LOCUS       NM_145266               7967 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens NudC domain containing 2 (NUDCD2), transcript variant
            1, mRNA.
ACCESSION   NM_145266
VERSION     NM_145266.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7967)
  AUTHORS   Xu,X., Huang,Y., Yang,F., Sun,X., Lin,R., Feng,J., Yang,M.,
            Shao,J., Liu,X., Zhou,T., Xie,S. and Yang,Y.
  TITLE     NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90
            at the midbody
  JOURNAL   Protein Cell 15 (10), 766-782 (2024)
   PUBMED   38801297
  REMARK    GeneRIF: NudCL2 is required for cytokinesis by stabilizing RCC2
            with Hsp90 at the midbody.
REFERENCE   2  (bases 1 to 7967)
  AUTHORS   Scheuerle,A.E., Ni,M., Ahmad,A.A., Timmons,C.F., Rakheja,D.,
            Gordon,E.E. and Boothe,M.
  TITLE     Biallelic variants in NUDCD2 associated with a multiple
            malformation syndrome with cholestasis and renal failure
  JOURNAL   Am J Med Genet A 191 (9), 2324-2328 (2023)
   PUBMED   37272762
  REMARK    GeneRIF: Biallelic variants in NUDCD2 associated with a multiple
            malformation syndrome with cholestasis and renal failure.
REFERENCE   3  (bases 1 to 7967)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7967)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7967)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 7967)
  AUTHORS   Chen,W., Wang,W., Sun,X., Xie,S., Xu,X., Liu,M., Yang,C., Li,M.,
            Zhang,W., Liu,W., Wang,L., Zhou,T. and Yang,Y.
  TITLE     NudCL2 regulates cell migration by stabilizing both myosin-9 and
            LIS1 with Hsp90
  JOURNAL   Cell Death Dis 11 (7), 534 (2020)
   PUBMED   32665550
  REMARK    GeneRIF: NudCL2 regulates cell migration by stabilizing both
            myosin-9 and LIS1 with Hsp90.
            Erratum:[Cell Death Dis. 2024 Dec 10;15(12):886. doi:
            10.1038/s41419-024-07256-7.. PMID: 39658555]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7967)
  AUTHORS   Li,M., Xu,X., Zhang,J., Liu,M., Wang,W., Gao,Y., Sun,Q., Zhang,J.,
            Lu,Y., Wang,F., Liu,W., Zhou,T. and Yang,Y.
  TITLE     NudC-like protein 2 restrains centriole amplification by
            stabilizing HERC2
  JOURNAL   Cell Death Dis 10 (9), 628 (2019)
   PUBMED   31427565
  REMARK    GeneRIF: NudC-like protein 2 restrains centriole amplification by
            stabilizing HERC2.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7967)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   9  (bases 1 to 7967)
  AUTHORS   Yang,Y., Yan,X., Cai,Y., Lu,Y., Si,J. and Zhou,T.
  TITLE     NudC-like protein 2 regulates the LIS1/dynein pathway by
            stabilizing LIS1 with Hsp90
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3499-3504 (2010)
   PUBMED   20133715
  REMARK    GeneRIF: NudCL2, a homolog of Aspergillus NudC, which shares
            significant homology with human NudC and NudCL was identified. It
            regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90
            chaperone.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA120610.1, BX538290.1 and AC112205.2.
