LOCUS       NM_006180               8666 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant a, mRNA.
ACCESSION   NM_006180 NM_001381928 XM_005252002
VERSION     NM_006180.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8666)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 8666)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8666)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8666)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 8666)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 8666)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 8666)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 8666)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 8666)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 8666)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13, AL596132.7 and
            AL445532.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Apr 20, 2020 this sequence version replaced
            NM_001381928.1, NM_006180.5.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF410899.1, SRR1803616.57704.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277120.8/ ENSP00000277120.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL390777.13        30541-30700
            161-744             AL390777.13        31189-31772
            745-819             AL390777.13        62971-63045
            820-891             AL390777.13        63160-63231
            892-960             AL390777.13        68656-68724
            961-1115            AL390777.13        71449-71603
            1116-1252           AL390777.13        84385-84521
            1253-1385           AL390777.13        85036-85168
            1386-1691           AL390777.13        88466-88771
            1692-1727           AL390777.13        102704-102739
            1728-1828           AL390777.13        105785-105885
            1829-1928           AL390777.13        112798-112897
            1929-1976           AL596132.7         40938-40985
            1977-2165           AL596132.7         47141-47329
            2166-2296           AL596132.7         114060-114190
            2297-2469           AL445532.8         6204-6376
            2470-2704           AL445532.8         13025-13259
            2705-2863           AL445532.8         77948-78106
            2864-8666           AL445532.8         78994-84796
FEATURES             Location/Qualifiers
     source          1..8666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..8666
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..160
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            161..744
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..3049
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant a; BDNF/NT-3 growth factors receptor; tyrosine
                     kinase receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform a
                     precursor"
                     /protein_id="NP_006171.2"
                     /db_xref="CCDS:CCDS6671.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNY
                     PDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM
                     LFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPS
                     SSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFG
                     KVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCV
                     EGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVY
                     LASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPES
                     IMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEV
                     YELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG"
     exon            745..819
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            820..891
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            892..960
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1115
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1252
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1385
