LOCUS       NM_015332               8036 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens NudC domain containing 3 (NUDCD3), mRNA.
ACCESSION   NM_015332
VERSION     NM_015332.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8036)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8036)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 8036)
  AUTHORS   Asante,D., Stevenson,N.L. and Stephens,D.J.
  TITLE     Subunit composition of the human cytoplasmic dynein-2 complex
  JOURNAL   J Cell Sci 127 (Pt 21), 4774-4787 (2014)
   PUBMED   25205765
REFERENCE   4  (bases 1 to 8036)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 8036)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   6  (bases 1 to 8036)
  AUTHORS   Cai,Y., Yang,Y., Shen,M. and Zhou,T.
  TITLE     Inhibition of cytokinesis by overexpression of NudCL that is
            localized to the centrosome and midbody
  JOURNAL   Cell Res 19 (11), 1305-1308 (2009)
   PUBMED   19806165
  REMARK    GeneRIF: overexpression of NudCL inhibits cytokinesis
REFERENCE   7  (bases 1 to 8036)
  AUTHORS   Zhou,T., Zimmerman,W., Liu,X. and Erikson,R.L.
  TITLE     A mammalian NudC-like protein essential for dynein stability and
            cell viability
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 9039-9044 (2006)
   PUBMED   16754861
  REMARK    GeneRIF: Data characterize a previously undescribed mammalian
            NudC-like protein (NudCL), which appears to influence the
            stabilization of dynein intermediate chain
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN386226.1, AB028991.1,
            AW138459.1 and AC004453.1.
            
            On Nov 24, 2018 this sequence version replaced NM_015332.3.
            
            Summary: The product of this gene functions to maintain the
            stability of dynein intermediate chain. Depletion of this gene
            product results in aggregation and degradation of dynein
            intermediate chain, mislocalization of the dynein complex from
            kinetochores, spindle microtubules, and spindle poles, and loss of
            gamma-tubulin from spindle poles. The protein localizes to the
            Golgi apparatus during interphase, and levels of the protein
            increase after the G1/S transition. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.47962.1, AB028991.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355451.8/ ENSP00000347626.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                CN386226.1         129-206
            79-4693             AB028991.1         1-4615
            4694-4789           AW138459.1         16-111              c
            4790-8036           AC004453.1         119010-122256
FEATURES             Location/Qualifiers
     source          1..8036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..8036
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /note="NudC domain containing 3"
                     /db_xref="GeneID:23386"
                     /db_xref="HGNC:HGNC:22208"
