LOCUS       NM_019094               9708 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens nudix hydrolase 4 (NUDT4), transcript variant 1, mRNA.
ACCESSION   NM_019094
VERSION     NM_019094.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9708)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 9708)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
REFERENCE   3  (bases 1 to 9708)
  AUTHORS   Fisher,D.I., Safrany,S.T., Strike,P., McLennan,A.G. and
            Cartwright,J.L.
  TITLE     Nudix hydrolases that degrade dinucleoside and diphosphoinositol
            polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP)
            pyrophosphatase activity that generates the glycolytic activator
            ribose 1,5-bisphosphate
  JOURNAL   J Biol Chem 277 (49), 47313-47317 (2002)
   PUBMED   12370170
REFERENCE   4  (bases 1 to 9708)
  AUTHORS   Leslie,N.R., McLennan,A.G. and Safrany,S.T.
  TITLE     Cloning and characterisation of hAps1 and hAps2, human diadenosine
            polyphosphate-metabolising Nudix hydrolases
  JOURNAL   BMC Biochem 3, 20 (2002)
   PUBMED   12121577
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9708)
  AUTHORS   Caffrey,J.J. and Shears,S.B.
  TITLE     Genetic rationale for microheterogeneity of human diphosphoinositol
            polyphosphate phosphohydrolase type 2
  JOURNAL   Gene 269 (1-2), 53-60 (2001)
   PUBMED   11376937
REFERENCE   6  (bases 1 to 9708)
  AUTHORS   Caffrey,J.J., Safrany,S.T., Yang,X. and Shears,S.B.
  TITLE     Discovery of molecular and catalytic diversity among human
            diphosphoinositol-polyphosphate phosphohydrolases. An expanding
            Nudt family
  JOURNAL   J Biol Chem 275 (17), 12730-12736 (2000)
   PUBMED   10777568
  REMARK    GeneRIF: This paper demonstrates that KIAA0487 (AB007956) is the
            3'-UTR for human diphosphoinositol polyphosphate phosphohydrolase
            type II
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124947.10, AF191649.1 and
            AC025260.29.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_019094.5.
            
            Summary: The protein encoded by this gene regulates the turnover of
            diphosphoinositol polyphosphates. The turnover of these high-energy
            diphosphoinositol polyphosphates represents a molecular switching
            activity with important regulatory consequences. Molecular
            switching by diphosphoinositol polyphosphates may contribute to
            regulating intracellular trafficking. Several alternatively spliced
            transcript variants have been described, but the full-length nature
            of some variants has not been determined. Isoforms DIPP2alpha and
            DIPP2beta are distinguishable from each other solely by DIPP2beta
            possessing one additional amino acid due to intron boundary
            skidding in alternate splicing. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 2. The
            encoded protein is the predominant isoform (alpha), and is shorter
