LOCUS       XM_011518718            8844 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens neurotrophic receptor tyrosine kinase 2
            (NTRK2), transcript variant X8, mRNA.
ACCESSION   XM_011518718
VERSION     XM_011518718.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011518718.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..8844
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 22 ESTs, 736 long SRA reads, 11 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 13 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     CDS             759..3227
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform X2"
                     /protein_id="XP_011517020.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNY
                     PDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM
                     LFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKI
                     PVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDK
                     ILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGD
                     LNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNC
                     LVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG
                     VVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRK
                     NIKGIHTLLQNLAKASPVYLDILG"
ORIGIN      
        1 ggaaaaacag attccgagcc gcaaaaggga agacggattc tcagacaagg cttgcaaatg
       61 ccccgcagcc atcatttaac tgcacccgca gaatagttac ggtttgtcac ccgaccctcc
      121 cggatcgcct aatttgtccc tagtgagacc ccgaggctct gcccgcgcct ggcttcttcg
      181 tagctggatg catatcgtgc tccgggcagc gcgggcgcag ggcacgcgtt cgcgcacacc
      241 ctagcacaca tgaacacgcg caagagctga accaagcacg gtttccattt caaaaaggga
      301 gacagcctct accgcgattg tagaagagac tgtggtgtga attagggacc gggaggcgtc
      361 gaacggagga acggttcatc ttagagcctc gaggtgcata ccggaccccc attcgcatct
      421 aacaaggaat ctgcgcccca gagagtcccg ggagcgccgc cggtcggtgc ccggcgcgcc
      481 gggccatgca gcgacggccg ccgcggagct ccgagcagcg gtagcgcccc cctgtaaagc
      541 ggttcgctat gccggggcca ctgtgaaccc tgccgcctgc cggaacactc ttcgctccgg
      601 accagctcag cctctgataa gctggactcg gcacgcccgc aacaagcacc gaggagttaa
      661 gagagccgca agcgcaggga aggcctcccc gcacgggtgg gggaaagcgg ccggtgcagc
      721 gcggggacag gcactcgggc tggcactggc tgctagggat gtcgtcctgg ataaggtggc
      781 atggacccgc catggcgcgg ctctggggct tctgctggct ggttgtgggc ttctggaggg
      841 ccgctttcgc ctgtcccacg tcctgcaaat gcagtgcctc tcggatctgg tgcagcgacc
      901 cttctcctgg catcgtggca tttccgagat tggagcctaa cagtgtagat cctgagaaca
      961 tcaccgaaat tttcatcgca aaccagaaaa ggttagaaat catcaacgaa gatgatgttg
     1021 aagcttatgt gggactgaga aatctgacaa ttgtggattc tggattaaaa tttgtggctc
     1081 ataaagcatt tctgaaaaac agcaacctgc agcacatcaa ttttacccga aacaaactga
     1141 cgagtttgtc taggaaacat ttccgtcacc ttgacttgtc tgaactgatc ctggtgggca
     1201 atccatttac atgctcctgt gacattatgt ggatcaagac tctccaagag gctaaatcca
     1261 gtccagacac tcaggatttg tactgcctga atgaaagcag caagaatatt cccctggcaa
     1321 acctgcagat acccaattgt ggtttgccat ctgcaaatct ggccgcacct aacctcactg
