LOCUS       NM_012344               1600 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens neurotensin receptor 2 (NTSR2), mRNA.
ACCESSION   NM_012344 XM_939298
VERSION     NM_012344.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1600)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1600)
  AUTHORS   Yang,Y., Zhang,W., Wei,K., Hu,F., Wu,S., Ma,Y. and Ouyang,Q.
  TITLE     Physiological and Pathological Roles of NTSR2 in Several Organs and
            Diseases (Review)
  JOURNAL   Protein Pept Lett 31 (1), 3-10 (2024)
   PUBMED   37962046
  REMARK    GeneRIF: Physiological and Pathological Roles of NTSR2 in Several
            Organs and Diseases (Review).
            Review article
REFERENCE   3  (bases 1 to 1600)
  AUTHORS   Qiu,S., Nikolaou,S., Zhu,J., Jeffery,P., Goldin,R., Kinross,J.,
            Alexander,J.L., Rasheed,S., Tekkis,P. and Kontovounisios,C.
  TITLE     Characterisation of the Expression of Neurotensin and Its Receptors
            in Human Colorectal Cancer and Its Clinical Implications
  JOURNAL   Biomolecules 10 (8), 1145 (2020)
   PUBMED   32764278
  REMARK    GeneRIF: Characterisation of the Expression of Neurotensin and Its
            Receptors in Human Colorectal Cancer and Its Clinical Implications.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1600)
  AUTHORS   Zhu,S., Tian,H., Niu,X., Wang,J., Li,X., Jiang,N., Wen,S., Chen,X.,
            Ren,S., Xu,C., Chang,C., Flores-Morales,A., Shang,Z., Sun,Y. and
            Niu,Y.
  TITLE     Neurotensin and its receptors mediate neuroendocrine
            transdifferentiation in prostate cancer
  JOURNAL   Oncogene 38 (24), 4875-4884 (2019)
   PUBMED   30770901
  REMARK    GeneRIF: A novel role of NTS in the development of
            Castration-resistant prostate cancer with Neuroendocrine
            differentiation (NED), and a possible strategy to prevent the onset
            of NED by targeting the NTS signaling pathway.
            Erratum:[Oncogene. 2019 Jun;38(24):4885. doi:
            10.1038/s41388-019-0827-1.. PMID: 31048775]
REFERENCE   5  (bases 1 to 1600)
  AUTHORS   Abbaci,A., Talbot,H., Saada,S., Gachard,N., Abraham,J., Jaccard,A.,
            Bordessoule,D., Fauchais,A.L., Naves,T. and Jauberteau,M.O.
  TITLE     Neurotensin receptor type 2 protects B-cell chronic lymphocytic
            leukemia cells from apoptosis
  JOURNAL   Oncogene 37 (6), 756-767 (2018)
   PUBMED   29059151
  REMARK    GeneRIF: High NTSR2 expression is associated with B-cell chronic
            lymphocytic leukemia.
REFERENCE   6  (bases 1 to 1600)
  AUTHORS   Martin,S., Vincent,J.P. and Mazella,J.
  TITLE     Recycling ability of the mouse and the human neurotensin type 2
            receptors depends on a single tyrosine residue
  JOURNAL   J Cell Sci 115 (Pt 1), 165-173 (2002)
   PUBMED   11801734
  REMARK    GeneRIF: Recycling ability depends on a single tyrosine residue
REFERENCE   7  (bases 1 to 1600)
  AUTHORS   Ramez,M., Bagot,M., Nikolova,M., Boumsell,L., Vita,N., Chalon,P.,
            Caput,D., Ferrara,P. and Bensussan,A.
  TITLE     Functional characterization of neurotensin receptors in human
            cutaneous T cell lymphoma malignant lymphocytes
  JOURNAL   J Invest Dermatol 117 (3), 687-693 (2001)
   PUBMED   11564178
REFERENCE   8  (bases 1 to 1600)
  AUTHORS   Vincent,J.P., Mazella,J. and Kitabgi,P.
  TITLE     Neurotensin and neurotensin receptors
  JOURNAL   Trends Pharmacol Sci 20 (7), 302-309 (1999)
   PUBMED   10390649
  REMARK    Review article
REFERENCE   9  (bases 1 to 1600)
  AUTHORS   Vita,N., Oury-Donat,F., Chalon,P., Guillemot,M., Kaghad,M.,
            Bachy,A., Thurneyssen,O., Garcia,S., Poinot-Chazel,C., Casellas,P.,
            Keane,P., Le Fur,G., Maffrand,J.P., Soubrie,P., Caput,D. and
            Ferrara,P.
  TITLE     Neurotensin is an antagonist of the human neurotensin NT2 receptor
            expressed in Chinese hamster ovary cells
  JOURNAL   Eur J Pharmacol 360 (2-3), 265-272 (1998)
   PUBMED   9851594
REFERENCE   10 (bases 1 to 1600)
  AUTHORS   Chalon,P., Vita,N., Kaghad,M., Guillemot,M., Bonnin,J., Delpech,B.,
            Le Fur,G., Ferrara,P. and Caput,D.
  TITLE     Molecular cloning of a levocabastine-sensitive neurotensin binding
            site
  JOURNAL   FEBS Lett 386 (2-3), 91-94 (1996)
   PUBMED   8647296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106875.5 and AC110754.3.
            
            On Nov 23, 2018 this sequence version replaced NM_012344.3.
