LOCUS       NM_001012758            1473 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens nudix hydrolase 17 (NUDT17), mRNA.
ACCESSION   NM_001012758 XM_496395
VERSION     NM_001012758.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1473)
  AUTHORS   Han,J., Liang,J., Zhou,W., Zhang,M. and Jin,T.
  TITLE     Association between NUDT17 polymorphisms and breast cancer risk
  JOURNAL   Expert Rev Mol Diagn 24 (5), 459-466 (2024)
   PUBMED   38756100
  REMARK    GeneRIF: Association between NUDT17 polymorphisms and breast cancer
            risk.
REFERENCE   2  (bases 1 to 1473)
  AUTHORS   Song,M.G., Bail,S. and Kiledjian,M.
  TITLE     Multiple Nudix family proteins possess mRNA decapping activity
  JOURNAL   RNA 19 (3), 390-399 (2013)
   PUBMED   23353937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC239808.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001012758.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.165022.1,
                                           SRR9304715.737834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334513.6/ ENSP00000334437.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC239808.3         18254-18456         c
            204-387             AC239808.3         17890-18073         c
            388-413             AC239808.3         17628-17653         c
            414-506             AC239808.3         17396-17488         c
            507-605             AC239808.3         16738-16836         c
            606-742             AC239808.3         16367-16503         c
            743-895             AC239808.3         15822-15974         c
            896-1473            AC239808.3         15132-15709         c
FEATURES             Location/Qualifiers
     source          1..1473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..1473
                     /gene="NUDT17"
                     /note="nudix hydrolase 17"
                     /db_xref="GeneID:200035"
                     /db_xref="HGNC:HGNC:26618"
     exon            1..203
                     /gene="NUDT17"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..998
                     /gene="NUDT17"
                     /note="nudix motif 17; nudix (nucleoside diphosphate
                     linked moiety X)-type motif 17"
                     /codon_start=1
                     /product="nucleoside diphosphate-linked moiety X motif 17"
                     /protein_id="NP_001012776.1"
                     /db_xref="CCDS:CCDS72865.1"
                     /db_xref="GeneID:200035"
                     /db_xref="HGNC:HGNC:26618"
                     /translation="MAEVRVQLLLSRRPESVSFARSVCGLLGAGPGLGTWPIHCSLKR
                     GRLVLSSRPFPGASARLPLQRPPFCPFAALEERPRVPGAELPTDRGVDLGVAVILQSS
                     DKTVLLTRRARTLSVSPNLWVPPGGHVELEEELLDGGLRELWEESGLHLPQGQFSWVP
                     LGLWESAYPPRLSWGLPKYHHIVLYLLVISQESQQQLQARIQPNPNEVSALMWLTPDV
                     AAAVAAAEDGTETPGLLPQDLPPSVLAVELEEDGRARPLVLHMSTLLRMIPTMAEDKE
                     RVSTGTKFALKLWLQHLGRTPPPCKSAAYLDPGPAKEEWNMDPLPPNQGSGK"
     exon            204..387
                     /gene="NUDT17"
                     /inference="alignment:Splign:2.1.0"
     exon            388..413
                     /gene="NUDT17"
                     /inference="alignment:Splign:2.1.0"
     exon            414..506
                     /gene="NUDT17"
                     /inference="alignment:Splign:2.1.0"
     exon            507..605
                     /gene="NUDT17"
                     /inference="alignment:Splign:2.1.0"
     exon            606..742
                     /gene="NUDT17"
                     /inference="alignment:Splign:2.1.0"
     exon            743..895
                     /gene="NUDT17"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1473
                     /gene="NUDT17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1447..1452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT17"
                     /note="hexamer: AATAAA"
     polyA_site      1473
                     /gene="NUDT17"
                     /note="major polyA site"
ORIGIN      
        1 agagtcgcgt tatggccgag gtgcgggtgc agctgctcct gtcccggcgt ccggagtcgg
       61 tgagcttcgc acggagtgtg tgtggcctcc tgggagccgg accagggctc gggacgtggc
      121 ccattcactg cagcttgaag cgaggacggc ttgtcctctc gagcaggccc ttcccaggcg
      181 cctccgctag gcttccgctc cagcgacccc ctttctgccc ttttgcggcc ctggaggagc
      241 ggcccagggt ccctggggct gagctgccca cagatcgagg tgtggacctg ggtgtggccg
      301 tcattctgca gtccagcgac aagactgtct tgctaacccg aagggcacgc accctgagcg
      361 tttcccccaa cctctgggta cccccgggtg ggcacgtgga acttgaggag gagctgctgg
      421 acggagggct tcgagaactt tgggaggaga gtggactaca cctgccccag ggccagttct
      481 cttgggtccc tctgggttta tgggagtctg cctaccctcc taggctgagc tggggtttac
      541 ccaaatacca tcacattgtt ctgtatctac tcgtgatctc ccaggaatca cagcagcagt
      601 tgcaggcccg gatccaacca aacccaaatg aggtgagcgc ccttatgtgg ctgacaccag
      661 atgtagctgc tgcagtggct gccgcagagg atgggacaga gacacccgga cttctccccc
      721 aggacctacc accctctgtc cttgcagtgg aactagagga ggatggaaga gcccgacctc
      781 tggtcctgca catgtccacc ctcctgcgga tgatcccaac catggcagag gacaaagaga
      841 gagtcagcac tggaaccaag tttgccctca agctctggct gcaacatctg ggcagaacac
      901 ccccaccgtg taaaagtgca gcttacctgg acccagggcc agcaaaggaa gaatggaaca
      961 tggaccctct tcccccaaac caggggtctg gaaagtgaag tgtaaaatcc cctccctagc
     1021 ccatctccat gacactcaca gaacattcac aacctttatt atgggtgaga gcttcactac
     1081 aactttagaa ataaaaagta aaattacaac ataggtccta ggccttggcg agcctgaaaa
     1141 agaagattgg gaaggagggc acagggtcct tccacctccc tggaaaggtg cagaatgagc
     1201 caggcctaac tacagggcca tgagcctcta gaagcttagg ggggaataag aaacactgtg
     1261 aacttagata tataaataga gagagaccca agcaataggc cgggcctgac tcccagaccc
     1321 ctgcagatca tggctaaggc cttacatcct cctctgtcat actggagtag gaggcagggg
     1381 aagtcatctt tggagtattt tggtttttct tatttatgta caaaaaagtc cacatccaca
     1441 atccaaaata aagttctctg tccatctctg aaa
//
