LOCUS       NM_001323596            1128 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens NUBP iron-sulfur cluster assembly factor 1, cytosolic
            (NUBP1), transcript variant 5, mRNA.
ACCESSION   NM_001323596
VERSION     NM_001323596.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1128)
  AUTHORS   Bargagna,B., Matteucci,S., Ciofi-Baffoni,S., Camponeschi,F. and
            Banci,L.
  TITLE     Unraveling the mechanism of [4Fe-4S] cluster assembly on the
            N-terminal cluster binding site of NUBP1
  JOURNAL   Protein Sci 32 (5), e4625 (2023)
   PUBMED   36916754
  REMARK    GeneRIF: Unraveling the mechanism of [4Fe-4S] cluster assembly on
            the N-terminal cluster binding site of NUBP1.
REFERENCE   2  (bases 1 to 1128)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1128)
  AUTHORS   Camponeschi,F., Prusty,N.R., Heider,S.A.E., Ciofi-Baffoni,S. and
            Banci,L.
  TITLE     GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic
            Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to
            NUBP1
  JOURNAL   J Am Chem Soc 142 (24), 10794-10805 (2020)
   PUBMED   32429669
  REMARK    GeneRIF: GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the
            Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S]
            Clusters to NUBP1.
REFERENCE   4  (bases 1 to 1128)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., He,X., Chanock,S. and Lan,Q.
  TITLE     PTEN identified as important risk factor of chronic obstructive
            pulmonary disease
  JOURNAL   Respir Med 103 (12), 1866-1870 (2009)
   PUBMED   19625176
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1128)
  AUTHORS   Shen,M., Vermeulen,R., Rajaraman,P., Menashe,I., He,X.,
            Chapman,R.S., Yeager,M., Thomas,G., Burdett,L., Hutchinson,A.,
            Yuenger,J., Chanock,S. and Lan,Q.
  TITLE     Polymorphisms in innate immunity genes and lung cancer risk in
            Xuanwei, China
  JOURNAL   Environ Mol Mutagen 50 (4), 285-290 (2009)
   PUBMED   19170196
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 1128)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
            Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
            Chanock,S.J., Zheng,T. and Lan,Q.
  TITLE     Pathway-based evaluation of 380 candidate genes and lung cancer
            susceptibility suggests the importance of the cell cycle pathway
  JOURNAL   Carcinogenesis 29 (10), 1938-1943 (2008)
   PUBMED   18676680
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1128)
  AUTHORS   Stehling,O., Netz,D.J., Niggemeyer,B., Rosser,R., Eisenstein,R.S.,
            Puccio,H., Pierik,A.J. and Lill,R.
  TITLE     Human Nbp35 is essential for both cytosolic iron-sulfur protein
            assembly and iron homeostasis
  JOURNAL   Mol Cell Biol 28 (17), 5517-5528 (2008)
   PUBMED   18573874
  REMARK    GeneRIF: The cytosolic soluble P-loop NTPase termed huNbp35 (also
            known as Nubp1) was identified as an Fe/S protein, and its role in
            the maturation of Fe/S proteins in HeLa cells, is defined.
REFERENCE   8  (bases 1 to 1128)
  AUTHORS   Taniguchi,N., Taniura,H., Niinobe,M., Takayama,C.,
            Tominaga-Yoshino,K., Ogura,A. and Yoshikawa,K.
  TITLE     The postmitotic growth suppressor necdin interacts with a
            calcium-binding protein (NEFA) in neuronal cytoplasm
  JOURNAL   J Biol Chem 275 (41), 31674-31681 (2000)
   PUBMED   10915798
REFERENCE   9  (bases 1 to 1128)
  AUTHORS   Nakashima,H., Grahovac,M.J., Mazzarella,R., Fujiwara,H.,
            Kitchen,J.R., Threat,T.A. and Ko,M.S.
  TITLE     Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome
            17, and Nubp1, mapped to chromosome 16--establish a new gene family
            of nucleotide-binding proteins in eukaryotes
  JOURNAL   Genomics 60 (2), 152-160 (1999)
   PUBMED   10486206
REFERENCE   10 (bases 1 to 1128)
  AUTHORS   Shahrestanifar,M., Saha,D.P., Scala,L.A., Basu,A. and Howells,R.D.
  TITLE     Cloning of a human cDNA encoding a putative nucleotide-binding
            protein related to Escherichia coli MinD
  JOURNAL   Gene 147 (2), 281-285 (1994)
   PUBMED   7926816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074136.4.
            
            On Aug 13, 2020 this sequence version replaced NM_001323596.1.