     1381 tggaggaagg aaagtctatc acattatcct gtagtgtggc aggtgatccg gttcctaata
     1441 tgtattggga tgttggtaac ctggtttcca aacatatgaa tgaaacaagc cacacacagg
     1501 gctccttaag gataactaac atttcatccg atgacagtgg gaagcagatc tcttgtgtgg
     1561 cggaaaatct tgtaggagaa gatcaagatt ctgtcaacct cactgtgcat tttgcaccaa
     1621 ctatcacatt tctcgaatct ccaacctcag accaccactg gtgcattcca ttcactgtga
     1681 aaggcaaccc caaaccagcg cttcagtggt tctataacgg ggcaatattg aatgagtcca
     1741 aatacatctg tactaaaata catgttacca atcacacgga gtaccacggc tgcctccagc
     1801 tggataatcc cactcacatg aacaatgggg actacactct aatagccaag aatgagtatg
     1861 ggaaggatga gaaacagatt tctgctcact tcatgggctg gcctggaatt gacgatggtg
     1921 caaacccaaa ttatcctgat gtaatttatg aagattatgg aactgcagcg aatgacatcg
     1981 gggacaccac gaacagaagt aatgaaatcc cttccacaga cgtcactgat aaaaccggtc
     2041 gggaacatct ctcggtctat gctgtggtgg tgattgcgtc tgtggtggga ttttgccttt
     2101 tggtaatgct gtttctgctt aagttggcaa gacactccaa gtttggcatg aaaggcccag
     2161 cctccgttat cagcaatgat gatgactctg ccagcccact ccatcacatc tccaatggga
     2221 gtaacactcc atcttcttcg gaaggtggcc cagatgctgt cattattgga atgaccaaga
     2281 tccctgtcat tgaaaatccc cagtactttg gcatcaccaa cagtcagctc aagccagaca
     2341 catttgttca gcacatcaag cgacataaca ttgttctgaa aagggagcta ggcgaaggag
     2401 cctttggaaa agtgttccta gctgaatgct ataacctctg tcctgagcag gacaagatct
     2461 tggtggcagt gaagaccctg aaggatgcca gtgacaatgc acgcaaggac ttccaccgtg
     2521 aggccgagct cctgaccaac ctccagcatg agcacatcgt caagttctat ggcgtctgcg
     2581 tggagggcga ccccctcatc atggtctttg agtacatgaa gcatggggac ctcaacaagt
     2641 tcctcagggc acacggccct gatgccgtgc tgatggctga gggcaacccg cccacggaac
     2701 tgacgcagtc gcagatgctg catatagccc agcagatcgc cgcgggcatg gtctacctgg
     2761 cgtcccagca cttcgtgcac cgcgatttgg ccaccaggaa ctgcctggtc ggggagaact
     2821 tgctggtgaa aatcggggac tttgggatgt cccgggacgt gtacagcact gactactaca
     2881 gggtcggtgg ccacacaatg ctgcccattc gctggatgcc tccagagagc atcatgtaca
     2941 ggaaattcac gacggaaagc gacgtctgga gcctgggggt cgtgttgtgg gagattttca
     3001 cctatggcaa acagccctgg taccagctgt caaacaatga ggtgatagag tgtatcactc
     3061 agggccgagt cctgcagcga ccccgcacgt gcccccagga ggtgtatgag ctgatgctgg
     3121 ggtgctggca gcgagagccc cacatgagga agaacatcaa gggcatccat accctccttc
     3181 agaacttggc caaggcatct ccggtctacc tggacattct aggctagggc ccttttcccc
     3241 agaccgatcc ttcccaacgt actcctcaga cgggctgaga ggatgaacat cttttaactg
     3301 ccgctggagg ccaccaagct gctctccttc actctgacag tattaacatc aaagactccg
     3361 agaagctctc gagggaagca gtgtgtactt cttcatccat agacacagta ttgacttctt
     3421 tttggcatta tctctttctc tctttccatc tcccttggtt gttccttttt ctttttttaa
     3481 attttctttt tctttttttt ttcgtcttcc ctgcttcacg attcttaccc tttcttttga
     3541 atcaatctgg cttctgcatt actattaact ctgcatagac aaaggcctta acaaacgtaa
     3601 tttgttatat cagcagacac tccagtttgc ccaccacaac taacaatgcc ttgttgtatt
     3661 cctgcctttg atgtggatga aaaaaaggga aaacaaatat ttcacttaaa ctttgtcact
     3721 tctgctgtac agatatcgag agtttctatg gattcacttc tatttattta ttattattac
     3781 tgttcttatt gtttttggat ggcttaagcc tgtgtataaa aaagaaaact tgtgttcaat
     3841 ctgtgaagcc tttatctatg ggagattaaa accagagaga aagaagattt attatgaacc