            
            On Nov 22, 2018 this sequence version replaced NM_145266.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.160724.1,
                                           SRR1803615.186965.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302764.9/ ENSP00000304854.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               DA120610.1         54-525
            473-791             BX538290.1         509-827
            792-792             AC112205.2         23428-23428         c
            793-4761            BX538290.1         829-4797
            4762-4762           AC112205.2         19458-19458         c
            4763-5878           BX538290.1         4799-5914
            5879-5879           AC112205.2         18341-18341         c
            5880-6689           BX538290.1         5916-6725
            6690-6690           AC112205.2         17530-17530         c
            6691-7965           BX538290.1         6727-8001
            7966-7967           AC112205.2         16253-16254         c
FEATURES             Location/Qualifiers
     source          1..7967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..7967
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /note="NudC domain containing 2"
                     /db_xref="GeneID:134492"
                     /db_xref="HGNC:HGNC:30535"
                     /db_xref="MIM:620136"
     exon            1..241
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..526
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /note="isoform 1 is encoded by transcript variant 1; nudC
                     domain-containing protein 2; NudC-like protein 2"
                     /codon_start=1
                     /product="nudC domain-containing protein 2 isoform 1"
                     /protein_id="NP_660309.1"
                     /db_xref="CCDS:CCDS4361.1"
                     /db_xref="GeneID:134492"
                     /db_xref="HGNC:HGNC:30535"
                     /db_xref="MIM:620136"
                     /translation="MSAPFEERSGVVPCGTPWGQWYQTLEEVFIEVQVPPGTRAQDIQ
                     CGLQSRHVALSVGGREILKGKLFDSTIADEGTWTLEDRKMVRIVLTKTKRDAANCWTS
                     LLESEYAADPWVQDQMQRKLTLERFQKENPGFDFSGAEISGNYTKGGPDFSNLEK"
     exon            242..290
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..442
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..7967
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      896..901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /note="hexamer: AATAAA"
     polyA_site      917
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /note="major polyA site"
     regulatory      996..1001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /note="hexamer: CATAAA"
     polyA_site      1016
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
     regulatory      3637..3642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /note="hexamer: TATAAA"
     polyA_site      3654
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
     regulatory      6874..6879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /note="hexamer: ATTAAA"
     polyA_site      6900
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
     regulatory      7948..7953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
                     /note="hexamer: ATTAAA"
     polyA_site      7967
                     /gene="NUDCD2"