            than isoform beta.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF191651.1, SRR1660805.79957.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415493.7/ ENSP00000406612.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC124947.10        85440-85664
            226-1402            AF191649.1         1-1177
            1403-9708           AC025260.29        153625-161930       c
FEATURES             Location/Qualifiers
     source          1..9708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..9708
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /note="nudix hydrolase 4"
                     /db_xref="GeneID:11163"
                     /db_xref="HGNC:HGNC:8051"
                     /db_xref="MIM:609229"
     exon            1..497
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..941
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /EC_number="3.6.1.52"
                     /EC_number="3.6.1.61"
                     /note="isoform alpha is encoded by transcript variant 1;
                     diphosphoinositol polyphosphate phosphohydrolase type 2;
                     DIPP-2; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase
                     2; nudix (nucleoside diphosphate linked moiety X)-type
                     motif 4; Diphosphoinositol polyphosphate phosphohydrolase
                     NUDT4B; Nucleoside diphosphate-linked moiety X motif 4B;
                     Nudix hydrolase 4B; Nudix motif 4B"
                     /codon_start=1
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     2 isoform alpha"
                     /protein_id="NP_061967.3"
                     /db_xref="CCDS:CCDS44952.1"
                     /db_xref="GeneID:11163"
                     /db_xref="HGNC:HGNC:8051"
                     /db_xref="MIM:609229"
                     /translation="MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPD
                     QWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTE
                     ILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLP
                     DNNALFVTAAQTSGLPSSVR"
     exon            498..608
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /inference="alignment:Splign:2.1.0"
     exon            609..653
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /inference="alignment:Splign:2.1.0"
     exon            654..738
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /inference="alignment:Splign:2.1.0"
     exon            739..9708
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3819..3824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /note="hexamer: AATAAA"
     polyA_site      3838
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /note="major polyA site"
     regulatory      4331..4336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /note="hexamer: AATACA"
     polyA_site      4355
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
     regulatory      7449..7454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /note="hexamer: AATAAA"
     polyA_site      7466
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