     3901 gcaatatggg aggaacaaag acaaccactg ggatcagctg gtgtcagtcc ctacttagga
     3961 aatactcagc aactgttagc tgggaagaat gtattcggca ccttcccctg aggacctttc
     4021 tgaggagtaa aaagactact ggcctctgtg ccatggatga ttcttttccc atcaccagaa
     4081 atgatagcgt gcagtagaga gcaaagatgg cttccgtgag acacaagatg gcgcatagtg
     4141 tgctcggaca cagttttgtc ttcgtaggtt gtgatgatag cactggtttg tttctcaagc
     4201 gctatccaca gaacctttgt caacttcagt tgaaaagagg tggattcatg tccagagctc
     4261 atttcggggt caggtgggaa agccaagaac ttggaaaaga taagacaagc tataaattcg
     4321 gaggcaagtt tcttttacaa tgaacttttc agatctcact tccctccgac ccctaacttc
     4381 catgcccacc cgtcctttta actgtgcaag caaaattgtg catggtcttc gtcgattaat
     4441 accttgtgtg cagacactac tgctccagac gtcgtttccc tgataggtag agcagatcca
     4501 taaaaaggta tgacttatac aattagggga agctaatgga gtttattagc tgagtatcaa
     4561 tgtctctgcg ttgtacggtg gtgatgggtt ttaatgaata tggaccctga agcctggaaa
     4621 tcctcatcca cgtcgaaccc acaggactgt gggaagggca gaatcaatcc ctaagggaaa
     4681 ggaaacctca ccctgagggc atcacatgca ctcatgttca gtgtacacag gtcaagtccc
     4741 ttgctctggg ctctagttgg gagagtggtt tcattccaag tgtactccat tgtcagtatg
     4801 ctgtttttgt ttccttcact ccattcaaaa agtcaaaata caaaatttgg cacagcatgc
     4861 caacgggagg ctgtgcccag accaagcact ggaagtgtgc ttctaggcat agtcattggt
     4921 tttgcaaaaa gagggctcaa atttaaatag aaatttacag ctatttgaat ggtcagatat
     4981 accaagaaag aaaaatattt ctgttcctca agaaaacttg ctaccctctg tgaggggaat
     5041 tttgctaaac ttgacatctt tataacatga gccagattga aagggagtga ttttcattca
     5101 tcttaggtca tgttatttca tatttgtttc tgaaggtgcg atagctctgt tttaggtttt
     5161 gcttgcgcct gttaattact ggaacacctt atttttcatt aaaggctttg aaagccaatt
     5221 ctcaaaaatt caaaagtgca aattaacaga acaaaaggaa atccagtagc aactgcagtc
     5281 aagcgaggga gttgacaaga taaaccttac gtccattcaa gttatatgct ggcctatgag
     5341 agatgagagt tgggtcgttt gttctctttg ttgatgattt taaaaaaacc ctctagaata
     5401 cacataataa cataatgaaa gccatatctc catgatatat atgtgcacat atatatacat
     5461 acatgtgcat gtatgtatca tattaaggac ccatggtact cttaaaacac tgtagaactc
     5521 tgtgacgcag taaggaaggg gcagatttgt acaaaaactt ttctagattc catcagcaaa
     5581 aaccaacaca ggtttgtcac gctgcatgtc tggccagcta atctcggggg aaaagctaca
     5641 agttatttat tttattttaa gagaataaag taggtaataa tttaagggat caaattcaag
     5701 gaggaatgtg caattttaga gcaaagattt gtttaaggca aatgagactt tgggagcatc
     5761 ccattccagt tttgtctttt ttttctctga aagaaaaaag caaaaaataa aataaaattc
     5821 cacttatacc ttctgacaag tccctaaagg tcttgaaata aaaggttcta tgcaagtgca
     5881 aagttttata gttattttta ttgctgatta ttactattac tatctctgtt gtcttaagag
     5941 tatgtgctga tttcagagac atctcaaatt gaaagaatat cagattgctt ttaaagtagc
     6001 tgaacgagcc acagaatatc tgaaattatt cattgttgtt cctccaccac cccctttctc
     6061 atggtctgat ttttagaaga gtggcatcct cgttctaaaa tgtaatgatc accaaatacg
     6121 gccttccatc aaatttgtga aaactacaac agtataacag tgacaaacct aattctctag
     6181 cccaaacctg gtctgacaat catttccatt tagaagtcat tgaatagttt tccaaacact
     6241 ttccatgtgt gttagcaaat tattcctatt ttgtgtagat gaggacgttg agactcagag
     6301 acattcagag gcacgctaga ggtctccagc ctagcttcca gcaccattgg gactgaatcc
