LOCUS       NM_006184               2406 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleobindin 1 (NUCB1), mRNA.
ACCESSION   NM_006184
VERSION     NM_006184.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2406)
  AUTHORS   Zhang,Y., Zhang,G., Zhong,J., Li,A., Wu,Y. and Guo,Z.
  TITLE     Expression and correlation of COX-2 and NUCB1 in colorectal
            adenocarcinoma
  JOURNAL   PeerJ 11, e15774 (2023)
   PUBMED   37547718
  REMARK    GeneRIF: Expression and correlation of COX-2 and NUCB1 in
            colorectal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2406)
  AUTHORS   Vignesh,R., Sjolander,A., Venkatraman,G., Rayala,S.K. and
            Aradhyam,G.K.
  TITLE     Aberrant environment and PS-binding to calnuc C-terminal tail
            drives exosomal packaging and its metastatic ability
  JOURNAL   Biochem J 478 (12), 2265-2283 (2021)
   PUBMED   34047336
  REMARK    GeneRIF: Aberrant environment and PS-binding to calnuc C-terminal
            tail drives exosomal packaging and its metastatic ability.
REFERENCE   3  (bases 1 to 2406)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2406)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2406)
  AUTHORS   Aradhyam,G.K., Balivada,L.M., Kanuru,M., Vadivel,P. and Vidhya,B.S.
  TITLE     Calnuc: Emerging roles in calcium signaling and human diseases
  JOURNAL   IUBMB Life 62 (6), 436-446 (2010)
   PUBMED   20503436
  REMARK    Review article
REFERENCE   6  (bases 1 to 2406)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
REFERENCE   7  (bases 1 to 2406)
  AUTHORS   Miura,K., Hirai,M., Kanai,Y. and Kurosawa,Y.
  TITLE     Organization of the human gene for nucleobindin (NUC) and its
            chromosomal assignment to 19q13.2-q13.4
  JOURNAL   Genomics 34 (2), 181-186 (1996)
   PUBMED   8661046
REFERENCE   8  (bases 1 to 2406)
  AUTHORS   Mochizuki,N., Hibi,M., Kanai,Y. and Insel,P.A.
  TITLE     Interaction of the protein nucleobindin with G alpha i2, as
            revealed by the yeast two-hybrid system
  JOURNAL   FEBS Lett 373 (2), 155-158 (1995)
   PUBMED   7589456
REFERENCE   9  (bases 1 to 2406)
  AUTHORS   Miura,K., Kurosawa,Y. and Kanai,Y.
  TITLE     Calcium-binding activity of nucleobindin mediated by an EF hand
            moiety
  JOURNAL   Biochem Biophys Res Commun 199 (3), 1388-1393 (1994)
   PUBMED   8147883
REFERENCE   10 (bases 1 to 2406)
  AUTHORS   Miura,K., Titani,K., Kurosawa,Y. and Kanai,Y.
  TITLE     Molecular cloning of nucleobindin, a novel DNA-binding protein that
            contains both a signal peptide and a leucine zipper structure
  JOURNAL   Biochem Biophys Res Commun 187 (1), 375-380 (1992)
   PUBMED   1520323
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315422.1, AC026803.7 and
            AI208532.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006184.5.
            
            Summary: This gene encodes a member of a small calcium-binding
            EF-hand protein family. The encoded protein is thought to have a
            key role in Golgi calcium homeostasis and Ca(2+)-regulated signal
            transduction events. [provided by RefSeq, Jun 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315422.1, SRR1803612.40534.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405315.9/ ENSP00000385923.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1458              AK315422.1         1-1458
            1459-2100           AC026803.7         159759-160400
            2101-2317           AI208532.1         7-223               c
            2318-2406           AC026803.7         160618-160706
FEATURES             Location/Qualifiers
     source          1..2406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2406
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /note="nucleobindin 1"
                     /db_xref="GeneID:4924"
                     /db_xref="HGNC:HGNC:8043"
                     /db_xref="MIM:601323"
     exon            1..61
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            62..207
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1458
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /codon_start=1
                     /product="nucleobindin-1 precursor"
                     /protein_id="NP_006175.2"
                     /db_xref="CCDS:CCDS12740.1"
                     /db_xref="GeneID:4924"
                     /db_xref="HGNC:HGNC:8043"
                     /db_xref="MIM:601323"
                     /translation="MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATES
                     PDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDE
                     LKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQT
                     ATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPK
                     VNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKV
                     YDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWE
                     TVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQA
                     VLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLE
                     RLPEVEVPQHL"
     exon            208..315
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            316..448
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            449..552
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            553..738
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            739..829
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            830..888
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            889..981
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1074
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1245
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1351
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..2406
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /note="hexamer: AATACA"
     polyA_site      2305
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /note="major polyA site"
     polyA_site      2364
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
     polyA_site      2406
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
ORIGIN      
        1 accaagaacg caccggaggt ccttgcccgc cctggaaaac gccctctgcg gtgaaggaga
       61 gaccacactg ccatgcctcc ctctgggccc cgaggaaccc tccttctgtt gccgctgctg
      121 ctgctgctcc tgcttcgcgc cgtgctggct gtccccctgg agcgaggggc gcccaacaag
      181 gaggagaccc ctgcgactga gagtcccgac acaggcctgt actaccaccg gtacctccag
      241 gaggtcatcg atgtactgga gacggatggg catttccgag agaagctgca ggctgccaat
      301 gcggaggaca tcaagagcgg gaagctgagc cgagagctgg actttgtcag ccaccacgtc
      361 cgcaccaagc tggatgagct caagcgacag gaggtgtcac ggctgcggat gctgctcaag
      421 gccaagatgg acgccgagca ggatcccaat gtacaggtgg atcatctgaa tctcctgaaa
      481 cagtttgaac acctggaccc tcagaaccag catacattcg aggcccgcga cctggagctg
      541 ctgatccaga cggccacccg ggaccttgcc cagtacgacg cagcccatca tgaagagttc
      601 aagcgctacg agatgcttaa ggaacacgag agacggcgtt atctggagtc actgggagag
      661 gagcagagaa aggaggcgga gaggaagctg gaagagcaac agcgccggca ccgcgagcac
      721 cctaaagtca acgtgcctgg cagccaagcc cagttgaagg aggtgtggga ggagctggat
      781 ggactggacc ccaacaggtt taaccccaag accttcttca tactgcatga tatcaacagt
      841 gatggtgtcc tggatgagca ggagctggag gcactcttca ccaaggagct ggagaaagtg
      901 tacgacccaa agaatgagga ggacgacatg cgggagatgg aggaggagcg actgcgcatg
      961 cgggagcatg tgatgaagaa tgtggacacc aaccaggacc gcctcgtgac cctggaggag
     1021 ttcctcgcat ccactcagag gaaggagttt ggggacaccg gggagggctg ggagacagtg
     1081 gagatgcacc ctgcctacac cgaggaagag ctgaggcgct ttgaagagga gctggctgcc
     1141 cgggaggcag agctgaatgc caaggcccag cgcctcagcc aggagacaga ggctctaggg
     1201 cggtcccagg gccgcctgga ggcccagaag agagagctgc agcaggctgt gctgcacatg
     1261 gagcagcgga agcagcagca gcagcagcag caaggccaca aggccccggc tgcccaccct
     1321 gaggggcagc tcaagttcca cccagacaca gacgatgtac ctgtcccagc tccagccggt
     1381 gaccagaagg aggtggacac ttcagaaaag aaacttctcg agcggctccc tgaggttgag
     1441 gtgccccagc atctgtgatc ctccgggacc ccagccctca ggattcctga tgctccaagg
     1501 cgactgatgg gcgctggatg aagtggcaca gtcagcttcc ctgggggctg gtgtcatgtt
     1561 gggctcctgg ggcgggggca cggcctggca tttcacgcat tgctgccacc ccaggtccac
     1621 ctgtctccac tttcacagcc tccaagtctg tggctcttcc cttctgtcct ccgaggggct
     1681 tgccttctct cgtgtccagt gaggtgctca gtgatcggct taacttagag aagcccgccc
     1741 cctccccttc tccgtctgtc ccaagagggt ctgctctgag cctgcgttcc taggtggctc
     1801 ggcctcagct gcctgggttg tggccgccct agcatcctgt atgcccacag ctactggaat
     1861 ccccgctgct gctccgggcc aagcttctgg ttgattaatg agggcatggg gtggtccctc
     1921 aagaccttcc cctacctttt gtggaaccag tgatgcctca aagacagtgt cccctccaca
     1981 gctgggtgcc aggggcaggg gatcctcagt atagccggtg aaccctgata ccaggagcct
     2041 gggcctccct gaacccctgg cttccagcca tctcatcgcc agcctcctcc tggacctctt
     2101 ggcccccagc cccttcccca cacagcccca gaagggtccc agagctgacc ccactccagg
     2161 acctaggccc agcccctcag cctcatctgg agcccctgaa gaccagtccc acccaccttt
     2221 ctggcctcat ctgacactgc tccgcatcct gctgtgtgtc ctgttccatg ttccggttcc
     2281 atccaaatac actttctgga acaaatgcat ggctccatgc ctgtgtatct ggactggtcc
     2341 ctccaaaacg ctattgccac gtcacctgcc ggagtcctca tctttgaaga ctggattcaa
     2401 gcatca
//
