LOCUS       NM_032869               3919 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens NudC domain containing 1 (NUDCD1), transcript variant
            1, mRNA.
ACCESSION   NM_032869
VERSION     NM_032869.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3919)
  AUTHORS   Han,B., He,J., Chen,Q., Yuan,M., Zeng,X., Li,Y., Zeng,Y., He,M.,
            Feng,D. and Ma,D.
  TITLE     Identifying the role of NUDCD1 in human tumors from clinical and
            molecular mechanisms: a study based on comprehensive bioinformatics
            and experimental validation
  JOURNAL   Aging (Albany NY) 15 (12), 5611-5649 (2023)
   PUBMED   37338527
  REMARK    GeneRIF: Identifying the role of NUDCD1 in human tumors from
            clinical and molecular mechanisms: a study based on comprehensive
            bioinformatics and experimental validation.
REFERENCE   2  (bases 1 to 3919)
  AUTHORS   Feng,W.M., Gong,H., Wang,Y.C., Wang,Y., Xue,T., Zhang,T. and Cui,G.
  TITLE     NudCD1 as a prognostic marker in colorectal cancer and its role in
            the upregulation of cellular spindle assembly checkpoint genes and
            LIS1 pathways
  JOURNAL   BMC Cancer 22 (1), 981 (2022)
   PUBMED   36104662
  REMARK    GeneRIF: NudCD1 as a prognostic marker in colorectal cancer and its
            role in the upregulation of cellular spindle assembly checkpoint
            genes and LIS1 pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3919)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3919)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3919)
  AUTHORS   Liu,Y.P., Wei,W., He,Y., You,C.J. and Lei,C.J.
  TITLE     Analysis of NudCD1 and NF-kappaBeta in the early detection and
            course evaluation of renal cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (23), 12109-12115 (2020)
   PUBMED   33336728
  REMARK    GeneRIF: Analysis of NudCD1 and NF-kappaBeta in the early detection
            and course evaluation of renal cancer.
REFERENCE   6  (bases 1 to 3919)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   7  (bases 1 to 3919)
  AUTHORS   Wang,Q., Li,M., Wang,Y., Zhang,Y., Jin,S., Xie,G., Liu,Z., Wang,S.,
            Zhang,H., Shen,L. and Ge,H.
  TITLE     RNA interference targeting CML66, a novel tumor antigen, inhibits
            proliferation, invasion and metastasis of HeLa cells
  JOURNAL   Cancer Lett 269 (1), 127-138 (2008)
   PUBMED   18534745
  REMARK    GeneRIF: CML66 may play an oncogenic role in ways of favoring tumor
            cells proliferation, invasion and metastasis-associated with
            multiple pathways.
REFERENCE   8  (bases 1 to 3919)
  AUTHORS   Jin,S., Wang,Y., Zhang,Y., Zhang,H.Z., Wang,S.J., Tang,J.Q.,
            Chen,H.J. and Ge,H.L.
  TITLE     Humoral immune responses against tumor-associated antigen OVA66
            originally defined by serological analysis of recombinant cDNA
            expression libraries and its potentiality in cellular immunity
  JOURNAL   Cancer Sci 99 (8), 1670-1678 (2008)
   PUBMED   18754882
  REMARK    GeneRIF: study identified a novel gene, OVA66, which was expressed
            significantly higher in cancer patients than normal controls; IgG
            level against OVA66 was significantly elevated in the serum of
            cancer patients from different histological types of cancer [OVA66]
REFERENCE   9  (bases 1 to 3919)
  AUTHORS   Yan,Y., Phan,L., Yang,F., Talpaz,M., Yang,Y., Xiong,Z., Ng,B.,
            Timchenko,N.A., Wu,C.J., Ritz,J., Wang,H. and Yang,X.F.
  TITLE     A novel mechanism of alternative promoter and splicing regulates
            the epitope generation of tumor antigen CML66-L
  JOURNAL   J Immunol 172 (1), 651-660 (2004)
   PUBMED   14688378
  REMARK    GeneRIF: An alternative promoter (CML66-S short isoform) has been
            identified in combination with alternative splicing as a novel
            mechanism for regulation of the epitope generation of a self-tumor
            antigen.
REFERENCE   10 (bases 1 to 3919)
  AUTHORS   Yang,X.F., Wu,C.J., McLaughlin,S., Chillemi,A., Wang,K.S.,
            Canning,C., Alyea,E.P., Kantoff,P., Soiffer,R.J., Dranoff,G. and
            Ritz,J.
