LOCUS       NM_006183               1239 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens neurotensin (NTS), mRNA.
ACCESSION   NM_006183
VERSION     NM_006183.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Zhao,H., Tian,X., Wu,B., Lu,Y., Du,J., Peng,S. and Xiao,Y.
  TITLE     Neurotensin contributes to cholestatic liver disease potentially
            modulating matrix metalloprotease-7
  JOURNAL   Int J Biochem Cell Biol 170, 106567 (2024)
   PUBMED   38522506
  REMARK    GeneRIF: Neurotensin contributes to cholestatic liver disease
            potentially modulating matrix metalloprotease-7.
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Li,J., Yang,L., Song,J., Yan,B., Morris,A.J., Moseley,H.,
            Flight,R., Wang,C., Liu,J., Weiss,H.L., Morris,E.F., Abdelhamid,I.,
            Gerl,M.J., Melander,O., Smyth,S. and Evers,B.M.
  TITLE     Neurotensin accelerates atherosclerosis and increases circulating
            levels of short-chain and saturated triglycerides
  JOURNAL   Atherosclerosis 392, 117479 (2024)
   PUBMED   38423808
  REMARK    GeneRIF: Neurotensin accelerates atherosclerosis and increases
            circulating levels of short-chain and saturated triglycerides.
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Gilliam-Vigh,H., Jorsal,T., Nielsen,S.W., Forman,J.L., Pedersen,J.,
            Poulsen,S.S., Vilsboll,T. and Knop,F.K.
  TITLE     Expression of Neurotensin and Its Receptors Along the Intestinal
            Tract in Type 2 Diabetes Patients and Healthy Controls
  JOURNAL   J Clin Endocrinol Metab 108 (9), 2211-2216 (2023)
   PUBMED   36916883
  REMARK    GeneRIF: Expression of Neurotensin and Its Receptors Along the
            Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Sentinelli,F., Barchetta,I., Cimini,F.A., Dule,S., Bailetti,D.,
            Cossu,E., Barbonetti,A., Totaro,M., Melander,O., Cavallo,M.G. and
            Baroni,M.G.
  TITLE     Neurotensin Gene rs2234762 C>G Variant Associates with Reduced
            Circulating Pro-NT Levels and Predicts Lower Insulin Resistance in
            Overweight/Obese Children
  JOURNAL   Int J Mol Sci 24 (7), 6460 (2023)
   PUBMED   37047432
  REMARK    GeneRIF: Neurotensin Gene rs2234762 C>G Variant Associates with
            Reduced Circulating Pro-NT Levels and Predicts Lower Insulin
            Resistance in Overweight/Obese Children.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Evers,B.M., Wang,X., Zhou,Z., Townsend,C.M. Jr., McNeil,G.P. and
            Dobner,P.R.
  TITLE     Characterization of promoter elements required for cell-specific
            expression of the neurotensin/neuromedin N gene in a human
            endocrine cell line
  JOURNAL   Mol Cell Biol 15 (7), 3870-3881 (1995)
   PUBMED   7791794
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Laurent,P., Clerc,P., Mattei,M.G., Forgez,P., Dumont,X.,
            Ferrara,P., Caput,D. and Rostene,W.
  TITLE     Chromosomal localization of mouse and human neurotensin receptor
            genes
  JOURNAL   Mamm Genome 5 (5), 303-306 (1994)
   PUBMED   8075503
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Bean,A.J., Dagerlind,A., Hokfelt,T. and Dobner,P.R.
  TITLE     Cloning of human neurotensin/neuromedin N genomic sequences and
            expression in the ventral mesencephalon of schizophrenics and
            age/sex matched controls
  JOURNAL   Neuroscience 50 (2), 259-268 (1992)
   PUBMED   1436492
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Mai,J.K., Triepel,J. and Metz,J.
  TITLE     Neurotensin in the human brain
  JOURNAL   Neuroscience 22 (2), 499-524 (1987)
   PUBMED   3670596
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Jennes,L., Stumpf,W.E. and Kalivas,P.W.
  TITLE     Neurotensin: topographical distribution in rat brain by
            immunohistochemistry
  JOURNAL   J Comp Neurol 210 (3), 211-224 (1982)
   PUBMED   6754769
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Helmstaedter,V., Taugner,C., Feurle,G.E. and Forssmann,W.G.
  TITLE     Localization of neurotensin-immunoreactive cells in the small
            intestine of man and various mammals
  JOURNAL   Histochemistry 53 (1), 35-41 (1977)
   PUBMED   409699
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312066.1 and AF157682.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006183.4.