     regulatory      9677..9682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /note="hexamer: AGTAAA"
     polyA_site      9708
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
ORIGIN      
        1 ggtcgccgcg gtgctgctgc tcagtgggag cgggtcttcg caactgtctc cgcgtggcgc
       61 gcgcctctag ccgcccttcc cctggcggct acggccggag ggagcggagg cgagcgggag
      121 tcgggctcca tggagagcgg cggacaactg ggcagaggcg gagctttcat ctcggcaccc
      181 tggttccagt gacccgcgct agcgtcccgt cccgcccgcg tcggagcggc cgccggcccc
      241 gggactgacc ggcctcgccg cacctcccgc accgactagc gctcccgggc gctcctgcgc
      301 ccgactcgcc ctcgccccca ctccccggcg gggtggcggc ggccgggccc ccacggcggc
      361 ggccggagca gcagcagcag cagcaggagc ccgcctctat gatgaagttc aagcccaacc
      421 agacgcggac ctacgaccgc gagggcttca agaagcgggc ggcgtgcctg tgcttccgga
      481 gcgagcagga ggacgaggtg ctgctggtga gtagcagccg gtacccagac cagtggattg
      541 tcccaggagg aggaatggaa cccgaggagg aacctggcgg tgctgccgtg agggaagttt
      601 atgaggaggc tggagtcaaa ggaaaactag gcagacttct gggcatattt gagaaccaag
      661 accgaaagca cagaacatat gtttatgttc taacagtcac tgaaatatta gaagattggg
      721 aagattctgt taatattgga aggaagagag agtggttcaa agtagaagat gctatcaaag
      781 ttctccagtg tcataaacct gtacatgcag agtatctgga aaagctaaag ctgggttgtt
      841 ccccagccaa tggaaattct acagtccctt cccttccgga taataatgcc ttgtttgtaa
      901 ccgctgcaca gacctctggg ttgccatcta gtgtaagata gagagaactg ggtaggcctc
      961 tcccaccatg tgcagtctca tggggagagg cttctttcgt ttcctcgtca aacatctgat
     1021 tgacgcttgc aaactgtctg aatttgccat gcaaggtttt caaacaattt gcatgttttt
     1081 cagatgcttt caaatctttt tttaaaaaaa tagtgtaaaa tattttaata agccaaagcc
     1141 atgtggaatt tttgtttaga tgccttaact gtgccacacc ccacaacccc ctatattatt
     1201 ttggttgtct atttctcaca gcatattttc agttttttgt ccatttgaca tcagtctgtg
     1261 gtttattttg tcatcagatt acttgtgggt atacctaccc caaaattgtt ttctcattca
     1321 cagcattagc atattcagca aatccatctg tggtgggaat taaaaatatt attggtatta
     1381 aagaaatcca ttcaccccaa aacttgtttt acaggattac aattttaatt caaaatttcc
     1441 agatttgggc tatttctgta tgatccaata acttattttg tcacagggct taatttgcca
     1501 tttttgggga tttgtcgact cattttgtct gaattttcac aactggtatt atgtcactag
     1561 ctacctgata cggctatttc ccttataact caatagtacc ttaacacaaa gtataactct
     1621 gtagagttgg tgaatatttt agggaaatat tagcaaaatg catgtagtaa agacatctta
     1681 tgaaaactgt attcatggaa tttgatttag catgctcagt tgccagttcc cattatcgat
     1741 actctttctt tgcagaatac cttagaaccg ttatttccct cagtgtagat tgctcttaaa
     1801 atgtattcag ttatttagtg gcccccacag gagtggagtc ttgaaatcta attctaaatg
     1861 ccagtcagtg atgatcgcat cacagttgag tgaaatggcc ttcctgttca gctgttagag
     1921 actgaagatt gttagggcac cttagaatgt ctcatctttt ctaggttgtc aacaggtact
     1981 atttgtcaca taactaactt tcgaggcact ggaacatacc tgaactaaga attaaatctt
     2041 ttactttata ctcacttaaa atcaagaatc ccatctaaaa cacataggta ccttatctga
     2101 aactcttgca cttccccaac cagggcagaa atgaggtggg agaagtttga ctaaaatgag
     2161 ggatggggga aagtaaaaga tgtttttttt tttttgagac tcgctttgtc acccaggctg
     2221 gagtgcaatg gcacaatctc aactcaccgc aacctccgcc tcccgggttc aagcgattct
     2281 cctgcctcag cctcccgagt agttgggatt acaggcgcct gcctccatgc ctggctaatt
