LOCUS       NM_006703               9900 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens nudix hydrolase 3 (NUDT3), mRNA.
ACCESSION   NM_006703
VERSION     NM_006703.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9900)
  AUTHORS   Dundr,P., Machado-Lopez,A., Mas,A., Veckova,Z., Mara,M.,
            Richtarova,A., Matej,R., Struzinska,I., Kendall Bartu,M.,
            Nemejcova,K., Dvorak,J. and Hojny,J.
  TITLE     Uterine leiomyoma with RAD51B::NUDT3 fusion: a report of 2 cases
  JOURNAL   Virchows Arch 484 (6), 1015-1022 (2024)
   PUBMED   37466765
  REMARK    GeneRIF: Uterine leiomyoma with RAD51B::NUDT3 fusion: a report of 2
            cases.
REFERENCE   2  (bases 1 to 9900)
  AUTHORS   Samper-Martin,B., Sarrias,A., Lazaro,B., Perez-Montero,M.,
            Rodriguez-Rodriguez,R., Ribeiro,M.P.C., Banon,A., Wolfgeher,D.,
            Jessen,H.J., Alsina,B., Clotet,J., Kron,S.J., Saiardi,A.,
            Jimenez,J. and Bru,S.
  TITLE     Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress
            response
  JOURNAL   Cell Rep 37 (7), 110004 (2021)
   PUBMED   34788624
  REMARK    GeneRIF: Polyphosphate degradation by Nudt3-Zn(2+) mediates
            oxidative stress response.
REFERENCE   3  (bases 1 to 9900)
  AUTHORS   Zong,G., Jork,N., Hostachy,S., Fiedler,D., Jessen,H.J., Shears,S.B.
            and Wang,H.
  TITLE     New structural insights reveal an expanded reaction cycle for
            inositol pyrophosphate hydrolysis by human DIPP1
  JOURNAL   FASEB J 35 (2), e21275 (2021)
   PUBMED   33475202
  REMARK    GeneRIF: New structural insights reveal an expanded reaction cycle
            for inositol pyrophosphate hydrolysis by human DIPP1.
REFERENCE   4  (bases 1 to 9900)
  AUTHORS   Sahu,S., Wang,Z., Jiao,X., Gu,C., Jork,N., Wittwer,C., Li,X.,
            Hostachy,S., Fiedler,D., Wang,H., Jessen,H.J., Kiledjian,M. and
            Shears,S.B.
  TITLE     InsP7 is a small-molecule regulator of NUDT3-mediated mRNA
            decapping and processing-body dynamics
  JOURNAL   Proc Natl Acad Sci U S A 117 (32), 19245-19253 (2020)
   PUBMED   32727897
  REMARK    GeneRIF: InsP7 is a small-molecule regulator of NUDT3-mediated mRNA
            decapping and processing-body dynamics.
REFERENCE   5  (bases 1 to 9900)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 9900)
  AUTHORS   Thorsell,A.G., Persson,C., Graslund,S., Hammarstrom,M., Busam,R.D.
            and Hallberg,B.M.
  TITLE     Crystal structure of human diphosphoinositol phosphatase 1
  JOURNAL   Proteins 77 (1), 242-246 (2009)
   PUBMED   19585659
REFERENCE   7  (bases 1 to 9900)
  AUTHORS   Fisher,D.I., Safrany,S.T., Strike,P., McLennan,A.G. and
            Cartwright,J.L.
  TITLE     Nudix hydrolases that degrade dinucleoside and diphosphoinositol
            polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP)
            pyrophosphatase activity that generates the glycolytic activator
            ribose 1,5-bisphosphate
  JOURNAL   J Biol Chem 277 (49), 47313-47317 (2002)
   PUBMED   12370170
REFERENCE   8  (bases 1 to 9900)
  AUTHORS   Yang,X., Safrany,S.T. and Shears,S.B.
  TITLE     Site-directed mutagenesis of diphosphoinositol polyphosphate
            phosphohydrolase, a dual specificity NUDT enzyme that attacks
            diadenosine polyphosphates and diphosphoinositol polyphosphates
  JOURNAL   J Biol Chem 274 (50), 35434-35440 (1999)
   PUBMED   10585413
REFERENCE   9  (bases 1 to 9900)
  AUTHORS   Safrany,S.T., Ingram,S.W., Cartwright,J.L., Falck,J.R.,
            McLennan,A.G., Barnes,L.D. and Shears,S.B.
