LOCUS       NM_006600               1792 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nuclear distribution C, dynein complex regulator
            (NUDC), mRNA.
ACCESSION   NM_006600
VERSION     NM_006600.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Biebl,M.M., Delhommel,F., Faust,O., Zak,K.M., Agam,G., Guo,X.,
            Muhlhofer,M., Dahiya,V., Hillebrand,D., Popowicz,G.M., Kampmann,M.,
            Lamb,D.C., Rosenzweig,R., Sattler,M. and Buchner,J.
  TITLE     NudC guides client transfer between the Hsp40/70 and Hsp90
            chaperone systems
  JOURNAL   Mol Cell 82 (3), 555-569 (2022)
   PUBMED   35063133
  REMARK    GeneRIF: NudC guides client transfer between the Hsp40/70 and Hsp90
            chaperone systems.
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Jeong,S.H., Park,M., Park,S.Y., Park,J., Kim,T.H., Lee,Y.J.,
            Jung,E.J., Ju,Y.T., Jeong,C.Y., Kim,J.Y., Ko,G.H., Kim,M., Nam,K.T.
            and Goldenring,J.R.
  TITLE     Transcriptome Analysis and the Prognostic Role of NUDC in Diffuse
            and Intestinal Gastric Cancer
  JOURNAL   Technol Cancer Res Treat 20, 15330338211019501 (2021)
   PUBMED   34060350
  REMARK    GeneRIF: Transcriptome Analysis and the Prognostic Role of NUDC in
            Diffuse and Intestinal Gastric Cancer.
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Islam,M.A., Choi,H.J., Dash,R., Sharif,S.R., Oktaviani,D.F.,
            Seog,D.H. and Moon,I.S.
  TITLE     N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1 in
            Dynein Motor Complex and Promotes Cell Migration
  JOURNAL   Int J Mol Sci 22 (1), 129 (2020)
   PUBMED   33374456
  REMARK    GeneRIF: N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1
            in Dynein Motor Complex and Promotes Cell Migration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   Zhou,T., Aumais,J.P., Liu,X., Yu-Lee,L.Y. and Erikson,R.L.
  TITLE     A role for Plk1 phosphorylation of NudC in cytokinesis
  JOURNAL   Dev Cell 5 (1), 127-138 (2003)
   PUBMED   12852857
  REMARK    GeneRIF: PLK1 phosphorylation of NudC plays an essential role in
            cytokinesis.
REFERENCE   6  (bases 1 to 1792)
  AUTHORS   Aumais,J.P., Williams,S.N., Luo,W., Nishino,M., Caldwell,K.A.,
            Caldwell,G.A., Lin,S.H. and Yu-Lee,L.Y.
  TITLE     Role for NudC, a dynein-associated nuclear movement protein, in
            mitosis and cytokinesis
  JOURNAL   J Cell Sci 116 (Pt 10), 1991-2003 (2003)
   PUBMED   12679384
  REMARK    GeneRIF: functions in mitosis and cytokinesis, in part by
            regulating microtubule organization at the midzone and midbody
REFERENCE   7  (bases 1 to 1792)
  AUTHORS   Aumais,J.P., Tunstead,J.R., McNeil,R.S., Schaar,B.T.,
            McConnell,S.K., Lin,S.H., Clark,G.D. and Yu-Lee,L.Y.
  TITLE     NudC associates with Lis1 and the dynein motor at the leading pole
            of neurons
  JOURNAL   J Neurosci 21 (24), RC187 (2001)
   PUBMED   11734602
REFERENCE   8  (bases 1 to 1792)
  AUTHORS   Matsumoto,N. and Ledbetter,D.H.
  TITLE     Molecular cloning and characterization of the human NUDC gene
  JOURNAL   Hum Genet 104 (6), 498-504 (1999)
   PUBMED   10453739
REFERENCE   9  (bases 1 to 1792)
  AUTHORS   Miller,B.A., Zhang,M.Y., Gocke,C.D., De Souza,C., Osmani,A.H.,
            Lynch,C., Davies,J., Bell,L. and Osmani,S.A.
  TITLE     A homolog of the fungal nuclear migration gene nudC is involved in
            normal and malignant human hematopoiesis
  JOURNAL   Exp Hematol 27 (4), 742-750 (1999)
   PUBMED   10210332
REFERENCE   10 (bases 1 to 1792)
  AUTHORS   Morris,S.M., Albrecht,U., Reiner,O., Eichele,G. and Yu-Lee,L.Y.
  TITLE     The lissencephaly gene product Lis1, a protein involved in neuronal
            migration, interacts with a nuclear movement protein, NudC
  JOURNAL   Curr Biol 8 (10), 603-606 (1998)
   PUBMED   9601647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007280.1 and AL356390.24.
            
            On Nov 23, 2018 this sequence version replaced NM_006600.3.
