LOCUS       NM_024815               1513 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens nudix hydrolase 18 (NUDT18), mRNA.
ACCESSION   NM_024815
VERSION     NM_024815.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1513)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1513)
  AUTHORS   Takagi,Y., Setoyama,D., Ito,R., Kamiya,H., Yamagata,Y. and
            Sekiguchi,M.
  TITLE     Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine
            and deoxyguanosine diphosphates: comparison with MTH1 and MTH2
  JOURNAL   J Biol Chem 287 (25), 21541-21549 (2012)
   PUBMED   22556419
  REMARK    GeneRIF: MTH3 is specifically active against 8-oxo-dGDP and hardly
            cleaves 8-oxo-dGTP. Other types of oxidized nucleoside
            diphosphates, 2-hydroxy-dADP and 8-hydroxy-dADP, were also
            hydrolyzed by MTH3.
REFERENCE   3  (bases 1 to 1513)
  AUTHORS   Simonis,N., Rual,J.F., Lemmens,I., Boxus,M., Hirozane-Kishikawa,T.,
            Gatot,J.S., Dricot,A., Hao,T., Vertommen,D., Legros,S., Daakour,S.,
            Klitgord,N., Martin,M., Willaert,J.F., Dequiedt,F., Navratil,V.,
            Cusick,M.E., Burny,A., Van Lint,C., Hill,D.E., Tavernier,J.,
            Kettmann,R., Vidal,M. and Twizere,J.C.
  TITLE     Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses
  JOURNAL   Retrovirology 9, 26 (2012)
   PUBMED   22458338
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1513)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   5  (bases 1 to 1513)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   6  (bases 1 to 1513)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA015404.1, BC016902.1 and
            AC091171.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024815.3.
            
            Summary: The protein encoded by this gene is a member of the Nudix
            hydrolase family. Nudix hydrolases eliminate potentially toxic
            nucleotide metabolites from the cell and regulate the
            concentrations and availability of many different nucleotide
            substrates, cofactors, and signaling molecules. This protein
            contains a Nudix hydrolase domain and hydrolyzes oxidized forms of
            guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep
            2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.192486.1,
                                           SRR1803614.173760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611621.2/ ENSP00000480722.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               DA015404.1         1-249
            250-1099            BC016902.1         262-1111
            1100-1513           AC091171.15        157352-157765       c
FEATURES             Location/Qualifiers
     source          1..1513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..1513
                     /gene="NUDT18"
                     /gene_synonym="MTH3"
                     /note="nudix hydrolase 18"
                     /db_xref="GeneID:79873"
                     /db_xref="HGNC:HGNC:26194"
                     /db_xref="MIM:615791"
     exon            1..281
                     /gene="NUDT18"
                     /gene_synonym="MTH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1091
                     /gene="NUDT18"
                     /gene_synonym="MTH3"
                     /EC_number="3.6.1.58"
                     /note="nucleoside diphosphate-linked moiety X motif 18;
                     nudix motif 18; mutT human homolog 3; mutT homolog 3;
                     2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine
                     phosphatase; nudix (nucleoside diphosphate linked moiety
                     X)-type motif 18"
                     /codon_start=1
                     /product="8-oxo-dGDP phosphatase NUDT18"
                     /protein_id="NP_079091.3"
                     /db_xref="CCDS:CCDS75706.1"
                     /db_xref="GeneID:79873"
                     /db_xref="HGNC:HGNC:26194"
                     /db_xref="MIM:615791"
                     /translation="MASEGLAGALASVLAGQGSSVHSCDSAPAGEPPAPVRLRKNVCY
                     VVLAVFLSEQDEVLLIQEAKRECRGSWYLPAGRMEPGETIVEALQREVKEEAGLHCEP
                     ETLLSVEERGPSWVRFVFLARPTGGILKTSKEADAESLQAAWYPRTSLPTPLRAHDIL
                     HLVELAAQYRQQARHPLILPQELPCDLVCQRLVATFTSAQTVWVLVGTVGMPHLPVTA
                     CGLDPMEQRGGMKMAVLRLLQECLTLHHLVVEIKGLLGLQHLGRDHSDGICLNVLVTV
                     AFRSPGIQDEPPKVRGENFSWWKVMEEDLQSQLLQRLQGSSVVPVNR"
     exon            282..495
                     /gene="NUDT18"
                     /gene_synonym="MTH3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..1513
                     /gene="NUDT18"
                     /gene_synonym="MTH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT18"
                     /gene_synonym="MTH3"
                     /note="hexamer: AGTAAA"
     polyA_site      1513
                     /gene="NUDT18"
                     /gene_synonym="MTH3"
                     /note="major polyA site"
ORIGIN      
        1 ctcgtgagct cccggcccgc tgccgcaggg actgggagcg ggctccgcag cgcactctag
       61 cccgcggctc ggctcagtcg gtctgcgagg atccggcccg ccgccccccg ggggacccga
      121 tggcctcgga gggcctggcg ggggcgctgg cttccgtgct ggctggccag gggtccagcg
      181 tgcacagctg cgactcggcg ccggccgggg agccgccggc gcccgtgcgg ctgcggaaga
      241 acgtgtgcta cgtggtgctg gccgtgttcc tcagcgagca ggatgaggtg ctactgatcc
      301 aggaggccaa gagggagtgc cgggggtcgt ggtacctgcc tgcggggaga atggagccag
      361 gggagaccat cgtggaggcg ctgcagcggg aggtgaagga ggaggcgggg ctgcactgtg
      421 agcccgagac actgctgtcc gtggaggagc ggggcccctc ctgggtccgc ttcgtgttcc
      481 tcgctcgccc cacaggtgga attctcaaga cttccaagga ggccgatgcg gagtccctgc
      541 aggctgcctg gtacccacgg acctccctgc ccactccgct gcgagcccat gacatcctgc
      601 acctggttga actagccgcc cagtatcgcc agcaagccag gcaccctctc attctgcccc
      661 aagagctacc ctgtgatctg gtctgccagc ggctcgtggc tacctttacc agcgcccaga
      721 cagtgtgggt gttagtgggc acagtgggga tgcctcactt gcctgtcact gcctgtggcc
      781 tcgaccctat ggagcagagg ggtggcatga agatggccgt cctgcggctg ctgcaggagt
      841 gtctgaccct gcaccacttg gtggtggaga tcaaggggtt gcttggactg cagcacctgg
      901 gccgagatca cagtgatggc atctgtttga atgtgctggt gaccgtggct tttcggagcc
      961 cagggatcca ggatgaaccc ccaaaagttc ggggtgagaa cttctcttgg tggaaggtga
     1021 tggaggaaga cctgcaaagc cagctcctcc agcggcttca gggatcctct gttgtcccag
     1081 tgaacagata gagaggtggg ggaggtgaca gggagctagg cagccgtgct ccctccagtg
     1141 cggacttgtc tccctctgag ggaggcaaga ggctggcgat cagggatctt gttgcattgg
     1201 gagcaggggc ggctctcctg gtccccagga gagatgcttt gaggagcatt cctctagatt
     1261 gcacaaggga cagtgccttt aaccaagcga ggagtccaaa gctcaggacc tgactaccct
     1321 gagggcacgc tgacgcctct tcccaggggg atggggagct ttctgcaccc ccagtggcat
     1381 ctcctcatca cgttctgtgc cgtccttggg aaaggcctgc attctgatcc ttccaggccc
     1441 ttcgagcatg gaggggcact ggggaaggtc ccccgaggga ggagcacgtt gctgagtaaa
     1501 gaggtgttac tca
//
