LOCUS       NM_015901               2101 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nudix hydrolase 13 (NUDT13), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_015901
VERSION     NM_015901.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2101)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2101)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2101)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2101)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   5  (bases 1 to 2101)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB035851.1, AL521667.3, BC046173.2 and AL050114.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015901.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.170839.1,
                                           SRR5189667.202424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357321.9/ ENSP00000349874.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                DB035851.1         186-262
            78-319              AL521667.3         1-242
            320-326             BC046173.2         253-259
            327-674             AL521667.3         253-600
            675-2101            AL050114.1         315-1741
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..2101
                     /gene="NUDT13"
                     /note="nudix hydrolase 13"
                     /db_xref="GeneID:25961"
                     /db_xref="HGNC:HGNC:18827"
                     /db_xref="MIM:609233"
     exon            1..113
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     exon            114..205
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1181
                     /gene="NUDT13"
                     /EC_number="3.6.1.22"
                     /note="isoform a is encoded by transcript variant 1;
                     nucleoside diphosphate-linked moiety X motif 13; nudix
                     motif 13; nudix (nucleoside diphosphate linked moiety
                     X)-type motif 13; NAD(P)H pyrophosphatase NUDT13,
                     mitochondrial"
                     /codon_start=1
                     /product="NAD(P)H pyrophosphatase NUDT13, mitochondrial
                     isoform a"
                     /protein_id="NP_056985.3"
                     /db_xref="CCDS:CCDS31220.1"
                     /db_xref="GeneID:25961"
                     /db_xref="HGNC:HGNC:18827"
                     /db_xref="MIM:609233"
                     /translation="MSLYCGIACRRKFFWCYRLLSTYVTKTRYLFELKEDDDACKKAQ
                     QTGAFYLFHSLAPLLQTSAHQYLAPRHSLLELERLLGKFGQDAQRIEDSVLIGCSEQQ
                     EAWFALDLGLDSSFSISASLHKPEMETELKGSFIELRKALFQLNARDASLLSTAQALL
                     RWHDAHQFCSRSGQPTKKNVAGSKRVCPSNNIIYYPQMAPVAITLVSDGTRCLLARQS
                     SFPKGMYSALAGFCDIGESVEETIRREVAEEVGLEVESLQYYASQHWPFPSGSLMIAC
                     HATVKPGQTEIQVNLRELETAAWFSHDEVATALKRKGPYTQQQNGTFPFWLPPKLAIS
                     HQLIKEWVEKQTCSSLPA"
     exon            206..345
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     exon            346..480
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     exon            481..587
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     exon            588..713
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     exon            714..825
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     exon            826..980
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     exon            981..2101
                     /gene="NUDT13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2083..2088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT13"
                     /note="hexamer: AATAAA"
     polyA_site      2101
                     /gene="NUDT13"
                     /note="major polyA site"
ORIGIN      
        1 agaagcagca atggtccctc cagggaacgg aagccgttga acgtgaacat ttggagtttc
       61 ctcttttgtg ctgattcctg aggactagga aggtgccccg aaaagaattc agagacctga
      121 caatgtccct gtattgtgga atagcttgca ggagaaaatt tttttggtgc tataggctgc
      181 tgtcaaccta tgttactaag acacggtatt tatttgaact gaaggaagat gatgatgcat
      241 gtaaaaaagc ccagcaaaca ggagcgtttt acctctttca tagtctggct cctctgcttc
      301 agacttcagc acatcaatac ctggcccccc ggcacagcct gttagagttg gaaaggctcc
      361 tgggtaaatt tggacaggat gcacaaagaa tagaagattc tgtgctgatt ggatgctctg
      421 agcagcagga agcatggttt gctctggatc taggtctgga tagctccttt tccataagtg
      481 cctccttaca caaacctgaa atggagacag agctcaaggg gtctttcatt gagctgagaa
      541 aggcactctt tcaactcaat gcaagggatg cctccttgct gtccacggct caagctcttc
      601 tccgctggca tgatgctcat cagttctgca gcagaagtgg gcagcccacc aagaagaacg
      661 tggctggcag caagcgtgtg tgcccttcca ataatataat ctattatcca cagatggctc
      721 ctgtggcgat cacgctggtg tcagatggga cccgatgcct gcttgcccgc caaagctcct
      781 ttcccaaggg aatgtattct gccttggcag gtttttgtga tataggtgaa agtgtggaag
      841 agaccatccg ccgagaagtt gcagaagagg tgggattgga ggtggaaagc ctgcagtact
      901 atgcatccca gcattggccc ttccctagtg gctcactcat gattgcttgc catgcaactg
      961 tgaaaccagg gcagacagaa atccaggtga acttgagaga attagagaca gctgcctggt
     1021 tcagtcatga tgaggtagcc acagccctga agagaaaggg cccctatact cagcaacaga
     1081 atgggacttt cccattctgg ctgcccccta agttagccat ctcccaccaa ctgattaagg
     1141 agtgggtgga aaaacagacc tgttcttccc tgcctgctta gcccggatca agtcacttag
     1201 atcgctcctt ggtattcctg agggacaaac tagagatcag ttgacaaagg agaagtgaca
     1261 aaagataagc tgcagaagga cctcagaagg gcagagcaaa gggtgagcct acagtaagac
     1321 acttctatca gcagtgttaa tggaagaaat tcctaccaat gggcaatcaa aaaagccagt
     1381 gtgagaagaa aactgatgag ctgtcaactg tcaaaaatca gggggaaggg ggaagcatta
     1441 gtttggatgt aggcccttgt tcagtcattt tctctaaggc cttggaagca aacatcttct
     1501 ggcatatggc ttgttaatgt tgtgtttaca ctaactgcca aaatgtgcct gttgtaagtt
     1561 tggttaaaac ttttatctta gtattgaaaa tatatagcaa gttttaagtc attactgagt
     1621 tacttgttac ccttacagaa ttaagaaaaa tagcacagta tgacatttta aaattcatgt
     1681 acaggtgcat tctagttaca tgaacatgct agttaaataa aagtcacaat taagtcatta
     1741 tgactcagag tactttataa taaatcagat gccctgaggc tctgttgagg aagtagaatc
     1801 ccaatgggac tccagacagt aaatcttttt cgctgttttc agctctgtca catgctcagt
     1861 ttgtgaccca gggaaaagac tattgctttg ccatgcctgt tttcctaaat aaaacagttg
     1921 ctggcatttg cacatccaca acgtgttgat taacaaaggg attggtggag ataaacagat
     1981 gccaaacctg acctatttct taaactttat ggaataaact aaatttagga tttctcatca
     2041 ttcatatatg atgccataag ggagaagagt ttatttgggg aaaataaaag aaatttccac
     2101 a
//
