LOCUS       NM_001304963            1925 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nudix hydrolase 10 (NUDT10), transcript variant 2,
            mRNA.
ACCESSION   NM_001304963 XM_005262042
VERSION     NM_001304963.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Chen,D., Zhang,R., Xie,A., Yuan,J., Zhang,J., Huang,Y., Zhang,H.
            and Zhang,F.
  TITLE     Clinical correlations and prognostic value of Nudix hydroxylase 10
            in patients with gastric cancer
  JOURNAL   Bioengineered 12 (2), 9779-9789 (2021)
   PUBMED   34696672
  REMARK    GeneRIF: Clinical correlations and prognostic value of Nudix
            hydroxylase 10 in patients with gastric cancer.
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Chang,B.L., Spangler,E., Gallagher,S., Haiman,C.A., Henderson,B.,
            Isaacs,W., Benford,M.L., Kidd,L.R., Cooney,K., Strom,S.,
            Ingles,S.A., Stern,M.C., Corral,R., Joshi,A.D., Xu,J., Giri,V.N.,
            Rybicki,B., Neslund-Dudas,C., Kibel,A.S., Thompson,I.M.,
            Leach,R.J., Ostrander,E.A., Stanford,J.L., Witte,J., Casey,G.,
            Eeles,R., Hsing,A.W., Chanock,S., Hu,J.J., John,E.M., Park,J.,
            Stefflova,K., Zeigler-Johnson,C. and Rebbeck,T.R.
  TITLE     Validation of genome-wide prostate cancer associations in men of
            African descent
  JOURNAL   Cancer Epidemiol Biomarkers Prev 20 (1), 23-32 (2011)
   PUBMED   21071540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1925)
  AUTHORS   Kim,S.T., Cheng,Y., Hsu,F.C., Jin,T., Kader,A.K., Zheng,S.L.,
            Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     Prostate cancer risk-associated variants reported from genome-wide
            association studies: meta-analysis and their contribution to
            genetic Variation
  JOURNAL   Prostate 70 (16), 1729-1738 (2010)
   PUBMED   20564319
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1925)
  AUTHORS   Gudmundsson,J., Sulem,P., Rafnar,T., Bergthorsson,J.T.,
            Manolescu,A., Gudbjartsson,D., Agnarsson,B.A., Sigurdsson,A.,
            Benediktsdottir,K.R., Blondal,T., Jakobsdottir,M., Stacey,S.N.,
            Kostic,J., Kristinsson,K.T., Birgisdottir,B., Ghosh,S.,
            Magnusdottir,D.N., Thorlacius,S., Thorleifsson,G., Zheng,S.L.,
            Sun,J., Chang,B.L., Elmore,J.B., Breyer,J.P., McReynolds,K.M.,
            Bradley,K.M., Yaspan,B.L., Wiklund,F., Stattin,P., Lindstrom,S.,
            Adami,H.O., McDonnell,S.K., Schaid,D.J., Cunningham,J.M., Wang,L.,
            Cerhan,J.R., St Sauver,J.L., Isaacs,S.D., Wiley,K.E., Partin,A.W.,
            Walsh,P.C., Polo,S., Ruiz-Echarri,M., Navarrete,S., Fuertes,F.,
            Saez,B., Godino,J., Weijerman,P.C., Swinkels,D.W., Aben,K.K.,
            Witjes,J.A., Suarez,B.K., Helfand,B.T., Frigge,M.L.,
            Kristjansson,K., Ober,C., Jonsson,E., Einarsson,G.V., Xu,J.,
            Gronberg,H., Smith,J.R., Thibodeau,S.N., Isaacs,W.B.,
            Catalona,W.J., Mayordomo,J.I., Kiemeney,L.A., Barkardottir,R.B.,
            Gulcher,J.R., Thorsteinsdottir,U., Kong,A. and Stefansson,K.
  TITLE     Common sequence variants on 2p15 and Xp11.22 confer susceptibility
            to prostate cancer
  JOURNAL   Nat Genet 40 (3), 281-283 (2008)
   PUBMED   18264098
REFERENCE   7  (bases 1 to 1925)
  AUTHORS   Eeles,R.A., Kote-Jarai,Z., Giles,G.G., Olama,A.A., Guy,M.,
            Jugurnauth,S.K., Mulholland,S., Leongamornlert,D.A., Edwards,S.M.,
            Morrison,J., Field,H.I., Southey,M.C., Severi,G., Donovan,J.L.,
            Hamdy,F.C., Dearnaley,D.P., Muir,K.R., Smith,C., Bagnato,M.,
            Ardern-Jones,A.T., Hall,A.L., O'Brien,L.T., Gehr-Swain,B.N.,
            Wilkinson,R.A., Cox,A., Lewis,S., Brown,P.M., Jhavar,S.G.,
            Tymrakiewicz,M., Lophatananon,A., Bryant,S.L., Horwich,A.,
            Huddart,R.A., Khoo,V.S., Parker,C.C., Woodhouse,C.J., Thompson,A.,
            Christmas,T., Ogden,C., Fisher,C., Jamieson,C., Cooper,C.S.,
            English,D.R., Hopper,J.L., Neal,D.E. and Easton,D.F.