                     /db_xref="MIM:610296"
     exon            1..250
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1144
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /note="NudC-like protein"
                     /codon_start=1
                     /product="nudC domain-containing protein 3"
                     /protein_id="NP_056147.2"
                     /db_xref="CCDS:CCDS5490.2"
                     /db_xref="GeneID:23386"
                     /db_xref="HGNC:HGNC:22208"
                     /db_xref="MIM:610296"
                     /translation="METGAAELYDQALLGILQHVGNVQDFLRVLFGFLYRKTDFYRLL
                     RHPSDRMGFPPGAAQALVLQVFKTFDHMARQDDEKRRQELEEKIRRKEEEEAKTVSAA
                     AAEKEPVPVPVQEIEIDSTTELDGHQEVEKVQPPGPVKEMAHGSQEAEAPGAVAGAAE
                     VPREPPILPRIQEQFQKNPDSYNGAVRENYTWSQDYTDLEVRVPVPKHVVKGKQVSVA
                     LSSSSIRVAMLEENGERVLMEGKLTHKINTESSLWSLEPGKCVLVNLSKVGEYWWNAI
                     LEGEEPIDIDKINKERSMATVDEEEQAVLDRLTFDYHQKLQGKPQSHELKVHEMLKKG
                     WDAEGSPFRGQRFDPAMFNISPGAVQF"
     exon            251..567
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /inference="alignment:Splign:2.1.0"
     exon            568..700
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /inference="alignment:Splign:2.1.0"
     exon            701..844
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1033
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..8036
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3545..3550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /note="hexamer: AATAAA"
     polyA_site      3564
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /note="major polyA site"
     regulatory      4762..4767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
                     /note="hexamer: ACTAAA"
     polyA_site      4789
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
     polyA_site      8036
                     /gene="NUDCD3"
                     /gene_synonym="NudCL"
ORIGIN      
        1 agtcggcagg tctgaggcgg cgctgtgtgt gtgaagcgta cctagggcgg gaggcgacat
       61 ggagacaggg gcggccgagc tgtatgacca ggcccttttg ggcatcctgc agcacgtggg
      121 caacgtccag gatttcctgc gcgttctctt tggcttcctc taccgcaaga cagacttcta
      181 tcgcttgctg cgccacccat cggaccgcat gggcttcccg cccggggccg cgcaggcctt
      241 ggtgctgcag gtattcaaaa cctttgacca catggcccgt caggatgatg agaagagaag
      301 gcaggaactt gaagagaaaa tcagaagaaa ggaagaggaa gaggccaaga ctgtgtcagc
      361 tgctgcagct gagaaggagc cagtcccagt tccagtccag gaaatagaga ttgactccac
      421 cacagaattg gatgggcatc aggaagtaga gaaagtgcag cctccaggcc ctgtgaagga
      481 aatggcccat ggttcacagg aggcagaagc tccaggagca gttgctggtg ctgctgaagt
      541 ccctagggaa ccaccaattc ttcccaggat tcaggagcag ttccagaaaa atcccgacag
      601 ttacaatggt gctgtccgag agaactacac ctggtcacag gactatactg acctggaggt
      661 cagggtgcca gtacccaagc acgtggtgaa gggaaagcag gtctcagtgg cccttagcag
      721 cagctccatt cgtgtggcca tgctggagga aaatggggag cgcgtcctca tggaagggaa
