LOCUS       NM_012345               3480 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nuclear FMR1 interacting protein 1 (NUFIP1), mRNA.
ACCESSION   NM_012345
VERSION     NM_012345.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3480)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3480)
  AUTHORS   Wyant,G.A., Abu-Remaileh,M., Frenkel,E.M., Laqtom,N.N.,
            Dharamdasani,V., Lewis,C.A., Chan,S.H., Heinze,I., Ori,A. and
            Sabatini,D.M.
  TITLE     NUFIP1 is a ribosome receptor for starvation-induced ribophagy
  JOURNAL   Science 360 (6390), 751-758 (2018)
   PUBMED   29700228
  REMARK    GeneRIF: NUFIP1 is a receptor for the selective autophagy of
            ribosomes.
REFERENCE   5  (bases 1 to 3480)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3480)
  AUTHORS   McKeegan,K.S., Debieux,C.M., Boulon,S., Bertrand,E. and
            Watkins,N.J.
  TITLE     A dynamic scaffold of pre-snoRNP factors facilitates human box C/D
            snoRNP assembly
  JOURNAL   Mol Cell Biol 27 (19), 6782-6793 (2007)
   PUBMED   17636026
REFERENCE   7  (bases 1 to 3480)
  AUTHORS   Cabart,P., Chew,H.K. and Murphy,S.
  TITLE     BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by
            RNA polymerase II
  JOURNAL   Oncogene 23 (31), 5316-5329 (2004)
   PUBMED   15107825
  REMARK    GeneRIF: NUFIP is associated with preinitiation complexes, open
            transcription complexes, and elongation complexes and facilitates
            ATP-dependent dissociation of hyperphosphorylated pol II from open
            transcription complexes in vitro
REFERENCE   8  (bases 1 to 3480)
  AUTHORS   Bardoni,B., Willemsen,R., Weiler,I.J., Schenck,A., Severijnen,L.A.,
            Hindelang,C., Lalli,E. and Mandel,J.L.
  TITLE     NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic
            shuttling protein associated with active synaptoneurosomes
  JOURNAL   Exp Cell Res 289 (1), 95-107 (2003)
   PUBMED   12941608
REFERENCE   9  (bases 1 to 3480)
  AUTHORS   Bardoni,B., Giglio,S., Schenck,A., Rocchi,M. and Mandel,J.L.
  TITLE     Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to
            chromosome 13q14 and assignment of a pseudogene to chromosome 6q12
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 11-13 (2000)
   PUBMED   10894927
REFERENCE   10 (bases 1 to 3480)
  AUTHORS   Bardoni,B., Schenck,A. and Mandel,J.L.
  TITLE     A novel RNA-binding nuclear protein that interacts with the fragile
            X mental retardation (FMR1) protein
  JOURNAL   Hum Mol Genet 8 (13), 2557-2566 (1999)
   PUBMED   10556305
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA701559.1, AF159548.1 and
            AL354816.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012345.2.
            
            Summary: This gene encodes a nuclear RNA binding protein that
            contains a C2H2 zinc finger motif and a nuclear localization
            signal. This protein is associated with the nuclear matrix in
            perichromatin fibrils and, in neurons, localizes to the cytoplasm
            in association with endoplasmic reticulum ribosomes. This protein
            interacts with the fragile X mental retardation protein (FMRP), the
            tumor suppressor protein BRCA1, upregulates RNA polymerase II
            transcription, and is involved in box C/D snoRNP biogenesis. A
            pseudogene of this gene resides on chromosome 6q12. [provided by
            RefSeq, Feb 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF159548.1, SRR11853566.7738.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379161.5/ ENSP00000368459.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               DA701559.1         9-151
