LOCUS       XM_005252004            8770 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens neurotrophic receptor tyrosine kinase 2
            (NTRK2), transcript variant X6, mRNA.
ACCESSION   XM_005252004
VERSION     XM_005252004.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005252004.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..8770
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 15 ESTs, 676 long SRA reads, 9 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     CDS             637..3153
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform X1"
                     /protein_id="XP_005252061.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNY
                     PDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM
                     LFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPS
                     SSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFG
                     KVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCV
                     EGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVY
                     LASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPES
                     IMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEV
                     YELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG"
ORIGIN      
        1 ggaaaaacag attccgagcc gcaaaaggga agacggattc tcagacaagg cttgcaaatg
       61 ccccgcagcc atcatttaac tgcacccgca gaatagttac ggtttgtcac ccgaccctcc
      121 cggatcgcct aatttgtccc tagtgagacc ccgaggctct gcccgcgcct ggcttcttcg
      181 tagctggatg catatcgtgc tccgggcagc gcgggcgcag ggcacgcgtt cgcgcacacc
      241 ctagcacaca tgaacacgcg caagcctcga ggtgcatacc ggacccccat tcgcatctaa
      301 caaggaatct gcgccccaga gagtcccggg agcgccgccg gtcggtgccc ggcgcgccgg
      361 gccatgcagc gacggccgcc gcggagctcc gagcagcggt agcgcccccc tgtaaagcgg
      421 ttcgctatgc cggggccact gtgaaccctg ccgcctgccg gaacactctt cgctccggac
      481 cagctcagcc tctgataagc tggactcggc acgcccgcaa caagcaccga ggagttaaga
      541 gagccgcaag cgcagggaag gcctccccgc acgggtgggg gaaagcggcc ggtgcagcgc
      601 ggggacaggc actcgggctg gcactggctg ctagggatgt cgtcctggat aaggtggcat
      661 ggacccgcca tggcgcggct ctggggcttc tgctggctgg ttgtgggctt ctggagggcc
      721 gctttcgcct gtcccacgtc ctgcaaatgc agtgcctctc ggatctggtg cagcgaccct
      781 tctcctggca tcgtggcatt tccgagattg gagcctaaca gtgtagatcc tgagaacatc
      841 accgaaattt tcatcgcaaa ccagaaaagg ttagaaatca tcaacgaaga tgatgttgaa
      901 gcttatgtgg gactgagaaa tctgacaatt gtggattctg gattaaaatt tgtggctcat
      961 aaagcatttc tgaaaaacag caacctgcag cacatcaatt ttacccgaaa caaactgacg
     1021 agtttgtcta ggaaacattt ccgtcacctt gacttgtctg aactgatcct ggtgggcaat
     1081 ccatttacat gctcctgtga cattatgtgg atcaagactc tccaagaggc taaatccagt
     1141 ccagacactc aggatttgta ctgcctgaat gaaagcagca agaatattcc cctggcaaac
     1201 ctgcagatac ccaattgtgg tttgccatct gcaaatctgg ccgcacctaa cctcactgtg
     1261 gaggaaggaa agtctatcac attatcctgt agtgtggcag gtgatccggt tcctaatatg
     1321 tattgggatg ttggtaacct ggtttccaaa catatgaatg aaacaagcca cacacagggc
