LOCUS       NM_030952               3391 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens NUAK family kinase 2 (NUAK2), mRNA.
ACCESSION   NM_030952
VERSION     NM_030952.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3391)
  AUTHORS   Guo,Z. and Guo,L.
  TITLE     OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2
            expression, thus accelerating gastric cancer procession
  JOURNAL   Dig Liver Dis 56 (2), 352-362 (2024)
   PUBMED   37429790
  REMARK    GeneRIF: OTUD7B deubiquitinates and stabilizes YAP1 to upregulate
            NUAK2 expression, thus accelerating gastric cancer procession.
REFERENCE   2  (bases 1 to 3391)
  AUTHORS   Prasad,V., Cerikan,B., Stahl,Y., Kopp,K., Magg,V.,
            Acosta-Rivero,N., Kim,H., Klein,K., Funaya,C., Haselmann,U.,
            Cortese,M., Heigwer,F., Bageritz,J., Bitto,D., Jargalsaikhan,S.,
            Neufeldt,C., Pahmeier,F., Boutros,M., Yamauchi,Y., Ruggieri,A. and
            Bartenschlager,R.
  TITLE     Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase
            NUAK2
  JOURNAL   Mol Cell 83 (14), 2559-2577 (2023)
   PUBMED   37421942
  REMARK    GeneRIF: Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related
            kinase NUAK2.
REFERENCE   3  (bases 1 to 3391)
  AUTHORS   Dai,Y., Shi,W., Qiu,Y., Xu,T., Lin,J. and Su,Y.
  TITLE     Circ_0000033 up-regulates NUAK2 by sequestering miR-378a-3p to
            promote breast tumorigenesis
  JOURNAL   Environ Mol Mutagen 64 (6), 359-370 (2023)
   PUBMED   37357410
  REMARK    GeneRIF: Circ_0000033 up-regulates NUAK2 by sequestering
            miR-378a-3p to promote breast tumorigenesis.
REFERENCE   4  (bases 1 to 3391)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 3391)
  AUTHORS   Lin,R., Wu,W., Chen,H., Gao,H., Wu,X., Li,G., He,Q., Lu,H., Sun,M.
            and Liu,Z.
  TITLE     GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation
            and gut inflammation through downregulating NUAK2
  JOURNAL   Clin Transl Med 12 (3), e771 (2022)
   PUBMED   35343079
  REMARK    GeneRIF: GPR65 promotes intestinal mucosal Th1 and Th17 cell
            differentiation and gut inflammation through downregulating NUAK2.
REFERENCE   6  (bases 1 to 3391)
  AUTHORS   Legembre,P., Schickel,R., Barnhart,B.C. and Peter,M.E.
  TITLE     Identification of SNF1/AMP kinase-related kinase as an
            NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced
            motility and invasiveness
  JOURNAL   J Biol Chem 279 (45), 46742-46747 (2004)
   PUBMED   15345718
  REMARK    GeneRIF: SNARK is an NF-kappaB-regulated anti-apoptotic gene that
            contributes to the tumor-promoting activity of CD95 in
            apoptosis-resistant tumor cells
REFERENCE   7  (bases 1 to 3391)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   8  (bases 1 to 3391)
  AUTHORS   Suzuki,A., Kusakai,G., Kishimoto,A., Minegichi,Y., Ogura,T. and
            Esumi,H.
  TITLE     Induction of cell-cell detachment during glucose starvation through
            F-actin conversion by SNARK, the fourth member of the AMP-activated
            protein kinase catalytic subunit family
  JOURNAL   Biochem Biophys Res Commun 311 (1), 156-161 (2003)
   PUBMED   14575707
REFERENCE   9  (bases 1 to 3391)
  AUTHORS   Lefebvre,D.L., Bai,Y., Shahmolky,N., Sharma,M., Poon,R.,
            Drucker,D.J. and Rosen,C.F.
  TITLE     Identification and characterization of a novel
            sucrose-non-fermenting protein kinase/AMP-activated protein
            kinase-related protein kinase, SNARK
  JOURNAL   Biochem J 355 (Pt 2), 297-305 (2001)
   PUBMED   11284715
  REMARK    GeneRIF: This study describes the cloning and characterization of
            the rat SNARK homolog, mapping of the human SNARK gene to 1q32, and
            a potential functional role as mediator of the cellular response to
            metabolic stress.
