LOCUS       NM_007006               4393 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens nudix hydrolase 21 (NUDT21), mRNA.
ACCESSION   NM_007006
VERSION     NM_007006.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4393)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4393)
  AUTHORS   Liu,W., Pang,Y., Yu,X., Lu,D., Yang,Y., Meng,F., Xu,C., Yuan,L. and
            Nan,Y.
  TITLE     Pan-cancer analysis of NUDT21 and its effect on the proliferation
            of human head and neck squamous cell carcinoma
  JOURNAL   Aging (Albany NY) 16 (4), 3363-3385 (2024)
   PUBMED   38349866
  REMARK    GeneRIF: Pan-cancer analysis of NUDT21 and its effect on the
            proliferation of human head and neck squamous cell carcinoma.
REFERENCE   3  (bases 1 to 4393)
  AUTHORS   Liu,M., Chen,X., Gu,Z., He,H., Chen,M., Kuai,L., Jia,Z., Li,Y.,
            Chen,Y., Hong,M. and Xiao,F.
  TITLE     Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes
            for Coronary Atherosclerosis
  JOURNAL   Int J Med Sci 21 (3), 562-570 (2024)
   PUBMED   38322593
  REMARK    GeneRIF: Predictive Value of CFIm25 Expression in Peripheral Blood
            Monocytes for Coronary Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4393)
  AUTHORS   Huang,X.D., Chen,Y.W., Tian,L., Du,L., Cheng,X.C., Lu,Y.X.,
            Lin,D.D. and Xiao,F.J.
  TITLE     NUDT21 interacts with NDUFS2 to activate the PI3K/AKT pathway and
            promotes pancreatic cancer pathogenesis
  JOURNAL   J Cancer Res Clin Oncol 150 (1), 8 (2024)
   PUBMED   38195952
  REMARK    GeneRIF: NUDT21 interacts with NDUFS2 to activate the PI3K/AKT
            pathway and promotes pancreatic cancer pathogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4393)
  AUTHORS   Zhang,N., Liu,X., Huang,L., Zeng,J., Ma,C., Han,L., Li,W., Yu,J.
            and Yang,M.
  TITLE     LINC00921 reduces lung cancer radiosensitivity by destabilizing
            NUDT21 and driving aberrant MED23 alternative polyadenylation
  JOURNAL   Cell Rep 42 (12), 113479 (2023)
   PUBMED   37999979
  REMARK    GeneRIF: LINC00921 reduces lung cancer radiosensitivity by
            destabilizing NUDT21 and driving aberrant MED23 alternative
            polyadenylation.
REFERENCE   6  (bases 1 to 4393)
  AUTHORS   Kim,H. and Lee,Y.
  TITLE     Interaction of poly(A) polymerase with the 25-kDa subunit of
            cleavage factor I
  JOURNAL   Biochem Biophys Res Commun 289 (2), 513-518 (2001)
   PUBMED   11716503
REFERENCE   7  (bases 1 to 4393)
  AUTHORS   de Vries,H., Ruegsegger,U., Hubner,W., Friedlein,A., Langen,H. and
            Keller,W.
  TITLE     Human pre-mRNA cleavage factor II(m) contains homologs of yeast
            proteins and bridges two other cleavage factors
  JOURNAL   EMBO J 19 (21), 5895-5904 (2000)
   PUBMED   11060040
REFERENCE   8  (bases 1 to 4393)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 4393)
  AUTHORS   Ruegsegger,U., Blank,D. and Keller,W.
  TITLE     Human pre-mRNA cleavage factor Im is related to spliceosomal SR
            proteins and can be reconstituted in vitro from recombinant
            subunits
  JOURNAL   Mol Cell 1 (2), 243-253 (1998)
   PUBMED   9659921
REFERENCE   10 (bases 1 to 4393)
  AUTHORS   Ruegsegger,U., Beyer,K. and Keller,W.
  TITLE     Purification and characterization of human cleavage factor Im
            involved in the 3' end processing of messenger RNA precursors
  JOURNAL   J Biol Chem 271 (11), 6107-6113 (1996)
   PUBMED   8626397
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL535307.3, BC001403.2 and
            AC092140.4.
            
            On Nov 22, 2018 this sequence version replaced NM_007006.2.
