LOCUS       NM_001105663            1096 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens nudix hydrolase 7 (NUDT7), transcript variant 1, mRNA.
ACCESSION   NM_001105663 XM_001127131 XM_001131284
VERSION     NM_001105663.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1096)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 1096)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   3  (bases 1 to 1096)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1096)
  AUTHORS   Gasmi,L. and McLennan,A.G.
  TITLE     The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific
            for coenzyme A and its derivatives
  JOURNAL   Biochem J 357 (Pt 1), 33-38 (2001)
   PUBMED   11415433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX387030.2, BU579534.1,
            AK296963.1 and AI927964.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001105663.2.
            
            Summary: The protein encoded by this gene is a member of the Nudix
            hydrolase family. Nudix hydrolases eliminate potentially toxic
            nucleotide metabolites from the cell and regulate the
            concentrations and availability of many different nucleotide
            substrates, cofactors, and signaling molecules. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            found for this gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.207152.1,
                                           SRR5189652.51129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268533.9/ ENSP00000268533.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BX387030.2         23-58
            37-612              BU579534.1         5-580
            613-1094            AK296963.1         449-930
            1095-1096           AI927964.1         1-2                 c
FEATURES             Location/Qualifiers
     source          1..1096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..1096
                     /gene="NUDT7"
                     /note="nudix hydrolase 7"
                     /db_xref="GeneID:283927"
                     /db_xref="HGNC:HGNC:8054"
                     /db_xref="MIM:609231"
     exon            1..104
                     /gene="NUDT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..786
                     /gene="NUDT7"
                     /EC_number="3.6.1.77"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal coenzyme A diphosphatase NUDT7; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 7"
                     /codon_start=1
                     /product="peroxisomal coenzyme A diphosphatase NUDT7
                     isoform 1"
                     /protein_id="NP_001099133.1"
                     /db_xref="CCDS:CCDS42195.1"
                     /db_xref="GeneID:283927"
                     /db_xref="HGNC:HGNC:8054"
                     /db_xref="MIM:609231"
                     /translation="MSRLGLPEEPVRNSLLDDAKARLRKYDIGGKYSHLPYNKYSVLL
                     PLVAKEGKLHLLFTVRSEKLRRAPGEVCFPGGKRDPTDMDDAATALREAQEEVGLRPH
                     QVEVVCCLVPCLIDTDTLITPFVGLIDHNFQAQPNPAEVKDVFLVPLAYFLHPQVHDQ
                     HYVTRLGHRFINHIFEYTNPEDGVTYQIKGMTANLAVLVAFIILEKKPTFEVQFNLND
                     VLASSEELFLKVHKKATSRL"
     exon            105..258
                     /gene="NUDT7"
                     /inference="alignment:Splign:2.1.0"
     exon            259..417
                     /gene="NUDT7"
                     /inference="alignment:Splign:2.1.0"
     exon            418..1096
                     /gene="NUDT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      953..958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT7"
                     /note="hexamer: AGTAAA"
     polyA_site      977
                     /gene="NUDT7"
                     /note="major polyA site"
     regulatory      1073..1078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT7"
                     /note="hexamer: AATAAA"
     polyA_site      1096
                     /gene="NUDT7"
                     /note="major polyA site"
ORIGIN      
        1 gctctgcgca agcgcgaccg accgagcagc tccgaggagt ccgcccggaa acaaacattc
       61 cccagggcaa tgtcacgact tggtcttccc gaggagccag tcagaaacag tttgctagat
      121 gatgctaagg cccgcttaag aaagtatgat attggaggca aatattctca cttgccatat
      181 aacaaatact ccgtcctttt gccattggtg gctaaagaag gaaaactcca tttgttgttc
      241 accgtccggt cagagaagct aagaagggcc cctggagaag tttgcttccc tggaggtaag
      301 cgtgacccta cagacatgga tgatgcagcc acagctctcc gggaagccca ggaggaagtg
      361 ggtctccgtc ctcaccaagt ggaagttgtc tgctgcctgg tgccatgtct tattgataca
      421 gatacattga taactccatt tgtgggttta atagaccaca acttccaggc ccagccgaat
      481 cctgctgaag ttaaggatgt attcctggtg cctctggcct atttcctgca tccacaggtc
      541 catgaccagc attacgtcac acgtcttggt caccgtttta ttaatcatat ctttgagtac
      601 acaaaccctg aagacggtgt cacttaccag atcaagggaa tgacggcaaa ccttgcagtg
      661 ttggtggcct ttatcatttt ggaaaaaaaa cccacctttg aggttcaatt taatcttaat
      721 gatgtattag catcctctga agagttattc ctgaaggttc ataaaaaagc tacaagcagg
      781 ttatgattta ctagagcaag agacaaagaa ctattcacga ggattctgtg tgtgcttatt
      841 cgtagaacaa caacaatgcc agctgttgga atttgacagg tgtgaatatt ttttctgcag
      901 tatgtagtta gaatccttgc ctcttttcca gttgccttct attgtctgaa aaagtaaaag
      961 ccattcaaaa atgaaaacta tgttcatagt gttgcatatt ttcacccaca atatgttaat
     1021 aatatttttc ttacacatat aataaagaat atctggcaca tactaggccc ttaataaaga
     1081 ttttttgaat atataa
//