  TITLE     The diadenosine hexaphosphate hydrolases from Schizosaccharomyces
            pombe and Saccharomyces cerevisiae are homologues of the human
            diphosphoinositol polyphosphate phosphohydrolase. Overlapping
            substrate specificities in a MutT-type protein
  JOURNAL   J Biol Chem 274 (31), 21735-21740 (1999)
   PUBMED   10419486
REFERENCE   10 (bases 1 to 9900)
  AUTHORS   Safrany,S.T., Caffrey,J.J., Yang,X., Bembenek,M.E., Moyer,M.B.,
            Burkhart,W.A. and Shears,S.B.
  TITLE     A novel context for the 'MutT' module, a guardian of cell
            integrity, in a diphosphoinositol polyphosphate phosphohydrolase
  JOURNAL   EMBO J 17 (22), 6599-6607 (1998)
   PUBMED   9822604
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA803962.1, BC007727.2, Z98036.1, CA430332.1 and AL354740.29.
            
            On Nov 23, 2018 this sequence version replaced NM_006703.3.
            
            Summary: NUDT3 belongs to the MutT, or Nudix, protein family. Nudix
            proteins act as homeostatic checkpoints at important stages in
            nucleoside phosphate metabolic pathways, guarding against elevated
            levels of potentially dangerous intermediates, like 8-oxo-dGTP,
            which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed
            9822604]).[supplied by OMIM, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.223249.1,
                                           SRR1660803.243167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000607016.2/ ENSP00000476119.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA803962.1         12-39
            29-1240             BC007727.2         1-1212
            1241-1693           Z98036.1           5397-5849           c
            1694-2385           CA430332.1         15-706              c
            2386-5089           Z98036.1           2001-4704           c
            5090-9900           AL354740.29        147018-151828       c
FEATURES             Location/Qualifiers
     source          1..9900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..9900
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /note="nudix hydrolase 3"
                     /db_xref="GeneID:11165"
                     /db_xref="HGNC:HGNC:8050"
                     /db_xref="MIM:609228"
     exon            1..406
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..826
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /EC_number="3.6.1.52"
                     /EC_number="3.6.1.59"
                     /EC_number="3.6.1.62"
                     /EC_number="3.6.1.10"
                     /EC_number="3.6.1.61"
                     /note="nudix (nucleoside diphosphate linked moiety X)-type
                     motif 3; nudix motif 3; nucleoside diphosphate-linked
                     moiety X motif 3; diadenosine 5',5'''-P1,P6-hexaphosphate
                     hydrolase 1; ap6A hydrolase; endopolyphosphatase; m7GpppX
                     diphosphatase; m7GpppN-mRNA hydrolase; diadenosine
                     hexaphosphate hydrolase"
                     /codon_start=1
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     1"
                     /protein_id="NP_006694.1"
                     /db_xref="CCDS:CCDS4791.1"
                     /db_xref="GeneID:11165"
