LOCUS       NM_002531               4133 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neurotensin receptor 1 (NTSR1), mRNA.
ACCESSION   NM_002531
VERSION     NM_002531.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4133)
  AUTHORS   Libanje,F., Delille,R., Young,P.A., Rolland,S., Meyer-Losic,F.,
            Lewkowicz,E. and Klinz,S.
  TITLE     NTSR1 glycosylation and MMP dependent cleavage generate three
            distinct forms of the protein
  JOURNAL   Sci Rep 13 (1), 4663 (2023)
   PUBMED   36949141
  REMARK    GeneRIF: NTSR1 glycosylation and MMP dependent cleavage generate
            three distinct forms of the protein.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4133)
  AUTHORS   Moody,T.W., Ramos-Alvarez,I. and Jensen,R.T.
  TITLE     Adding of neurotensin to non-small cell lung cancer cells increases
            tyrosine phosphorylation of HER3
  JOURNAL   Peptides 156, 170858 (2022)
   PUBMED   35932909
  REMARK    GeneRIF: Adding of neurotensin to non-small cell lung cancer cells
            increases tyrosine phosphorylation of HER3.
REFERENCE   3  (bases 1 to 4133)
  AUTHORS   Maharana,J. and Shukla,A.K.
  TITLE     Feeling at home: Structure of the NTSR1-Gi complex in a lipid
            environment
  JOURNAL   Nat Struct Mol Biol 28 (4), 331-333 (2021)
   PUBMED   33785921
  REMARK    GeneRIF: Feeling at home: Structure of the NTSR1-Gi complex in a
            lipid environment.
REFERENCE   4  (bases 1 to 4133)
  AUTHORS   Wang,H., Huang,D. and Zhou,Z.
  TITLE     Effect of NTSR1 on the Proliferation and Invasion of Gastric
            Adenocarcinoma Cells, the Underlying Mechanism, and Clinical Role
  JOURNAL   Ann Clin Lab Sci 51 (2), 163-173 (2021)
   PUBMED   33941555
  REMARK    GeneRIF: Effect of NTSR1 on the Proliferation and Invasion of
            Gastric Adenocarcinoma Cells, the Underlying Mechanism, and
            Clinical Role.
REFERENCE   5  (bases 1 to 4133)
  AUTHORS   Zhang,M., Gui,M., Wang,Z.F., Gorgulla,C., Yu,J.J., Wu,H., Sun,Z.J.,
            Klenk,C., Merklinger,L., Morstein,L., Hagn,F., Pluckthun,A.,
            Brown,A., Nasr,M.L. and Wagner,G.
  TITLE     Cryo-EM structure of an activated GPCR-G protein complex in lipid
            nanodiscs
  JOURNAL   Nat Struct Mol Biol 28 (3), 258-267 (2021)
   PUBMED   33633398
  REMARK    GeneRIF: Cryo-EM structure of an activated GPCR-G protein complex
            in lipid nanodiscs.
REFERENCE   6  (bases 1 to 4133)
  AUTHORS   Boudin,H., Pelaprat,D., Rostene,W., Pickel,V.M. and Beaudet,A.
  TITLE     Correlative ultrastructural distribution of neurotensin receptor
            proteins and binding sites in the rat substantia nigra
  JOURNAL   J Neurosci 18 (20), 8473-8484 (1998)
   PUBMED   9763490
REFERENCE   7  (bases 1 to 4133)
  AUTHORS   Le,F., Groshan,K., Zeng,X.P. and Richelson,E.
  TITLE     Characterization of the genomic structure, promoter region, and a
            tetranucleotide repeat polymorphism of the human neurotensin
            receptor gene
  JOURNAL   J Biol Chem 272 (2), 1315-1322 (1997)
   PUBMED   8995438
REFERENCE   8  (bases 1 to 4133)
  AUTHORS   Vincent,J.P.
  TITLE     Neurotensin receptors: binding properties, transduction pathways,
            and structure
  JOURNAL   Cell Mol Neurobiol 15 (5), 501-512 (1995)
   PUBMED   8719037
  REMARK    Review article
REFERENCE   9  (bases 1 to 4133)
  AUTHORS   Laurent,P., Clerc,P., Mattei,M.G., Forgez,P., Dumont,X.,
            Ferrara,P., Caput,D. and Rostene,W.
  TITLE     Chromosomal localization of mouse and human neurotensin receptor
            genes
  JOURNAL   Mamm Genome 5 (5), 303-306 (1994)
   PUBMED   8075503
REFERENCE   10 (bases 1 to 4133)
  AUTHORS   Vita,N., Laurent,P., Lefort,S., Chalon,P., Dumont,X., Kaghad,M.,
            Gully,D., Le Fur,G., Ferrara,P. and Caput,D.
  TITLE     Cloning and expression of a complementary DNA encoding a high
            affinity human neurotensin receptor
  JOURNAL   FEBS Lett 317 (1-2), 139-142 (1993)
   PUBMED   8381365
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357033.19, X70070.1,
            AL035669.43 and BC040711.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002531.2.