            
            Summary: This gene encodes a nuclear distribution protein that
            plays an essential role in mitosis and cytokinesis. The encoded
            protein is involved in spindle formation during mitosis and in
            microtubule organization during cytokinesis. Pseudogenes of this
            gene are found on chromosome 2. [provided by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1095184.1,
                                           SRR3476690.1146415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321265.10/ ENSP00000319664.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1317              BC007280.1         11-1327
            1318-1792           AL356390.24        87568-88042         c
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1792
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /note="nuclear distribution C, dynein complex regulator"
                     /db_xref="GeneID:10726"
                     /db_xref="HGNC:HGNC:8045"
                     /db_xref="MIM:610325"
     exon            1..187
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1102
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /note="nuclear distribution gene C homolog; nuclear
                     distribution C homolog; nuclear distribution protein C
                     homolog; nudC nuclear distribution protein"
                     /codon_start=1
                     /product="nuclear migration protein nudC"
                     /protein_id="NP_006591.1"
                     /db_xref="CCDS:CCDS292.1"
                     /db_xref="GeneID:10726"
                     /db_xref="HGNC:HGNC:8045"
                     /db_xref="MIM:610325"
                     /translation="MGGEQEEERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFI
                     GGEEGMAEKLITQTFSHHNQLAQKTRREKRARQEAERREKAERAARLAKEAKSETSGP
                     QIKELTDEEAERLQLEIDQKKDAENHEAQLKNGSLDSPGKQDTEEDEEEDEKDKGKLK
                     PNLGNGADLPNYRWTQTLSELDLAVPFCVNFRLKGKDMVVDIQRRHLRVGLKGQPAII
                     DGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWSRLVSSDPEINTKKINPENSKL
                     SDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKAKFN"
     exon            188..265
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     exon            266..469
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     exon            470..535
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     exon            536..652
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     exon            653..847
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     exon            848..931
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1050
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1792
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1297..1302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /note="hexamer: ATTAAA"
     polyA_site      1318
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /note="major polyA site"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
                     /note="hexamer: AATAAA"
     polyA_site      1775
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
     polyA_site      1792
                     /gene="NUDC"
                     /gene_synonym="HNUDC; MNUDC; NPD011"
ORIGIN      
        1 gcggaaggcg gacgactaga gtcgttgggc ccggcgcgac ccgcaggagc gtagagagcg
       61 cgggactaga gtgcagagct ccgggacgtg gatcggagcc ggcgcgatgg gcggagagca
      121 ggaggaggag cggttcgacg gcatgttgct ggccatggct cagcagcacg agggcggcgt
      181 gcaggagctt gtgaacacct tcttcagctt ccttcgacgc aaaacagact ttttcattgg
      241 aggagaagaa gggatggcag agaagcttat cacacagact ttcagccacc acaatcagct
      301 ggcacagaag acccggcggg agaagagagc ccggcaggag gccgagcggc gggagaaggc
      361 ggagcgggcg gccagactgg ccaaggaagc caagtcagag acctcagggc cccagatcaa
      421 ggagctaact gatgaagagg cagagaggct gcagctagag attgaccaga aaaaggatgc
      481 agagaatcat gaggcccagc tcaagaacgg cagccttgac tccccaggga agcaggatac
      541 tgaggaagat gaggaggaag atgagaagga caaaggaaaa ctgaagccca acctaggcaa
      601 cggggcagac ctgcccaatt accgctggac ccagaccctg tcggagctgg acctggcggt
      661 ccctttctgt gtgaacttcc ggctgaaagg gaaggacatg gtggtggaca tccagcggcg
      721 gcacctccgg gtggggctca aggggcagcc agcgatcatt gatggggagc tctacaatga
      781 agtgaaggtg gaggagagct cgtggctcat tgaggacggc aaggtggtga ctgtgcatct
      841 ggagaagatc aataagatgg agtggtggag ccgcttggtg tccagtgacc ctgagatcaa
      901 caccaagaag attaaccctg agaattccaa gctgtcagac ctggacagtg agactcgcag
      961 catggtggaa aagatgatgt atgaccagcg acagaagtcc atggggctgc caacttcaga
     1021 cgaacagaag aaacaggaga ttctgaagaa gttcatggat caacatccgg agatggattt
     1081 ttccaaggct aaattcaact agcccctgtt ttttcctccc tgaactcttg gggctgagct
     1141 gcaaccaccc aactttcttt cccactcttc tctgggactt gtgggcctca gggcttgggg
     1201 caggcatggg actggcccag gcacacaggt cccggggcat caggagaaag gctgggtctt
     1261 gggaccttgt cctccccagt tggcctactg ttacacatta aaacgatttg cccagctcct
     1321 tctgtgtcct ctcttgcctc tggcctttct ctggggcaca ggcctcttac ggctgctgct
     1381 gggaactggg agtttggctt ctagcccaga ttctgccatg tgacctaggg cacatccttg
     1441 cccctctctg ggcctcagtt tctcattact taaagattaa aacaaggctt ggccgggtgt
     1501 gatggttcat gtctgtaatc ccagcacttt gggaggctga ggggagcaga tcacctgatg
     1561 tcaggagttt gagaccagct tggccaacat ggagaaaccc agtctctact aaaaatacaa
     1621 aaattagccg ggtgtggtgg tgcacacctg taatcccagc tactcgggag gctgaggcag
     1681 gagaatcgct tgaacccggg tggcggaggt tgcagtgagc cgagattgca ctacttcact
     1741 ccagcatggg tgacagagac tccatctcaa aaaaataaat aaataaaaca ag
//
