LOCUS       NM_014840               5744 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens NUAK family kinase 1 (NUAK1), mRNA.
ACCESSION   NM_014840 XM_374996
VERSION     NM_014840.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5744)
  AUTHORS   Sheng,M., Huo,S., Jia,L., Weng,Y., Liu,W., Lin,Y. and Yu,W.
  TITLE     NUAK1 promotes metabolic dysfunction-associated steatohepatitis
            progression by activating Caspase 6-driven pyroptosis and
            inflammation
  JOURNAL   Hepatol Commun 8 (7), e0479 (2024)
   PUBMED   38967580
  REMARK    GeneRIF: NUAK1 promotes metabolic dysfunction-associated
            steatohepatitis progression by activating Caspase 6-driven
            pyroptosis and inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5744)
  AUTHORS   Elkady,N., Aldesoky,A.I. and Dawoud,M.M.
  TITLE     Evaluation of ARK5 and SIRT3 expression in renal cell carcinoma and
            their clinical significance
  JOURNAL   Diagn Pathol 18 (1), 125 (2023)
   PUBMED   37996927
  REMARK    GeneRIF: Evaluation of ARK5 and SIRT3 expression in renal cell
            carcinoma and their clinical significance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5744)
  AUTHORS   Whyte,D., Skalka,G., Walsh,P., Wilczynska,A., Paul,N.R.,
            Mitchell,C., Nixon,C., Clarke,W., Bushell,M., Morton,J.P.,
            Murphy,D.J. and Muthalagu,N.
  TITLE     NUAK1 governs centrosome replication in pancreatic cancer via
            MYPT1/PP1beta and GSK3beta-dependent regulation of PLK4
  JOURNAL   Mol Oncol 17 (7), 1212-1227 (2023)
   PUBMED   36975767
  REMARK    GeneRIF: NUAK1 governs centrosome replication in pancreatic cancer
            via MYPT1/PP1beta and GSK3beta-dependent regulation of PLK4.
REFERENCE   4  (bases 1 to 5744)
  AUTHORS   Yao,C.Y., Gao,Z.X., Hou,L.L. and Fang,D.
  TITLE     DKK1 promotes NUAK1 transcriptional expression through the
            activation Akt in hepatocellular carcinoma
  JOURNAL   Cell Biol Int 47 (2), 383-393 (2023)
   PUBMED   36480792
  REMARK    GeneRIF: DKK1 promotes NUAK1 transcriptional expression through the
            activation Akt in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 5744)
  AUTHORS   Xue,L., He,J., Chen,H., Ren,C. and Fu,X.
  TITLE     Circ_0003998 upregulates ARK5 expression to elevate 5-Fluorouracil
            resistance in hepatocellular carcinoma through binding to
            miR-513a-5p
  JOURNAL   Anticancer Drugs 33 (10), 1103-1113 (2022)
   PUBMED   36255069
  REMARK    GeneRIF: Circ_0003998 upregulates ARK5 expression to elevate
            5-Fluorouracil resistance in hepatocellular carcinoma through
            binding to miR-513a-5p.
REFERENCE   6  (bases 1 to 5744)
  AUTHORS   Suzuki,A., Kusakai,G., Kishimoto,A., Shimojo,Y., Miyamoto,S.,
            Ogura,T., Ochiai,A. and Esumi,H.
  TITLE     Regulation of caspase-6 and FLIP by the AMPK family member ARK5
  JOURNAL   Oncogene 23 (42), 7067-7075 (2004)
   PUBMED   15273717
  REMARK    GeneRIF: ARK5 negatively regulates procaspase-6 by phosphorylation
            at Ser257, leading to resistance to the FasL/Fas system.
REFERENCE   7  (bases 1 to 5744)
  AUTHORS   Suzuki,A., Lu,J., Kusakai,G., Kishimoto,A., Ogura,T. and Esumi,H.
  TITLE     ARK5 is a tumor invasion-associated factor downstream of Akt
            signaling
  JOURNAL   Mol Cell Biol 24 (8), 3526-3535 (2004)
   PUBMED   15060171
  REMARK    GeneRIF: Results report that a novel AMPK catalytic subunit family
            member, ARK5, plays a key role in tumor malignancy downstream of
            Akt.
REFERENCE   8  (bases 1 to 5744)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   9  (bases 1 to 5744)
  AUTHORS   Suzuki,A., Kusakai,G., Kishimoto,A., Lu,J., Ogura,T. and Esumi,H.
  TITLE     ARK5 suppresses the cell death induced by nutrient starvation and
            death receptors via inhibition of caspase 8 activation, but not by
            chemotherapeutic agents or UV irradiation
  JOURNAL   Oncogene 22 (40), 6177-6182 (2003)
   PUBMED   13679856
  REMARK    GeneRIF: ARK5 suppresses the apoptosis induced by nutrient
            starvation and death receptors via inhibition of caspase 8
            activation.