     2341 ttgtattttt agtagagaca gggtttcttc atgttggtca ggctggtctc aaactcctaa
     2401 cctcgtgatc cgcctgcctc gacctcccaa agtgctggga ttacaggcat gagccaccat
     2461 gcccagccaa agatcatttt tttatataga cttcagccct ttgtaaatat tgtaactggg
     2521 gagtatagag tagaaaaaaa gtatagttaa aacatttgtt ctacaaatta acctttaaaa
     2581 atataattac tgctaaaaat agagtgctgt tacacttaag gaaaattagt gccattttgg
     2641 aaatgagatc ttgtgccata aatacagctg aactgaatat aaatgttcac aaattaatgc
     2701 tgtcaaagga atgagtaaag cagaaaaact tttaaccagc aacatttcaa gtacgtagtg
     2761 tgatcaaaca tgatcatcca gaatttttat atttttttct ttgtacagag gttacatatt
     2821 ctgggtgttc ttttataaag gaaacatttt aaatcccaca aattgacact ttctatcttc
     2881 aatggactaa gatttttttg gtcagtaatc tctgaaattt ccttaaatta tatacttaac
     2941 atagcagaga aactggattg tttttgtata taagactgct tccacctgaa atgctgtcat
     3001 aagtactggg ggggtggggg agtgcccatc ttgtacatga tattcttaga ggtaataagg
     3061 taatgatgca tgaatttatt ttataaactc ttggactatg tatttgacat gtaaaatatg
     3121 tacagtatta acgtcaacca tctctttaaa gttagcctat aaatattgtt gtataatttt
     3181 ctttggtcag aaacacttgg actgaatagt gacactcggt aaggattttc agtgccattt
     3241 agcaaaacgt ctttagtcta tgcaactagc aaaaatctgc ataatgcaac aacacagttt
     3301 tcacacttca aattttacat gaggggttct tcacgattct cctggaaccc agtctagcaa
     3361 aatgagagga aaggccctag ggagatttat ttctgttaaa tagttaactc tgctgagtat
     3421 gacaaatagt gtctactatc tcaaccctcc aaaatttgca gagtgttggg actgtcattt
     3481 gtgatttttt tttttttttt ttggtggggt agttgaataa aattgggcag ctaaattttt
     3541 cagttccatg tgcctcccaa ataaaaaaca gaaaataagt agtttttgtg aattgacttg
     3601 cagacaaagt agaaactgtg ctgcatgatg ttattttgta aacagatgac attttctgac
     3661 caggcacatg ccatccaatt ttctgtcaat cacactgttg tataaagcag cagaactgaa
     3721 ggggaaaaat gattgttgta tacactgaat tgctttgcat ggtctcattt gagataattg
     3781 atgtaagaat cctgactttt ttatatttgg aaacatcaaa taaaaatgga aaaaatgatc
     3841 atggctttaa aaaaaaaaca aaaacacaca cacatgaact cagatttgca aaccaggttt
     3901 ctgaaacttt gggtaaggtg tatgctttta actttgaaat gtataaacac ccagcggaaa
     3961 cgtatacctt tcagtgcata gtgcattgtg tgcttaccct gggttgttta aacttgtgtt
     4021 caaatattcc ccctccaagt gaaagcctgt cgggaattcc acagtaacac ctttactgtt
     4081 ctcccattga tgatcatata cgttacctct tcctagcggt acatttgtat gatccttact
     4141 actggaatta ccgggttaaa aggaaatgct taccactaag atgtcagtat tctcctcatg
     4201 gatattttca gtctcaatgt tgccagtcta atagtatagt atgtggttgc tttactgctg
     4261 ttctccccac ccccgtggag ttgtgtcatt attttaatga atgtgagctc ttgacttact
     4321 ctagaattct aatacagata ctttctgcac tagtatcact tttattattg cagttccatt
     4381 taaaagcata actggctaag tcaccgcccc acccgccgca ttacatttcc taaaacatac
     4441 tgctgccaaa gaccaactgt agaatcctta agtcctgttc aagtgtcact tcatttttta
     4501 ttaggggttt cttagttgga gggcatgaga aacttggccc tttccaatgt tgtcttcaca
     4561 ttggagtata agaattctct ataggactct ttaatttttt tttttttttg gtagagatgg
     4621 ggtcttgctg tgttgcccag gctggtctca aactcctagg cttaagcagt cctccagcct
     4681 cagccttctc aaagtgctag gatgattggc atgagccacc tcgtctggcc tgcaggtctt
     4741 tttaagcatt tgctgttcaa taataagcat cttctttatg cctagtattt gtgataagag