  CONSRTM   UK Genetic Prostate Cancer Study Collaborators; British Association
            of Urological Surgeons' Section of Oncology; UK ProtecT Study
            Collaborators
  TITLE     Multiple newly identified loci associated with prostate cancer
            susceptibility
  JOURNAL   Nat Genet 40 (3), 316-321 (2008)
   PUBMED   18264097
REFERENCE   8  (bases 1 to 1925)
  AUTHORS   Fisher,D.I., Safrany,S.T., Strike,P., McLennan,A.G. and
            Cartwright,J.L.
  TITLE     Nudix hydrolases that degrade dinucleoside and diphosphoinositol
            polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP)
            pyrophosphatase activity that generates the glycolytic activator
            ribose 1,5-bisphosphate
  JOURNAL   J Biol Chem 277 (49), 47313-47317 (2002)
   PUBMED   12370170
REFERENCE   9  (bases 1 to 1925)
  AUTHORS   Hidaka,K., Caffrey,J.J., Hua,L., Zhang,T., Falck,J.R., Nickel,G.C.,
            Carrel,L., Barnes,L.D. and Shears,S.B.
  TITLE     An adjacent pair of human NUDT genes on chromosome X are
            preferentially expressed in testis and encode two new isoforms of
            diphosphoinositol polyphosphate phosphohydrolase
  JOURNAL   J Biol Chem 277 (36), 32730-32738 (2002)
   PUBMED   12105228
  REMARK    GeneRIF: The NUDT10 gene, located on chromosome X, is
            preferentially expressed in the testis
REFERENCE   10 (bases 1 to 1925)
  AUTHORS   Leslie,N.R., McLennan,A.G. and Safrany,S.T.
  TITLE     Cloning and characterisation of hAps1 and hAps2, human diadenosine
            polyphosphate-metabolising Nudix hydrolases
  JOURNAL   BMC Biochem 3, 20 (2002)
   PUBMED   12121577
  REMARK    GeneRIF: Cloning and characterisation of NUDT10 as a diadenosine
            polyphosphate-metabolising Nudix hydrolase.
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX449265.2, BC050700.1,
            CN399689.1 and BC049383.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001304963.1.
            
            Summary: This gene is a member of the nudix (nucleoside diphosphate
            linked moiety X)-type motif containing family. The encoded protein
            is a phosphohydrolase and may regulate the turnover of
            diphosphoinositol polyphosphates. The turnover of these high-energy
            diphosphoinositol polyphosphates represents a molecular switching
            activity with important regulatory consequences. Molecular
            switching by diphosphoinositol polyphosphates may contribute to the
            regulation of intracellular trafficking. In some populations
            putative prostate cancer susceptibility alleles have been
            identified for this gene. Alternatively spliced transcript
            variants, which differ only in the 5' UTR, have been found for this
            gene. [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.746620.1,
                                           SRR3476690.1132745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356450.3/ ENSP00000348831.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BX449265.2         14-21
            9-328               BC050700.1         1-320
            329-1114            CN399689.1         11-796
            1115-1925           BC049383.1         1049-1859
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..1925
                     /gene="NUDT10"
                     /gene_synonym="APS2; DIPP3-alpha; DIPP3a"
                     /note="nudix hydrolase 10"
                     /db_xref="GeneID:170685"
                     /db_xref="HGNC:HGNC:17621"
                     /db_xref="MIM:300527"
     exon            1..638
                     /gene="NUDT10"
                     /gene_synonym="APS2; DIPP3-alpha; DIPP3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..639
                     /gene="NUDT10"
                     /gene_synonym="APS2; DIPP3-alpha; DIPP3a"
                     /EC_number="3.6.1.52"
