LOCUS       NM_007083               1227 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nudix hydrolase 6 (NUDT6), transcript variant 1, mRNA.
ACCESSION   NM_007083
VERSION     NM_007083.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1227)
  AUTHORS   Debar,L., Ishak,L., Moretton,A., Anoosheh,S., Morel,F.,
            Jenninger,L., Garreau-Balandier,I., Vernet,P., Hofer,A., van den
            Wildenberg,S. and Farge,G.
  TITLE     NUDT6 and NUDT9, two mitochondrial members of the NUDIX family,
            have distinct hydrolysis activities
  JOURNAL   Mitochondrion 71, 93-103 (2023)
   PUBMED   37343711
  REMARK    GeneRIF: NUDT6 and NUDT9, two mitochondrial members of the NUDIX
            family, have distinct hydrolysis activities.
REFERENCE   2  (bases 1 to 1227)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1227)
  AUTHORS   Holliday,E.G., Attia,J., Hancock,S., Koloski,N., McEvoy,M.,
            Peel,R., D'Amato,M., Agreus,L., Nyhlin,H., Andreasson,A.,
            Almazar,A.E., Saito,Y.A., Scott,R.J. and Talley,N.J.
  TITLE     Genome-wide association study identifies two novel genomic regions
            in irritable bowel syndrome
  JOURNAL   Am J Gastroenterol 109 (5), 770-772 (2014)
   PUBMED   24797007
REFERENCE   4  (bases 1 to 1227)
  AUTHORS   Lan,C.C., Ko,Y.C., Tu,H.P., Wu,C.S., Lee,C.H., Wu,C.S. and Yu,H.S.
  TITLE     Association study between keratinocyte-derived growth factor gene
            polymorphisms and susceptibility to vitiligo vulgaris in a
            Taiwanese population: potential involvement of stem cell factor
  JOURNAL   Br J Dermatol 160 (6), 1180-1187 (2009)
   PUBMED   19416273
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 1227)
  AUTHORS   Duplan,S.M., Theoret,Y. and Kenigsberg,R.L.
  TITLE     Antitumor activity of fibroblast growth factors (FGFs) for
            medulloblastoma may correlate with FGF receptor expression and
            tumor variant
  JOURNAL   Clin Cancer Res 8 (1), 246-257 (2002)
   PUBMED   11801566
  REMARK    GeneRIF: FGF-2 exhibits antitumor activity in vitro and correlates
            with expression of FGF receptors expression in medulloblastoma
            cells
REFERENCE   6  (bases 1 to 1227)
  AUTHORS   Asa,S.L., Ramyar,L., Murphy,P.R., Li,A.W. and Ezzat,S.
  TITLE     The endogenous fibroblast growth factor-2 antisense gene product
            regulates pituitary cell growth and hormone production
  JOURNAL   Mol Endocrinol 15 (4), 589-599 (2001)
   PUBMED   11266510
REFERENCE   7  (bases 1 to 1227)
  AUTHORS   Gagnon,M.L., Moy,G.K. and Klagsbrun,M.
  TITLE     Characterization of the promoter for the human antisense fibroblast
            growth factor-2 gene; regulation by Ets in Jurkat T cells
  JOURNAL   J Cell Biochem 72 (4), 492-506 (1999)
   PUBMED   10022609
REFERENCE   8  (bases 1 to 1227)
  AUTHORS   Li,A.W., Too,C.K., Knee,R., Wilkinson,M. and Murphy,P.R.
  TITLE     FGF-2 antisense RNA encodes a nuclear protein with MutT-like
            antimutator activity
  JOURNAL   Mol Cell Endocrinol 133 (2), 177-182 (1997)
   PUBMED   9406864
REFERENCE   9  (bases 1 to 1227)
  AUTHORS   Knee,R.S., Pitcher,S.E. and Murphy,P.R.
  TITLE     Basic fibroblast growth factor sense (FGF) and antisense (gfg) RNA
            transcripts are expressed in unfertilized human oocytes and in
            differentiated adult tissues
  JOURNAL   Biochem Biophys Res Commun 205 (1), 577-583 (1994)
   PUBMED   7999082
REFERENCE   10 (bases 1 to 1227)
  AUTHORS   Murphy,P.R. and Knee,R.S.
  TITLE     Identification and characterization of an antisense RNA transcript
            (gfg) from the human basic fibroblast growth factor gene
  JOURNAL   Mol Endocrinol 8 (7), 852-859 (1994)
   PUBMED   7984147
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF019633.2, CB128685.1,
            BG386740.1, BC009842.2 and AC021205.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_007083.4.