     4801 cacaaaacaa ttttctaatc tcaaagagct tatattctag tggggtagag ataagtgatt
     4861 tatcttggtg tagttttggc ttttttgttt gtttttttga gacagcatct cacactgtcg
     4921 cccaggctgg agtgcagtgg tgcaatctca gcttactgta acctccgcct gccaggttca
     4981 agcgattctc ctgcctcatc ctcccgagga gctgggatca caggcgcctg ccaccacgcc
     5041 cggctaattt ttttgtattt ttagtagaga cggggtttca ccatattggc caggctggtc
     5101 tcaaactcct gacctcgtga tccgcctgcc tcggcctccc taagtgctgg gattatgggc
     5161 gtgaaccacc gcacctggcc tatcttggtg tttttacatc cttcagtatt tttcaaggtt
     5221 ttacagcttt tttatctata gacttatacc atcttcaaaa gcaatacaat tttatttgta
     5281 gacgtgattt cccccaccaa atgcacattt tatggagctc taggacaaaa gtcaggatga
     5341 aaagtaatct atcgctggtg ctactttaat accttcctga ctggtgccac tggctaaatt
     5401 ctagcagtac gatgagaggg ccattaaggc ctatcttagc aagcaagaca ttatagcaaa
     5461 gacctaaaca ctcaaaggtt caacgtcttc tagccaggga actattctct aattcttcca
     5521 ccttgatatg atttcagcaa attctgataa cccggtatta ctcttaatgc atttttgtaa
     5581 catttgacaa acatctccca atatgtagac tcccactctc ctgatgctaa tcagtatcag
     5641 acaatggaag taaattttcc tgcttttctc aacttttcct caaattcatg ttagtgaagt
     5701 actttcattt ggccatcatt atttatcaac cttaagaaac atgcctattg acgaagtaaa
     5761 tatactagga attcaacgta tctacgggaa tgtggacaaa gacatatacc aagacaaggc
     5821 actagagtga aaagccatta aaataaaatg ctcagcagca aaggatttgt aatggttaac
     5881 ttgcaatata tccatatggt gtaatattac agtcattaga aatgacattt gcgtaaggat
     5941 ctgagtggaa actgatacag cctgtcggag agctactgag tagtatttta tcacagctgc
     6001 atacataccc tttcacccaa cagttccact cctgggagtc tagtcaacaa atggacaagt
     6061 tgcacaacca agctatggtc aaatatgtgt gttgtaggat ttatgaaact ggtaccaatt
     6121 taatattcaa atgtgattaa gtcatggcaa tctatttact ggatactttg tggttaccaa
     6181 agagctatgt gctgccacag ggagtccttt caatagtgat tgaaaaaggc agaacactac
     6241 tagacagaac tacctgtttt atgcatgtat tggcatacac tgaaaaagct tagtcactta
     6301 aaatgaggtt gtacagattg tagattttgt ttttaaacgc ctgtatggtt taaaaaatgt
     6361 tttgggaaat agacatgagc agggcagaga actacaacct acaggccaaa ccccacccca
     6421 ctgcctgttt gtacggccaa caagtttaaa atttttttaa tgttttaggt tttttttttt
     6481 ttaaaaaaaa tactatgccc atttgtttac aaatcgtctg tgggtgcttt ctcactacaa
     6541 tggcagaatt cagtagttga gacagaccta tggtccacaa aggccgaaat atttactgtt
     6601 ttaggagaaa aaaacaacat gaattgtaat aacttggact tacttggttg ctcagtcctg
     6661 atgtgtcctg ttaaaaccta agagaaacag caccaagttc aatctagtgc aatcagccta
     6721 tcacatctaa gctgcttttg ccagatctga tatctactcc cgaccttaag ccaggagact
     6781 ttgtaaactt actaggttat aataaaactt aagaactatc gatatttact aatctacatc
     6841 atggaactat ttcaaaagca gtcatatggt aagatggatc aggagtcttt aaaaataaaa
     6901 ctgagaaaga aaaatcatgt gatcaattca gtagtagaga cagaggttgg tatcaagtct
     6961 atgttcatac acttaccagt gccacccagc agggccatac aagacacatg aaatgagatc
     7021 agctcaaggg tgacaagatg aaactgggag agggccgggg agacccgaac tcttaatatt
     7081 ggattccaca caagaggaaa aattttagtc cagctcccag catggcagct aatggcaagt
     7141 tagtaccata aagccaactc ttggaatata cctgacttcc acgataaaat ggagatgagt
     7201 gcaggggtga gtgtatagtt aagaaaacaa acaatatatt actagtccag gtggtagatg