      781 gctcacccac aagatcaaca ctgagagttc tctctggagt ctcgagcccg ggaagtgcgt
      841 tttggtgaac ctgagcaagg tgggcgagta ttggtggaac gccatcctgg agggagaaga
      901 gcccatcgac attgacaaga tcaacaagga gcgctccatg gccaccgtgg atgaggagga
      961 acaggcggtg ttggacaggc ttacctttga ctaccaccag aagctgcagg gcaagccaca
     1021 gagccatgag ctgaaagtcc atgagatgct gaagaagggg tgggatgctg aaggttctcc
     1081 cttccgaggc cagcgattcg accctgccat gttcaacatc tccccggggg ctgtgcagtt
     1141 ttaatgacca gaaggaaagg aaaccctcgc cggtggggag gcagagcctt atcctcggct
     1201 gcccttcttg gctccctgca ttccagggac ttgctcgtct tgtttacccc tagccatcct
     1261 ttctttcaag ggtgaaccag gccttccacc ctgaccttgc atctccagac tgttccagag
     1321 aaggtgcggg gccagctgct atgtggtggc cgctgtggct gacactgagt gaaggtgttt
     1381 gaaatgcagg agaggatatc ccagcaaatt gggatcacat gcttttgtct ccacagcaac
     1441 cagccactgc aggcagcatg tctttcctcc cctgctctct gcttgctgtt gttttgacgc
     1501 tattctgctt gcatgtcttc tggttgggat gtggagttgt tgctggactc tcaggcgaag
     1561 ctgaagtcat tgaagtgtgt gaagctctgt gcttgcatga gggcaagcaa ggaatggctg
     1621 tgcctgaggc tgctctggga aactccttgc cccttgacct cttttgagag cattcacgtg
     1681 gtcttcttgc tcatcccctt ataaatgtgc tttgcctgcc tcagcctcat ggtcagagca
     1741 gtggagactg gagccctgtt tgcacgttct agttgttcgg agaaagccta ggttctgggc
     1801 tcaggtccag atgcagcggg gattctgttc tctgactgtg gcgaccttgc tttggttctt
     1861 gttgaagtga accaagcccg gccaccacgc atggcatgct gtgcttggct ccccataaga
     1921 cgtcctcttt gggtgcacgg tgtcaaagtg tgggcaggag tggagagctg gtgccctcag
     1981 gaggagacca cagcatgtcc atcagctcag cagagctcga cagccacaag tcctgagaag
     2041 ctttgacctt gaagggcttc tgggagagga ggaatttctg catggggcgt gaaggcacac
     2101 tgtcccacca caactgaacc agaagagagt gaagactccc ctcttcccat cctctgtgcc
     2161 aggtgccaga ctgtgctcct tggaacttat ggcccaatct tacctgttct ccagggactg
     2221 gtcactgcct caggaccccc aagcctatgc cctgagccat ggctgctgac tgactccagc
     2281 caaggtgcaa agacgagatt atgagacagg tcctcaggcc tgtgttccaa gtactcacag
     2341 gggctctggg tgcccatcgc cgggagtatg gttcagctgc caccggcact gtccatttgc
     2401 ctgtctgtca agctcagagc atggataagc cacacagcag ggcagtgcac cctggcacca
     2461 tgcacggcca gcaagaatca aggcccgcag atgctaagag ggcctattgt caggggaagg
     2521 tccccgctcc tgcacactct ctatggatac ttgggttgtg ggggctctct tggagagtaa
     2581 gtttgtggtt tgtttctggt ttacagtggt ggctgacacc ccttgtaaga aagcattcct
     2641 gggaagtctt ctgtgggtcc aaacatgttg ctccgatcat cacaggagag caaaaggccc
     2701 tagatacccc ctttggaatg tgagagtctt gttgtctgat atttgccact gagctggtga
     2761 agcccctcta aagagatctc gaccctgggg agcagaattc ttgtcatcta tgaggggtcc
     2821 tgagaaagac ttgtcatttt ttttcctgga gttcttccca ttgaggtcct aggatttgca
     2881 caccactgtc ccacaagagc tttcctgcct aatgaaagga ggtcttgtgg tgtgtgtctc
     2941 ctctcttctc tatagttccc gagttggccc ccattgcagc ccccaccctg tgggtagtct
     3001 tccagaagtg atgcagtggt gtgagatgcc ctacaccttg ttatttggga gactttgaga
     3061 gtcattcact tccatggtga ctagtgtttg ttttgcctga ttttatattc tgtgttgcat
     3121 ttctccccac tccctgccct gctttaataa acagcaaacc aatatctagg aagaatgact
     3181 gagggatagt attgggtatt ggccccatgg caggaacagc cacttgcatc tggtcccggt