REFERENCE   10 (bases 1 to 3391)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098933.2.
            
            On Dec 20, 2018 this sequence version replaced NM_030952.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017306.2, AL136891.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367157.6/ ENSP00000356125.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AC098933.2         84431-84778         c
            349-469             AC098933.2         74738-74858         c
            470-621             AC098933.2         71614-71765         c
            622-687             AC098933.2         71198-71263         c
            688-807             AC098933.2         69221-69340         c
            808-940             AC098933.2         68232-68364         c
            941-3391            AC098933.2         65096-67546         c
FEATURES             Location/Qualifiers
     source          1..3391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3391
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /note="NUAK family kinase 2"
                     /db_xref="GeneID:81788"
                     /db_xref="HGNC:HGNC:29558"
                     /db_xref="MIM:608131"
     exon            1..348
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..2004
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /EC_number="2.7.11.1"
                     /note="SNF1/AMP activated protein kinase; NUAK family,
                     SNF1-like kinase, 2; SNF1/AMP kinase-related kinase;
                     omphalocele kinase 2"
                     /codon_start=1
                     /product="NUAK family SNF1-like kinase 2"
                     /protein_id="NP_112214.3"
                     /db_xref="CCDS:CCDS1453.3"
                     /db_xref="GeneID:81788"
                     /db_xref="HGNC:HGNC:29558"
                     /db_xref="MIM:608131"
                     /translation="MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHH
                     HKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIE
                     IMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIV
                     SAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASP
                     EIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDA
                     CGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMAD
                     WLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTA
                     DDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILK
                     KPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLNGKF
                     SQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEP
                     PLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVC
                     SKLT"
     exon            349..469
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /inference="alignment:Splign:2.1.0"
     exon            470..621
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /inference="alignment:Splign:2.1.0"
     exon            622..687
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /inference="alignment:Splign:2.1.0"
     exon            688..807
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /inference="alignment:Splign:2.1.0"
     exon            808..940
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /inference="alignment:Splign:2.1.0"
     exon            941..3391
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /note="hexamer: AATAAT"
     polyA_site      3234
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /note="hexamer: ATTAAA"
     polyA_site      3391
                     /gene="NUAK2"
                     /gene_synonym="ANPH2; SNARK"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgctctg gtactgctgt ggctccccgt cctggtgcgg gacctgtgcc ccgcgcttca
       61 gccctccccg cacagcctac tgattcccct gccgcccttg ctcacctcct gctcgccatg
      121 gagtcgctgg ttttcgcgcg gcgctccggc cccactccct cggccgcaga gctagcccgg
      181 ccgctggcgg aagggctgat caagtcgccc aagcccctaa tgaagaagca ggcggtgaag