     7261 acagattttt attatttaca cttctctcaa attattacat tcagcatgtt ttgcttttta
     7321 tgttatttaa agtataaacc ctcatataat tccctaagat gggtggcatg ccaagtagct
     7381 aaatgaaata tcatcccagc ccaaaagtac ttattcgaat gaaatattac atttttctta
     7441 aataaagcaa taaattaggt accctattat catggtattt tcttttttgg ccagcttttc
     7501 tagataaggt tgtattgcta ctgcaactaa caaaaaagat gtggcagggc tgggcacggt
     7561 ggctcacgcc tgtaatccca gcactttggg aggccgaggc gggcagatca cgaggtcagg
     7621 agatggagac catcctggcc caacatggtg aaaccccgtc tctactaaaa atacaaaaaa
     7681 ttagccaggt gtggtggcag gtgtctgtag tcccagctcc tcaggaggct gaggcaggag
     7741 aatcgcttga acgcgggagg cagaacctgc agtgagccaa gatcatgcca cagcactcca
     7801 gcctaaacta cagagctaga aagtggctag agcagccaaa aaaaaaaaaa aaaaaaaaaa
     7861 aaaaaaaggt tcctgaacca ttcaacagaa aaatgaggcc tattcctatc atttcctcga
     7921 tccaatttag ttccacttag gtcactgtgt ttataatgtc ttttaggaca gatttccttc
     7981 cccattctcc atcaaacaac catagcacct gtgactttta tctgttggtt tgtatttaat
     8041 cttattttta agtgcttctt tgaaattgtt ttacaagtac attcttggtc tagagtaagg
     8101 ttctatatag ttggccctcc atatccatgg gttccacttc cgtggattca aacaaccaga
     8161 caaaatattc caaaaaacat tgtgtctgta gtcaacatgt atatttttgt cattattcct
     8221 taaacaatag tgtaactatt tacatagcac ttacattata ataggtatta taagtaatct
     8281 aaatattaac ataagcggga ggatttgtgt agattgtatg catatacaac atcattttat
     8341 tccagagact tgagcatctg cgaatttgga tatccaaagg aagtcctaga accagttccc
     8401 gacaaatacc aagagatgac tttactttag acctaagatc ttgctagaca gcctttgaga
     8461 ggatgaagga taactagagc agaagcaaat cgcagcgaag tagactacaa caatcaagtc
     8521 aaaaaacata aagctcctat caacacctca agattttaga aaagcctctt aacgggcaat
     8581 tttcttttaa ataaagactg ggtcccacta tgttagccag gctggtcaca aactcctgga
     8641 ctcaagtgat cctcctgcct tggcctccta aagtgctggg attacaggca tgagccactg
     8701 tgcccggcct gggcagtcga ttttcaggaa gccacttaat gttcagattc ttttcttctc
     8761 tcccaggact ttgcagatgc tgctgttccc tctgcctgga gatgttcatc tggcctgaat
     8821 ccaaaagtct gtccaagtta cttctctttt ccatgacaga gttacaacta tttgtctgtc
     8881 ccccttcccc attagagtat atggtcccca aaggaaagcc ccatgccatt cactcaccac
     8941 ctaatcatcc ccaacaacta gtgggcaaac atgaaacact tttgttgaat aatgtgtttc
     9001 ctttagccca gggattacaa agtcaaaggc ttacaagggg gaaggactag caggtgtgct
     9061 cggaggggac tctagccaac tggagagtaa ctggtgagaa gacaatgaca tgctcttagg
     9121 gtgtctgcta ctcagatcct ctcagttaag tcccgtgcac aaaggtgggt caggtctact
     9181 gttgccagat cttcagatca ttcaaaagtt acccgaattc tggattttca tgcaaatctc
     9241 ccaattttta aaaatgttgg catcaaattc agaatgtttt aaccagccac actgtgtggg
     9301 ccagggaaaa caggcccaaa ggccaggtga agctgcagtt ttcaactgct gccttggcct
     9361 ctcccagagc cccttaagtc ctaagaaggc tcagtcaaca cactggcact cgtttcatcc
     9421 cactggttga gaaagcaagt cttagcaaag taatggggga gtcttaccaa aactgcaaag
     9481 gaaaaaaata tgataccatg aaattagaaa ttcactgcat ttgaaatgaa aatgacttat
     9541 ttctgtactt ctataactca caaatttagc agacatcatt tagacatttt tgtagtgcaa
     9601 cagatttaaa tctggaattt catggtttgt aaatcactat gtgatactag ctataaccat
     9661 gagcaatatt acgggcagta aatgttgatt tctatttcgt ttcttgaa
//