                     /db_xref="HGNC:HGNC:8050"
                     /db_xref="MIM:609228"
                     /translation="MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPD
                     RWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTE
                     VLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTY
                     SVSAQSSMSGIR"
     exon            407..517
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..562
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..647
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..9900
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9876..9881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /note="hexamer: AATAAA"
     polyA_site      9900
                     /gene="NUDT3"
                     /gene_synonym="DIPP; DIPP-1; DIPP1"
                     /note="major polyA site"
ORIGIN      
        1 acgccgctga cgcatcgcgc ccaagatggc ggcgcggtcg tcgtcggggg tggcggcggc
       61 agagggggcg gcggccctgg cggcagcgga gacggcagcc gtgacggtgg cagcggcggc
      121 gcgggacctg ggcctggggg aatgaggcgg ccgcggcggg ccagcggcgg agccgtgtag
      181 cggagaagct ccccctccct gcttcccttg gccgagccgg gggcgcgcgc gcacgcggcc
      241 gtccagagcg ggctccccac ccctcgactc ctgcgacccg caccgcaccc ccacccgggc
      301 ccggaggatg atgaagctca agtcgaacca gacccgcacc tacgacggcg acggctacaa
      361 gaagcgggcc gcatgcctgt gtttccgcag cgagagcgag gaggaggtgc tactcgtgag
      421 cagtagtcgc catccagaca gatggattgt ccctggagga ggcatggagc ccgaggagga
      481 gccaagtgtg gcagcagttc gtgaagtctg tgaggaggct ggagtaaaag ggacattggg
      541 aagattagtt ggaatttttg agaaccagga gaggaagcac aggacgtatg tctatgtgct
      601 cattgtcact gaagtgctgg aagactggga agattcagtt aacattggaa ggaagaggga
      661 atggtttaaa atagaagacg ccataaaagt gctgcagtat cacaaacccg tgcaggcatc
      721 atattttgaa acattgaggc aaggctactc agccaacaat ggcaccccag tcgtggccac
      781 cacatactcg gtttctgctc agagctcgat gtcaggcatc agatgactga agacttcctg
      841 taagagaaat ggaaattgga aactagactg aagtgcaaat cttccctctc accctggctc
      901 tttccacttc tcacaggcct cctctttcaa ataaggcatg gtgggcagca aagaaagggt
      961 gtattgataa tgttgctgtt tggtgttaag tgatggggct ttttcttctg tttttattga
     1021 gggtgggggt tgggtgtgta atttgtaagt acttttgtgc atgatctgtc cctccctctt
     1081 cccacccctg cagtcctctg aagagaggcc aacagccttc ccctgccttg gattctgaag
     1141 tgttcctgtt tgtcttatcc tggccctggc cagacgtttt ctttgatttt taattttttt
     1201 tttttattaa aagataccag tatgagatga aaacttccaa taatttgtcc tataatgtgc
     1261 tgtacagttc agtagagtgg tcactttcac tgcagtatac atttatctac acattatata
     1321 tcggacatat aatatgtaaa taaatgactt ctagaaagag aaatttgttt aatttttcaa
     1381 ggtttttttc tcttttaatt tgggcatttc tagaattgag agcctcacaa ttaacatacc
     1441 tttttgtttt cgatgctagt ggctgggcag gttgccctgt cctttctcta tttcccagtc
     1501 attgactgta gatatgggaa gagtttagct accttcatag tgctcccagg actcatggcc
     1561 tttccttctt taagctgtat ttccctgccc agaaagaaac aggaagaaac ctttttttat
     1621 ttttttattt ttttttaacc aagcaaggag caaatggcct cagcccagat ctgtaaaaac
     1681 aatgatagaa attgaattct gccccacatg ttgacagtag agttggaact ggattcttgg
     1741 gattacttat ctaaaaaact ggagcatcag gtccatttct gttctgctgg tttggaatct
     1801 tttccgtaat gctatttatt gccaacaatg gcctctcttt gtgtccatat atgccttaca
     1861 ccgtgctgac ctgggtatca tccatgtgct ctgaagcatc caactttact ttgcaggtgc
     1921 atcaatgtag tcctgtccct gaactgagta accgtgttcc tgaaaagtac actagggaaa
