LOCUS       NM_001105570            3103 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens nudix hydrolase 19 (NUDT19), mRNA.
ACCESSION   NM_001105570 XM_372723 XM_939641
VERSION     NM_001105570.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3103)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3103)
  AUTHORS   Lan,C., Wang,Y., Su,X., Lu,J. and Ma,S.
  TITLE     LncRNA LINC00958 Activates mTORC1/P70S6K Signalling Pathway to
            Promote Epithelial-Mesenchymal Transition Process in the
            Hepatocellular Carcinoma
  JOURNAL   Cancer Invest 39 (6-7), 539-549 (2021)
   PUBMED   33979257
  REMARK    GeneRIF: LncRNA LINC00958 Activates mTORC1/P70S6K Signalling
            Pathway to Promote Epithelial-Mesenchymal Transition Process in the
            Hepatocellular Carcinoma.
REFERENCE   3  (bases 1 to 3103)
  CONSRTM   GENDEP Investigators; MARS Investigators; STAR*D Investigators
  TITLE     Common genetic variation and antidepressant efficacy in major
            depressive disorder: a meta-analysis of three genome-wide
            pharmacogenetic studies
  JOURNAL   Am J Psychiatry 170 (2), 207-217 (2013)
   PUBMED   23377640
REFERENCE   4  (bases 1 to 3103)
  AUTHORS   van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
            Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
            Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
            Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
            Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
            Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
            Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
            Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
            Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
            Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
            Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
            Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
            Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
            Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
            Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
            Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
            Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
            Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
            Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
            Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
            Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
            Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
            Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
            Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
            Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
            Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
            Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
            Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
            Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
            Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
            Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
            Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
            Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
            Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
            Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
            Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
            Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
            Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
            Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
            Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
  TITLE     Seventy-five genetic loci influencing the human red blood cell
  JOURNAL   Nature 492 (7429), 369-375 (2012)
   PUBMED   23222517
REFERENCE   5  (bases 1 to 3103)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3103)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   7  (bases 1 to 3103)
  AUTHORS   Ofman,R., Speijer,D., Leen,R. and Wanders,R.J.
  TITLE     Proteomic analysis of mouse kidney peroxisomes: identification of
            RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase
            activity
  JOURNAL   Biochem J 393 (Pt 2), 537-543 (2006)
   PUBMED   16185196
  REMARK    GeneRIF: Isolation and functional characterization of the NUDT19
            ortholog in mouse.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008736.6.
            
            On Sep 23, 2020 this sequence version replaced NM_001105570.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1220231.1,
                                           SRR14038192.3476430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000397061.4/
                                                  ENSP00000380251.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-854               AC008736.6         112191-113044       c
            855-1062            AC008736.6         95473-95680         c
            1063-3103           AC008736.6         91073-93113         c
FEATURES             Location/Qualifiers
     source          1..3103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..3103
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /note="nudix hydrolase 19"
                     /db_xref="GeneID:390916"
                     /db_xref="HGNC:HGNC:32036"
     exon            1..854
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1268
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /EC_number="3.6.1.77"
