LOCUS       NM_022731               6399 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens nuclear casein kinase and cyclin dependent kinase
            substrate 1 (NUCKS1), mRNA.
ACCESSION   NM_022731 XM_001724068 XM_001724822
VERSION     NM_022731.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6399)
  AUTHORS   Ji,R., Wang,Y., Pan,D., Han,J., Wang,Y., Zheng,S., Zhao,W., Li,X.,
            Han,C. and Zhang,L.
  TITLE     NUCB2 inhibition antagonizes osteosarcoma progression and promotes
            anti-tumor immunity through inactivating NUCKS1/CXCL8 axis
  JOURNAL   Cancer Lett 591, 216893 (2024)
   PUBMED   38636892
  REMARK    GeneRIF: NUCB2 inhibition antagonizes osteosarcoma progression and
            promotes anti-tumor immunity through inactivating NUCKS1/CXCL8
            axis.
REFERENCE   2  (bases 1 to 6399)
  AUTHORS   Li,B., Chen,B., Wang,X., Xiao,M., Zhang,K., Ye,W., Zhao,D.,
            Wang,X., Yu,Y., Li,J., Xu,X., Zhang,W. and Zhang,Y.
  TITLE     Roles of increased NUCKS1 expression in endometriosis
  JOURNAL   BMC Womens Health 23 (1), 432 (2023)
   PUBMED   37582772
  REMARK    GeneRIF: Roles of increased NUCKS1 expression in endometriosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6399)
  AUTHORS   Zhu,L.L., Shi,J.J., Guo,Y.D., Yang,C., Wang,R.L., Li,S.S.,
            Gan,D.X., Ma,P.X., Li,J.Q. and Su,H.C.
  TITLE     NUCKS1 promotes the progression of colorectal cancer via activating
            PI3K/AKT/mTOR signaling pathway
  JOURNAL   Neoplasma 70 (2), 272-286 (2023)
   PUBMED   37226932
  REMARK    GeneRIF: NUCKS1 promotes the progression of colorectal cancer via
            activating PI3K/AKT/mTOR signaling pathway.
REFERENCE   4  (bases 1 to 6399)
  AUTHORS   Li,L., Wei,D., Zhang,J., Deng,R., Tang,J. and Su,D.
  TITLE     miR-641 Inhibited Cell Proliferation and Induced Apoptosis by
            Targeting NUCKS1/PI3K/AKT Signaling Pathway in Breast Cancer
  JOURNAL   Comput Math Methods Med 2022, 5203839 (2022)
   PUBMED   35069784
  REMARK    GeneRIF: miR-641 Inhibited Cell Proliferation and Induced Apoptosis
            by Targeting NUCKS1/PI3K/AKT Signaling Pathway in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6399)
  AUTHORS   Yu,J., Zhang,H., Zhao,C., Li,G., Zhang,Y. and Sun,Y.
  TITLE     CircRNA circ_0008037 facilitates tumor growth and the Warburg
            effect via upregulating NUCKS1 by binding to miR-433-3p in
            non-small cell lung cancer
  JOURNAL   Thorac Cancer 13 (2), 162-172 (2022)
   PUBMED   34850570
  REMARK    GeneRIF: CircRNA circ_0008037 facilitates tumor growth and the
            Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in
            non-small cell lung cancer.
REFERENCE   6  (bases 1 to 6399)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 6399)
  AUTHORS   Grundt,K., Skjeldal,L., Anthonsen,H.W., Skauge,T., Huitfeldt,H.S.
            and Ostvold,A.C.
  TITLE     A putative DNA-binding domain in the NUCKS protein
  JOURNAL   Arch Biochem Biophys 407 (2), 168-175 (2002)
   PUBMED   12413487
REFERENCE   8  (bases 1 to 6399)
  AUTHORS   Thompson,H.G., Harris,J.W., Wold,B.J., Quake,S.R. and Brody,J.P.