  TITLE     CML66, a broadly immunogenic tumor antigen, elicits a humoral
            immune response associated with remission of chronic myelogenous
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7492-7497 (2001)
   PUBMED   11416219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF283301.1, AK307663.1, AC021237.5 and BC043406.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032869.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.42673.1,
                                           SRR1803615.106059.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239690.9/ ENSP00000239690.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-832               AF283301.1         156-987
            833-1823            AK307663.1         768-1758
            1824-3525           AC021237.5         136900-138601
            3526-3919           BC043406.1         3528-3921
FEATURES             Location/Qualifiers
     source          1..3919
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..3919
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="NudC domain containing 1"
                     /db_xref="GeneID:84955"
                     /db_xref="HGNC:HGNC:24306"
                     /db_xref="MIM:606109"
     exon            1..195
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1829
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chronic myelogenous leukemia tumor antigen 66; nudC
                     domain-containing protein 1; tumor antigen CML66"
                     /codon_start=1
                     /product="nudC domain-containing protein 1 isoform 1"
                     /protein_id="NP_116258.2"
                     /db_xref="CCDS:CCDS6312.1"
                     /db_xref="GeneID:84955"
                     /db_xref="HGNC:HGNC:24306"
                     /db_xref="MIM:606109"
                     /translation="MEVAANCSLRVKRPLLDPRFEGYKLSLEPLPCYQLELDAAVAEV
                     KLRDDQYTLEHMHAFGMYNYLHCDSWYQDSVYYIDTLGRIMNLTVMLDTALGKPREVF
                     RLPTDLTACDNRLCASIHFSSSTWVTLSDGTGRLYVIGTGERGNSASEKWEIMFNEEL
                     GDPFIIIHSISLLNAEEHSIATLLLRIEKEELDMKGSGFYVSLEWVTISKKNQDNKKY
                     EIIKRDILRGKSVPHYAAIEPDGNGLMIVSYKSLTFVQAGQDLEENMDEDISEKIKEP
                     LYYWQQTEDDLTVTIRLPEDSTKEDIQIQFLPDHINIVLKDHQFLEGKLYSSIDHESS
                     TWIIKESNSLEISLIKKNEGLTWPELVIGDKQGELIRDSAQCAAIAERLMHLTSEELN
                     PNPDKEKPPCNAQELEECDIFFEESSSLCRFDGNTLKTTHVVNLGSNQYLFSVIVDPK
                     EMPCFCLRHDVDALLWQPHSSKQDDMWEHIATFNALGYVQASKRDKKFFACAPNYSYA
                     ALCECLRRVFIYRQPAPMSTVLYNRKEGRQVGQVAKQQVASLETNDPILGFQATNERL
                     FVLTTKNLFLIKVNTEN"
     exon            196..350
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     exon            351..536
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     exon            537..717
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     exon            718..900
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1105
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1250
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1376
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1536
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..3919
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="hexamer: AATAAA"
     polyA_site      2163
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="major polyA site"
     regulatory      3531..3536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="hexamer: AATAAA"
     polyA_site      3554
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
     regulatory      3892..3897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="hexamer: AATAAA"
     polyA_site      3919
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
ORIGIN      
        1 agtctctgtg cgaggcgtga agcgcggacc tttcaacaag ggctttatta attctcacgc
       61 tgcggccctg gaaagcgatg gaggtggcgg ctaattgctc cctacgggtg aagagacctc
      121 tgttggatcc ccgcttcgag ggttacaagc tctctcttga gccgctgcct tgttaccagc
      181 tggagcttga cgcagctgtg gcagaggtaa aacttcgaga tgatcaatat acactggaac
      241 acatgcatgc ttttggaatg tataattacc tgcactgtga ttcatggtat caagacagtg
      301 tctactatat tgataccctt ggaagaatta tgaatttaac agtaatgctg gacactgcct
      361 taggaaaacc acgagaggtg tttcgacttc ctacagattt gacagcatgt gacaaccgtc
      421 tttgtgcatc tatccatttc tcatcttcta cctgggttac cttgtcagat ggaactggaa
