LOCUS       NM_177533                854 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens nudix hydrolase 14 (NUDT14), transcript variant 1,
            mRNA.
ACCESSION   NM_177533
VERSION     NM_177533.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 854)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 854)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 854)
  AUTHORS   Wang,G., Ren,G., Cui,X., Lu,Z., Ma,Y., Qi,Y., Huang,Y., Liu,Z.,
            Sun,Z. and Ruan,Q.
  TITLE     Human cytomegalovirus RL13 protein interacts with host NUDT14
            protein affecting viral DNA replication
  JOURNAL   Mol Med Rep 13 (3), 2167-2174 (2016)
   PUBMED   26781650
  REMARK    GeneRIF: the interaction between the RL13 protein and NUDT14
            protein may be involved in human cytomegalovirus DNA replication.
REFERENCE   4  (bases 1 to 854)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   5  (bases 1 to 854)
  AUTHORS   Yagi,T., Baroja-Fernandez,E., Yamamoto,R., Munoz,F.J., Akazawa,T.,
            Hong,K.S. and Pozueta-Romero,J.
  TITLE     Cloning, expression and characterization of a mammalian Nudix
            hydrolase-like enzyme that cleaves the pyrophosphate bond of
            UDP-glucose
  JOURNAL   Biochem J 370 (Pt 2), 409-415 (2003)
   PUBMED   12429023
REFERENCE   6  (bases 1 to 854)
  AUTHORS   Yuryev,A. and Wennogle,L.P.
  TITLE     Novel raf kinase protein-protein interactions found by an
            exhaustive yeast two-hybrid analysis
  JOURNAL   Genomics 81 (2), 112-125 (2003)
   PUBMED   12620389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB096906.1 and BC041584.1.
            
            On Nov 22, 2018 this sequence version replaced NM_177533.4.
            
            Summary: The protein encoded by this gene is a member of the Nudix
            hydrolase family. Nudix hydrolases eliminate potentially toxic
            nucleotide metabolites from the cell and regulate the
            concentrations and availability of many different nucleotide
            substrates, cofactors, and signaling molecules. This enzyme
            contains a Nudix hydrolase domain and is a UDPG pyrophosphatase
            that hydrolyzes UDPG to produce glucose 1-phosphate and UMP.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jan
            2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041584.1, SRR1803613.388340.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392568.7/ ENSP00000376349.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                DB096906.1         10-96
            88-854              BC041584.1         61-827
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..854
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /note="nudix hydrolase 14"
                     /db_xref="GeneID:256281"
                     /db_xref="HGNC:HGNC:20141"
                     /db_xref="MIM:609219"
     exon            1..184
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..772
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /EC_number="3.6.1.45"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UDP-sugar diphosphatase; UDPG pyrophosphatase; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 14;
                     uridine diphosphate glucose pyrophosphatase NUDT14"
                     /codon_start=1
                     /product="uridine diphosphate glucose pyrophosphatase
                     NUDT14 isoform 1"
                     /protein_id="NP_803877.2"
                     /db_xref="CCDS:CCDS10000.1"
                     /db_xref="GeneID:256281"
                     /db_xref="HGNC:HGNC:20141"
                     /db_xref="MIM:609219"
                     /translation="MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVT
                     VLLFNSSRRSLVLVKQFRPAVYAGEVERRFPGSLAAVDQDGPRELQPALPGSAGVTVE
                     LCAGLVDQPGLSLEEVACKEAWEECGYHLAPSDLRRVATYWSGVGLTGSRQTMFYTEV
                     TDAQRSGPGGGLVEEGELIEVVHLPLEGAQAFADDPDIPKTLGVIFGVSWFLSQVAPN
                     LDLQ"
     exon            185..228
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /inference="alignment:Splign:2.1.0"
     exon            229..293
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /inference="alignment:Splign:2.1.0"
     exon            294..531
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /inference="alignment:Splign:2.1.0"
     exon            532..854
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      833..838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /note="hexamer: AATAAA"
     polyA_site      854
                     /gene="NUDT14"
                     /gene_synonym="UGPP; UGPPase"
                     /note="major polyA site"
ORIGIN      
        1 agagccgcgg tcacgcgccc gcccgaaggc tcctgtcggg acagggcgcc gccccgtgtc
       61 ggcccccgca gagctcgcgg cccccgcctg tccgggcgcc gccatggagc gcatcgaggg
      121 ggcgtccgtg ggccgctgcg ccgcctcacc ctacctgcgg ccgctcacgc tgcattaccg
      181 ccagaatggt gcccagaagt cctgggactt catgaagacg catgacagcg tgaccgttct
      241 cttattcaac tcttctcgga ggagcctggt gttggtgaag cagttccggc cagctgtgta
      301 tgcgggtgag gtggagcgcc gcttcccagg gtccctagca gctgtagacc aggacgggcc
      361 tcgggagcta cagccagccc tgcccggctc agcgggggtg acagttgagc tgtgtgccgg
      421 cctcgtggac cagcctgggc tctcgctgga ggaagtggct tgcaaggagg cttgggagga
      481 gtgtggctac cacttggccc cctctgatct gcgccgggtc gccacatact ggtctggagt
      541 gggactgact ggctccagac agaccatgtt ctacacagag gtgacagatg cccagcgtag
      601 cggtccaggt gggggcctgg tggaggaggg tgagctcatt gaggtggtgc acctgcccct
      661 ggaaggcgcc caggcctttg cagacgaccc ggacatcccc aagaccctcg gcgtcatctt
      721 tggtgtctca tggttcctca gccaggtggc ccccaacctg gatctccagt gagactccag
      781 ggttctagac agaggccagt cttggccact caccccacac cccgcggacc ccaataaagg
      841 cttgcatagc tcca
//