            
            Summary: The protein encoded by this gene is one subunit of a
            cleavage factor required for 3' RNA cleavage and polyadenylation
            processing. The interaction of the protein with the RNA is one of
            the earliest steps in the assembly of the 3' end processing complex
            and facilitates the recruitment of other processing factors. This
            gene encodes the 25kD subunit of the protein complex, which is
            composed of four polypeptides. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537360.1, SRR1660803.7601.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300291.10/ ENSP00000300291.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL535307.3         18-39
            23-894              BC001403.2         1-872
            895-4390            AC092140.4         122667-126162       c
            4391-4393           AC092140.4         122664-122666       c
FEATURES             Location/Qualifiers
     source          1..4393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..4393
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /note="nudix hydrolase 21"
                     /db_xref="GeneID:11051"
                     /db_xref="HGNC:HGNC:13870"
                     /db_xref="MIM:604978"
     exon            1..246
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..814
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /note="pre-mRNA cleavage factor Im (25kD); cleavage and
                     polyadenylation specific factor 5, 25 kD subunit; cleavage
                     factor Im complex 25 kDa subunit; cleavage and
                     polyadenylation specific factor 5, 25 kDa; pre-mRNA
                     cleavage factor Im, 25kD subunit; nudix motif 21; CPSF 25
                     kDa subunit; pre-mRNA cleavage factor Im 25 kDa subunit;
                     nucleoside diphosphate-linked moiety X motif 21; cleavage
                     and polyadenylation specificity factor 25 kDa subunit;
                     nudix (nucleoside diphosphate linked moiety X)-type motif
                     21; pre-mRNA cleavage factor Im 68 kDa subunit"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 5"
                     /protein_id="NP_008937.1"
                     /db_xref="CCDS:CCDS10760.1"
                     /db_xref="GeneID:11051"
                     /db_xref="HGNC:HGNC:13870"
                     /db_xref="MIM:604978"
                     /translation="MSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTN
                     YTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTT
                     FFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPY
                     IPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQL
                     LSRFNFIYN"
     exon            247..447
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            448..511
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            512..601
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            602..677
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            678..792
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            793..4393
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      881..886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /note="hexamer: AATAAA"
     polyA_site      901
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /note="major polyA site"
     regulatory      1085..1090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /note="hexamer: ATTAAA"
     polyA_site      1105
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /note="hexamer: AATAAA"
     polyA_site      1850
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
     regulatory      4371..4376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
                     /note="hexamer: AATAAA"
     polyA_site      4379
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
     polyA_site      4393
                     /gene="NUDT21"
                     /gene_synonym="CFIM25; CPSF5"
ORIGIN      
        1 ctcctcttgc gctgtcctgt taatggcggg cagtagccgc tgaggggatt gcagataacc
       61 gcttcccgca cggggaaagt ctaccctgcc tgccactttc tgctcgccgt cagcgccgga
      121 gctcgccagc atgtctgtgg taccgcccaa tcgctcgcag accggctggc cccggggggt
      181 cactcagttc ggcaacaagt acatccagca gacgaagccc ctcaccctgg agcgcaccat
      241 caacctgtac cctcttacca attatacttt tggtacaaaa gagcccctct acgagaagga
      301 cagctctgtt gcagccagat ttcagcgcat gagggaagaa tttgataaaa ttggaatgag
      361 gaggactgta gaaggggttc tgattgtaca tgagcaccgg ctaccccatg tgttactgct
      421 gcagctggga acaactttct tcaaactacc tggtggtgaa cttaacccag gagaagatga
      481 agttgaagga ctaaaacgct taatgacaga gatactgggt cgtcaggatg gagttttgca
      541 agactgggtc attgacgatt gcattggtaa ctggtggaga ccaaattttg aacctcctca