            
            Summary: Neurotensin receptor 1 belongs to the large superfamily of
            G-protein coupled receptors. NTSR1 mediates the multiple functions
            of neurotensin, such as hypotension, hyperglycemia, hypothermia,
            antinociception, and regulation of intestinal motility and
            secretion. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70070.1, AY429106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370501.4/ ENSP00000359532.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL357033.19        72555-72555
            2-970               AL357033.19        72556-73524
            971-1986            X70070.1           971-1986
            1987-3883           AL035669.43        9802-11698
            3884-4133           BC040711.1         1203-1452
FEATURES             Location/Qualifiers
     source          1..4133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..4133
                     /gene="NTSR1"
                     /gene_synonym="NTR"
                     /note="neurotensin receptor 1"
                     /db_xref="GeneID:4923"
                     /db_xref="HGNC:HGNC:8039"
                     /db_xref="MIM:162651"
     exon            1..1086
                     /gene="NTSR1"
                     /gene_synonym="NTR"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1629
                     /gene="NTSR1"
                     /gene_synonym="NTR"
                     /note="NTR1; NTRH; NT-R-1; high-affinity
                     levocabastine-insensitive neurotensin receptor;
                     neurotensin receptor 1 (high affinity)"
                     /codon_start=1
                     /product="neurotensin receptor type 1"
                     /protein_id="NP_002522.2"
                     /db_xref="CCDS:CCDS13502.1"
                     /db_xref="GeneID:4923"
                     /db_xref="HGNC:HGNC:8039"
                     /db_xref="MIM:162651"
                     /translation="MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASE
                     RVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVH
                     YHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVA
                     SLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQH
                     AGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQV
                     CTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQW
                     TPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKR
                     PAFSRKADSVSSNHTLSSNATRETLY"
     exon            1087..1288
                     /gene="NTSR1"
                     /gene_synonym="NTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1379
                     /gene="NTSR1"
                     /gene_synonym="NTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..4133
                     /gene="NTSR1"
                     /gene_synonym="NTR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4103..4108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTSR1"
                     /gene_synonym="NTR"
                     /note="hexamer: AATAAA"
     polyA_site      4133
                     /gene="NTSR1"
                     /gene_synonym="NTR"
                     /note="major polyA site"
ORIGIN      
        1 acaagctcgc cccgcgcagc ccgagccggg ctgggcgctg tcctcggggg cctggggaac
       61 cgcgcggttt ggagatcgga ggcacctgga acccgtggca agcgccgagc cgggagacag
      121 cccgaggaac cacgggttct ggagctagga gccggaagct gggagtccgg aggagagcgg
      181 agcccggagc ccggagcccg gggcggcgcg tctgggtctg gcgcttcccg actggacggc
      241 gcgcccgctg gtcttcgcca cgcgccctcc cctgggctcc cgttcatcgg tccccgcctg
      301 agacgcgccc actcctgccc ggacttccag ccccggaggc gccggacaga gccgcggact
      361 ccagcgccca ccatgcgcct caacagctcc gcgccgggaa ccccgggcac gccggccgcc
      421 gaccccttcc agcgggcgca ggccggactg gaggaggcgc tgctggcccc gggcttcggc
      481 aacgcttcgg gcaacgcgtc ggagcgcgtc ctggcggcac ccagcagcga gctggacgtg
      541 aacaccgaca tctactccaa ggtgctggtg accgccgtgt acctggcgct cttcgtggtg
      601 ggcacggtgg gcaacacggt gacggcgttc acgctggcgc ggaagaagtc gctgcagagc
      661 ctgcagagca cggtgcatta ccacctgggc agcctggcgc tgtccgacct gctcaccctg
      721 ctgctggcca tgcccgtgga gctgtacaac ttcatctggg tgcaccaccc ctgggccttc