            
            Summary: This gene encodes a common precursor for two peptides,
            neuromedin N and neurotensin. Neurotensin is a secreted
            tridecapeptide, which is widely distributed throughout the central
            nervous system, and may function as a neurotransmitter or a
            neuromodulator. It may be involved in dopamine-associated
            pathophysiological events, in the maintenance of gut structure and
            function, and in the regulation of fat metabolism. Neurotensin also
            exhibits antimicrobial activity against bacteria and fungi.
            Tissue-specific processing may lead to the formation in some
            tissues of larger forms of neuromedin N and neurotensin. The large
            forms may represent more stable peptides that are also biologically
            active. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF157682.1, SRR5189655.114135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000256010.7/
                                                  ENSP00000256010.5
            Protein has antimicrobial activity :: PMID: 12074933
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               AK312066.1         1-622
            623-1239            AF157682.1         599-1215
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..1239
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /note="neurotensin"
                     /db_xref="GeneID:4922"
                     /db_xref="HGNC:HGNC:8038"
                     /db_xref="MIM:162650"
     exon            1..182
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..622
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /note="neurotensin/neuromedin N;
                     pro-neurotensin/neuromedin"
                     /codon_start=1
                     /product="neurotensin/neuromedin N preproprotein"
                     /protein_id="NP_006174.1"
                     /db_xref="CCDS:CCDS9029.1"
                     /db_xref="GeneID:4922"
                     /db_xref="HGNC:HGNC:8038"
                     /db_xref="MIM:162650"
                     /translation="MMAGMKIQLVCMLLLAFSSWSLCSDSEEEMKALEADFLTNMHTS
                     KISKAHVPSWKMTLLNVCSLVNNLNSPAEETGEVHEEELVARRKLPTALDGFSLEAML
                     TIYQLHKICHSRAFQHWELIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENKPRRP
                     YILKRDSYYY"
     exon            183..244
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..469
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..1239
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      791..796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /note="hexamer: AATAAA"
     polyA_site      814
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /note="major polyA site"
     regulatory      1211..1216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="NTS"
                     /gene_synonym="NMN-125; NN; NT; NT/N; NTS1"
ORIGIN      
        1 atagttcact cactttcaaa gccagctgaa ggaaagagga agtgctagag agagccccct
       61 tcagtgtgct tctgactttt acggacttgg cttgttagaa ggctgaaaga tgatggcagg
      121 aatgaaaatc cagcttgtat gcatgctact cctggctttc agctcctgga gtctgtgctc
      181 agattcagaa gaggaaatga aagcattaga agcagatttc ttgaccaata tgcatacatc
      241 aaagattagt aaagcacatg ttccctcttg gaagatgact ctgctaaatg tttgcagtct
      301 tgtaaataat ttgaacagcc cagctgagga aacaggagaa gttcatgaag aggagcttgt
      361 tgcaagaagg aaacttccta ctgctttaga tggctttagc ttggaagcaa tgttgacaat
      421 ataccagctc cacaaaatct gtcacagcag ggcttttcaa cactgggagt taatccagga
      481 agatattctt gatactggaa atgacaaaaa tggaaaggaa gaagtcataa agagaaaaat
      541 tccttatatt ctgaaacggc agctgtatga gaataaaccc agaagaccct acatactcaa
      601 aagagattct tactattact gagagaataa atcatttatt tacatgtgat tgtgattcat
      661 catcccttaa ttaaatatca aattatattt gtgtgaaaat gtgacaaaca cacttatctg
      721 tctcttctac aattgtggtt tattgaatgt gatttttctg cactaatata aattagacta
      781 agtgttttca aataaatcta aatcttcagc atgatgtgtt gtgtataatt ggagtagata
      841 ttaattaagt cacctgtata atgttttgta attttgcaaa acatatcttg agttgtttaa
      901 acagtcaaaa tgtttgatat tttataccag cttatgagct caaagtacta cagcaaagcc
      961 tagcctgcat atcattcacc caaaacaaag taatagcgcc tcttttatta ttttgactga
     1021 atgttttatg gaattgaaag aaacatacgt tcttttcaag acttcctcat gaatctctca
     1081 attataggaa aagttattgt gataaaatag gaacagctga aagattgatt aatgaactat
     1141 tgttaattct tcctatttta atgaatgaca ttgaactgaa ttttttgtct gttaaatgaa
     1201 cttgatagct aataaaaaga caactagcca tcaaaatca
//