REFERENCE   10 (bases 1 to 5744)
  AUTHORS   Suzuki,A., Kusakai,G., Kishimoto,A., Lu,J., Ogura,T., Lavin,M.F.
            and Esumi,H.
  TITLE     Identification of a novel protein kinase mediating Akt survival
            signaling to the ATM protein
  JOURNAL   J Biol Chem 278 (1), 48-53 (2003)
   PUBMED   12409306
  REMARK    GeneRIF: Data suggest that a novel AMPK family member, ARK5, is the
            tumor cell survival factor activated by Akt and acts as an ATM
            kinase under the conditions of nutrient starvation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB011109.1, CK001516.1, BQ694341.1, BG831390.1, R61142.1,
            AK027302.1 and AC011595.13.
            
            On Aug 11, 2020 this sequence version replaced NM_014840.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152462.1, AB011109.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261402.7/ ENSP00000261402.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2620              AB011109.1         1080-3699
            2621-2708           CK001516.1         102-189
            2709-3077           BQ694341.1         140-508
            3078-3191           BQ694341.1         510-623
            3192-3356           AB011109.1         4279-4443
            3357-3401           BG831390.1         30-74
            3402-3796           AB011109.1         4489-4883
            3797-4628           AB011109.1         4885-5716
            4629-4633           R61142.1           315-319
            4634-4657           R61142.1           321-344
            4658-4674           R61142.1           346-362
            4675-4682           R61142.1           364-371
            4683-4692           R61142.1           374-383
            4693-5404           AB011109.1         5781-6492
            5405-5628           AK027302.1         1386-1609
            5629-5742           AB011109.1         6715-6828
            5743-5744           AC011595.13        93242-93243         c
FEATURES             Location/Qualifiers
     source          1..5744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..5744
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /note="NUAK family kinase 1"
                     /db_xref="GeneID:9891"
                     /db_xref="HGNC:HGNC:14311"
                     /db_xref="MIM:608130"
     exon            1..541
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..2287
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /EC_number="2.7.11.1"
                     /note="AMP-activated protein kinase family member 5;
                     AMPK-related protein kinase 5; omphalocele kinase 1; NUAK
                     family, SNF1-like kinase, 1"
                     /codon_start=1
                     /product="NUAK family SNF1-like kinase 1"
                     /protein_id="NP_055655.1"
                     /db_xref="CCDS:CCDS31892.1"
                     /db_xref="GeneID:9891"
                     /db_xref="HGNC:HGNC:14311"
                     /db_xref="MIM:608130"
                     /translation="MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKR
                     HHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRR
                     EIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFR
                     QIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLY
                     ASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQP
                     SDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDW
                     HHRSTGLQADTEAKMKGLAKPTTSEVMLERQRSLKKSKKENDFAQSGQDAVPESPSKL
                     SSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEV
                     PGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPD
                     PARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSRSYS
                     RPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRPQY
                     LKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKLN"