     1381 tccttaagga taactaacat ttcatccgat gacagtggga agcagatctc ttgtgtggcg
     1441 gaaaatcttg taggagaaga tcaagattct gtcaacctca ctgtgcattt tgcaccaact
     1501 atcacatttc tcgaatctcc aacctcagac caccactggt gcattccatt cactgtgaaa
     1561 ggcaacccca aaccagcgct tcagtggttc tataacgggg caatattgaa tgagtccaaa
     1621 tacatctgta ctaaaataca tgttaccaat cacacggagt accacggctg cctccagctg
     1681 gataatccca ctcacatgaa caatggggac tacactctaa tagccaagaa tgagtatggg
     1741 aaggatgaga aacagatttc tgctcacttc atgggctggc ctggaattga cgatggtgca
     1801 aacccaaatt atcctgatgt aatttatgaa gattatggaa ctgcagcgaa tgacatcggg
     1861 gacaccacga acagaagtaa tgaaatccct tccacagacg tcactgataa aaccggtcgg
     1921 gaacatctct cggtctatgc tgtggtggtg attgcgtctg tggtgggatt ttgccttttg
     1981 gtaatgctgt ttctgcttaa gttggcaaga cactccaagt ttggcatgaa agatttctca
     2041 tggtttggat ttgggaaagt aaaatcaaga caaggtgttg gcccagcctc cgttatcagc
     2101 aatgatgatg actctgccag cccactccat cacatctcca atgggagtaa cactccatct
     2161 tcttcggaag gtggcccaga tgctgtcatt attggaatga ccaagatccc tgtcattgaa
     2221 aatccccagt actttggcat caccaacagt cagctcaagc cagacacatt tgttcagcac
     2281 atcaagcgac ataacattgt tctgaaaagg gagctaggcg aaggagcctt tggaaaagtg
     2341 ttcctagctg aatgctataa cctctgtcct gagcaggaca agatcttggt ggcagtgaag
     2401 accctgaagg atgccagtga caatgcacgc aaggacttcc accgtgaggc cgagctcctg
     2461 accaacctcc agcatgagca catcgtcaag ttctatggcg tctgcgtgga gggcgacccc
     2521 ctcatcatgg tctttgagta catgaagcat ggggacctca acaagttcct cagggcacac
     2581 ggccctgatg ccgtgctgat ggctgagggc aacccgccca cggaactgac gcagtcgcag
     2641 atgctgcata tagcccagca gatcgccgcg ggcatggtct acctggcgtc ccagcacttc
     2701 gtgcaccgcg atttggccac caggaactgc ctggtcgggg agaacttgct ggtgaaaatc
     2761 ggggactttg ggatgtcccg ggacgtgtac agcactgact actacagggt cggtggccac
     2821 acaatgctgc ccattcgctg gatgcctcca gagagcatca tgtacaggaa attcacgacg
     2881 gaaagcgacg tctggagcct gggggtcgtg ttgtgggaga ttttcaccta tggcaaacag
     2941 ccctggtacc agctgtcaaa caatgaggtg atagagtgta tcactcaggg ccgagtcctg
     3001 cagcgacccc gcacgtgccc ccaggaggtg tatgagctga tgctggggtg ctggcagcga
     3061 gagccccaca tgaggaagaa catcaagggc atccataccc tccttcagaa cttggccaag
     3121 gcatctccgg tctacctgga cattctaggc tagggccctt ttccccagac cgatccttcc
     3181 caacgtactc ctcagacggg ctgagaggat gaacatcttt taactgccgc tggaggccac
     3241 caagctgctc tccttcactc tgacagtatt aacatcaaag actccgagaa gctctcgagg
     3301 gaagcagtgt gtacttcttc atccatagac acagtattga cttctttttg gcattatctc
     3361 tttctctctt tccatctccc ttggttgttc ctttttcttt ttttaaattt tctttttctt
     3421 ttttttttcg tcttccctgc ttcacgattc ttaccctttc ttttgaatca atctggcttc
     3481 tgcattacta ttaactctgc atagacaaag gccttaacaa acgtaatttg ttatatcagc
     3541 agacactcca gtttgcccac cacaactaac aatgccttgt tgtattcctg cctttgatgt
     3601 ggatgaaaaa aagggaaaac aaatatttca cttaaacttt gtcacttctg ctgtacagat
     3661 atcgagagtt tctatggatt cacttctatt tatttattat tattactgtt cttattgttt
     3721 ttggatggct taagcctgtg tataaaaaag aaaacttgtg ttcaatctgt gaagccttta
     3781 tctatgggag attaaaacca gagagaaaga agatttatta tgaaccgcaa tatgggagga
