LOCUS       NM_001355407            3642 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens nudix hydrolase 4B (NUDT4B), mRNA.
ACCESSION   NM_001355407 NR_002212 XM_496393 XR_247003
VERSION     NM_001355407.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3642)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3642)
  AUTHORS   Caffrey,J.J. and Shears,S.B.
  TITLE     Genetic rationale for microheterogeneity of human diphosphoinositol
            polyphosphate phosphohydrolase type 2
  JOURNAL   Gene 269 (1-2), 53-60 (2001)
   PUBMED   11376937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245389.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001355407.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660809.16751.1, SRR1660805.112162.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322209.5/ ENSP00000492425.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3642              AC245389.1         128250-131891
FEATURES             Location/Qualifiers
     source          1..3642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..3642
                     /gene="NUDT4B"
                     /gene_synonym="DIPP-2B; NUDT4P1"
                     /note="nudix hydrolase 4B"
                     /db_xref="GeneID:440672"
                     /db_xref="HGNC:HGNC:18012"
     exon            1..3642
                     /gene="NUDT4B"
                     /gene_synonym="DIPP-2B; NUDT4P1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..725
                     /gene="NUDT4B"
                     /gene_synonym="DIPP-2B; NUDT4P1"
                     /EC_number="3.6.1.52"
                     /note="nudix (nucleoside diphosphate linked moiety X)-type
                     motif 4 pseudogene 1; nudix motif 4B; nucleoside
                     diphosphate-linked moiety X motif 4B"
                     /codon_start=1
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     NUDT4B"
                     /protein_id="NP_001342336.1"
                     /db_xref="CCDS:CCDS86013.1"
                     /db_xref="GeneID:440672"
                     /db_xref="HGNC:HGNC:18012"
                     /translation="MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPD
                     QWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGIFEQNQDRKHRTYVYVLTVT
                     EILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSL
                     PDNNALFVTAAQTSGLPSSVR"
     regulatory      1450..1455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT4B"
                     /gene_synonym="DIPP-2B; NUDT4P1"
                     /note="hexamer: AGTAAA"
     polyA_site      1470
                     /gene="NUDT4B"
                     /gene_synonym="DIPP-2B; NUDT4P1"
                     /note="major polyA site"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT4B"
                     /gene_synonym="DIPP-2B; NUDT4P1"
                     /note="hexamer: AATGAA"
     polyA_site      3642
                     /gene="NUDT4B"
                     /gene_synonym="DIPP-2B; NUDT4P1"
                     /note="major polyA site"
ORIGIN      
        1 gtcggagcgg ccgccggccc cgggactgac cggcctcgcc gcacctcccg caccgactag
       61 cgctcccggg cgctcctgcg cccgactcgc cctcgccccc actccccggc ggggtggcgg
      121 cggccgggcc cccacggcgg cggccggagc agcagcagca gcagcaggag cccgcctcta
      181 tgatgaagtt caagcccaac cagacgcgga cctacgaccg cgagggcttc aagaagcggg
      241 cggcgtgcct gtgcttccgg agcgagcagg aggacgaggt gctgctggtg agtagcagcc
      301 ggtacccaga ccagtggatt gtcccaggag gaggaatgga acccgaggag gaacctggcg
      361 gtgctgccgt gagggaagtt tatgaggagg ctggagtcaa aggaaaacta ggcagacttc
      421 tgggcatatt tgagcagaac caagaccgaa agcacagaac atatgtttat gttctaacag
      481 tcactgaaat attagaagat tgggaagatt ctgttaatat tggaaggaag agagagtggt
      541 tcaaagtaga agatgctatc aaagttctcc agtgtcataa acctgtacat gcagagtatc