                     /note="nucleoside diphosphate-linked moiety X motif 19,
                     mitochondrial; nudix motif 19; CTC-379B2.4; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 19;
                     acyl-coenzyme A diphosphatase NUDT19"
                     /codon_start=1
                     /product="acyl-coenzyme A diphosphatase NUDT19 precursor"
                     /protein_id="NP_001099040.1"
                     /db_xref="CCDS:CCDS42543.1"
                     /db_xref="GeneID:390916"
                     /db_xref="HGNC:HGNC:32036"
                     /translation="MSSSLRPGPSRWRRAASIVLAAGWSRPETATPPSRPPPAEGFRL
                     LLLQRSPHQGFMPGAHVFSGGVLDAADRSADWLGLFAPHHGPPRFGLGPAPFSRTAFP
                     SLPDTDDHKTDNTGTLPEDVAFRICAVREAFEEAGVLLLRPRTSPPGPAPGPGLALEP
                     PPGLASWRDRVRQDPRHFLRLCAHLDCTPDIWALHNWSAWLTPFLRGTTRRFDTAFFL
                     CCLREPPPVYPDLAEVVGYQWSSPSEATESFLSKEIWLPPPQFYEVRRLANFASLSDL
                     HKFCLGRALEGLERWLPIILLTADGMVHLLPGDELYLEDSDFLENLMSTEKKTEEIMK
                     EGKQFHRIVTYHRHLYDIHVTVQPKYKHVYPKNSVVRKSHL"
     exon            855..1062
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..3103
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3063..3068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /note="hexamer: CATAAA"
     regulatory      3079..3084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /note="hexamer: AATAAA"
     polyA_site      3084
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /note="major polyA site"
     polyA_site      3103
                     /gene="NUDT19"
                     /gene_synonym="RP2"
                     /note="major polyA site"
ORIGIN      
        1 aaacgcccag gttcacccaa cgccagaggc tcgtcctcaa ttcccgcgag gcccccggag
       61 gtgctggggt ccctgcaggg ccgggccacc tgccgtggag ctcaggccgc gccagaatcg
      121 gatccgggaa gctgcgcgcc atgagcagct ccctgcggcc gggccccagc cgctggcggc
      181 gggcggccag catcgtcctg gcggctggct ggtcgcgccc ggagaccgcc accccgccgt
      241 cgcgcccgcc gccggccgag ggcttccggc tgctgctgct gcagcgctcc ccgcaccaag
      301 gcttcatgcc gggcgcgcac gtcttctccg gcggagtgct ggatgcggcc gaccgctcgg
      361 cggactggct gggcctcttc gcgccgcacc acgggccgcc gcgcttcggc ctgggcccgg
      421 cgccattcag ccgcaccgct ttcccgtcgc tgcccgacac cgatgaccac aagaccgaca
      481 acactgggac gctgcctgag gacgtagcct tccgcatctg cgccgtgcgg gaggcctttg
      541 aggaggcggg cgtgctgctg ctgcggccca ggacttcccc accaggccca gcacccgggc
      601 ctggcctcgc cctggagcca ccgccgggcc tggcctcctg gcgcgaccgc gtgcgccagg
      661 acccgcgcca cttcctgcgg ctgtgcgccc acctcgactg cacacccgac atctgggcgc
      721 tgcacaactg gagcgcctgg ctcacccctt tcttgcgggg caccactcgc cgctttgaca
      781 cggccttctt cctgtgctgc ctgcgcgagc cgccgcccgt ctaccccgac ttggcggagg
      841 tggtgggcta ccagtggtca tctccatcag aggcaactga aagtttctta tcaaaagaaa
      901 tttggttgcc acccccacag ttctacgaag tgagaagact tgcaaacttt gcctctctct
      961 ctgacttgca caaattttgt ttgggtcgtg cattagaagg actggaaagg tggctgccga
     1021 tcatcttgtt aactgctgat gggatggtcc atcttttacc aggtgatgag ctatatttag
     1081 aagattcaga ctttttggaa aatcttatgt ctactgaaaa aaagactgag gaaatcatga
     1141 aggaaggcaa gcagtttcac cggatagtga cataccatcg ccacctttat gatatccacg
     1201 tgactgttca gccaaagtat aaacacgttt atcctaagaa ctctgtagta agaaaaagcc
     1261 atttgtaggg tgcttaagct tgtttgtaaa atggcctact tgaagtcctc atgaataatg
     1321 agggttgact ttcatttgct tgaaacttaa ggaagtttgt gcctataaaa gttactgcaa
     1381 ttcagtattt ctttattttt ttcgagacag agtctcaatc tgtcgcccag gctggagtgc
     1441 agtggcatga tataggctca ctggaagctc tgcctcaggg gttcatgcca ttctcctgcc
     1501 tcagcctccc gagtagctgg gactacaggc gcccgccacc atgcccagct aatttttttt
     1561 tgtattttta gtagagacgg gttttcaccg tgttagccag gatggtctca atctcttgac
     1621 ctcgtgatac gcccgccttg gcctcccaaa gtgctgggat tacaggtgtg ggccaccaca
     1681 cccagccttt tttttttttt tttttttttt ttttgagaca gagtgtctca ctcttgccca
     1741 gaacccaggc tggagtgcag tggcccaatc tcggctcact gcaacctcca cctcccaggt
     1801 tccagcgatt ctcatgcctc agcctcctga gtagctggga ctataggcat gcaccaccat
     1861 gccccactaa attttgtatt tttagtagaa acagagtttc accatgttgg ccaggctggt
     1921 ctcgatctcc tgacctcatg atctgcccgc cttggcctcc caaagtgtgg gattacaggc
     1981 gtgagccact gtgcccagca tggtgtttct tatatcaggt gttttaggga gctcgcttgc
     2041 ttattccatt ctttaatcct tacagtgtgc cacacgtata aagtttataa cgtattaatg
     2101 atctcattac ccaaaaccag aacataattt cacaagggtt cctacttctg tattgtttta
     2161 ttatctcaaa aatttaaata acatgttctg ctgtttattg ttcttgttat ccactgtatt
     2221 agcaccttcc ctgatgtgct ttggaggttg atcaatgaat ttctgagact ttctgctgga
     2281 attactttaa gggtgtctta ttagatgatg aaaagttggc tgagacaccc ttcaagtgac
     2341 catgtcattg ttttcttgct atgtctttag cttaatgatt aagatacaat tctttttaaa
     2401 atcaaatggt attagttatt atgtttccca aattagaaat cgattttagt taacatttta
     2461 ttttatttta ttctatttta tttatttttg agacagagtc tcgctctgtt gcccaggctg
     2521 gagtacaatg gcgcaatctc agctcactcc aatctccgcc tcccaggttc aagcgatttt
     2581 tctgcctcag cctcccgagt agctgggatt acaggcaccc actaccatgc ccagctaatc
     2641 tttgtatttt tagtagagac ggggtttcac catgttggcc agtccggtct cgaacttctg
     2701 acctgaggtg atctgcccac cttggcctca caaagtgctg agattacagg cttgagccac
     2761 cacgcctggc ctagttagca ttttaaagaa acacaaagcc ataacaaaaa ccatcattgt
     2821 ttgtattcca cactgttaat gaatgtaaag aggttagaaa tgtagtgttt gattaatgat
     2881 gtttattttt actgtattta atatgagtaa tttttcatca tctttcaaga ggaataatgt
     2941 ttattgatta aaggtgagaa atgatagtta agacaccaat tccatgtcca gatctttgac
     3001 tgtatcatgc attgtacaat tgatttcata ttttatgaaa tgccttaatt ttcctactat
     3061 aacataaaga caatgatgaa taaagtttat gtgtatgatt aaa
//