      601 gtatccatat attcctgcac atattacaaa gcctaaggaa cataagaagt tgtttctggt
      661 tcagcttcaa gaaaaagcct tgtttgcagt ccctaaaaat tacaagctgg tagctgcacc
      721 attgtttgaa ttgtatgaca atgcaccagg atatggaccc atcatttcta gtctccctca
      781 gctgttgagc aggttcaatt ttatttacaa ctgaattcct gcgcagtgga gaagtaaaag
      841 aagccgcttg tctctgtgag cacagctata tacagtgtag aataaatgtg gtagaaaagt
      901 ttttttggtt ttatctcttt tgcgatccct aaattgccac ctttctattg tttgaatagt
      961 aaaattaata tgaagaacta gatagtggtg taaacaaatg tgataatgtt tatttacttt
     1021 cggttctgct catacttttt tgtacaacat taaagaaaat ggactttttt tattttaatt
     1081 tctcattaaa cttctaaaat tcttataggt gaggatcatt tttcccccca ccttaggatg
     1141 gtgaatgttg caacacaatg acaggtttaa gtcagtcaag tttattggac ccttgctttg
     1201 ataccattct tgggcacata ctccaagatt gtattagatt tttgtgatga agagcttcca
     1261 ttacttctga aaactatatt tatctgagtg agtccaaggt gcaactccta aatgaattgt
     1321 gttgcagaga actcccagta taattcactg accagtacat tttataacca tccaggcctt
     1381 ggtttgcaag caacagacct taaacataca ggaaactatt aaaattggct cgatcagtag
     1441 tcataggaat tggtataaga agagactcat ttagagctca gagttttctt cacataatgg
     1501 gggtattaat tatttgtgct gttgcgaaat tatgtgtctt attcttaaag ccatggtaaa
     1561 aatagggatc tgtgaaggaa atttctaaaa ttggatgtat taggttttga actctgagat
     1621 tgcacaaata ttcaattaac ttgaagttgt gtacatagag aagaaaattt ggttttagca
     1681 aatgacagag ccttcaaaaa tatttttgga ataatgtgaa tcaaccgaaa actgggggca
     1741 aggcagagga caggttttct caggttaaga gaaaaacgaa attttaaaaa ctttaaaaaa
     1801 tactgataaa ttcggatcaa atttggggga ataaaaaata ttagagcaaa ggagtttgct
     1861 ggttgtgtca ttatttaatg atcaaagtat agcatgtatg ccttattaca gacttgttga
     1921 ctataggctt aatgtaaaaa ggaatcttgc cagatgtagc tacttaagga aaaaagggtt
     1981 tttaatagaa atgaactttt gattagtatg gtgccagtca cagggctatt ttcctgaata
     2041 ttgggtgatg tcaaaggtat atgatacttg aggaaatcag gccaagtgta gctgagcaat
     2101 taataaacac tcaagttttt ttagttgggg tcatgtcaaa ccctcacatg gtggttaagt
     2161 agtgactaac tgtgcatgtc cttcatggta ggtgagcacc agtctccatg atcaaaaatg
     2221 ccccagtttc ctttgaaaaa gccactagtt ctgtgaattg tccttttccc tcctgcccct
     2281 aacagtccta cccctctagc ctacattagc atatttctca tgtaatgtat tttgctggta
     2341 agctcatcca ttagctgcgt ccttcagcta ttcctttaga ttggaggaag tggatatgaa
     2401 gatggattga ttcagctcac cttccatgat tgcttttgag ggaaaagcta cagtggccac
     2461 atttcagatg ttcacttttg caatttgtgg agggtggaga gaggtagact tttgttgtgt
     2521 gttttataaa gtactctcag taaggagtgt ttgagttgaa gagtcatctg attcgaggcc
     2581 actcatgttc tttgtaactt aaactttgac caagaaattc ttcacttctc acttcttcac
     2641 ttcttcccaa tatacagtaa gtacgtgagc cagtcatcca tacactaagg cctagttgag
     2701 aaaaaccttt gattcaggat ggctgggtta ctaaccttga aatgtaagag atctggtttt
     2761 gaatgtaaaa gttgcaacac acaaacggaa gtcttaaaaa ctttttgctc tggtcagtta
     2821 caggtggatc cccaataatc tgtttttggt tttctgatgg aaataataga attaggggaa
     2881 atcaaatctg gttggtaggt gtctacagta ttagaagagg gtataagggc actgtttaac
     2941 actaagttct aatacttcca gaaactgtgc attccagatc tacatactaa atgctcttat
     3001 cattttgaaa tgggctcttg attaatagac ccatattttt tagtggcttc tatgttgtat
     3061 atttgtctaa aatgaaagct cttttgcgtt ctaaaactac aatatatgtc atcttatttt
     3121 ccctgagtat ccaagtatag tgcagattct atgtaaaact actaaatgac actggaatat
     3181 gtttagtaga ttagggggaa aaactataaa ggtttataca attgtttgta gttacattta
     3241 ggatggactt atccctttgg agaagagtga agtttgtttt ttcgccatgt gatgaagacc
     3301 actgtgattt tttaaaaaag tagataatac ttaaaatggc gtaataattc tgcacttgaa
     3361 tttgtactgt taacagcaca tttggaagat tttaaaactt tttattgtct tataaatagc
     3421 attcacttat tattttggat atttaagggt tccattaagt taacactgta tttggacaaa
     3481 gtgtgaccaa attagccagt ctgttttctt ccatgtttaa ttagaagtga gaggtagaag
     3541 tacttcaaat tcaacaggcc agcaagcaat cggcttaaaa ttccctttct taaatgttgt
     3601 gctcttatgt tctcggcttt ttaatgactt tatttttaca gtacttgttc agtcacttga
     3661 gatgaaatgc ttggggtagc ttttccatcc tcaaacttaa tgtttttact agttcatagt
     3721 gtttggaaca gtatatgcca atcactgaga ctgcatcaga gtttgcaatt ttgtatgttt
     3781 cattgccaaa gaaggcttag tggttgttga ctgtagtata agtcagcttt ctgtagcata
     3841 agatttgatt ttcccatact tacttcactt gttatacatc actgattatt tgggttaaac
     3901 tggactcatt tcaagcagtt tgcttttgtt caaatcgtga tgagaaacct aatactgtaa
     3961 tttgatttga gccataaaac acattttaat attagcttgt attatagtta ttaagcttgt
     4021 ttttgtggaa aaaaacttac taaaacctag gtaactctag attaggccag ttcaggtgta
     4081 ttttgtatct tagtaatgga tcatatcgta aaaatagaga taagttggga agatatattg
     4141 attatgctgt tctgttgagg gaaaggtcat gtatttagaa atttaaactt ttggttattg
     4201 tgttcacatc atagtattca agcatcattt atagtttggt tttgagaact tttctggtat
     4261 tacgtttatg gcaaatgtat aaaagaaaca agttttggtt atatttttat atttgtaaag
     4321 taagtttggt taaagtgatc actgttcttt ttttatttta ttgtcatttc aataaaaaat
     4381 atttgaaaga gaa
//
