LOCUS       NP_006175                461 aa            linear   PRI 27-APR-2025
DEFINITION  nucleobindin-1 precursor [Homo sapiens].
ACCESSION   NP_006175
VERSION     NP_006175.2
DBSOURCE    REFSEQ: accession NM_006184.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 461)
  AUTHORS   Zhang,Y., Zhang,G., Zhong,J., Li,A., Wu,Y. and Guo,Z.
  TITLE     Expression and correlation of COX-2 and NUCB1 in colorectal
            adenocarcinoma
  JOURNAL   PeerJ 11, e15774 (2023)
   PUBMED   37547718
  REMARK    GeneRIF: Expression and correlation of COX-2 and NUCB1 in
            colorectal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 461)
  AUTHORS   Vignesh,R., Sjolander,A., Venkatraman,G., Rayala,S.K. and
            Aradhyam,G.K.
  TITLE     Aberrant environment and PS-binding to calnuc C-terminal tail
            drives exosomal packaging and its metastatic ability
  JOURNAL   Biochem J 478 (12), 2265-2283 (2021)
   PUBMED   34047336
  REMARK    GeneRIF: Aberrant environment and PS-binding to calnuc C-terminal
            tail drives exosomal packaging and its metastatic ability.
REFERENCE   3  (residues 1 to 461)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 461)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (residues 1 to 461)
  AUTHORS   Aradhyam,G.K., Balivada,L.M., Kanuru,M., Vadivel,P. and Vidhya,B.S.
  TITLE     Calnuc: Emerging roles in calcium signaling and human diseases
  JOURNAL   IUBMB Life 62 (6), 436-446 (2010)
   PUBMED   20503436
  REMARK    Review article
REFERENCE   6  (residues 1 to 461)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
REFERENCE   7  (residues 1 to 461)
  AUTHORS   Miura,K., Hirai,M., Kanai,Y. and Kurosawa,Y.
  TITLE     Organization of the human gene for nucleobindin (NUC) and its
            chromosomal assignment to 19q13.2-q13.4
  JOURNAL   Genomics 34 (2), 181-186 (1996)
   PUBMED   8661046
REFERENCE   8  (residues 1 to 461)
  AUTHORS   Mochizuki,N., Hibi,M., Kanai,Y. and Insel,P.A.
  TITLE     Interaction of the protein nucleobindin with G alpha i2, as
            revealed by the yeast two-hybrid system
  JOURNAL   FEBS Lett 373 (2), 155-158 (1995)
   PUBMED   7589456
REFERENCE   9  (residues 1 to 461)
  AUTHORS   Miura,K., Kurosawa,Y. and Kanai,Y.
  TITLE     Calcium-binding activity of nucleobindin mediated by an EF hand
            moiety
  JOURNAL   Biochem Biophys Res Commun 199 (3), 1388-1393 (1994)
   PUBMED   8147883
REFERENCE   10 (residues 1 to 461)
  AUTHORS   Miura,K., Titani,K., Kurosawa,Y. and Kanai,Y.
  TITLE     Molecular cloning of nucleobindin, a novel DNA-binding protein that
            contains both a signal peptide and a leucine zipper structure
  JOURNAL   Biochem Biophys Res Commun 187 (1), 375-380 (1992)
   PUBMED   1520323
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315422.1, AC026803.7 and
            AI208532.1.
            
            On Apr 8, 2002 this sequence version replaced NP_006175.1.
            
            Summary: This gene encodes a member of a small calcium-binding
            EF-hand protein family. The encoded protein is thought to have a
            key role in Golgi calcium homeostasis and Ca(2+)-regulated signal
            transduction events. [provided by RefSeq, Jun 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315422.1, SRR1803612.40534.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405315.9/ ENSP00000385923.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     Protein         1..461
                     /product="nucleobindin-1 precursor"
                     /calculated_mol_wt=51146
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2752
     Region          42..51
                     /region_name="O-glycosylated at one site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02818.4)"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by FAM20C.
                     /evidence=ECO:0000269|PubMed:26091039; propagated from
                     UniProtKB/Swiss-Prot (Q02818.4)"
     Site            148
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by FAM20C.
                     /evidence=ECO:0000269|PubMed:26091039,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q02818.4)"
     Region          193..221
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02818.4)"
     Region          228..321
                     /region_name="Binds to GNAI2 and GNAI3.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02818.4)"
     Region          246..319
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          303..333
                     /region_name="GBA. /evidence=ECO:0000269|PubMed:30194280"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02818.4)"
     Region          368..461
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02818.4)"
     Site            369
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by FAM20C.
                     /evidence=ECO:0000269|PubMed:26091039; propagated from
                     UniProtKB/Swiss-Prot (Q02818.4)"
     CDS             1..461
                     /gene="NUCB1"
                     /gene_synonym="CALNUC; NUC"
                     /coded_by="NM_006184.6:73..1458"
                     /db_xref="CCDS:CCDS12740.1"
                     /db_xref="GeneID:4924"
                     /db_xref="HGNC:HGNC:8043"
                     /db_xref="MIM:601323"
ORIGIN      
        1 mppsgprgtl lllpllllll lravlavple rgapnkeetp atespdtgly yhrylqevid
       61 vletdghfre klqaanaedi ksgklsreld fvshhvrtkl delkrqevsr lrmllkakmd
      121 aeqdpnvqvd hlnllkqfeh ldpqnqhtfe ardlelliqt atrdlaqyda ahheefkrye
      181 mlkeherrry leslgeeqrk eaerkleeqq rrhrehpkvn vpgsqaqlke vweeldgldp
      241 nrfnpktffi lhdinsdgvl deqelealft kelekvydpk needdmreme eerlrmrehv
      301 mknvdtnqdr lvtleeflas tqrkefgdtg egwetvemhp ayteeelrrf eeelaareae
      361 lnakaqrlsq etealgrsqg rleaqkrelq qavlhmeqrk qqqqqqqghk apaahpegql
      421 kfhpdtddvp vpapagdqke vdtsekklle rlpevevpqh l
//