      781 ggcgacgccg gctgccgcgg ctactacttc ctgcgcgacg cctgcaccta cgccacggcc
      841 ctcaacgtgg ccagcctgag tgtggagcgc tacctggcca tctgccaccc cttcaaggcc
      901 aagaccctca tgtcccgaag ccgcaccaag aagttcatca gcgccatctg gctcgcctcg
      961 gccctgctgg cggtgcctat gctgttcacc atgggcgagc agaaccgcag cgccgacggc
     1021 cagcacgccg gcggcctggt gtgcaccccc accatccaca ctgccaccgt caaggtcgtc
     1081 atacaggtca acaccttcat gtccttcata ttccccatgg tggtcatctc ggtcctgaac
     1141 accatcatcg ccaacaagct gaccgtcatg gtacgccagg cggccgagca gggccaagtg
     1201 tgcacggtcg ggggcgagca cagcacattc agcatggcca tcgagcctgg cagggtccag
     1261 gccctgcggc acggcgtgcg cgtcctacgt gcagtggtca tcgcctttgt ggtctgctgg
     1321 ctgccctacc acgtgcggcg cctcatgttc tgctacatct cggatgagca gtggactccg
     1381 ttcctctatg acttctacca ctacttctac atggtgacca acgcactctt ctacgtcagc
     1441 tccaccatca accccatcct gtacaacctc gtctctgcca acttccgcca catcttcctg
     1501 gccacactgg cctgcctctg cccggtgtgg cggcgcagga ggaagaggcc agccttctcg
     1561 aggaaggccg acagcgtgtc cagcaaccac accctctcca gcaatgccac ccgcgagacg
     1621 ctgtactagg ctgtgcgccc cggaacgtgt ccaggaggag cctggccatg ggtccttgcc
     1681 cccgacagac agagcagccc ccacccggga gccttgatgg gggtcaggca gaggccagcc
     1741 tgcactggag tctgaggcct gggacccccc cctcccaccc cctaacccat gtttctcatt
     1801 agtgtctccc gggcctgtcc ccaactcctc cccacccctc ccccatctcc tctttgaaag
     1861 ccagaacaag agagcgctcc tctcccagat aggaaaaggg cctctaacaa ggagaaatta
     1921 gtgtgcggca aaaggcagtt ttctttgttc tcagactaat ggatggttcc agagaaggaa
     1981 atgaaaggtg ctgggtgggg ccgggcctcc ggcggcccgg ctgctgttcc catgtccaca
     2041 tctctgaggc ctgcaccccc tctgtctagc tcggggagtc cagccccagt cccgcaggct
     2101 ccgtggcttt gggcctcacg tgcagaccct gccatgcaga cccatgcccc cctcccccag
     2161 gcagctccaa gaaagctccc tgactcgccc cttcaggcct ggcaagctgg gggcccatcg
     2221 ccgtggggag tccctcccac caccctcgcc gcaggcagct gcagccccca gaggggacca
     2281 caagcccaaa aaggacaaaa atgggctggc ctggaatggc ccagacccca gcctcccctc
     2341 ctccctccca tcctcaccca ggccaaggcc caggggctct gccaggacac cacatgggag
     2401 ggggctcagg cctcagcctc aagatcttca gctgtggcct ctcgggctcg gcagaaggga
     2461 cgccggatca ggggcctggt ctccagcacc tgcccgagtg gccgtggcca ggatggggtg
     2521 cgcattccgt gtgctttgct tgtggctgtg caggctgagg tctggagcca ggcccagagc
     2581 tggcttcagg gtggggcctt gagaagggga atgtgggaca ggggcgatgg tgcctggtct
     2641 ctgagtaaga tgccaggtcc caggaactca ggcttcaggt gagaaggagc ggtgtgtcca
     2701 ggcaccgctg gccggcagcc ctgggctgag gcacagactc atttgtcacc ttctggcggc
     2761 ggcagccctg gccccggcct ccaagcagtt gaaaaagctg gcgcctcctt ggtctctagg
     2821 atccaggctc cacagagcac atgactagcc aggcccctgg cttaagaagg tcgcctaagc
     2881 ctaagagaag acagtcccag gagaagctgg ccgggaccag ccaggagctg ggagccacag
     2941 gaagcaaaag tcagcctttt cttcaaggga tttccctgtc tcagagcagc ctttgcccca
     3001 gggaaatggg ctctgggctg gctgcctgca ccggccatgt cgacccagga cccggacacc
     3061 tggtcttggg ctgtgttcag ccactttgcc ttctctggac tcagtttccc cgtctgagaa
     3121 atgagagtcg aatgctacag tatctgcagt cgcttggatc tggctgttga gttgacgggt
     3181 tccttgaacc ccacaaaatc cctctccaac cacaggaccc ttcggctcac caagaacagg
     3241 gcccagggga gtcaggccta ttcgctgcac ttcctgccaa actttgcccc cacaagcctg
     3301 gtcatcagcc aggcagccct cccagtgccc aagggccacc aaccccaggg aaacagggcc
     3361 agcacagagg ggccttcctc ccccacagag cccccatgac atagtctgct ctgggcggaa
     3421 gagctttgct gccagccagg gatgtccaga ggtcagtgca gcccctaccc ctgctcagga
     3481 gtgggctcag agtctagcaa atgctaaggc ccctcaggct gggctctgaa cgaggacctg
     3541 gactcagagc cagacagggc agcctcagac ccttctctgg ggctcctgga ccttgggcca
     3601 taatttctga gcctcggttt ccccatctaa ggaacagatg tggtcgttcc gccctctcag
     3661 ctggatgaga ctgtcctgga ggatccaccc cggaacagac agaatggtgt ctctcaggat
     3721 ggtgctctga gagagggcag agtggatgcc ccactgccct agaccctcgg tagacgtggg
     3781 gtctctgggg cggggtctgt ggctgtgact gaagtcggct tttcccgttg atgtcttgat
     3841 gctcctatct gtgcacttac cgtaggtagg gacacgtgtc cacgcaccac agacacaccc
     3901 acgacacctg atctcgtatc actagcttgc ggccaggtca tgatgtggcc ccggaagctg
     3961 gccctgcgtg ccatgagtgc gtcggtcatg gagtccggag cccctgagcc ggcccctggt
     4021 gacggcacag ccctcacagc tcaaacgccc acccccactc ccaccatctg caggtggtga
     4081 aaacaaaccc cgtgtatctc tcaataaagg tggccgaagg gcctcgatgt gga
//