  TITLE     Identification and confirmation of a module of coexpressed genes
  JOURNAL   Genome Res 12 (10), 1517-1522 (2002)
   PUBMED   12368243
REFERENCE   9  (bases 1 to 6399)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6399)
  AUTHORS   Ostvold,A.C., Norum,J.H., Mathiesen,S., Wanvik,B., Sefland,I. and
            Grundt,K.
  TITLE     Molecular cloning of a mammalian nuclear phosphoprotein NUCKS,
            which serves as a substrate for Cdk1 in vivo
  JOURNAL   Eur J Biochem 268 (8), 2430-2440 (2001)
   PUBMED   11298763
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ638451.1, BC000805.1,
            AB049824.1, AK025133.1, AC119673.3, AK095855.1 and AA760780.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022731.4.
            
            Summary: This gene encodes a nuclear protein that is highly
            conserved in vertebrates. The conserved regions of the protein
            contain several consensus phosphorylation sites for casein kinase
            II and cyclin-dependent kinases, two putative nuclear localization
            signals, and a basic DNA-binding domain. It is phosphorylated in
            vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq,
            Aug 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.769867.1,
                                           SRR3476690.1175122.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367142.5/ ENSP00000356110.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               BQ638451.1         95-625
            532-990             BC000805.1         515-973
            991-1098            AB049824.1         982-1089
            1099-1240           BC000805.1         1072-1213
            1241-1603           AK025133.1         1100-1462
            1604-2997           AC119673.3         43003-44396         c
            2998-4281           AK095855.1         95-1378
            4282-5985           AC119673.3         40015-41718         c
            5986-6399           AA760780.1         11-424              c
FEATURES             Location/Qualifiers
     source          1..6399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..6399
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="nuclear casein kinase and cyclin dependent kinase
                     substrate 1"
                     /db_xref="GeneID:64710"
                     /db_xref="HGNC:HGNC:29923"
                     /db_xref="MIM:611912"
     exon            1..226
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..941
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="nuclear ubiquitous casein kinase and
                     cyclin-dependent kinase substrate; potential LAG1
                     interactor; P1"
                     /codon_start=1
                     /product="nuclear ubiquitous casein and cyclin-dependent
                     kinase substrate 1"
                     /protein_id="NP_073568.2"
                     /db_xref="CCDS:CCDS30987.1"
                     /db_xref="GeneID:64710"
                     /db_xref="HGNC:HGNC:29923"
                     /db_xref="MIM:611912"
                     /translation="MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREA
                     KNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASK
                     QREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKS
                     KPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEK
                     KTSTSPPPEKSGDEGSEDEAPSGED"
     exon            227..276
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /inference="alignment:Splign:2.1.0"
     exon            277..382
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /inference="alignment:Splign:2.1.0"
     exon            383..438
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /inference="alignment:Splign:2.1.0"
     exon            439..591
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /inference="alignment:Splign:2.1.0"
     exon            592..741
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /inference="alignment:Splign:2.1.0"
     exon            742..6399
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1213..1218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="hexamer: AATGAA"
     polyA_site      1234
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="major polyA site"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="hexamer: AATAAA"
     polyA_site      1933
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="major polyA site"
     regulatory      6006..6011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="hexamer: TATAAA"
     polyA_site      6028
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
     regulatory      6139..6144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="hexamer: AATAAA"
     polyA_site      6161
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
     regulatory      6374..6379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
                     /note="hexamer: AATAAA"
     polyA_site      6399
                     /gene="NUCKS1"
                     /gene_synonym="JC7; NUCKS"
ORIGIN      
        1 atccattttg aagagacggg ggagcggggg gctcgtctgt tccaggagcc ctgaaccaaa
       61 gagcagcgga gtttgagaag ccagcagctc ggggttcggc agcagcggtc ccatcggctg
      121 aagttcgggg ggggtggggc gccgagcgcg cggggtgggg ggggtcctgg tctttggctt
      181 ctcgactcgg tcctgtttcg acagcgaaca tgtcgcggcc tgtcagaaat aggaaggttg
      241 ttgattactc acagtttcag gaatctgatg atgcagatga agattatgga agagattcgg
      301 gccctcccac taagaaaatt cgatcatctc cccgagaagc taaaaataag aggcgatctg
      361 gaaagaattc acaggaagat agtgaggact cagaagacaa agatgtgaag accaagaagg
      421 atgattctca ctcagcagag gatagtgaag atgaaaaaga agatcataaa aatgtgcgcc
      481 aacaacggca ggcggcatct aaagcagctt ctaaacagag agagatgctc atggaagatg
      541 tgggcagtga ggaagaacaa gaagaggagg atgaggcacc attccaggag aaagattccg
      601 gcagcgatga agatttccta atggaagatg atgacgatag tgactatggc agttcgaaaa
      661 agaaaaacaa aaagatggtt aagaagtcca aacctgaaag aaaagaaaag aaaatgccca
      721 aacccagact aaaggctaca gtgacgccaa gtccagtgaa aggcaaaggg aaagtgggtc
      781 gccccacagc ttcaaaggca tcaaaggaaa agactccttc tcccaaagaa gaagatgagg
      841 aaccggaaag cccgccagaa aagaaaacat ctacaagccc cccacccgag aaatctgggg
      901 atgaagggtc tgaagatgaa gccccttctg gggaggatta aaagtgatga tggtctgggg
      961 agagatttta ttaaaaaaaa aaagaaaaaa aaagaaaaaa gagggaggaa aaaaaagaac
     1021 ctacttaaga tagaacatgg ttttggctat ggcttgactc atgggctttc agtgcttttt
     1081 tccatttgtt gaaagtaaca tttctctctc tctctctttt tttttttttt tttttaaagc