            
            Summary: This gene overlaps and lies on the opposite strand from
            FGF2 gene, and is thought to be the FGF2 antisense gene. The two
            genes are independently transcribed, and their expression shows an
            inverse relationship, suggesting that this antisense transcript may
            regulate FGF2 expression. This gene has also been shown to have
            hormone-regulatory and antiproliferative actions in the pituitary
            that are independent of FGF2 expression. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009842.2, SRR1163658.365558.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304430.10/ ENSP00000306070.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AF019633.2         10-20
            12-36               CB128685.1         22-46
            37-647              BG386740.1         24-634
            648-1160            BC009842.2         637-1149
            1161-1227           AC021205.6         82493-82559         c
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..1227
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /note="nudix hydrolase 6"
                     /db_xref="GeneID:11162"
                     /db_xref="HGNC:HGNC:8053"
                     /db_xref="MIM:606261"
     exon            1..263
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..976
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /note="isoform a is encoded by transcript variant 1;
                     antisense basic fibroblast growth factor; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 6"
                     /codon_start=1
                     /product="nucleoside diphosphate-linked moiety X motif 6
                     isoform a"
                     /protein_id="NP_009014.2"
                     /db_xref="CCDS:CCDS43268.1"
                     /db_xref="GeneID:11162"
                     /db_xref="HGNC:HGNC:8053"
                     /db_xref="MIM:606261"
                     /translation="MRQPLSWGRWRAMLARTYGPGPSAGYRWASGAQGYVRNPPVGAC
                     DLQGELDRFGGISVRLARLDALDRLDAAAFQKGLQAAVQQWRSEGRTAVWLHIPILQS
                     RFIAPAASLGFCFHHAESDSSTLTLWLREGPSRLPGYASHQVGVAGAVFDESTRKILV
                     VQDRNKLKNMWKFPGGLSEPEEDIGDTAVREVFEETGIKSEFRSVLSIRQQHTNPGAF
                     GKSDMYIICRLKPYSFTINFCQEECLRCEWMDLNDLAKTENTTPITSRVARLLLYGYR
                     EGFDKIDLTVEELPAVYTGLFYKLYHKELPENYKTMKGID"
     exon            264..467
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..523
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..578
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..1227
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /note="hexamer: AATAAA"
     polyA_site      1160
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /note="major polyA site"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
                     /note="hexamer: TATAAA"
     polyA_site      1227
                     /gene="NUDT6"
                     /gene_synonym="ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1"
ORIGIN      
        1 aacggacgaa ttaagcggcg tggagatgcg gcagccactg agctggggcc gctggcgcgc
       61 gatgcttgcc cgaacctacg gccccgggcc ttcggcgggt taccgctggg cctcgggcgc
      121 acagggttac gtgcggaatc cgccagttgg agcgtgcgat ctgcagggcg agctggacag
      181 attcgggggc atctcggtgc gcctggcgcg gctcgatgcg ctggaccgcc tggacgctgc
      241 cgccttccag aagggcttgc aggctgcagt acagcaatgg cgatcagaag gtagaacagc
      301 tgtatggctg cacattccca tcctccaaag ccgatttatt gcccctgctg cttccctggg
      361 cttctgcttt caccacgcag aatcggattc atcaacgttg actctgtggc tgagagaagg
      421 gcccagcaga ttaccaggat atgcttcaca tcaagtagga gttgcaggag ctgtatttga
      481 tgaaagtact agaaaaatac tggttgtaca agatcgaaat aaattgaaaa atatgtggaa
      541 gtttccagga ggcctgtcag agcctgaaga agatattgga gacacagcgg ttcgagaagt
      601 ttttgaagag actggtataa aatcagaatt caggtccgtc ctgagtattc ggcaacagca
      661 cacaaatcct ggagcttttg ggaagtcaga tatgtatatc atctgccgcc taaagccata
      721 ttcattcacc ataaattttt gccaggaaga atgcttaaga tgtgagtgga tggatctcaa
      781 tgacctggcg aagactgaaa atacaactcc catcaccagc agagttgcta ggctgctgct
      841 gtatgggtac agagaagggt ttgacaaaat tgacctgact gtggaagaac ttccagcagt
      901 ttacacagga ctgttttata aactctatca taaggaactg ccagagaatt ataaaactat
      961 gaaaggaatt gattaaattc acatttatat gtttagaaac atgtagacta acgaatgaca
     1021 taagaaatag tggacatttt ggattgatta aacatctgac tgtgattttc taatgtatat
     1081 gatttccatg aagaaatttt gtttctaaac atgcacattt taaaagcctc ttttcgaata
     1141 aagcaaatgc gtgaaaaaga tcattgctct aggtaagctt cactgggtaa cagcagatgc
     1201 aatataaaag ggagaatata catttta
//
