LOCUS       NM_032344               1110 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens nudix hydrolase 22 (NUDT22), transcript variant 1,
            mRNA.
ACCESSION   NM_032344
VERSION     NM_032344.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1110)
  AUTHORS   Walter,M., Mayr,F., Hanna,B.M.F., Cookson,V., Mortusewicz,O.,
            Helleday,T. and Herr,P.
  TITLE     NUDT22 promotes cancer growth through pyrimidine salvage
  JOURNAL   Oncogene 42 (16), 1282-1293 (2023)
   PUBMED   36871087
  REMARK    GeneRIF: NUDT22 promotes cancer growth through pyrimidine salvage.
REFERENCE   2  (bases 1 to 1110)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1110)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1110)
  AUTHORS   Carter,M., Jemth,A.S., Carreras-Puigvert,J., Herr,P., Martinez
            Carranza,M., Vallin,K.S.A., Throup,A., Helleday,T. and Stenmark,P.
  TITLE     Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a
            Unique Structural Fold
  JOURNAL   Structure 26 (2), 295-303 (2018)
   PUBMED   29413322
REFERENCE   5  (bases 1 to 1110)
  AUTHORS   Mick,E., McGough,J., Loo,S., Doyle,A.E., Wozniak,J., Wilens,T.E.,
            Smalley,S., McCracken,J., Biederman,J. and Faraone,S.V.
  TITLE     Genome-wide association study of the child behavior checklist
            dysregulation profile
  JOURNAL   J Am Acad Child Adolesc Psychiatry 50 (8), 807-17 (2011)
   PUBMED   21784300
REFERENCE   6  (bases 1 to 1110)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 1110)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1110)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006334.1 and AP001453.6.
            
            On May 17, 2019 this sequence version replaced NM_032344.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006129.1, SRR7346977.593779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000279206.8/
                                                ENSP00000279206.3
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AP006334.1         25000-25153
            155-652             AP006334.1         25361-25858
            653-751             AP006334.1         26294-26392
            752-849             AP001453.6         1429-1526
            850-943             AP001453.6         1660-1753
            944-1110            AP001453.6         2032-2198
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1110
                     /gene="NUDT22"
                     /note="nudix hydrolase 22"
                     /db_xref="GeneID:84304"
                     /db_xref="HGNC:HGNC:28189"
     exon            1..154
                     /gene="NUDT22"
                     /inference="alignment:Splign:2.1.0"
     exon            155..652
                     /gene="NUDT22"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1084
                     /gene="NUDT22"
                     /EC_number="3.6.1.45"
                     /note="isoform a is encoded by transcript variant 1;
                     nucleoside diphosphate-linked moiety X motif 22; nudix
                     motif 22; nudix (nucleoside diphosphate linked moiety
                     X)-type motif 22; UGPPase; UDPG pyrophosphatase; uridine
                     diphosphate glucose pyrophosphatase NUDT22"
                     /codon_start=1
                     /product="uridine diphosphate glucose pyrophosphatase
                     NUDT22 isoform a"
                     /protein_id="NP_115720.2"
                     /db_xref="CCDS:CCDS8061.1"
                     /db_xref="GeneID:84304"
                     /db_xref="HGNC:HGNC:28189"
                     /translation="MDPEVTLLLQCPGGGLPQEQIQAELSPAHDRRPLPGGDEAITAI
                     WETRLKAQPWLFDAPKFRLHSATLAPIGSRGPQLLLRLGLTSYRDFLGTNWSSSAAWL
                     RQQGATDWGDTQAYLADPLGVGAALATADDFLVFLRRSRQVAEAPGLVDVPGGHPEPQ
                     ALCPGGSPQHQDLAGQLVVHELFSSVLQEICDEVNLPLLTLSQPLLLGIARNETSAGR
                     ASAEFYVQCSLTSEQVRKHYLSGGPEAHESTGIFFVETQNVQRLLETEMWAELCPSAK
                     GAIILYNRVQGSPTGAALGSPALLPPL"
     exon            653..751
                     /gene="NUDT22"
                     /inference="alignment:Splign:2.1.0"
     exon            752..849
                     /gene="NUDT22"
                     /inference="alignment:Splign:2.1.0"
     exon            850..943
                     /gene="NUDT22"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1110
                     /gene="NUDT22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1089..1094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT22"
                     /note="hexamer: AATAAA"
     polyA_site      1110
                     /gene="NUDT22"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctgag ggacccggcg gctggtgagc gcccgctgga ggctggagct tccgggccct
       61 ggaaaggggt ccccgcgcgc cccgggtcgg aggcagaccc ctgggtttgg gggacatggg
      121 catttggggc gcctgaaccc aagacctctg gatgagctgc cccgttcaga ccatggatcc
      181 tgaggtgacc ttgctgctgc agtgccctgg cgggggcctg ccccaggagc agatacaggc
      241 cgagctgagc cccgcccatg accgtcgccc actgccaggt ggggacgagg ccatcactgc
      301 catctgggag acccggctaa aggcccaacc ctggctcttc gacgccccca agttccgcct
      361 gcactcagcc accctggcgc ctattggctc tcgggggcca cagctgctcc tgcgcctggg
      421 ccttacttcc taccgagact tcctgggcac caactggtcc agctcagctg cctggctgcg
      481 acagcagggt gccaccgact ggggtgacac gcaggcctat ctggcggacc cactgggggt
      541 gggcgctgca ctagccacag ccgatgactt ccttgtcttc ctgcgccgct cccggcaggt
      601 ggctgaggcc cctgggctgg tggacgtacc tggtgggcac cctgagcctc aggccctgtg
      661 ccctggtggc agcccccagc accaggacct cgctgggcag ctggtggtac atgaactctt
      721 ttccagtgtc cttcaggaga tctgtgatga ggtgaacctg ccgctgctca ccctgagcca
      781 gcccctgctg ttgggcatcg cccgaaatga gaccagtgct ggccgagcca gtgccgagtt
      841 ctatgtccag tgcagcctga cttctgagca ggtgaggaag cactacctga gtgggggacc
      901 cgaggcccac gagtctacag gaatcttctt tgtggagaca cagaacgtgc agagattgct
      961 cgagacggag atgtgggctg aactctgccc ctcggccaaa ggcgccatca tcctctacaa
     1021 ccgggttcag ggaagtccca ctggagcggc cctagggtcc ccagccctac tcccgccgct
     1081 ctgaaaataa taaacgactt tattcttgga
//