      241 cggcaccacc acaagcacaa cctgcggcac cgctacgagt tcctggagac cctgggcaaa
      301 ggcacctacg ggaaggtgaa gaaggcgcgg gagagctcgg ggcgcctggt ggccatcaag
      361 tcaatccgga aggacaaaat caaagatgag caagatctga tgcacatacg gagggagatt
      421 gagatcatgt catcactcaa ccaccctcac atcattgcca tccatgaagt gtttgagaac
      481 agcagcaaga tcgtgatcgt catggagtat gccagccggg gcgaccttta tgactacatc
      541 agcgagcggc agcagctcag tgagcgcgaa gctaggcatt tcttccggca gatcgtctct
      601 gccgtgcact attgccatca gaacagagtt gtccaccgag atctcaagct ggagaacatc
      661 ctcttggatg ccaatgggaa tatcaagatt gctgacttcg gtctctccaa cctctaccat
      721 caaggcaagt tcctgcagac attctgtggg agccccctct atgcctcgcc agagattgtc
      781 aatgggaagc cctacacagg cccagaggtg gacagctggt ccctgggtgt tctcctctac
      841 atcctggtgc atggcaccat gccctttgat gggcatgacc ataagatcct agtgaaacag
      901 atcagcaacg gggcctaccg ggagccacct aaaccctctg atgcctgtgg cctgatccgg
      961 tggctgttga tggtgaaccc cacccgccgg gccaccctgg aggatgtggc cagtcactgg
     1021 tgggtcaact ggggctacgc cacccgagtg ggagagcagg aggctccgca tgagggtggg
     1081 caccctggca gtgactctgc ccgcgcctcc atggctgact ggctccggcg ttcctcccgc
     1141 cccctcctgg agaatggggc caaggtgtgc agcttcttca agcagcatgc acctggtggg
     1201 ggaagcacca cccctggcct ggagcgccag cattcgctca agaagtcccg caaggagaat
     1261 gacatggccc agtctctcca cagtgacacg gctgatgaca ctgcccatcg ccctggcaag
     1321 agcaacctca agctgccaaa gggcattctc aagaagaagg tgtcagcctc tgcagaaggg
     1381 gtacaggagg accctccgga gctcagccca atccctgcga gcccagggca ggctgccccc
     1441 ctgctcccca agaagggcat tctcaagaag ccccgacagc gcgagtctgg ctactactcc
     1501 tctcccgagc ccagtgaatc tggggagctc ttggacgcag gcgacgtgtt tgtgagtggg
     1561 gatcccaagg agcagaagcc tccgcaagct tcagggctgc tcctccatcg caaaggcatc
     1621 ctcaaactca atggcaagtt ctcccagaca gccttggagc tcgcggcccc caccaccttc
     1681 ggctccctgg atgaactcgc cccacctcgc cccctggccc gggccagccg accctcaggg
     1741 gctgtgagcg aggacagcat cctgtcctct gagtcctttg accagctgga cttgcctgaa
     1801 cggctcccag agcccccact gcggggctgt gtgtctgtgg acaacctcac ggggcttgag
     1861 gagcccccct cagagggccc tggaagctgc ctgaggcgct ggcggcagga tcctttgggg
     1921 gacagctgct tttccctgac agactgccag gaggtgacag cgacctaccg acaggcactg
     1981 agggtctgct caaagctcac ctgagtggag taggcattgc cccagcccgg tcaggctctc
     2041 agatgcagct ggttgcaccc cgaggggaga tgccttctcc cccacctccc aggacctgca
     2101 tcccagctca gaaggctgag agggtttgca gtggagccct gagcagggct ggatatggga
     2161 agtaggcaaa tgaaatgcgc caagggttca gtgtctgtct tcagccctgc tgaacgaaga
     2221 ggatactaaa gagaggggaa cgggaatgcc cgcgacagag tccacattgc ctgtttcttg
     2281 tgtacatggg ggggccacag agacctggaa agagaactct cccagggccc atctcctgca
     2341 tcccatgaat actctgtaca catggtgcct tctaaggaca gctccttccc tactcattcc
     2401 ctgcccaagt ggggccagac ctctttacac acacattccc gttcctacca accaccagaa
     2461 ctggatggtg gcacccctaa tgtgcatgag gcatcctggg aatggtctgg agtaacgctt
     2521 cgttattttt atttttattt ttatttattt atttattttt ttgagacgga gtttcgctct
     2581 tggtgcccag gctagagtgc aatggcgcga tctcagctca cctcaacctc cgcctcccgg
     2641 gttcaagcga ttctcctgcc tcagcctccc tagtagctgg gattacaggc gcccgccacc
     2701 atgcccggct aattttgtat ttttagtaga gacagggttt ctccatgttg gtcaggctgg
     2761 tctcaaactc ccgacctcag gtgatccacc cacctcggcc tcccaaagtg ctgggattac
     2821 aggcgtgagc caccgcgccc cacctaaccc ttccttattt agcctaggag taagagaaca
     2881 caatctctgt ttcttcaatg gttctcttcc cttttccatc ctccaaacct ggcctgagcc
     2941 tcctgaagtt gctgctgtga atctgaaaga cttgaaaagc ctccgcctgc tgtgtggact
     3001 tcatctcaag gggcccagcc tcctctggac tccaccttgg acctcagtga ctcagaactt
     3061 ctgcctctaa gctgctctaa agtccagact atggatgtgt tctctaggcc ttcaggactc
     3121 tagaatgtcc atatttattt ttatgttctt ggctttgtgt tttaggaaaa gtgaatcttg
     3181 ctgttttcaa taatgtgaat gctatgttct gggaaaatcc actatgacat ctaagttttg
     3241 tgtacagaga gatatttttg caactatttc cacctcctcc cacaaccccc cacactccac
     3301 tccacactct tgagtctctt tacctaatgg tctctaccta atggacctcc gtggccaaaa
     3361 agtaccatta aaaccagaaa ggtgattgga a
//