      481 gattgtatgt cattggaaca ggtgaacgtg gaaatagcgc ttctgaaaaa tgggagatta
      541 tgtttaatga agaacttggg gatcctttta ttataattca cagtatctca ctgctaaatg
      601 ctgaagaaca ttctatagct accctacttc ttcgaataga gaaagaggaa ttggatatga
      661 aaggaagtgg tttctatgtt tctctggagt gggtcactat cagtaagaaa aatcaagata
      721 ataaaaaata tgaaattatt aagcgtgata ttctccgtgg aaagtcagtg ccacattatg
      781 ctgctattga gcctgatgga aatggtctaa tgattgtatc ctacaagtct ttaacatttg
      841 ttcaggctgg tcaagatctt gaagaaaata tggatgaaga catatcagag aaaatcaaag
      901 aacctctgta ttactggcaa cagactgaag atgatttgac agtaaccata cggcttccag
      961 aagacagtac taaggaggac attcaaatac agtttttgcc tgatcacatc aacattgtac
     1021 tgaaggatca ccagttttta gaaggaaaac tctattcatc tattgatcat gaaagcagta
     1081 catggataat taaagagagt aatagcttgg agatttcctt gattaagaag aatgaaggac
     1141 tgacctggcc agagctagta attggagata aacaagggga acttataaga gattcagccc
     1201 agtgtgctgc aatagctgaa cgtttgatgc atttgacctc tgaagaactg aatccaaatc
     1261 cagataaaga aaaaccacct tgcaatgctc aagagttaga agaatgtgat attttctttg
     1321 aagagagctc cagtttatgc agatttgatg gcaatacatt aaaaactact catgtggtga
     1381 atcttggaag caaccagtac cttttctctg tcatagtgga tcctaaagaa atgccctgct
     1441 tctgtttgcg ccatgatgtt gatgccctac tctggcaacc acactccagc aaacaagatg
     1501 atatgtggga gcacatcgca actttcaatg ctttaggcta tgtccaagca tcaaagagag
     1561 acaaaaaatt ttttgcctgt gctccaaatt actcgtatgc agccctttgt gagtgccttc
     1621 gtcgagtatt catctatcgt cagcctgctc ccatgtccac tgtactttac aacagaaagg
     1681 aaggcaggca agtaggacag gttgctaagc agcaagtagc aagcctagaa accaatgatc
     1741 ctattttagg atttcaggca acaaatgaga gattatttgt tcttactacc aaaaacctct
     1801 ttttaataaa agtaaataca gagaattaat tattctaaca tattggcctc tttgtactgg
     1861 aaaagtattc agtggtacct ggaggtctgg acagttatac tgtaacctct taagttttaa
     1921 tgtgctaaat atatcttgta tgatttttta ttttttaata acattggaaa tatattcaag
     1981 agattatgat tctgtaaagc tgtggaatga agctgcagat ttagagaaca ttggcttctg
     2041 aaaaaaaaaa agagtgaaga tagtactagc aagtatactt attttttaaa acaggctaga
     2101 atctcatgtt ttatatgaaa gatgtacaat tcagtgttta aaaataaaaa tatttattgt
     2161 gtactctgtt cgttgattag ttgctacagg ctgtacctat aagatgtaca ggataatagt
     2221 taaatgttga gtattgtaca tatgtattta agtggattga ataactgagt ctacatggag
     2281 gaggaaatgc tagagaacag caggtctaat attttttaag tttactgaga gacctttatt
     2341 attattttca aattaagtat agctttatgt aacttttagc cagttgctct gccacagaca
     2401 tagacaaaga gagataagat ttcacattat ccatcactgc ataacaaacc acaccaaaac
     2461 tcagtggttt aaaacaagga cttttattat ttttcacgat tcagtgagtt ggctgtctct
     2521 gctgtacagg gcctctcagc ctccagtaga ctagacgaat cttctttcca tagtagagaa
     2581 aacatcttaa gagagcaagc tccaatatgc aagagcttat cgatcctgta catctatcat
     2641 atttactaat gttccattgg acaaagcaaa tcacatggcc aagtctagag tcagaatgag
     2701 gggactacac aagctgacag cggatggtat gactcattgg gggccattga tggaacaatc
     2761 ttaccacaca aggacaaatt ataatttatc cttgtggctc tctttatttt tctaacaact
     2821 tcaacaaaat aatcctgttt atatgttata gtttcttgcc acaaattttg ttttttcaaa
     2881 cttacctttc caggtttgtt ttagtatgta tgtacctgga aatttttatt actttttata
     2941 ccatttcaag atatgtatct tatataaacc tcaagttgga ttttatattt taataaggaa
     3001 gttaagacct tcatttaaga ggcagaagat taagataaga aatataagat agaaaagctt
     3061 tgttcctaac atatcttttg cctgtctggg caagtatttg actcaactaa attttaatga
     3121 acgaatgaat gacagagagg aggaaaaaag atgaggattg catacatgtt ctaaaccctt
     3181 tgtcagattg cagtttccta gagagtattg aggtgctagg tagaaagtta ggaaaggtcc
     3241 tgaggactgg tattgacaat tggagtccta atagtactct attcgtatta ggaaagagag
     3301 actagatacc aaacatcacg agatcataga gatggaaaac tgtatagtaa ccaaaaacca
     3361 aaacagtgat atttccagaa ctttttagta ttgttgtaaa acttcatgaa acaaaagacc
     3421 atttaaatag tgaattatta aaaatcttta tgatgggaaa gtagatctaa attttctcta
     3481 aaattttccc caaagataat atcctcttag ggaacataag aaaaatgtat aataaaaatg
     3541 tggtgcttaa ttaaccatga ctatgtatat attgccaatt ttagtaatca atattctttg
     3601 tgcatgtgat ttttttgcat gattaatgtt gaattgaaag ctctcaggat aattaatcct
     3661 aaatattgtc gcatgttgac ctacgttaaa agatgaatag gtctagagcc gtgatttcaa
     3721 gctattttcc tgaaatgctt cagggattcc ataaacattt aaacaatgtt ctaaggtaca
     3781 tatacttaga acattgagat atatactaca agtgctaaga atatagtacc ttgtattttt
     3841 gttgattttt atcatgtttt aaataggaat ttataaaata tttatgatag taataaagta
     3901 gtattttatg tgttttgca
//