     1981 ttcacctgct tgcttgtctt tgtattggca tggcacttgt gattgcacca tggagcatgc
     2041 tcagagctat taaattggtc tcccatctcc caccaggata tgaaaggtcc atatgggagg
     2101 ccacgtaatc acttattaca gtggttacat aatacactgg ctcactgcag actctcttgt
     2161 tttttgatac agtttcgtgc tggcttcatt tgccaattgt gttgtttagt tcggaagtaa
     2221 gagggtcttg agattgaggg gtagggaggg ctacactgac tgatccgtgg cttaagacag
     2281 gagattatct ctgtactcca gtggcatctc cttagccaag atgtgaaatt aaaatcatag
     2341 ttcgcctcat ttaaaaattc taataaagca ctcaaacttt gaaaagcttt tacttttccc
     2401 tcctactaaa agaaatgtat gtacctcata gccctgtgtc atttagtgtt cagcactttt
     2461 gggaacatca gttggtgaac tttaaatttt gctgtctact cactgggcac ggtggctcac
     2521 acctgtaatc ccagcacttt gggaggctga ggcaggtgga tcacctgagg tcaggagttt
     2581 gagaccagcc tgaccaacat ggtgaaaccc cgtctctact aaaaatgcag aaattaggtg
     2641 ggcgcctgta atcccagcta cttgggaggc tgaggcgaga taatcgcttg aacctgggag
     2701 gcagaggttg cagtgagccg agattgcacc actgtcgtcc agcctgggtg ataagagtga
     2761 aactccatct caaaaaaaaa aaaaaaaaat tttttttttt ttttttgcta tatactctta
     2821 gtttacatcc tctcccccaa tcttcacaca cagagccaaa gagcagttat attcttggga
     2881 taccatgata cctctgggaa aggaattata ttcccaagga gaggtcccat tggataagaa
     2941 caataccatg ggacttgagt ctgaatgcca acttactatt cacacatcct tcttaaaaac
     3001 gaacacactg tttcttttcc tgacctagag cattctaaag ttctgttcaa ataaataaag
     3061 ggcaaaataa agtagattta accaagtgcc aggtggaatt caaaaaacac attcttccag
     3121 ataaattcta cctttatggt atggatttga aagtactttg caggaaaaca gtcagtactc
     3181 tttaaaaagg gactgcaggg ctgggtgtag tggctcacac ctgtaatccc agcactttgg
     3241 gaggccaagg caggtgggtc acttgaggcc aggagtttga gaccagcctg accaacatgg
     3301 caaaacccca tctctactaa aatacaaaaa ttagctgggc atgatggtgc actcctgtaa
     3361 tcccagctac ttggtaggct gaagcatgag aattgcttaa acctgggagg cagaggttgc
     3421 agtaagccaa gatcatgcca ctgcactcca gcctgggcaa cagagtaaga ctctgtctta
     3481 ataaataaat aagaaaataa aacggaactg cagtgctaac agtaatttat acatttttaa
     3541 atgttctgag tatgttttga ctgggctagt gtaacaatat actaccctga aagtgcagtt
     3601 ttgattgttg ttggtgtctt tgggtcagga aagtgaactg tgccaagaag tatttttcag
     3661 tgacatgaat ggattcctgt taatgcaatt gactgagaga ttgtgcttac gctttcttaa
     3721 ctgacaaaaa gaggctttgt ccaacatcag aattgttgaa actggtgctg ttttctgttg
     3781 cactgggatt ctgatgatct gggattttcc ctccttggca cagtaaacac catgactgtc
     3841 tttattgaga atgtcgtcac agtcctttag tgatagatta gttagaccca tggttgcaat
     3901 acctttatct ccccaaagaa aataatcaaa agaaagcaca aaagctaccc tgtttgcaga
     3961 atatttcact gacattgatt tgtcattaat tctaccagag ctgacctcat tcaggcttga
     4021 tagaaacagg ttcctatgtt tagggcagat ccctagcctc tcgctcacag tgagtctgca
     4081 tgtcctagat tctggttatt gctggagcat ccattaaagt ctaccaaact caggacagaa
     4141 gaagatagca gtggatttgt aaaaattttt agtttataaa ttacagtcat tggggaaaca
     4201 ctagtaaggt catgtgatct tttggaccag gattttctct ctgtcttctc tctgggtgtg
     4261 tgtgtgtgta tgtacagaag ggctaccagg aagtgtcaac catgttagat tttctgtagt
     4321 cttccagaaa cagtgcagcc catacaacag gaatcttaat tttcctcaca gcaaatataa
     4381 caggatggaa cagttagtgt tttgttttca caagtgtcca ccactccatc tgccctgcat
     4441 ggagagggct ctctcactgc tagatctagg ctgagccatc tggaaggatc aaagggtgtg
     4501 ggagtatcac cccctctcag gctgcagaag gtctcgaggg tggcgtcaca gcaggatttc
     4561 cgccttctgc attgcactgc acagccccat ggaacatgag gcacttgagg ccttgcttct