     exon            542..662
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /inference="alignment:Splign:2.1.0"
     exon            663..814
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /inference="alignment:Splign:2.1.0"
     exon            815..880
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1000
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1133
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..5744
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5724..5729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /note="hexamer: AATAAA"
     polyA_site      5744
                     /gene="NUAK1"
                     /gene_synonym="ARK5"
                     /note="major polyA site"
ORIGIN      
        1 accctctccc ctccctcctg caaacaccac cgcctcccct gccaccgccg ccacctcgcc
       61 cgacgctcca cagctcgccg cggccggggg gcggtgcgcg gaccgtgcgc gccgcgggcg
      121 ccagatgtgc agtccccgcc gccgccagtg accgagccgc agtccgagcg gtatcgggcc
      181 gcctccctga tgctgcgggg gcgaccttga gcgtacagcg gcttccctcg gtggggaccc
      241 cgacatccca gcgctgtgcc cggtcttgcc ctctgtagcc cggctcgccc cgcgcttgga
      301 catggaaggg gccgccgcgc ctgtggcggg ggaccgcccc gacttggggc tgggggcgcc
      361 gggctctccc cgagaggcgg tggcgggggc gactgcagcc ctggagccca ggaagccgca
      421 cggggtgaag cggcatcacc acaagcacaa cttgaagcac cgctacgagc tgcaggagac
      481 cctgggcaaa ggcacctacg gcaaagtcaa gcgggccacc gagaggtttt ctggccgagt
      541 ggttgctata aaatccattc gtaaggacaa aattaaggat gaacaagaca tggttcacat
      601 cagacgagag attgagatca tgtcatctct caaccatcct catatcatca gtatttatga
      661 agtgtttgag aacaaagata agattgtgat catcatggaa tatgccagca aaggggagct
      721 gtacgattac atcagtgagc ggcgacgcct cagtgagagg gagacccggc acttcttccg
      781 gcagatcgtc tctgctgtgc actattgtca caagaacggt gtggtccacc gggacttgaa
      841 gctggaaaat atactgctcg atgacaactg caatattaag attgctgact ttgggctttc
      901 caacctgtac cagaaggata agttcttaca aacgttttgt gggagtccac tctatgcatc
      961 tcctgagatt gtcaatggga gaccttaccg agggccagag gtggacagct gggccctggg
     1021 tgtgttgctt tacactcttg tttatggaac aatgcccttc gatggtttcg atcacaaaaa
     1081 cctcattcgg caaatcagca gcggagagta ccgggagcca acacagccct cagatgctcg
     1141 aggactcata cggtggatgc tgatggtgaa ccccgatcgc cgggccacta ttgaggacat
     1201 tgccaaccac tggtgggtga actggggcta taagagcagc gtgtgtgact gtgatgccct
     1261 ccatgactct gagtccccac tcctggctcg gatcattgac tggcaccacc gttccacagg
     1321 gctgcaggct gacaccgaag ccaaaatgaa gggcctggcc aaacccacga cctctgaggt
     1381 catgctagag cggcagcggt cgctgaagaa atccaagaaa gagaatgact ttgctcagtc
     1441 tggtcaggat gcagtgcctg aaagcccatc caagttgagt tctaagaggc ccaaggggat
     1501 cctgaagaag cgaagcaaca gcgagcatcg ctctcacagc actggcttca ttgaaggtgt
     1561 agttggtcct gccttaccct ctactttcaa gatggagcag gacttgtgca ggactggcgt
     1621 gctcctccca agctcaccag aggcagaggt gccgggaaaa ctcagcccca agcagtcggc
     1681 cacgatgccc aagaaaggca tcttgaaaaa gacccagcag agagaatcag gttactactc
     1741 ttccccagag cgcagtgagt cttcggagct gttggacagt aatgatgtga tgggcagcag
     1801 catcccctcc cccagccccc cggacccagc cagggtaacc tcccacagcc tctcctgccg
     1861 gaggaagggc atcttgaaac acagcagcaa atactcagcg ggcaccatgg acccagccct
     1921 ggtcagccct gaaatgccca cactggaatc cctgtcagag cctggtgtcc ctgccgaggg
     1981 cctctcccgg agctacagcc gcccttccag tgtcatcagc gatgacagcg tgctgtccag
     2041 cgactctttt gacttgctgg atttgcagga gaatcgccct gcccgccagc gcatccgcag
     2101 ctgcgtctct gcagaaaact tcctccagat ccaggacttt gaggggctcc agaaccggcc
     2161 ccggccccag tacctgaagc ggtaccggaa ccggctggca gacagcagct tctccctcct
     2221 cacagacatg gatgatgtga ctcaggtcta caagcaagcg ctggagatct gcagcaagct
     2281 caactagcat tccagggcgc ccaggggcgg gcgggggtac gagggaggaa ggggagcaag
     2341 acttgggctc acaggctggt tacctctttg ctggctgtga caacagactg aaaaaggatt
     2401 ggcactgtct cacttggcca agtttgcagc cttgagccaa cacctaaaag ggagaggtgg
     2461 gctcttctgc cagttctgtc aattgtcagt cagaatttgg gccctgtttg gcatttgctt
     2521 tatggcacct cctagaggac cagctgtcca ggggaggtgg tattgaccgg cactcagtgg
