat attttggttt atttgatcaa
     9661 atagaaatgg aaagtaattc aaactgaaag accctttttt gtcatatgga acttggtgac
     9721 gattttttgt cttaaagctg gtttaaaggt aggataggct tttaccttta ttgctttagc
     9781 ataaatttgg tttactgaat tgactggctt gagattagaa ttattcagtt gtttgtaaga
     9841 tcaaagcact ggttgtttta aagataacgt gtatctttta aaaaattgcc caagctgatt
     9901 agaacaagtt taggagttgg gtacatttgg ttcaagtgct gcaatctgta tgtactaaat
     9961 agctttactt tgtgtatgtg tacttataat gtgtagatgt actactaccc aggttttgtc
    10021 aaatcatctt ttttaaagtt tttttttttt taattggttc aggacctttg taggagaggc
    10081 taatatgttt aagtagaaga tattactgat agcattttcc ccatgctcct acataaaaaa
    10141 taaatatttc cattttatag ctttttcaat atacagaaga gggttacttc ttcatcaagt
    10201 atattgttgc ctttgaggac acagcaaaac ccttctatat gtatcttcat tgatagtggc
    10261 agttaaaaac taagttatcc agttaagact taaaaggtga cccatattaa ttgcatggcc
    10321 ttaaaaggca gaaatgcagg agtgtagcaa gcatcatttt agatggctat ggttcctctt
    10381 ccgcatctgt cagtagttca cttatgttca gtcttagaac ctactggagg agtgaagtaa
    10441 tttctctgtc tcgtgcagag gcactaagga gctgagttac ctcttaatct gggggaatgg
    10501 ataataagtg gagtacagtt atgttaaagg atgttccccc cgctcaaaaa aaagtttcaa
    10561 tgtttgtttt gcccagtcaa aaatataggt cttttctaca tataagaaca gtcaccagaa
    10621 attttccctt ttgctaaatg cttaggtatt tgctatagct gtttctgatg tcatggattc
    10681 tgaggaagtg tcatttacgt gatgatcttc ctttattgat gtcttcatca tgttcagtgt
    10741 tttaaaaata taaattacaa acactctaca accataccca gatttactta ttttatcaga
    10801 aaaaaaactt gagaaatttg tagatcaaat tgagagacaa taagtgtaca ttgttgaata
    10861 aaaaatttta aagtttc
//