     1141 aaaccattgt atgtgtaagt gtttaagtta cctttttgtc tattggtctc tttgccagcc
     1201 ctcccctttc ccaatgaaag ccatgtcaaa ttaatcactg gattgactgc ttcatctttt
     1261 tatttttaat gaaaggtgta ccacggttgt aaagcaataa gatttgagat gaacactatt
     1321 gaaacttcgc tttttgctaa aaaatagcaa gttgaatagt aatcaaaaaa catagaaaga
     1381 ttttagttca aaatgattgc tcctttctct acctggactt ttaaaaaatc aattgtcatc
     1441 taatatgagt ttatttgtct atagacacaa gtatcaatgt ctaaaaaaaa tcatgacttt
     1501 aaacttccac cgatgaggca ggtaggagat aaagatgaat tctgaactgt tactaaaagt
     1561 actcattttt taccttgtag ggagggtggg caatggggtt acctgacctt atttgagggt
     1621 atgggctttc ttttttattt catcacttgt tatctcaaag agactcggag ccagtgatcc
     1681 ttttatcctg ctacagtctt tagggagcta aaaaaaaaaa aaaagcaggg gctgccaaaa
     1741 ctcttgattt catatttcct tctctaaata tatatgtatc ctgttttttg gataaaattt
     1801 taccaagaat ccaaaaaaaa aaaaacccta gaatttaatc aacaagatca gtctacaggt
     1861 cacagtggat ttcttttcaa actgacaatg tttaggtttt aagcaaataa agttccagtt
     1921 aatgtgaaac tcagtcacaa agagttgaga tttttccttt atgaaataga attgacattc
     1981 ttttatgcta taaatgtgca ttcaggtccc attaaccatg ctctgctttt atttggggat
     2041 agaacatttt ctttttcata tcccgatctt cccatttctt catagaaatg tgataagaag
     2101 tacatccctg tgatcctgct gcttcgtaga gcaccactgc acaccctacc ccgagtgcca
     2161 accacctctg ctataggaca ctattttcct ggccctattc ttcacttact tcccatcctg
     2221 tccttgacta ggaatatgtt aaatgctgct cccatacaat tcagttagct cttgtctttt
     2281 tatttggtcc aacccctgct ttactgctca tgctgcttaa agcaggaggg actagagaaa
     2341 caaggcattt taggaggcct gtgtgcagtt gaaaaccgac ttttacacgc cttataaaag
     2401 cagtcaggag atagatccgt aggtttgatc cttcacatct aataccaggc gctaatggga
     2461 acaaggttta aagggtcctg gtatgctaat aaattgaaaa attagtgaaa tttaaacttc
     2521 tgcctttttt tcctgccttt taatctagat ttgcttcctc aatatcctac tttgtggttt
     2581 actaggaaca tgcttactct gatctttttt taaaaaacac acagtggcag agtcatttca
     2641 ctattgcact gtgtgttaaa gaatgaataa ggagttttca gttacatggc caaaaataca
     2701 ggacttgaac ataaatagca gttggatcat tctctttcat gacggttaaa ttcagaggtg
     2761 tgaactttgt aatgagggtg ttaaagatta atctatttgc ctaaatgggt ttgttcaggt
     2821 atccattttt aacaaagaag tttgtgttca tatagtaaaa gacctatcag tgtttccacc
     2881 atgcacttct attttttagg agtttataat tttaagtctt acattcctag taacatttgg
     2941 gcttttctta ggttatgttt cgtgaagatt tggggggagg gctcttttaa aacttcagcc
     3001 tcagttgttt aacagtctct ttaatatatt aatctgcact aacatctctg tgatatatgc
     3061 acatatttta gaggtaatca tgtcttctag attacttgtg tgcatttgat tgggcttctt
     3121 gtttagggtc ccttttaaaa ttaattcatt agattgaaaa atgtattcta tatttctgat
     3181 agactggaca gaaggatctg tgtccccaag tgagacaggc tctgaataac ctttgttttc
     3241 tccacttttt attgatgatt taaaacactc tagtcttccc ctcaaatcat gcatgcaaat
     3301 aggaggacag tggtggtgac tcaactggat acaggtgctc aatagtcagg cttgatagtg
     3361 atgtcaggac gcattacaag ctgtaagccg atactgactg gccattggca ccatccttga
     3421 ctaaccttcc tctttttctc tagtgtgcct atggtgaaat ggcaatagca ttcactgtcg
     3481 tattttgcag tgctcaggaa gtgggacgtt aactttgaag gtgcttgttt gtattagctc
     3541 tgctaggttt acctctacaa cgtagatttc agcagctatg ctgactgaca ctacattcta
     3601 gttcttaaga ttttttttcc agatcccccc ttccccagct agacatacgt agcatacttt
     3661 catcttattc agtctttctg taacctgctg ctgcttttag tcctcctcac ctcagatcgg
     3721 aatcaatgga gtgggcccag aggatacatt ttaattccag taatggtagg tagatttgtc