     4621 tggagcctct ggggagcaga gtaggtcact gccctctggg agtgttttgc agtagttttg
     4681 taaatgtgtt gctacatagt caagttcctt tgtggcaaag aaatattttg ttttgatatt
     4741 aggagccagc ccatgtaatg cctctcaggc ttgcttgctt agaagaaaaa agtcaccctt
     4801 tgtggttttt aagaaaaaaa ttctgtgcag atctgttcct cctcctgctc cttccctttt
     4861 ctctacatac agtgctcatt ggaggctcct gctaaacctt cttaaccaga gaaataatag
     4921 gtatttgtta gacctgagtg tacatttcac atgttatcct tcacatattt ctcattttca
     4981 tctagtactt tcttaatgcc tttgttggag tccgcatcct catctttaaa aaaaaaaaaa
     5041 aaaaaacagc ttagcctaag ccacattcac tttttttagt tcacaaaaag gatttaatag
     5101 ccacaatgtg atttttgcca caactgtgtg attttaatat tctctaatat caagggcgga
     5161 tttagaattg caggaaatac ctggagaaat cacagtggaa tgaatttttg ctttaagaga
     5221 aatgagagtt ggctgtctct gtaattgata atacagcttc atcctagtcc catctgcatt
     5281 tcagaaaata accctcatct ttacaaaaca caggacactt gtgggacagt taactcaagc
     5341 agctatgggg agggaggaga ttattgaatg gtgattaaat aatgcaaatg gctcttctgt
     5401 ttcttaaaga ctgtggaaga ggtcagactg cccagttgag gtgggcagtt catactgctc
     5461 agttgaggtg gcagtcattt attctgagtc ctgttggata gagcctatct cctcaaggct
     5521 acagaggctt ccaggatatg gagctgtgca tgttaatggc tcagccttgc ctccatcagg
     5581 gcacctgcct aacttggagc aagtgggaga gcaccctaga gtcatcctct gtgctgtttc
     5641 gtgagttttg cagcggagac ttcaccatcc ggaggagctg tgtttctgtg tcacttggga
     5701 tatcacctaa aaatgaaaca tttgatattt taaggtataa aaaaaaagta aattggggaa
     5761 cattggctgc agtccctaaa agatactgtt gtctgtgcat caggttagct tgaggtcacc
     5821 acaggtcctg ggagcccaga gagtttaggc atactctcct ttggaggcca gcagcctttc
     5881 acaaaccctg cctctaaaag ggcggtttca catttgacca tgtttttgca ttagcctcag
     5941 aaactcttgt ctttagctga taacctttga gggatgtgag aagcctagtt ggagcatctg
     6001 agaaaatgat acctctcacc ttcaaattaa tcaaatagtt tgtccttcta gtccccttat
     6061 aaattaataa atggagggct ggtcatggtg gctcacgcct gtaatcccag cactttggga
     6121 ggccgaggcg ggtggatcac aaggtcagga gttcaagacc agcctgacca atatggtgaa
     6181 accccatctc tactaaaaat acaaaaatta gccaggtgta gtggcacgct cctgtagtcc
     6241 cagctactcg ggaggctgag gcaggagaat cgcttgaacc caggaggtgg atgttgcagt
     6301 gagccgagat cccgccactg cactgcagcc taggcgacag agcaagactc cgtctcaaaa
     6361 aaaaaaaaaa aaaaaagaaa agggaaggga atcccatttt gtgatgattt gggcacacta
     6421 cttgagctga ggctagcagt cacatgattt tggctgtctc tgacctgaag cttttgaagt
     6481 aaggttatgt ctcttccctg aagctttgtt tatagtggta atttggtgag tttgagcttt
     6541 gagcttgtct tagaaaataa gactgtccac ctggggaggg gagcttatag ggaacccgtg
     6601 ttaactcaga atgctgaaga aagtgctttt agccaacaaa agtaagatta ctatctagaa
     6661 ggtggaaaga agtcattgct tctgttcctc cagcagtcag ttgactctag gtttcctttg
     6721 gtttatatcc ccagttctta atactaaaac ttatttgact tcctatcagg aagcacacaa
     6781 aaaaagcgtc atttaaaacc ctggatatag gctttaaagg atacaaaaac agcagcattg
     6841 tcgttttgcc aggttcatca ccattttgat gtgctaccca tccttccacc ctccctttcc
     6901 tgcccccaag cctcccagcc aggccagatg tgaagattct attaatcact gtttcagaga
     6961 acattaattc ttgtatagaa taattatcta ctaaattgct tattatctgt gactaccttg
     7021 cagagaacat ctcaacagtg cagtaaaata gctctcctag acttgagctt ccagccaggc
     7081 atttagatca ctcttaagcc tttgtggaat tctgaggaaa aaaagcaaga tgcctcaatg
     7141 ccaatgctgg gccataagat tctactcccc tccctgtagg gtggggcgcg tggctcagct
     7201 ttggaaaatc attttgccag taatattgcc tgtgaatccc tttaagaagt cgtcctgatc