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1691
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1727
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1828
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1928
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..1976
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2165
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2296
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2469
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2704
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2863
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..8666
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8646..8651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      8666
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 cttcgccagc agtagcagag gcggcggcgg cggctcccgg aattgggttg gagcaggagc
       61 ctcgctggct gcttcgctcg cgctctacgc gctcagtccc cggcggtagc aggagcctgg
      121 acccaggcgc cgccggcggg cgtgaggcgc cggagcccgg cctcgaggtg cataccggac
      181 ccccattcgc atctaacaag gaatctgcgc cccagagagt cccgggagcg ccgccggtcg
      241 gtgcccggcg cgccgggcca tgcagcgacg gccgccgcgg agctccgagc agcggtagcg
      301 cccccctgta aagcggttcg ctatgccggg gccactgtga accctgccgc ctgccggaac
      361 actcttcgct ccggaccagc tcagcctctg ataagctgga ctcggcacgc ccgcaacaag
      421 caccgaggag ttaagagagc cgcaagcgca gggaaggcct ccccgcacgg gtgggggaaa
      481 gcggccggtg cagcgcgggg acaggcactc gggctggcac tggctgctag ggatgtcgtc
      541 ctggataagg tggcatggac ccgccatggc gcggctctgg ggcttctgct ggctggttgt
      601 gggcttctgg agggccgctt tcgcctgtcc cacgtcctgc aaatgcagtg cctctcggat
      661 ctggtgcagc gacccttctc ctggcatcgt ggcatttccg agattggagc ctaacagtgt
      721 agatcctgag aacatcaccg aaattttcat cgcaaaccag aaaaggttag aaatcatcaa
      781 cgaagatgat gttgaagctt atgtgggact gagaaatctg acaattgtgg attctggatt
      841 aaaatttgtg gctcataaag catttctgaa aaacagcaac ctgcagcaca tcaattttac
      901 ccgaaacaaa ctgacgagtt tgtctaggaa acatttccgt caccttgact tgtctgaact
      961 gatcctggtg ggcaatccat ttacatgctc ctgtgacatt atgtggatca agactctcca
     1021 agaggctaaa tccagtccag acactcagga tttgtactgc ctgaatgaaa gcagcaagaa
     1081 tattcccctg gcaaacctgc agatacccaa ttgtggtttg ccatctgcaa atctggccgc
     1141 acctaacctc actgtggagg aaggaaagtc tatcacatta tcctgtagtg tggcaggtga
     1201 tccggttcct aatatgtatt gggatgttgg taacctggtt tccaaacata tgaatgaaac
     1261 aagccacaca cagggctcct taaggataac taacatttca tccgatgaca gtgggaagca
     1321 gatctcttgt gtggcggaaa atcttgtagg agaagatcaa gattctgtca acctcactgt
     1381 gcattttgca ccaactatca catttctcga atctccaacc tcagaccacc actggtgcat
     1441 tccattcact gtgaaaggca accccaaacc agcgcttcag tggttctata acggggcaat
     1501 attgaatgag tccaaataca tctgtactaa aatacatgtt accaatcaca cggagtacca
     1561 cggctgcctc cagctggata atcccactca catgaacaat ggggactaca ctctaatagc
     1621 caagaatgag tatgggaagg atgagaaaca gatttctgct cacttcatgg gctggcctgg
     1681 aattgacgat ggtgcaaacc caaattatcc tgatgtaatt tatgaagatt atggaactgc
     1741 agcgaatgac atcggggaca ccacgaacag aagtaatgaa atcccttcca cagacgtcac
     1801 tgataaaacc ggtcgggaac atctctcggt ctatgctgtg gtggtgattg cgtctgtggt
     1861 gggattttgc cttttggtaa tgctgtttct gcttaagttg gcaagacact ccaagtttgg
     1921 catgaaagat ttctcatggt ttggatttgg gaaagtaaaa tcaagacaag gtgttggccc
     1981 agcctccgtt atcagcaatg atgatgactc tgccagccca ctccatcaca tctccaatgg
     2041 gagtaacact ccatcttctt cggaaggtgg cccagatgct gtcattattg gaatgaccaa
     2101 gatccctgtc attgaaaatc cccagtactt tggcatcacc aacagtcagc tcaagccaga
     2161 cacatttgtt cagcacatca agcgacataa cattgttctg aaaagggagc taggcgaagg
     2221 agcctttgga aaagtgttcc tagctgaatg ctataacctc tgtcctgagc aggacaagat
     2281 cttggtggca gtgaagaccc tgaaggatgc cagtgacaat gcacgcaagg acttccaccg
     2341 tgaggccgag ctcctgacca acctccagca tgagcacatc gtcaagttct atggcgtctg
     2401 cgtggagggc gaccccctca tcatggtctt tgagtacatg aagcatgggg acctcaacaa
     2461 gttcctcagg gcacacggcc ctgatgccgt gctgatggct gagggcaacc cgcccacgga