                     /gene_synonym="NudCL2"
ORIGIN      
        1 gcgcgtgcgc tcggctccgc ctggtgcggc cgcggccggg agggactgga ttatgtcggc
       61 cccgtttgag gagcggagtg gggtggtacc gtgcgggacc ccgtggggcc agtggtacca
      121 gaccttggag gaggtgttca ttgaagttca ggtgccgcca ggcacgcgcg cccaggatat
      181 ccagtgcggc ctccagagcc ggcatgtggc gctgtcggtg ggcggccgcg agatcctcaa
      241 gggcaaactc tttgattcta caatagctga tgagggaaca tggactttgg aggacagaaa
      301 aatggttcgt attgttctta caaagacaaa gagagatgca gcaaattgtt ggacttctct
      361 actagaatct gaatatgcag cggatccttg ggtgcaagac caaatgcaga gaaagcttac
      421 attagagaga ttccaaaaag aaaatcctgg ttttgacttc agtggagcag aaatctcagg
      481 aaactacact aaaggtggac cagatttctc aaaccttgag aaataactgc tttttttcct
      541 gcattctgtg gatcctagca gatattgcca acttaatcag ataaacagat tatgtaatgg
      601 aagaaaaatg cggatgccta cagttaacag attgcaaaat gtatcttaaa atggttctaa
      661 aaattgcatt caaacataat ttacatagga aatgtactgt gggaactatt ctatggatat
      721 atggtaaagt tgttttggac ttgtttttgc tcagcatgaa gttttatatg ctgcatttta
      781 ctaattccat atttaaccat atttttaata caaaagaaca ttagagtata gatcatgtga
      841 aatgaagggt gcctttgggg aaaattaact ttttcttttg ataagtatga tattcaataa
      901 aattttctaa ataggaattg tgtacccctt tgtctaagta taacaattca cacaaaatta
      961 tagtgctgaa aacaatttta ataaaggaaa aagtccataa atgtatttta agtaaattaa
     1021 gagttaatgt aaatttctta attagaatat tattacttga gggattactt tatgtcaaga
     1081 agtttaaaaa tagttaaaac cctaacaata gaagtggatt aacacaaaag agaagtgtga
     1141 tcatggtaat taggtgagtc ctttgtggca gaaagcaaag taaggtcact aattgtatat
     1201 cagtggcatc attttgattg taagtgattt aggcatatag gtaggaattg tctatagaca
     1261 ttttattcaa tatcctattt atgtcctttt tattttttgc cctttttaac tcttgaaaaa
     1321 attttaaatc tcatgcatag aaaagttaca gataattttt ttctttctga accatttgtg
     1381 atttagttga agacatgatt cctcattact gattactatc tgcttcaaat tatcttacat
     1441 gactacaatg caaccattag aatcaggaaa tttacgttga cacattacta ccctctaatc
     1501 ctcagatctt cacttcattc acattgaact gattgtccca ataatgtcca tatagcaaga
     1561 ggatccagtc agaatcatgc ctttcattta gatgtcagct gtctttagtt tacttcattc
     1621 tggaacaaat tctcatttgt ttccttttac aacttagtac ttttgacaat tatgggctag
     1681 ttttgtagaa caccccttat tttgagttct gtctgatact tcatgattag attgaggtta
     1741 ttcatctttg gcaggaatgt gatagaagtg catcctgtca ttgtttaata atttcagttt
     1801 gtctcatttc tgatggtgtt tcttagatga ctgattaagg tagtgtctgc cagacttctc
     1861 cactgtagtt atttttataa ttatttcttg agaagatagt tgcaaaatac taccttgttt
     1921 ctgatcagac tttaaattta tcgtatctct ataaactcat tattttctat tttattcagc
     1981 aggttaaaaa acctattatc attacattgg tgctcaaaat tattgtacat ttggctggta
     2041 gaagtccatt ctgggtggcc tctgtgtcct tctgacacat tcccatcatt attcaatgaa
     2101 tttgttactc tctggcataa gatataccag gcttctcatg ctgtcctcga cctaacccaa
     2161 gaatcagcca tttttccgta gagcctgggt tctctttagt gagtaatatt taaaagccaa
     2221 gatctgtgct agtgtgcaat tgccgttggt gtgtatatat aatgcatgtc tttacatcta
     2281 tatttctgca tctatgtata ttgaaaacca tgaattcaca tataaattct gatcccatgg
     2341 gcttcatttt cattttttcc ttctccacat ttataaccgt tttcagtacc agtgagaaac
     2401 ctgattccta tttgattatt tgtggggttt ttttttttta aggtggagtt tcactcttgt
     2461 tgcccagact ggagtgcagt cgcgcgatct cggcttactg caacctccgc ctcctgggtt
     2521 caagcgattc tcctgcctca gcctcccaag tagctgggat tacaggcatg cgctgccaca
     2581 cctggctaat ttttaatttt tggtagagac ggggtttctc catgttggtc aggctggtct