     3781 ctgctttcta aaacatctcc tcatttcata tttccactcc atattgattc cataagggaa
     3841 aattaatggg tgtttcctcc tttagggagg taatgcaaag agtgtggaca tcttctaatc
     3901 ttgaggaaca gtagttgatt tcccttgaag gagcttacat attgactgtt ttcacaataa
     3961 cctgtttgcc ccagttcaat cctcatttta atacttaatt tggtactggc tcaaatagca
     4021 ttttcttaca gataacaaat caagagtgaa atttgaggtt atactccagt aaagttttta
     4081 acacttgtga atatggtcag ctagactaaa cttgactctt ttttttaatg gcttttttat
     4141 ctgtgaacat tcagataagt ggattttcaa gtactggttg gggatgggaa tcgtgctttt
     4201 ctttaaactt cagtttacga gatgctttga gagcgttagg caaaagcaga aataaatatc
     4261 aggagcaacg gggaaagctt tataaaagat catggtggcc actgttgcag ctttgaagaa
     4321 tgagtgctgg cttgaacagt tctttgcctg catcattggt agctgcactg aaaggaaaaa
     4381 actttcacct taagaatttg aaaaggaaga aacctgggct ctggtcttca tggcatttag
     4441 actgagatgc ttaaacagaa cagaagtaat acgcatttcc tgccatagga tagggaaaat
     4501 gtaacaagct ggttgctctt gaggttagaa aattgtctgt ttctctgtgg atgaagctgg
     4561 atttacttga aaatggagag ttggcttatt gtttgaatat tgggacatca agctatctat
     4621 agccaagttt cagtcgcaac cagttttccc tttgtctggg gtaaattcga tacaaaatga
     4681 ttctttttga atcctgaatc cataaattac actttttttt ttcaaattca caaaattcac
     4741 agtggtgctg actgtgtaat aaccactatt gggaaacatc ccgtaaacct gcctgttgcc
     4801 atgccaatgg agtgactgaa ctggtgacat ctgtttgagc atgctttgtg tggctggtag
     4861 aatgccaccg ttgtgcatac actttgtaca tcaggggtga agggagggtt ttctagatta
     4921 ttgggggagg gtaaaattgg gatttttttg ttgttccttt tttgatgggg tgtgggggta
     4981 tagtactcag cttatgccct aaaataacat gtataaaaac ccctgaagta ttgtgtgggt
     5041 gtgtacgtgt gagtgtgtgt ttgtatacat ctggcaatta aagctttgtc ttctggaact
     5101 tagtgaattc ttttctcttt ttcctccaga agtatttgtt acaagatttg taaataagag
     5161 ctctacttag tttgtttacc atgaacatgt tgcagcaaac cttatgcatc taattcctac
     5221 aaggttaaag aaaggctttt agacttgcca ggttaagcaa cagccaagtt ctcagtaatt
     5281 gtttgccttg atttatcttt tagacttcat tttgccagct ctaaaactcc cagtcttcct
     5341 tgattttagt ccttaatctt ttatgttctg agcaggaagg gtaaaagaca ggaacctgct
     5401 tcactgtatt aactagtcca tgggctgaga ccggggcatc tcttttcttc atactgcaat
     5461 gttgctagat acatgatcag acaccagagg gttgggcatt cttgcaatac cttaacagtg
     5521 ctgaaatctg cagcatggta ctaaggaagt taaagtttga atgtaaccac tttatttaaa
     5581 aggttttttt ctttaattta aatgaaatgg ggttgaagtg aacatgattt tgttgaccat
     5641 gttcgtgaat tacagatgca acatgcattg gtagaatcgt gtgatggtct tttgtgatac
     5701 ttaattttta catatcccag tctctgtatg tatctgcata gacaaagaaa aaacaaactc
     5761 ctgctttgct tttattgaag ggtttccagg actgcgtgtc tgctcctgag ctctgtttta
     5821 agtatgtgta tcctttgctt gtattttgta ttaaaaaaat aagaaaaaga agcctttatt
     5881 gttgagcatg ttggcattgt cccctttatt tttttctctt tttgggacat atgaagcaag
     5941 ttattctttt tctgtatctt tttttctttt gtaaactttt tttttgtttt gtttaaaaat
     6001 ggctttataa aagggctttt ataacccaga tgtgtgctct gtgtacttct tgtaatacct
     6061 taaagcaaac acactaactt acacagcttt gttaatcagc tcccagttca gcctgacttt
     6121 gtgggaactt atttccctaa taaattattt agaaacttta acagtgacca tccctgttgt
     6181 tggtaaaaga taaacatgtc ttggttcaaa agttaatacc tcaggatgga atcaagaagc
     6241 agtagactta ccagtttgat taattaaggg agcactggac tgggtgcgta aggattctta
     6301 attagcattt tttctcatgt ttacatccaa ggttatgaag tgttgtggaa agcaaagttt
     6361 aacaatcata tataataaaa gataatgttt atactcaca
//