     7261 tgagcctgtc tttctgagca ctttggtgct gaattgaaaa tggtaagcta aagcagtgac
     7321 agatccacgt agcctcttta acctctttat tatcttgcca aaaaaaaagt ttctcaggtt
     7381 aaacctttgt ctttaacctc cctttgttgt ggagaaaatg tgtcactaat cagtggtcca
     7441 agggatatct agctttggtt actcagttcc tgcagcataa cagatatgac ttatgccagg
     7501 gaaggtagag gctgattatg gagacaccca ggaacaggaa taagaaggga taggtctgct
     7561 ccacgtagaa cctccccaga tcggaagtta agtcttggag agtttccaaa gtgctgaagt
     7621 aaaaaggaga cttggagggc ctttgcttaa tgagcaagag gcttgtgtcc tcccaagaac
     7681 atgagggagt tcagaaggga gctatagctc acagacagaa acctgcccgc tcaccccatc
     7741 cctcgtgact gggagcatgt ttgctcagaa ttttctaaga ggactctccc ttcaaaaatc
     7801 caatttgctc ccagaatgtt gtttagcctc tgagaatctc actctttcat ttccatctgt
     7861 gaatggacat agatgtgttg ctcagggatc agaaacatca gagtccaggg cccagtggca
     7921 tggtgttgca ttagtagtta gaaaagtaat tggtcagctc tactgtaaaa gaaataagta
     7981 tgtagtacag ttttgtaaat gtcaggtctg ttctattgtt ttgtgatctg aagactgtca
     8041 aactggttga taatcaaaga aaaggttggt ggttagaata agtaaaattt cagttagaaa
     8101 gatatagctt accagttttc catgtgctta aggaagtcaa gaatatttca ggttgttgag
     8161 aactgttgta aaatggaatt gaagctagtg tctctcacct tcttaggtgt atcagagaga
     8221 ggaagtggaa ggccagtagt agcatcttca tacttacttt tgccagccca gcctccattt
     8281 caaagacttt gtcttccatc ctatccaatg acatggtcag ggatgggctc tgaggaggca
     8341 gtgaggcccc accttggttt gctccactgt ggtgtgtagt ctccaaacag cttaagggtt
     8401 tttaagtttt ctcacgatta cctccactcc actcatctac tatcagcatc agaaaggtta
     8461 acatccctgg gaccattcta cttataaaag agatgaacta gtgtgctttc tccccttttc
     8521 caggtgtgcc atccatatac aatctcctct tggccaagtt caacaaatgt ttccagggaa
     8581 ccccgtgggt tgaggcaaag tagccaagat gtattgagtt aagtttttct agaggacaaa
     8641 agtatttctt gtcccttttc cctcatgctc atatgtttta gctgaggcgt aaatggccaa
     8701 gttgagtaat atctgtggaa ctgagacaga gagccaggga cccatgtacc cagggaccag
     8761 tcccctgggg aatcacacag tggctcagac tagactgctc tatcccacca gaactctgct
     8821 gctgttcatt tccatcagga ccacccagga aagcaaataa gttagccttc tcatcattag
     8881 gtcacctaat ctcttgggtt gcaggatgag agcatatata gatctcctgt ttagagagtg
     8941 tgttcataat tgtagaaagg gatagaaaat ggaataacca agaggctgtg tcatttttta
     9001 agaggatggc aaggatgacc tcaaatgagc tcaacaaaac tgggaatcca aggaatggtg
     9061 cttgtaggga aagagaggtc agttgtggtc cttaaacctc ttggcacctt gtgcgggtta
     9121 taaaacaagg agctggagta aaattgccct tacccccaat ccaaatgctg tccaggattt
     9181 aggagctacc caacctgtgg ttatatggtg ttggtttcca ttttttgttt gtttgcttgt
     9241 ttccaaaata gccttgcttg gtactgcatg gaaagttcaa gcttttcttc ttgcccgctc
     9301 agggctggcc tcttccccgt gtcttcacag cgtccctaag gaagattttt gcagcactct
     9361 ctggagctga ggggagtgaa atttggtcca gagaaggcgg aaggaaatag ttttcctgtt
     9421 tccttttctc gaggtggatg tcctcaggct tccttcacac ctccttctca tgggtgcggc
     9481 tggcagtaca gtcaggctgt ggaggagggc tgagaagaaa ggggcactgg tccagcccca
     9541 ggtttggtct gagacaggta cacagcagat accatcccac cttcctctct aaagaacagg
     9601 ccagccacac atataaccct ttccctactt tactaatgta tcccttatgt ggtaccagca
     9661 atggaggaca ggcagactta ccccctgcca tctagagaga atgttgttat tacccgtaaa
     9721 acttgaccac ccccatatcc cactcctttt tgtaaaaaca aatgcttaaa cctgtgagcc
     9781 tgccgttcct ttctatgtgt taatcagttt ccttccattt gagctgtgtg ggagggaagg
     9841 gcattgaaat tgtaggttgt aatcttgtgc caaccaataa aaaccagtat ttcacacaca
//