     2641 cgaactccgg acatcaggtg atccgcccgc ctgggcctcc caaattgctg ggattacagg
     2701 tgtgagccac tgcgcctggc ctgattctct attgtaggtc atctccccac atgaatgtct
     2761 tcctcaccct gcttaggctt cgcatcctat gctgagcagg aatgtcctcc tcatcctgcc
     2821 tggaccctaa tacctcactc caggccatgg cagtccattc accctgtgat tcctatcttg
     2881 ctcattttag gaatgaattg tcgggggaag aggctatttt tcttttaatt ttattctctt
     2941 tgacatttaa caaaattttt tgagtaaagt aaaattaact tttttggtgt atggtttggt
     3001 gaattttaag tatagatatg tgtaaacacc tccacagtca gagtattgaa gagttcaatc
     3061 accgtaaaaa ctctcgtgct ctctttgtac tctacacacc ctactcccag cccctaaacc
     3121 ttggaaacca ctgatctaat ccccatctcc atatttttgt cttcaagcat gttataaatg
     3181 ggatcatata taattaagaa aaacgcttta ttgtaacaac atacatttca cccatttaag
     3241 gtgtgtaatt cagtagcttt tagtatatac acagataaat gcaaccattc caataatcaa
     3301 ttttagaatg ttttcatcac ctcagataga aaccttgtat agtttagctt ttatccttct
     3361 cctgtcatcc cccgccatcc atactacctc ttttcatctc atagatttcc ttattctgga
     3421 catttcatgt acatggaatc ataatacgtg gtctttggtt actggcttcc ttcactttac
     3481 atgtcttaag aggttcatct atattcgagc atgtatcagc acattcatta gtatgtctga
     3541 aaatacttca ttgtatggct gtagcacttt gtttatacat ttgtaagttg gacattttgg
     3601 gtatttccac cctttggctg tcctgactaa agctgctata aacgtgtaca agtctttatg
     3661 tgcatatgtg ttttcatttc ttacctagga gtagaatttt taggttatat gataactatg
     3721 ttaatcattt gaggagctgt cattgtttcc caaagcagct acatcttttt actttcccac
     3781 cagcagtgta tgcaggttcc attttctctg catccttgcc aatacttgtt tacctgacat
     3841 tttgatttta gtcactctag tggatatgaa atgggatctc tatctagttt tggtttgcta
     3901 ttctctgata ctatgttgag cattctttct tgtgcttatt ggctatttgt gtatcttcct
     3961 taaagcagtg tttattcaaa ttatttaccc atttttttag ttgtcttatt gggtagtaag
     4021 agtctttata tattctgggt acaagtctct taccaggtat atgatttgta atttctccta
     4081 ttctctcttt actttgttga tagtgtcttt tgaagcacag acttaatttt gatgaagtct
     4141 tatccatcat gccattggtg gatcatgttt ttggtgtcat gtctaggaac cttaacccca
     4201 ggtcatgagg aatttttctt ttttcttttt ttgactcaca ttctcactct gtcacccagg
     4261 ctggggtgca gtggcacaat ctccactcac tgcaacctct gcctgctggg ttcaagtgat
     4321 tcttgtgctt cagtctccca agtagctggg actacaggtg tgcaccacca ctcccagccc
     4381 attttttttt tattttttat ttttagtaga gttgggattt caccatatag gctaggctgg
     4441 tcttgaactg acctcaacgg atctgcccgc ctcagcctct gaagtgctgg gattacaggc
     4501 atgagccacc gtgcccggcc tatggatttt tttcttctaa aaattttata aatttagttc
     4561 tacatttaga tccgtgatcc attttaggtt aatttttgta taagctgtga aatttaggta
     4621 ggtttatttt tttgcatatg gatgttcagt tgttttaaaa tcgtctgttg aaaaactctc
     4681 cattccccat tgagttgtct tttcaccttt gtcagaaatc aattgctatt tatgtgagtc
     4741 tggttttgga ctttattcca tcgatctatg tgtttatcct ttcataaata ccagattgcc
     4801 ttgattatca cagctttata gtaagtctta aaactgggca gcatgattcc ttcaaaattt
     4861 ttttgaaatc tttttcaaaa ttgttttggc taatttagtt tctttgcctt ccatatgaat
     4921 tttagaatta gctactctgt atctacaaaa aatcctactg gggttttgaa tgcaattttg
     4981 tgtcttccaa tccatgaaca tgaggtatct atttaggacc tctttcattt cagttatcag
     5041 cattttatgt catttttcag catatattcc acagtgttca ttttggagga actattgtta
     5101 agttgtatta tttttgaaac atgggtttcc aattgcacat cgctagtatg tacaaatgtg
     5161 tttgattttt gtttgttgac cttgtatcct gtgaccttgc taaacttcat tagttttggg
     5221 agttattttg ttgttaactc attaagtttt ctacataaac tacgaataga aacagtttta