                     /EC_number="3.6.1.60"
                     /note="nudix motif 10; nucleoside diphosphate-linked
                     moiety X motif 10; diadenosine 5',5'''-P1,P6-hexaphosphate
                     hydrolase 3-alpha; diadenosine hexaphosphate hydrolase
                     (AMP-forming); nudix (nucleoside diphosphate linked moiety
                     X)-type motif 10"
                     /codon_start=1
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     3-alpha"
                     /protein_id="NP_001291892.1"
                     /db_xref="CCDS:CCDS35278.1"
                     /db_xref="GeneID:170685"
                     /db_xref="HGNC:HGNC:17621"
                     /db_xref="MIM:300527"
                     /translation="MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDR
                     WIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGVFEQNQDPKHRTYVYVLTVTE
                     LLEDWEDSVSIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSMAPSSP
                     DSDP"
     exon            639..1925
                     /gene="NUDT10"
                     /gene_synonym="APS2; DIPP3-alpha; DIPP3a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDT10"
                     /gene_synonym="APS2; DIPP3-alpha; DIPP3a"
                     /note="hexamer: AATAAA"
     polyA_site      1925
                     /gene="NUDT10"
                     /gene_synonym="APS2; DIPP3-alpha; DIPP3a"
                     /note="major polyA site"
ORIGIN      
        1 agacggcaga cggaggcgcc tctctctccc cgcccctctc ctcggccctt tctcttccca
       61 gcacctcggc tgctgcccgg cagcggcagc agctgcgtcg gcggcccaca cagcagcgag
      121 aggcgagagg aggctgcctc gaggatgaag tgcaaaccca accagacacg gacctacgac
      181 cccgaggggt tcaagaagcg ggcggcgtgc ctgtgcttcc ggagcgagcg cgaggacgag
      241 gtcctgttag tgagtagcag ccggtacccg gaccgctgga tcgtgccggg cgggggcatg
      301 gagcccgagg aggagccggg cggtgcggcg gtccgagagg tgtacgaaga ggcgggagtc
      361 aaggggaagt taggccggct cctgggcgtc ttcgaacaga accaggaccc caagcacaga
      421 acgtacgtgt atgtactgac tgtcacggag ctgctggagg attgggaaga ttcggttagc
      481 attgggagga agcgagagtg gttcaaagtc gaagatgcca tcaaggttct ccagtgccac
      541 aagcccgtgc acgccgaata tctggagaaa ctaaagctgg gcggttcccc aaccaatgga
      601 aactccatgg ccccatcctc gccagatagc gatccctagt gaatggcata gatgttgttc
      661 agatttactt tgaaagaatc aagtatgtga atggatggat gaatggaatt gtgaagcaca
      721 gatgagctct ttcacactcc aaggacacag ctcatcctat gcttttggac acttcttccc
      781 tgtttattac aatgactatt ctccaggttg ttgcactacc gctgtatctg tacataattc
      841 taacttggca cctgtggcct tttttgtgct cttatgtgtc tgtatttccc ggcagagtat
      901 acgcccttga atgccaggaa cttgtttcct tagtcttttt tatatatcta gcatataaga
      961 tattgcttag aatatggtag acatcactga agatttgttt cagtagttca tattttgtaa
     1021 tgatactgaa tggttaaaca atccctttct aatctgtcta gcatatatgt gacttttgtt
     1081 tatcaagtgt cacacaactg cttcaaggca gctgtgagat actagaaagc aaaaattctt
     1141 actcctatgt ctgtgtcatc ccagatgtgt gcctccagat ggcagtatac tacactatct
     1201 gtaaaatata tttgcaaagc caggcacagt gttacgcgtc tgcctcagga ggctgaggca
     1261 gaagaatagc ttgagcccag gagctttagt ctagcctgag caatataatg agactccgtc
     1321 tcttaaaata tttgcccaaa cattgaacct aaatttgacc atgcccctag aaataattcc
     1381 taatctttag aaaatagggc agagaaacat tattttacac catggagatg agatcagcag
     1441 aatccagact ataagaaact acaggacaca tgacctagtt tcttctgtaa ataacttgca
     1501 aggatgaaag atggaggatg aacctataga tttaaagaga cttaagagac atattaacca
     1561 attgttaatt ggatcttatt tgaattgtga tttgaccgaa ctgtaaaacg aatacattta
     1621 tgagacaatc ggggtaattt gaacattggt ggggtatttg gtattagaat aatggtttta
     1681 tcattatgtt agaaagaagg gtcctcatct acattctcaa acatctgtgg ctgatatgat
     1741 atgattcttg gaatttgctt caaaataata agtctggatg ttaagtgcat tggaaatatt
     1801 gatgaaacga aattggcctt gataattgtt gaagctgggt gatggctaaa atgatggttc
     1861 attatatatg ttcatctcta tttttgtatg tttggcattt tccgtaataa agtttataaa
     1921 aataa
//