     6361 aagtactctc actctgaact tcgtggttct gtccactaga gactctaata tgcaaacaag
     6421 cagttcagga aagaaagcat gctaacacat tcatgaagca gtatatgaag ttagaagaac
     6481 aaaaggaaat acaggagatg acaagcaact gagatattgt gatatataat catgctctta
     6541 gcttcagcta aattcagcta aattcttgta cactgaacca atgtcataat caggcttatt
     6601 tagaaaacac tttgaactat gctataaaag attatatcag aattcatatt atacatgtgt
     6661 tcacatcagc gctacctgtg atgttttcat gtatttatgt atgtgttata aatacttgat
     6721 ttatacatat acaaatgcac atacgtagtg tgtttgtgtg tttatgtata aatttatagg
     6781 cacacaataa tagaggtaat tataagtagg atgcggtatg aataatttgc ttaaaatatg
     6841 ctaaataacc aaaactgttt aacgtcatgt tgctgttagt gcttccatac tccacgtggg
     6901 taggactaca tcacactttt caactctgtg cagtactgca tgggtggaag acatatttaa
     6961 gataatgtgc ttcccaaaac aactgaataa aagccatccc actacattga gtgctttctc
     7021 tggctccttg caaagaaaga tactttttgt aatggtccag gaaaggaaca ttgctttctt
     7081 tttgtctttc agcacatttg tattatgctc accttgtctc tgtctcactg tgaccccttt
     7141 acacttgagt tcagagttca agcattccaa atataaattg gaatgttggc agcccagtgg
     7201 cttgaaggcc aatgatgagc agtccaagac cccacagcga gatgagcaac tcttaggaat
     7261 tcccacatcc tagagtgaat gcaccaacta acagtataga atgctgtcct tttcaaagcg
     7321 tcctaacagc aggattacct ggtcaagtat ggactttctt tgaatctttc ttttcacaaa
     7381 ttggactgcc tgtaatacca ataacattgt tgtatctaac taaataaatg actgcatata
     7441 cacacatacc ctcaattctc ttgcttcccc attttctttt tcatcccctg tctcaggact
     7501 tttattttca atgttgacct ttggtttggc catatatcac tgttatagga aatctcatga
     7561 gaggaatggc tagtgaccca actctccaaa tgtctaagtt agtagttaca gctgattttt
     7621 tatgatgcat aattggaatg tggagcctct gaggttgtga tagcttgtac atgaatttca
     7681 aatgtcattc taaagaatga ggggtgggag ggatttatag ttagaaacga cagtgcagga
     7741 aggggtattt tcttgttgtc agggctggaa tgaatcactg ctgctcaagt caaaggttct
     7801 tgaatatcct tagtttttgc atttcccctc cttttccttt gacctttatt tatttaatta
     7861 tgtatttatt tatttattta tatacttttg ctccattcag cacaaacaca aagcaaagca
     7921 aaaaaaaaaa tatatatata tatatctgta tatgtgttgt aggcaaaaca ctgtgaattt
     7981 cacaacaacc accaccaagc aactattttg ccatcttaac atacatctca ggagacgaaa
     8041 tgagaaaaga tggggatgtc attttttagt ctatgcgttt gaggccaggt ccatgtttat
     8101 ttatttcttt agtctatgca ttaatgaaaa tgatcctgag tggaggttag ctgaacgttc
     8161 aatgtactgg agcaagcatc ataaaagctg ctagtagcca tgtgtttgaa caggaaaaat
     8221 attacagaaa atgaaatgta aaggcctata tcttgcagct tgtatatctt actattgctt
     8281 aaaaaatgta taaagcagct ggaaatgttt taaatacaag gtctttgaat taaatgtgga
     8341 ttttaaatat gtaatccctt gacaaatgac caaattatgg tgaactattg ctccctgcgt
     8401 tctttgatca ttacctatga cttacaaatc tgcctggaga tgtggacatt ctgcatttgc
     8461 ttctgtatct ggagagatgt ttgtatatat ccaggccgta tacacacaca tttccatatc
     8521 tctctacaga tatatttccc cttcaatcgt gacctggtat ttggaactct ccttttcatt
     8581 tggcttatct tccttttaat gtgatgtctc tgtgctaata cttaccagtt cttgttttgc
     8641 aatctgtttt gaggtccatt gctttactaa gacccactgc atcttggctg atttcaaagt
     8701 gacacctgaa tacagtgttt aaaaaaaaaa aagttttgtt tgtaaatcat gtgaccagct
     8761 tctctcaacc tgacatggaa agtctcttgt actacagtgt atttaataaa aatgatgtct
     8821 tacaataaat aacatactcc aaaa
//