            
            Summary: NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding
            proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by
            OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.519876.1,
                                           SRR14327317.560468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC074136.4         84221-84261         c
            42-146              AC074136.4         84038-84142         c
            147-280             AC074136.4         80827-80960         c
            281-349             AC074136.4         75425-75493         c
            350-382             AC074136.4         72350-72382         c
            383-473             AC074136.4         71323-71413         c
            474-628             AC074136.4         70076-70230         c
            629-739             AC074136.4         66629-66739         c
            740-823             AC074136.4         60071-60154         c
            824-1128            AC074136.4         58752-59056         c
FEATURES             Location/Qualifiers
     source          1..1128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..1128
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /note="NUBP iron-sulfur cluster assembly factor 1,
                     cytosolic"
                     /db_xref="GeneID:4682"
                     /db_xref="HGNC:HGNC:8041"
                     /db_xref="MIM:600280"
     exon            1..41
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..802
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /note="isoform 5 is encoded by transcript variant 5;
                     nucleotide binding protein 1 (MinD homolog, E. coli);
                     nucleotide binding protein 1 (E.coli MinD like); cytosolic
                     Fe-S cluster assembly factor NUBP1; nucleotide binding
                     protein (e.coli MinD like); NBP 1; nucleotide-binding
                     protein 1"
                     /codon_start=1
                     /product="cytosolic Fe-S cluster assembly factor NUBP1
                     isoform 5"
                     /protein_id="NP_001310525.1"
                     /db_xref="GeneID:4682"
                     /db_xref="HGNC:HGNC:8041"
                     /db_xref="MIM:600280"
                     /translation="MEEVPHDCPGADSAQAGRGASCQGCPNQRLCASGAGATPDTAIE
                     EIKEKMKTVKHKILVLSGKGGVGKSTFSAHLAHGLAEDENTQIALLDIDICGPSIPKI
                     MGLEGEQVHQSGSGWSPVYVEDNLGVMSVGFLLSSPDDAVIWRGPKKNGMIKQFLRDV
                     DWGEVDYLIVDTPPGTSDEHLSVVRYLATAHIDGAVIITTPQEVSLQDVRKEINFCRK
                     VKLPIIGVVENMSGFICPKCKVRIVTKASLFSLTPQIPQPR"
     exon            42..146
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     exon            147..280
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     exon            281..349
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     exon            350..382
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     exon            383..473
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     exon            474..628
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     exon            629..739
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     exon            740..823
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1128
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1108..1113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /note="hexamer: AATAAA"
     polyA_site      1128
                     /gene="NUBP1"
                     /gene_synonym="CIAO5; NBP; NBP1; NBP35"
                     /note="major polyA site"
ORIGIN      
        1 cgaaggcggc aaaggcgacg gaatggagga ggtgcctcac gactgtccag gggccgacag
       61 cgcccaggcg ggcagagggg cttcatgtca gggatgcccc aaccagcggc tgtgcgcttc
      121 tggagcgggg gccactccgg acacggctat agaggaaatc aaagagaaaa tgaagactgt
      181 aaaacacaaa atcttggtat tgtctgggaa aggcggtgtt gggaaaagca cattcagcgc
      241 ccaccttgcc catggcctag cagaggatga aaacacacag attgctcttc tagacatcga
      301 tatatgtggg ccatcgattc ccaagataat gggattggaa ggagagcagg ttcaccagag
      361 tggctcaggc tggtctccag tgtacgtgga agacaacctg ggggtgatgt cagtgggctt
      421 cctgctcagc agtcctgatg atgctgttat ctggagggga cccaagaaaa acggcatgat
      481 caagcagttc ctccgagatg tggactgggg agaggtcgac tacctcattg tggacacccc
      541 acctgggacg tcggatgaac acctctcggt cgtccggtac ctggccacag cacacatcga
      601 tggagcagtg atcatcacca ctccccagga ggtgtcactc caggatgtcc ggaaagaaat
      661 caacttctgc cgcaaggtga agctgcccat catcggggtg gtggagaaca tgagtggctt
      721 catctgtcct aagtgcaagg taagaattgt gacaaaggcc agtctttttt cattgacgcc
      781 ccagattccc cagccacgtt agcctacaga agtataattc agagaatcca agagttttgt
      841 aatctccatc agtcaaaaga agagaacctc atcagttcct gaaacgagag aatgttcagg
      901 accaagcagt taccgagcga ggcactcact gggcagcaca tccagccaga cccgaccagc
      961 tccgggatgg ggtgggtcac agcaaaagga ccagatgctg gtgtggtccg aagccacttt
     1021 ctcagagaca ctttaatcat tgagtatttg tacacttttc tttagaacat atataaaggg
     1081 cattctctac aaatgtgccg ttttaagaat aaaaccccct caaatctc
//