            144-1468            AF159548.1         109-1433
            1469-3480           AL354816.5         120473-122484       c
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.12"
     gene            1..3480
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /note="nuclear FMR1 interacting protein 1"
                     /db_xref="GeneID:26747"
                     /db_xref="HGNC:HGNC:8057"
                     /db_xref="MIM:604354"
     exon            1..447
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1523
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /note="NUFIP1, FMR1 interacting protein 1; nuclear
                     FMRP-interacting protein 1"
                     /codon_start=1
                     /product="FMR1-interacting protein NUFIP1"
                     /protein_id="NP_036477.2"
                     /db_xref="CCDS:CCDS9393.1"
                     /db_xref="GeneID:26747"
                     /db_xref="HGNC:HGNC:8057"
                     /db_xref="MIM:604354"
                     /translation="MAEPTSDFETPIGWHASPELTPTLGPLSDTAPPRDSWMFWAMLP
                     PPPPPLTSSLPAAGSKPSSESQPPMEAQSLPGAPPPFDAQILPGAQPPFDAQSPLDSQ
                     PQPSGQPWNFHASTSWYWRQSSDRFPRHQKSFNPAVKNSYYPRKYDAKFTDFSLPPSR
                     KQKKKKRKEPVFHFFCDTCDRGFKNQEKYDKHMSEHTKCPELDCSFTAHEKIVQFHWR
                     NMHAPGMKKIKLDTPEEIARWREERRKNYPTLANIERKKKLKLEKEKRGAVLTTTQYG
                     KMKGMSRHSQMAKIRSPGKNHKWKNDNSRQRAVTGSGSHLCDLKLEGPPEANADPLGV
                     LINSDSESDKEEKPQHSVIPKEVTPALCSLMSSYGSLSGSESEPEETPIKTEADVLAE
                     NQVLDSSAPKSPSQDVKATVRNFSEAKSENRKKSFEKTNPKRKKDYHNYQTLFEPRTH
                     HPYLLEMLLAPDIRHERNVILQCVRYIIKKDFFGLDTNSAKSKDV"
     exon            448..530
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..629
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..692
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..769
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..862
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1056
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1173
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1406
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..3480
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /note="hexamer: AATAAA"
     polyA_site      1714
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /note="major polyA site"
     regulatory      3461..3466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
                     /note="hexamer: ATTAAA"
     polyA_site      3480
                     /gene="NUFIP1"
                     /gene_synonym="bA540M5.1; NUFIP; Rsa1"
ORIGIN      
        1 acagtcgcgt gctagactcc ggacccgcca gtggtatggc tgagccgact agtgatttcg
       61 agactcctat cgggtggcat gcgtctcccg agctgactcc cacgttaggg cccctgagcg
      121 acactgcccc gccgcgggac agctggatgt tctgggcaat gctgccgcca ccgccaccac
      181 cacttacgtc ctcgcttccc gcagccgggt caaagccttc ctctgagtcg cagcccccca
      241 tggaggccca gtctctcccc ggggctccgc cccccttcga cgcccagatt cttcccgggg
      301 cgcaaccccc cttcgacgcc cagtctcccc ttgattctca gcctcaaccc agcggccagc
      361 cttggaattt ccatgcttcc acatcgtggt attggagaca gtcttctgat aggtttcctc
      421 ggcatcagaa gtccttcaac cctgcagtta aaaattctta ttatccacga aagtatgatg
      481 caaaattcac agacttcagc ttacctccca gtagaaaaca gaaaaaaaag aaaagaaagg
      541 aaccagtttt tcactttttt tgtgatacct gtgatcgtgg ttttaaaaat caagaaaagt
      601 atgacaaaca catgtctgaa catacaaaat gccctgaatt agattgctct tttactgcac