      601 tggaaaagct aaagctgggt tgttccccag ccaatggaaa ttctacagtc ccttcccttc
      661 cggataataa tgccttgttt gtaaccgctg cacagacctc tgggttgcca tctagtgtaa
      721 gatagagaga actgggtagg cctctcccac catgtgcagt ctcatgggga gaggcttctt
      781 tcgtttcctc gtcaaacatc tgattgacgc ttgcaaactg tctgaatttg ccatgcaagg
      841 ttttcaaaca atttgcatgt ttttcagatg ctttcaaatc tttttttaaa aaaatagtgt
      901 aaaatatttt aataagccaa agccatgtgg aatttttgtt tagatgcctt aactgtgcca
      961 caccccacaa ccccctatat tattttggtt gtctatttct cacagcatat tttcagtttt
     1021 ttgtccattt gacatcagtc tgtggtttat tttgtcatca gattacttgt gggtatacct
     1081 accccaaaat tgttttctca ttcacagcat tagcatattc agcaaatcca tctgtggtgg
     1141 gaattaaaaa tattattggt tttaaagaaa tccattcacc ccaaaacttg ttttacagga
     1201 ttacaatttt aattcaaaat ttccagattt gggctatttc tgtatgatcc aataacttat
     1261 tttgtcacag ggcttaattt gccatttttg gggatttgtc gactcatttt gtctgaattt
     1321 tcacaactgg tattatgtca ctagctacct gatatggcta tttcccttat aactcaatag
     1381 taccttaaca caaagtataa ctctgtagag ttggtgaata ttttagggaa atattagcaa
     1441 aatgcatgta gtaaagacat cttatgaaaa ctgtattcat ggaatttgat ttagcatgct
     1501 cagttgccag ttcccattat cgatactctt tctatgcaga ataccttaga accgttattt
     1561 ccctcagtgt agattgctct taaaatgtat tcagttattt agtggccccc acaggagtgg
     1621 agtcttgaaa tctaattcta aatgccagtc agtgatgatc gcatcacagt tgagtgaaat
     1681 ggccttcctg ttcagctgtt agagactgaa gattgttagg gcaccttaga atgtctcatc
     1741 ttttctaggt tgtcaacagg tactatttgt cacataacta actttcgagg cactggaaca
     1801 tacctgaact aagaattaag tcttttactt tatactcact taaaatcaag aatcccatct
     1861 aaaacacata ggtaccttat ctgaaactct tgcacttccc caaccagggc agaaatgagg
     1921 tgggagaagt ttgactaaaa tgagggatgg gggaaagtaa aagatgtttt tttttttttt
     1981 gagactcgct ttgtcaccca ggctggagtg caatggcaca atctcaactc accgcaacct
     2041 ccgcctccca ggttcaagcg attctcctgc ctcagcctcc cgagtagttg ggattacagg
     2101 agcctgcctc catgcctggc taattttgta tttttagtag agacagggtt tcttcatgtt
     2161 ggtcaggctg gtctcaaact cctaacctcg tgatccgcct gcctcgacct cccaaagtgc
     2221 tggtattaca ggcatgagcc accatgccca gccaaagatc atttttttat atagacttca
     2281 gccctttgta aatattgtaa ctggggagta tagagtagaa aaaaagtata gttaaaacat
     2341 ttgttctaca aattaacctt taaaaatata attactgcta aaaatagagt gctgttacac
     2401 ttaaggaaaa ttagtgccat tttggaaatg agatcttgtg ccataaatac agctgaactg
     2461 aatataaatg ttcacaaatt aatgctgtca aaggaatgag taaagcagaa aaacttttaa
     2521 ccagcaacat ttcaagtacg tagtgtgatc aaacatgatc atccagaatt tgtatatttt
     2581 tttctttgta cagaggttac atattctggg tgttctttta taaaggaaac attttaaatc
     2641 ccacaaattg acactttcta tcttcaatgg actaagattt ttttggtcag taatctctga
     2701 aatttcctta aattatatac ttaacatagc agagaaactg gattgttttt gtatataaga
     2761 ctgcttccac ctgaaatgct gtcataagta ctgggggggt gggggagtgc ccatcttgta
     2821 catgatattc ttagaggtaa taaggtaatg atgcatgaat ttattttata aactcttgga
     2881 ctatgtattt gacatgtaaa atatgtacag tattaacgtc aaccatctct ttaaagttag
     2941 cctataaata ttgttgtata attttctttg gtcagaaaca cttgtactga atagtgacac
     3001 tcggtaagga ttttcagtgc catttagcaa aacgtcttta gtctatgcaa ctagcaaaaa
     3061 tctgcataat gcaacaacac agttttcaca cttcaaattt tacatgaggg gttcttcacg
     3121 attctcctgg aacccagtct agcaaaatga gaggaaaggc cctagggaga tttatttctg
     3181 ttaaatagtt aactctgctg agtatgacaa atagtgtcta ctatctcaac cctccaaaat
     3241 ttgcagagtg ttgggactgt catttgtgat tttttttttt tttttttggt ggggtagttg
     3301 aataaaattg ggcagctaaa tttttcagtt ccatgtgcct cccaaataaa aaacagaaaa
     3361 taagtagttt ttgtgaattg acttgcagac aaagtagaaa ctgtgctgca tgatgttatt
     3421 ttgtaaacag atgacatttt ctgaccaggc acatgccatc caattttctg tcaatcacac
     3481 tgttgtataa agcagcagaa ctgaagggga aaaatgattg ttgtatacac tgaattgctt
     3541 tgcatggtct catttgagat aattgatgta agcatcctga cttttttata tttggaaaca
     3601 tcaaataaaa atggaaaaaa tgaaaaaaaa aaaaaaaaag aa
//