     3841 acaaagacaa ccactgggat cagctggtgt cagtccctac ttaggaaata ctcagcaact
     3901 gttagctggg aagaatgtat tcggcacctt cccctgagga cctttctgag gagtaaaaag
     3961 actactggcc tctgtgccat ggatgattct tttcccatca ccagaaatga tagcgtgcag
     4021 tagagagcaa agatggcttc cgtgagacac aagatggcgc atagtgtgct cggacacagt
     4081 tttgtcttcg taggttgtga tgatagcact ggtttgtttc tcaagcgcta tccacagaac
     4141 ctttgtcaac ttcagttgaa aagaggtgga ttcatgtcca gagctcattt cggggtcagg
     4201 tgggaaagcc aagaacttgg aaaagataag acaagctata aattcggagg caagtttctt
     4261 ttacaatgaa cttttcagat ctcacttccc tccgacccct aacttccatg cccacccgtc
     4321 cttttaactg tgcaagcaaa attgtgcatg gtcttcgtcg attaatacct tgtgtgcaga
     4381 cactactgct ccagacgtcg tttccctgat aggtagagca gatccataaa aaggtatgac
     4441 ttatacaatt aggggaagct aatggagttt attagctgag tatcaatgtc tctgcgttgt
     4501 acggtggtga tgggttttaa tgaatatgga ccctgaagcc tggaaatcct catccacgtc
     4561 gaacccacag gactgtggga agggcagaat caatccctaa gggaaaggaa acctcaccct
     4621 gagggcatca catgcactca tgttcagtgt acacaggtca agtcccttgc tctgggctct
     4681 agttgggaga gtggtttcat tccaagtgta ctccattgtc agtatgctgt ttttgtttcc
     4741 ttcactccat tcaaaaagtc aaaatacaaa atttggcaca gcatgccaac gggaggctgt
     4801 gcccagacca agcactggaa gtgtgcttct aggcatagtc attggttttg caaaaagagg
     4861 gctcaaattt aaatagaaat ttacagctat ttgaatggtc agatatacca agaaagaaaa
     4921 atatttctgt tcctcaagaa aacttgctac cctctgtgag gggaattttg ctaaacttga
     4981 catctttata acatgagcca gattgaaagg gagtgatttt cattcatctt aggtcatgtt
     5041 atttcatatt tgtttctgaa ggtgcgatag ctctgtttta ggttttgctt gcgcctgtta
     5101 attactggaa caccttattt ttcattaaag gctttgaaag ccaattctca aaaattcaaa
     5161 agtgcaaatt aacagaacaa aaggaaatcc agtagcaact gcagtcaagc gagggagttg
     5221 acaagataaa ccttacgtcc attcaagtta tatgctggcc tatgagagat gagagttggg
     5281 tcgtttgttc tctttgttga tgattttaaa aaaaccctct agaatacaca taataacata
     5341 atgaaagcca tatctccatg atatatatgt gcacatatat atacatacat gtgcatgtat
     5401 gtatcatatt aaggacccat ggtactctta aaacactgta gaactctgtg acgcagtaag
     5461 gaaggggcag atttgtacaa aaacttttct agattccatc agcaaaaacc aacacaggtt
     5521 tgtcacgctg catgtctggc cagctaatct cgggggaaaa gctacaagtt atttatttta
     5581 ttttaagaga ataaagtagg taataattta agggatcaaa ttcaaggagg aatgtgcaat
     5641 tttagagcaa agatttgttt aaggcaaatg agactttggg agcatcccat tccagttttg
     5701 tctttttttt ctctgaaaga aaaaagcaaa aaataaaata aaattccact tataccttct
     5761 gacaagtccc taaaggtctt gaaataaaag gttctatgca agtgcaaagt tttatagtta
     5821 tttttattgc tgattattac tattactatc tctgttgtct taagagtatg tgctgatttc
     5881 agagacatct caaattgaaa gaatatcaga ttgcttttaa agtagctgaa cgagccacag
     5941 aatatctgaa attattcatt gttgttcctc caccaccccc tttctcatgg tctgattttt
     6001 agaagagtgg catcctcgtt ctaaaatgta atgatcacca aatacggcct tccatcaaat
     6061 ttgtgaaaac tacaacagta taacagtgac aaacctaatt ctctagccca aacctggtct
     6121 gacaatcatt tccatttaga agtcattgaa tagttttcca aacactttcc atgtgtgtta
     6181 gcaaattatt cctattttgt gtagatgagg acgttgagac tcagagacat tcagaggcac
     6241 gctagaggtc tccagcctag cttccagcac cattgggact gaatccaagt actctcactc