      661 acgagaagat tgtccagttc cattggagaa atatgcatgc tcctggcatg aagaagatca
      721 agttagacac tccagaggaa attgcacggt ggagggaaga aagaaggaaa aactatccaa
      781 ctctggccaa tattgaaagg aagaagaagt taaaacttga aaaggagaag agaggagcag
      841 tattgacaac aacacaatat ggcaagatga aggggatgtc cagacattca caaatggcaa
      901 agatcagaag tcctggcaag aatcacaaat ggaaaaacga caattctaga cagagagcag
      961 tcactggatc aggcagtcac ttgtgtgatt tgaagctaga aggtccaccg gaggcaaatg
     1021 cagatcctct tggtgttttg ataaacagtg attctgagtc tgataaggag gagaaaccac
     1081 aacattctgt gatacccaag gaagtgacac cagccctatg ctcactaatg agtagctatg
     1141 gcagtctttc agggtcagag agtgagccag aagaaactcc catcaagact gaagcagacg
     1201 ttttggcaga aaaccaggtt cttgatagca gtgctcctaa gagtccaagt caagatgtta
     1261 aagcaactgt tagaaatttt tcagaagcca agagtgagaa ccgaaagaaa agctttgaaa
     1321 aaacaaaccc taagaggaaa aaagattatc acaactatca aacgttattc gaaccaagaa
     1381 cacaccatcc atatctcttg gaaatgcttc tagctccgga cattcgacat gaaagaaatg
     1441 tgattttgca gtgtgttcgg tacatcatca aaaaagactt ttttggactg gatactaatt
     1501 ctgcgaaaag taaagatgta taggcatctg gtgtttcagc atacataact gaagcatgtg
     1561 aaacagtatc atcctcgtta gtagaggaaa accaaaaccc ttttttccgt caaaattgga
     1621 tttgtaatta aattgtaagc ctcgtaggat gtatgttgga attttaagtc tttcctttgg
     1681 ttctatgcaa ataaaaaaat aactgatttt ttaagactgt gtctgtattg ttgggattga
     1741 atctagtatt tgctgggaga attttttctt tgtatttatt ttaatgtatt gttctcatgt
     1801 aagaatgact gatgttgtgt tagttaagaa ttgaagatag gtttagcagt aaagaagaaa
     1861 gcttttaaaa ggattgattc agctaagcaa agttgggcag agaaatacag ccattttgtt
     1921 tttaatgcag aaaaggaaga tgttctgtag caagggggaa tattttaaaa ataaaccaga
     1981 tcaaattaat acaatcagaa ggtttcgaaa tgtaaatatt ccttatttaa gacatgttta
     2041 aattcaccta ctagcacgac ttacatagct caaatattga atgtttaaaa tattaataca
     2101 gatggggcct ctttatgttt agataaaatt gaagtactta attgaagctt tttaaaaatt
     2161 gtaaagtaaa tgaaagctat tgagatcttt ttgtctccta taataccagg gaatttgagc
     2221 ttgtgttcta gtcattgtac tagctgtagc tattggtctg tccttttgac atacagctaa
     2281 aagggactaa atttgtaaaa aattagtttg ttatagttga agattaactt ttcctaacat
     2341 tgtgattatt gaagttcatg aatcttgctg tcaaggaaga aaggtaagaa agctgatagc
     2401 tcctccatgt tggtaaaatc ctctccagaa tcttggaaca cctggcatgt gaccctagtg
     2461 acgtcacaga cctgagatga agattcatgt ttagccagtg ttttccagcc ttgtacccac
     2521 catacagatc tgtttattct gtttcaccct actcctccag tgagccccat attttgggaa
     2581 attatctgcc ttatacatta actaattcaa ttcatgtaac actgttgagt gcttactctt
     2641 tgtacctcta ttgtgcctat attaaaggta tacaaataaa taaggccatg tctgacttca
     2701 aggaactcag tttaattttg atatattcaa agatgtgatt cccaaccaac tcaggatgaa
     2761 gtaactagtg ttacaactga gttgatattc taaaatataa cacagtttgt acttttatta
     2821 ctagttagca tacacatttt ataggcttat gggttaataa atgaattcat ggactcctgg
     2881 actactttca ttgatgacca tatctccagg gatgttgttg atccccacac tgccttaagg
     2941 tatattatag aaacagtttt attttccatt tttcttgttt cctgataata aatgtattta
     3001 ggactgaaaa tactcctgag tactcccttg gctgtatgtc tgacagtctt tagctatggt
     3061 gactattgtt tatttttaat gggtatttca gattccaagt gtatttaaaa tttctaagga
     3121 gatataatat agcctgtatg gtttctactt tatggaatta tatggtcaat atttgtaaat
     3181 attctatgag ttttgggtgg gtagaggggt gctttgcctg ttttgggtac aggttttttt
     3241 ggatttagct tgttaattgt tcaaactttc tgccttctac attcctatct tattgttcgt
     3301 ttaatcagtt tctgaaatgt aagcattaca tgactattgg tgagttgtgc cttttataac
     3361 tgaaatactt tactttttct catatcctct ataattgact tctattttcc ttaatcaaac
     3421 cagctctggg aaatttaata catttatatt aattgagatt attaaaacat ttggactatt
//