     3241 gccacactgc ggtgcttggt gtggttgtgg agcctgtccc tgcgcgcctt gctcccgttg
     3301 agccacgctg tctggtgggt gattctctgc cctgagccac caccctggac tggcccagtc
     3361 tccagagctg gcacaccctg cctgttttct ctttttagac acaacagccg cagtttggcc
     3421 agccactaag tcccaccagc tgaggtccga ggaaagcggg gtgactcatt tcccttgtcc
     3481 agggcccgag gagagtgagg tgtccagcct gcaaagctat tccagctcct tggtgttggt
     3541 ttgcaataaa ttggtattta agcagttctg ggtctgcgtg tgacatttgc tgctgagaca
     3601 gttctgtctg tgcatggtca ttattgttgc attctagcct tgaggtccca ggccaacgta
     3661 cacagcaaac accagcatgg ggaattctta ggggttgttt cccatctggt ctgaatgcac
     3721 tgggcaagat ctcaatacag ctttagaaat cctgtaagat tttgaccagt ggggagaaaa
     3781 agaatgtagc tatagatctt acatcctttc aaacaggttc tggaattctg tagttactgg
     3841 aaagcttagg gtgagtgcag agttgggaat gattccactg aagggccacc tttgcccacc
     3901 aggctccaag gccctccttg gtctccaggt gcatacctgc tgttaacttt gctgagccct
     3961 cgcaatgggc ttcctccagg acataacgcc gtgtctgaca cagaagtctc ccaggtggct
     4021 ggccacctgc ttcttcctca gtcagatctt tgactctcct tctctgtgcc caccccatct
     4081 ccagcctcct ctgaccctgc tcacccctgg ggacaggacc taggggtgtg agaagtactt
     4141 ggctgaataa agactgtttc aaaggcaatc cttagaattg cctagcatac tcccagggcc
     4201 agaaataacc cgccagaaag gagaggcgta tttgcccctg aagagtgcag gagggagaac
     4261 agttgagaag tgttttgtgt ggaaatgtgt ccaagaggcg tcagctgctg cacagagaac
     4321 tcactgccca gaacactgcg cttggggaac agacctcacc cccacctcaa atctgctctc
     4381 cactgggcct gttggcagcc agctcagctg gggaagggac agcatgactc gctttgtcga
     4441 tgaaaagcac gaagttgtca gcacagaacc tggccagtcc ttgagaaact ccctccttgg
     4501 tggtcagagg tcaagcagcc catgtggccc acggtcctga agaactgggc tatgtccctg
     4561 aggctcctct ctaccgtctg actgtggggt ctggggaaca ggcatttaaa ccaggctgct
     4621 gccctgggga gtgcccactg gacgccaggg tgccccatag ggacagggtc acaaagccct
     4681 ggggcttccc ctgccagtcc tggtgaggac agtgtggtca ctatctcaga gagacgaaaa
     4741 atgaatattc tgtcatttca gactaaacta ctcacccagc tcacactaat atggatttgt
     4801 taattttacc tttttttttc tttccaactt taggttcaag ggttgttaca tgggtaaatt
     4861 ggatcatagg ggtttggtgt acagataatt ttgtcaccca ggtaatcagc atgatacctg
     4921 atatgtagtt tttcagtcct caccttcctc ccactcggtt ttatttttta gtactgaaag
     4981 tttaacagat tggtcttacc tcagagggag ggaagaaacc cccccatcgc tgggctcctt
     5041 ggtgtgacag gggtctggta ggggttttca atcccaccac ccattcctcc acaccaaatg
     5101 cctgaagtcc ccactttgca cagggagaca gcatcgtgcc agggaagaga ggtcaggccc
     5161 ggctacccct cacaacttcc tgcttccccc tcagagggtg atggggagac cagagcccat
     5221 ggcaggatga actgtcactg aacccagctg gcacaggtct gccagaacac tctgggggta
     5281 tgcgctgggc tttctgggta aacccctggc aagctggcgt ttgctgtctt ctcagtgctg
     5341 atggagatag gcacacatgg ggtgtgggaa tgtggccacc ctcaggcagg ttcacgaggg
     5401 tactgtcagg cgctcaggtg tatgccgcct cctgtcaggc agggctgagg ctattctccc
     5461 tggagaagga cagcttagga aacacttgca ggaaagctgc ctggacctgg gaggtgaccc
     5521 tggccagcct ccctgctgcc tctctcagtc ctaggccttc ttccccagag ctggtcaggg
     5581 cctgagggac tttgtagtct aacccctcat tgtgctacaa tcacaggagt aagtaacact