     6301 tgaacttcgt ggttctgtcc actagagact ctaatatgca aacaagcagt tcaggaaaga
     6361 aagcatgcta acacattcat gaagcagtat atgaagttag aagaacaaaa ggaaatacag
     6421 gagatgacaa gcaactgaga tattgtgata tataatcatg ctcttagctt cagctaaatt
     6481 cagctaaatt cttgtacact gaaccaatgt cataatcagg cttatttaga aaacactttg
     6541 aactatgcta taaaagatta tatcagaatt catattatac atgtgttcac atcagcgcta
     6601 cctgtgatgt tttcatgtat ttatgtatgt gttataaata cttgatttat acatatacaa
     6661 atgcacatac gtagtgtgtt tgtgtgttta tgtataaatt tataggcaca caataataga
     6721 ggtaattata agtaggatgc ggtatgaata atttgcttaa aatatgctaa ataaccaaaa
     6781 ctgtttaacg tcatgttgct gttagtgctt ccatactcca cgtgggtagg actacatcac
     6841 acttttcaac tctgtgcagt actgcatggg tggaagacat atttaagata atgtgcttcc
     6901 caaaacaact gaataaaagc catcccacta cattgagtgc tttctctggc tccttgcaaa
     6961 gaaagatact ttttgtaatg gtccaggaaa ggaacattgc tttctttttg tctttcagca
     7021 catttgtatt atgctcacct tgtctctgtc tcactgtgac ccctttacac ttgagttcag
     7081 agttcaagca ttccaaatat aaattggaat gttggcagcc cagtggcttg aaggccaatg
     7141 atgagcagtc caagacccca cagcgagatg agcaactctt aggaattccc acatcctaga
     7201 gtgaatgcac caactaacag tatagaatgc tgtccttttc aaagcgtcct aacagcagga
     7261 ttacctggtc aagtatggac tttctttgaa tctttctttt cacaaattgg actgcctgta
     7321 ataccaataa cattgttgta tctaactaaa taaatgactg catatacaca cataccctca
     7381 attctcttgc ttccccattt tctttttcat cccctgtctc aggactttta ttttcaatgt
     7441 tgacctttgg tttggccata tatcactgtt ataggaaatc tcatgagagg aatggctagt
     7501 gacccaactc tccaaatgtc taagttagta gttacagctg attttttatg atgcataatt
     7561 ggaatgtgga gcctctgagg ttgtgatagc ttgtacatga atttcaaatg tcattctaaa
     7621 gaatgagggg tgggagggat ttatagttag aaacgacagt gcaggaaggg gtattttctt
     7681 gttgtcaggg ctggaatgaa tcactgctgc tcaagtcaaa ggttcttgaa tatccttagt
     7741 ttttgcattt cccctccttt tcctttgacc tttatttatt taattatgta tttatttatt
     7801 tatttatata cttttgctcc attcagcaca aacacaaagc aaagcaaaaa aaaaaatata
     7861 tatatatata tctgtatatg tgttgtaggc aaaacactgt gaatttcaca acaaccacca
     7921 ccaagcaact attttgccat cttaacatac atctcaggag acgaaatgag aaaagatggg
     7981 gatgtcattt tttagtctat gcgtttgagg ccaggtccat gtttatttat ttctttagtc
     8041 tatgcattaa tgaaaatgat cctgagtgga ggttagctga acgttcaatg tactggagca
     8101 agcatcataa aagctgctag tagccatgtg tttgaacagg aaaaatatta cagaaaatga
     8161 aatgtaaagg cctatatctt gcagcttgta tatcttacta ttgcttaaaa aatgtataaa
     8221 gcagctggaa atgttttaaa tacaaggtct ttgaattaaa tgtggatttt aaatatgtaa
     8281 tcccttgaca aatgaccaaa ttatggtgaa ctattgctcc ctgcgttctt tgatcattac
     8341 ctatgactta caaatctgcc tggagatgtg gacattctgc atttgcttct gtatctggag
     8401 agatgtttgt atatatccag gccgtataca cacacatttc catatctctc tacagatata
     8461 tttccccttc aatcgtgacc tggtatttgg aactctcctt ttcatttggc ttatcttcct
     8521 tttaatgtga tgtctctgtg ctaatactta ccagttcttg ttttgcaatc tgttttgagg
     8581 tccattgctt tactaagacc cactgcatct tggctgattt caaagtgaca cctgaataca
     8641 gtgtttaaaa aaaaaaaagt tttgtttgta aatcatgtga ccagcttctc tcaacctgac
     8701 atggaaagtc tcttgtacta cagtgtattt aataaaaatg atgtcttaca ataaataaca
     8761 tactccaaaa
//
