LOCUS       NM_001243750             745 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nudix hydrolase 8 (NUDT8), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001243750
VERSION     NM_001243750.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 745)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 745)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 745)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   4  (bases 1 to 745)
  AUTHORS   Gasmi,L. and McLennan,A.G.
  TITLE     The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific
            for coenzyme A and its derivatives
  JOURNAL   Biochem J 357 (Pt 1), 33-38 (2001)
   PUBMED   11415433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB140633.1, AK123561.1 and AP003385.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001243750.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.549547.1,
                                           SRR1163658.22651.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376693.3/ ENSP00000365883.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CB140633.1         1-16
            17-744              AK123561.1         1-728
            745-745             AP003385.2         26332-26332         c
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..745
                     /gene="NUDT8"
                     /note="nudix hydrolase 8"
                     /db_xref="GeneID:254552"
                     /db_xref="HGNC:HGNC:8055"
     exon            1..220
                     /gene="NUDT8"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..737
                     /gene="NUDT8"
                     /EC_number="3.6.1.77"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleoside diphosphate-linked moiety X motif 8,
                     mitochondrial; nudix motif 8; nudix (nucleoside
                     diphosphate linked moiety X)-type motif 8; mitochondrial
                     coenzyme A diphosphatase NUDT8"
                     /codon_start=1
                     /product="mitochondrial coenzyme A diphosphatase NUDT8
                     isoform 1"
                     /protein_id="NP_001230679.1"
                     /db_xref="CCDS:CCDS58151.1"
                     /db_xref="GeneID:254552"
                     /db_xref="HGNC:HGNC:8055"
                     /translation="MLPDCLSAEGELRCRRLLAGATARLRARPASAAVLVPLCSVRGV
                     PALLYTLRSSRLTGRHKGDVSFPGGKCDPADQDVVHTALRETREELGLAVPEEHVWGL
                     LRPVYDPQKATVVPVLAGVGPLDPQSLRPNSEEVDEVFALPLAHLLQTQNQGYTHFCR
                     GGHFRYTLPVFLHGPHRVWGLTAVITEFALQLLAPGTYQPRLAGLTCSGAEGLARPKQ
                     PLASPCQASSTPGLNKGL"
     exon            221..353
                     /gene="NUDT8"
                     /inference="alignment:Splign:2.1.0"
     exon            354..431
                     /gene="NUDT8"
                     /inference="alignment:Splign:2.1.0"
     exon            432..745
                     /gene="NUDT8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      723..728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT8"
                     /note="hexamer: AATAAA"
     polyA_site      745
                     /gene="NUDT8"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcccgg ccgcgcagga cttgacatgc tgcccgactg cctgtcggcc gagggcgagc
       61 tgcgctgccg ccggctgctg gcaggggcca cggcccggct ccgcgcgcgg cccgcgtcgg
      121 ccgcggtgct cgtgccgctc tgctcagtgc gtggggtccc ggcgctgctg tacacgctgc
      181 ggtccagccg cctgaccggg aggcacaagg gcgacgtcag tttcccaggc ggcaagtgcg
      241 acccggctga ccaagatgtg gtgcacacgg ccctgcggga aacccgggag gagctgggcc
      301 tggcagtgcc cgaggagcac gtgtggggcc tgctgcggcc tgtgtatgat ccgcaaaagg
      361 ccaccgtggt gccagtgctt gctggtgtag gcccactgga tccccagagc ctcaggccca
      421 actcggagga ggtagatgag gtgtttgcac tgccgctggc ccacctgctg cagacgcaga
      481 atcagggcta tacccacttc tgccggggtg gccacttccg ctacacacta cccgtcttcc
      541 tgcatggacc acaccgggtc tggggcctca cagctgtcat cactgagttt gccctgcagc
      601 tgctggcacc tggtacctac cagccccgcc tggccggcct gacctgctca ggggctgagg
      661 gtctggcccg ccctaagcag cccctggctt caccctgtca ggccagctcc actccaggac
      721 tgaataaagg tctttgacag ctcta
//