            
            Summary: The protein encoded by this gene belongs to the G
            protein-coupled receptor family that activate a
            phosphatidylinositol-calcium second messenger system. Binding and
            pharmacological studies demonstrate that this receptor binds
            neurotensin as well as several other ligands already described for
            neurotensin NT1 receptor. However, unlike NT1 receptor, this gene
            recognizes, with high affinity, levocabastine, a histamine H1
            receptor antagonist previously shown to compete with neurotensin
            for low-affinity binding sites in brain. These activities suggest
            that this receptor may be of physiological importance and that a
            natural agonist for the receptor may exist. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.9445.1,
                                           SRR3476690.1178643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306928.6/ ENSP00000303686.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-690               AC106875.5         4551-5240           c
            691-964             AC110754.3         20515-20788         c
            965-1055            AC110754.3         18591-18681         c
            1056-1600           AC110754.3         16726-17270         c
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..1600
                     /gene="NTSR2"
                     /gene_synonym="NTR2"
                     /note="neurotensin receptor 2"
                     /db_xref="GeneID:23620"
                     /db_xref="HGNC:HGNC:8040"
                     /db_xref="MIM:605538"
     exon            1..690
                     /gene="NTSR2"
                     /gene_synonym="NTR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1299
                     /gene="NTSR2"
                     /gene_synonym="NTR2"
                     /note="neurotensin receptor, type 2;
                     levocabastine-sensitive neurotensin receptor; NT-R-2"
                     /codon_start=1
                     /product="neurotensin receptor type 2"
                     /protein_id="NP_036476.2"
                     /db_xref="CCDS:CCDS1681.1"
                     /db_xref="GeneID:23620"
                     /db_xref="HGNC:HGNC:8040"
                     /db_xref="MIM:605538"
                     /translation="METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWA
                     LGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWV
                     FGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSW
                     AASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLP
                     LALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGG
                     QVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYN
                     FYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQS
                     PTLMDTASGFGDPPETRT"
     exon            691..964
                     /gene="NTSR2"
                     /gene_synonym="NTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1055
                     /gene="NTSR2"
                     /gene_synonym="NTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1600
                     /gene="NTSR2"
                     /gene_synonym="NTR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTSR2"
                     /gene_synonym="NTR2"
                     /note="hexamer: AATAAA"
     polyA_site      1600
                     /gene="NTSR2"
                     /gene_synonym="NTR2"
                     /note="major polyA site"
ORIGIN      
        1 actaaccagg cagctcgccc agactccggg cagtgagagg gagggagcgc cggccgcggg
       61 agcgggatgg aaaccagcag cccgcggccc ccgcggccca gctccaaccc ggggctgagc
      121 ctggacgccc ggctgggcgt ggacactcgc ctctgggcca aggtgctgtt caccgcgctc
      181 tacgcactca tctgggcgct gggcgcggcg ggcaatgcgc tgtccgcgca cgtggtgctg
      241 aaggcgcggg ccgggcgcgc ggggcgcctg cgccaccacg tgctcagcct ggcgctcgcg
      301 ggcctgctgc tgctgctggt cggcgtgccg gtggagctct acagcttcgt gtggttccac
      361 tacccctggg tcttcggcga cctgggctgc cgcggctact acttcgtgca cgagctgtgc
      421 gcctacgcca cggtgctgag cgtggcaggc ctgagcgccg agcgctgcct agccgtgtgc
      481 cagcccctgc gtgcccgcag cctgctgacg ccacgccgga cccggtggct ggtggcgctc
      541 tcgtgggccg cctcgctcgg cctcgccctg cccatggccg tcatcatggg gcagaagcac
      601 gaactcgaga cggcggacgg ggagccggag cccgcctcgc gagtgtgcac ggtgctggtg
      661 agccgcaccg cgctccaagt ctttatccag gtgaatgtgc tggtgtcctt cgtgctcccc
      721 ttggcactaa ctgctttcct gaatggggtc acagtgagcc acctgctggc cctctgctcc
      781 caagtgccgt ccacttctac cccgggcagc tccaccccca gccgcctgga gctgctgagt
      841 gaggagggtc tcctcagctt catcgtatgg aagaagacct ttatccaggg aggccaggtc
      901 agcctggtga gacataaaga cgtgcgccgg atccgcagcc tccagcgcag cgtccaggtt
      961 ctcagagcca tcgtggtcat gtatgtcatc tgctggctgc cgtaccatgc ccgcaggctc
     1021 atgtactgct acgtacctga tgacgcgtgg actgacccac tgtacaattt ctaccactac
     1081 ttctacatgg tgaccaacac acttttctac gtcagctcag ctgtgactcc tcttctctac
     1141 aacgccgtgt cctcctcctt cagaaaactc ttcctggaag ccgtcagctc cctgtgtgga
     1201 gagcaccacc ccatgaagcg gttacccccg aagccccaga gtcccaccct aatggataca
     1261 gcttcaggct ttggggatcc cccagaaacc cggacctgaa tgtaatgcaa gaatgaacag
     1321 aacaagcaaa atgaccagct gcttagtcac ctggcaaagc aggtgagcaa cctcatcact
     1381 aatcattcaa gcttcgcagc cagggcgact tctatcaacc cctgctctgc tgagaaccat
     1441 caagcgcagg gaagccacgt gacccctcct agcctcaggc tccctcgtct gtgtagtgga
     1501 gataaagaac agcacccatc tcttagtgtt gcctgagact aaagtgctta gcacagaacc
     1561 tggtgcgtag tagatgctca ataaattttt gctggcacga
//