     5641 cccaaggcca tgtggctggt gactcggggg gcccaggtcc aggatcctgc cccatctgca
     5701 ggccagtggt tccttgtctc ctatttgctt cttggagcag cctcctcata agccaacagc
     5761 tccttcacct gagcccagtc actttgcgct cctccccaga accaaagagc aagaccatct
     5821 gccccaggta cagtcctggc catgccacac tctctgtggc atcatgacca aggtgagtgg
     5881 cagatactga aatcatccag ggccactgca ggccccattc ccagtggact gttcatcaag
     5941 ggaccctgtc tcaggccatc tcagccaacc ttgttgccca gcacaggtct ggcacattgg
     6001 agatgatctg tgttggatgg ggaaggcaga gggaggatcc tccagcattg atcacccatc
     6061 aaaaccctca acaacccaga cattgccgct gcactgaccc catgctatga ggaggtcact
     6121 caggctgtta ggagcctgct gactcaggca ttgggctggg gccctgcctg ccttgtctgc
     6181 ctgccagcgg agcactgccc caagcccttc ttactgcaga gacaggctct tgcctcccag
     6241 tgtgcacttt gtgcaagaca caggcaggta agggtctacc agaggacagg aagtgttgtt
     6301 ggggcactgt ggggtttgga ggaggcccct ctagcaggga aagcgagccc taacctctgc
     6361 tggactaggg agtttaggaa gctgctctgg ttcagggaac tggggatcca gataactggg
     6421 gatcaaggcc atcttgtgac cccagtggtg gtccctagtg ggactgctga gctccagcct
     6481 gagagttcat gaactcaaca gtgattgctt gtgggtacta atgacccagt gtgtggagac
     6541 ctcatttacc aggtgtgcct agcctgcagg caaatcccaa ggcagtgacc cttagggaag
     6601 agacagcgtt tggggtcatc aaaggctggg aaacccaggt acctgtcagg gaatgggcta
     6661 cagactggag ctaagcctta aggtggggaa gattccagca cccctgagtg accacctctt
     6721 ttggtaatgc aaagaaggga ttttgtgact ccagggtgac atttctaagc ttggcatcat
     6781 gcagggtggg cttgggctca atatgggtga ctgttagtct agggctgtct caatgaggct
     6841 gtccaggcag aaaggcttac acacctggca ggcagagggt ctagagagga aggggcaaca
     6901 ggcctaagga ggggacagcc aggcaaggag gtagaatagg ccttgtctgg acagtggtca
     6961 cctgttaggt ccacagcttg tcctccctgg cctgaccagc caggtgagga gagatccaaa
     7021 ccatccacct gaaagcattc agggtgcctg atgacaagac cccagccact gtgggctctc
     7081 atgtcctggt aggaaggtat acctaaagca ggtggacctg gtagtggtgg acgctgtctg
     7141 cctccccggg gcttgtctgt ttatgccaga ccgttttccc atttgcttcc acctccagct
     7201 cagagaggaa tcaccttcac acctctgcta aaactaaccc agctctgcac ccaccattcc
     7261 ccactgtgca acacctgcta ctggagaacc ctgccccctc aaatacacgt catcctcagg
     7321 gccctgcgat gtgctgtggt ctccctgcca ccattcaagg ggccacagcc aggtccagcc
     7381 tgtcttccct ggcaccaggc tctatgcagt gggggaaact cgggcacccc taaactattc
     7441 tccagtgttc tcaccagagg tggtcagcca tgtgatggca agagtcactt cttaagcttt
     7501 tgctatcccc agaaacttaa agcaacacca accacaccca aaagtcaagt gatatccaga
     7561 cagcaacagt agagcattaa ctgagtgcag ggccgtggtg actcctcgac actccaggct
     7621 ctcctgctgg taacctccca ttggcagagc caggcactca gcaaagccct ggacagtcag
     7681 cagcctcctg aacaggctct gctgtcccca ctcacgactt cagagcagct aggactcctg
     7741 tgaccacccc tgtcccctgt tcccccccac cccgccccgc cccgccaact gcctcatctc
     7801 tgtcccaaga taactgctct ccagaatttt ccatgatatg gtcattttaa aagttttttt
     7861 tttttttgag acagagtttt tcctgtgttg cccagactgg actcaaacct ctgggctcaa
     7921 gtgatcctcc tgcttcagcc tcccaagtag ctgggactgt aagtgtgcac cactgtgcct
     7981 ggcttgatgg tgtcattttt cactgtacgt gtatttgtaa accgtataaa tcagta
//