     2581 gtggagagga agcatatgtg gaaggagcat ttccttagaa gtcatccaga tgcttctgga
     2641 ggaggggcag gagacacttg ggctgtttgc cttgggtgag cccaaagaac ttgccccttt
     2701 tctccttgta ttagcaagct aggtctggct gcgtggagct ggcaagtaga tttcagcaac
     2761 ttgagcttga gttgacgatc aattaatagt ggctgccagt tgtgctggcg taagtggccc
     2821 acatcatggg gaaggagtgc tgtgattgac tagtaatggc taccacggga aagggaaggg
     2881 gaagcagtag cactaatgct atgtagttgt catctttgat ctggctaggc cctgggaatc
     2941 gggtttagtc atcctgtggg atctatgtta actctttcat gccactggtg aggcatttgt
     3001 taatttgcta ctcaactttg aggaaagaca gggccttggt cagagagaga atgctctgaa
     3061 ctctgctaag gacatagagt cagcccatgg tgatttagct ccttgctgtt cacctcctct
     3121 ttcctgatgt ctgccttgct ctacagcaca acctcttgag ggtggacagg gagaaagatg
     3181 atggtgtcag aggtcaaaac tattatatat gacagggcac aagatggtct gtgatctttg
     3241 cacagatgaa tggaagttga tgcacaccaa caagaggcaa cttgtcactt tctttctcaa
     3301 tattaactgg aatgctgcct cttgggttct cacctgcatg gatgctttga gttggacgtg
     3361 atactgtcca tattctccag aggattacct ggctgaacca ttggctctgt tcaccagtga
     3421 cagatggttt ccccatccac tgagtgtagc atcctcagag gtaggcaagt ttgcttctag
     3481 ggagttagca tgtagatggg atattgggat gaggaaagga aaatcaggta gatggtgctt
     3541 tttttccccc aaatctaagt attctatgtc atggttttaa actttgccat gaactcctgg
     3601 gctttggggg aagagaaagt tccattcatt taaatgaata aggtgttgaa agagtgcagg
     3661 gggttgggag gaagcatgta agagagggaa catttcctta gatgttaccc agatggttct
     3721 gggggagaca gaaaagaggt gcggcaggac tcttatctta aaaagtaaac aaaacaaaac
     3781 aaaacaaaac aaaaaactag atatgtaatt tctaaacacc cagatcacaa tgacaagatg
     3841 ccactccaac catgggacac cttcatgata ctaggtttgt acttcctggt ctctgggatg
     3901 acttcagatt ctgctggcca aggcaaattg aactcagttc aagatggcca ccactggtag
     3961 acgtgtagat agaaaagagg actggtcttg ggaacatctt tggaaaaacc aacaaacaat
     4021 agttctaggg agatgagaaa aaaattcacc ttacagtgct aagaaagtgc attagaatgg
     4081 aattgccctt tccttaagga gacagtttgg gctctcccct tgccaccggc tctggtgttt
     4141 tggcttatgc gttccttcag gttgagctga gcagtgtgtt atgggaagct gctcaatttc
     4201 ctttcattca attccacctc cttcctgaac tctaatagag gttaaaaggg aaaaaaaaaa
     4261 ttctgtagat agcaaattgt gtgtgtgggg gggggtgggg gtgtgggtgc atggaggaca
     4321 acctgcaact ctgagctccc tacttcctgc ctcatttcat gcagtctttt ctgaacagcc
     4381 tatgctgctg ccctgctggc cccttgtgca cggcagctgg ccgtgtccgt agctgtcagt
     4441 atgacttaga tctagctcct acctactggt tgatgtgttt tttccttttg ccaagtgatt
     4501 gagtctgttt agtagtttcc atcattctag tctttaagta aaaatgacac tattgaggaa
     4561 agtcagtcta ctcccttctt cctcccccca aacacgtgtt ctcttttgtc aggaaactca
     4621 gccagtggac tgtggcagag aaagtcctcc actcagaggc agagactgag ttaagtcata
     4681 ggtggcctta ggcatctgca ttgtttgcag gggttaagtt ttccttccag tgagggctgg
     4741 agggatgaat tagctggtac ctgaagcccc gcttagctct gacactctgc caacatcctc
     4801 tgattctagg tgtggtgttg actgtccttt caaggaaaaa cttgcaatag agggaaaagc
     4861 cattaaagca gctccctgct tcatcattaa gtcctgtcat ccctaccagc caatcccagt
     4921 caaagaagtt atgctttatt cacttctgtg gaattacaag tgagagacac ttttaggacc
     4981 tgatggacaa agcaggagat tcactgtcag ctttcctggt cctctcctta cttctgtggg
     5041 ccttgcaccg tcttagttta cacatctgcc aaaggggtag aattacactt ctttttacag
     5101 gtaaatgtca aggcacaatc agttttcagg aagtgcttca agaccccagg tgaaatgaaa
     5161 atgctaagta ccctctgaat ggccatgcct gttaccaggt gctgcttctt cagatgatgg
     5221 ggagcacttt tcagggtgaa attcaggcga gttttgccca ggcctgctgt cttgagtaca
     5281 aatgtgaatg atcgactgac tgcttgttgc caaactggaa atgttctgta gggatttact
     5341 ggcatggtat cattcctaga agaaaaaaag agagaaactt gactgcacat taaaaaaaaa
     5401 aaaaaatcca cattgtgact tttatttaat ttctattttt tttggtaata aaaagttgac
     5461 ttttttattt gaatttgtct tttttattta ttggtctgaa aggcatttca aaggtattat
     5521 aataatatat tggtgtaatt taattggtgc aacatgcttt atggctcctg tcaaaattgg
     5581 ttttcactca tttgattggt ttgagcccag aacagcctac aggggaaaaa caagctggat
     5641 aaccacccaa agtgtttgta ttttcgttgg aaactgattt ttgtttcatt ttggtttttg
     5701 tttctgtttt tatttttaaa ttaaataaat tgcaatgaac tgaa
//