     5281 ttttattctt tttagtctat gatttttctt gcctgatttt gttgttaact cattaagttt
     5341 tctacataaa ctacgaatag gaacagtttt attttattct ttttagtcta tgatttttct
     5401 tgcctgattg cagtggccag aacaataaca tggagaaagt ggccatctca gtcttgttct
     5461 ggatcttagg attttgaaag cattgttttt gaccattatg tatgcaagct gtaggctttt
     5521 cttaaattcc ctttgtcatg ttgagcaagt tcccatctat taatttgttg ttagcagagt
     5581 ttcatgagtg gatgctgaat tttctatgct ctttctgtat cagtttggtc attctttttg
     5641 tttagactgt taaaatcatg gattttactg attccagaat tttgaaacag cttatatttc
     5701 ctcccaaccc caaacttggt catggtacat tattcagctt atgtatctag atttttattt
     5761 tttgaggatt tttatgtctg tgttcatttt ggatattgtg caattgtttt tgtttgtttt
     5821 ttccttgtgt tatctttatc ttggtatggt atcatgttaa ttctggtctt gtaaaatgaa
     5881 ttgcaaagtg attattcttt ctggaagaga tttgtagaat ttgttatatc tttaaatgtt
     5941 ttatgaattt gctagtaagg ttttaaacaa tggttcaatt tttaaaaata gagaatttat
     6001 tgaggtttat ttaagtttgg gtactgtatg cctttcaagg aattggttca tctaatccta
     6061 tgtgcataga gttgttcatg gtattttctt tgtgtcgttc taatgaggat ctatactgtt
     6121 atcttttctt tgattcctaa gattggaatc aaagattgga attccttctc tttttttgtc
     6181 aattttgcca gaggtttatc aattttactg ctcttttcaa aaattagttt tttgattgtt
     6241 ttctattaat ttgtttacaa ttgcatttat tttctgcctc tttttttttt ttcttctttc
     6301 tgcttgcttt aggtttagtt tgggcttctt ttttttgtag acaggtctca cttcatcacc
     6361 cagactggag tagtgttatg atcatagctc actgcagcct caaactcgtg gggtcatgat
     6421 cctcctacct cagccttctg agtggctggg actatagtgg tgtgccacca cacccagtta
     6481 gattttccta ctttcttaaa gtgggagctt agagtgttaa tttgagaact ttttcttgtt
     6541 tagtaaaaag cagtcgattg ttataaattg cagcaccagc atggctgcat tccaagcacg
     6601 gtgatatttt catttatttt aaaatatttt ttaagacttc cctgtagtat catgagttat
     6661 ttagaaatgt gttgtttaat ttccaagtgt ttggagattt tcttgctgtt actgatttct
     6721 agattatggt caaaaaacat attttatatg atttcatctc ttttaaattt gttaaggttt
     6781 aagacccatg atgtggttta tcttggtgag tgttccatgt gtacttgaaa agaatgctta
     6841 ttctgctgtt ttaggtagaa gggttttatg tcaattaaat ctagctggtt attagtatta
     6901 ttccattttc ctacatcttt gctaattttc tattaattct atggactact gagagaggaa
     6961 tgtttaagtt tccaactgta aatgaagatt tgtccagtcc tccttttaat gctaccactt
     7021 tttgcttcat gttttttttt ttttttttga gtcttaccct gtcactcagg ctggagcata
     7081 gcaactctgt catgcttcac tgcagcctca aactcctggg ctcagacagt cttcccacct
     7141 caggctcctc agtacctagg actacagatg tatatcacta tgcctagcta atttttgatt
     7201 ttttgtagag atagggtctc cctatgttga gtaggctggt cttgaactct tggcctcaag
     7261 caatcctccc accttggctt cccaaagcat tggaattaca ggaatgaatg agtctctgta
     7321 cctggtctct tcatgtattt ttaagatctg ataataagtg cttacacttt tagcactgtc
     7381 ttggtgaatt ttatcattat ataatgtccc taattatcct tggcaatttt ggttgttcct
     7441 aactctactt tgatgaatat aaaaatggct ttttaattta ttttttgaga caagagcctc
     7501 actctgttgc ccaggttgga gagcagtggt gtgatcttgt ctcactgcct cacaggttca
     7561 agcaattctc ctgcctcagt ctctggagta actggtacta caggcatgcg ccaccacacc
     7621 cagctgattt ttgtattttt agtagagatg gggtttcacc atgttggcca tgctggtctc
     7681 gaactcctgg cctcaagtga tccgtccacc ttggcctccc aaagtgctgg gattacaggt
     7741 gtgagccact gcgctcggcc ttaaaaattg gcttatcttt taattcatct tgactcatgt
     7801 ttactgtttt ttggtttctg aaaaatagat ttaataaata ataacatttt atcaaagtta
     7861 ttagtataga gaaataaatt gagtgttgtt attattctat gatcatgatg acagcacaga
     7921 agttaatgtg gccagcatat agttttgatt aaaaattata caagcaa
//