     2521 actgacgcag tcgcagatgc tgcatatagc ccagcagatc gccgcgggca tggtctacct
     2581 ggcgtcccag cacttcgtgc accgcgattt ggccaccagg aactgcctgg tcggggagaa
     2641 cttgctggtg aaaatcgggg actttgggat gtcccgggac gtgtacagca ctgactacta
     2701 cagggtcggt ggccacacaa tgctgcccat tcgctggatg cctccagaga gcatcatgta
     2761 caggaaattc acgacggaaa gcgacgtctg gagcctgggg gtcgtgttgt gggagatttt
     2821 cacctatggc aaacagccct ggtaccagct gtcaaacaat gaggtgatag agtgtatcac
     2881 tcagggccga gtcctgcagc gaccccgcac gtgcccccag gaggtgtatg agctgatgct
     2941 ggggtgctgg cagcgagagc cccacatgag gaagaacatc aagggcatcc ataccctcct
     3001 tcagaacttg gccaaggcat ctccggtcta cctggacatt ctaggctagg gcccttttcc
     3061 ccagaccgat ccttcccaac gtactcctca gacgggctga gaggatgaac atcttttaac
     3121 tgccgctgga ggccaccaag ctgctctcct tcactctgac agtattaaca tcaaagactc
     3181 cgagaagctc tcgagggaag cagtgtgtac ttcttcatcc atagacacag tattgacttc
     3241 tttttggcat tatctctttc tctctttcca tctcccttgg ttgttccttt ttcttttttt
     3301 aaattttctt tttctttttt ttttcgtctt ccctgcttca cgattcttac cctttctttt
     3361 gaatcaatct ggcttctgca ttactattaa ctctgcatag acaaaggcct taacaaacgt
     3421 aatttgttat atcagcagac actccagttt gcccaccaca actaacaatg ccttgttgta
     3481 ttcctgcctt tgatgtggat gaaaaaaagg gaaaacaaat atttcactta aactttgtca
     3541 cttctgctgt acagatatcg agagtttcta tggattcact tctatttatt tattattatt
     3601 actgttctta ttgtttttgg atggcttaag cctgtgtata aaaaagaaaa cttgtgttca
     3661 atctgtgaag cctttatcta tgggagatta aaaccagaga gaaagaagat ttattatgaa
     3721 ccgcaatatg ggaggaacaa agacaaccac tgggatcagc tggtgtcagt ccctacttag
     3781 gaaatactca gcaactgtta gctgggaaga atgtattcgg caccttcccc tgaggacctt
     3841 tctgaggagt aaaaagacta ctggcctctg tgccatggat gattcttttc ccatcaccag
     3901 aaatgatagc gtgcagtaga gagcaaagat ggcttccgtg agacacaaga tggcgcatag
     3961 tgtgctcgga cacagttttg tcttcgtagg ttgtgatgat agcactggtt tgtttctcaa
     4021 gcgctatcca cagaaccttt gtcaacttca gttgaaaaga ggtggattca tgtccagagc
     4081 tcatttcggg gtcaggtggg aaagccaaga acttggaaaa gataagacaa gctataaatt
     4141 cggaggcaag tttcttttac aatgaacttt tcagatctca cttccctccg acccctaact
     4201 tccatgccca cccgtccttt taactgtgca agcaaaattg tgcatggtct tcgtcgatta
     4261 ataccttgtg tgcagacact actgctccag acgtcgtttc cctgataggt agagcagatc
     4321 cataaaaagg tatgacttat acaattaggg gaagctaatg gagtttatta gctgagtatc
     4381 aatgtctctg cgttgtacgg tggtgatggg ttttaatgaa tatggaccct gaagcctgga
     4441 aatcctcatc cacgtcgaac ccacaggact gtgggaaggg cagaatcaat ccctaaggga
     4501 aaggaaacct caccctgagg gcatcacatg cactcatgtt cagtgtacac aggtcaagtc
     4561 ccttgctctg ggctctagtt gggagagtgg tttcattcca agtgtactcc attgtcagta
     4621 tgctgttttt gtttccttca ctccattcaa aaagtcaaaa tacaaaattt ggcacagcat
     4681 gccaacggga ggctgtgccc agaccaagca ctggaagtgt gcttctaggc atagtcattg
     4741 gttttgcaaa aagagggctc aaatttaaat agaaatttac agctatttga atggtcagat
     4801 ataccaagaa agaaaaatat ttctgttcct caagaaaact tgctaccctc tgtgagggga
     4861 attttgctaa acttgacatc tttataacat gagccagatt gaaagggagt gattttcatt
     4921 catcttaggt catgttattt catatttgtt tctgaaggtg cgatagctct gttttaggtt
     4981 ttgcttgcgc ctgttaatta ctggaacacc ttatttttca ttaaaggctt tgaaagccaa
     5041 ttctcaaaaa ttcaaaagtg caaattaaca gaacaaaagg aaatccagta gcaactgcag
     5101 tcaagcgagg gagttgacaa gataaacctt acgtccattc aagttatatg ctggcctatg
     5161 agagatgaga gttgggtcgt ttgttctctt tgttgatgat tttaaaaaaa ccctctagaa
     5221 tacacataat aacataatga aagccatatc tccatgatat atatgtgcac atatatatac
     5281 atacatgtgc atgtatgtat catattaagg acccatggta ctcttaaaac actgtagaac
     5341 tctgtgacgc agtaaggaag gggcagattt gtacaaaaac ttttctagat tccatcagca
     5401 aaaaccaaca caggtttgtc acgctgcatg tctggccagc taatctcggg ggaaaagcta
     5461 caagttattt attttatttt aagagaataa agtaggtaat aatttaaggg atcaaattca
     5521 aggaggaatg tgcaatttta gagcaaagat ttgtttaagg caaatgagac tttgggagca
     5581 tcccattcca gttttgtctt ttttttctct gaaagaaaaa agcaaaaaat aaaataaaat
     5641 tccacttata ccttctgaca agtccctaaa ggtcttgaaa taaaaggttc tatgcaagtg
     5701 caaagtttta tagttatttt tattgctgat tattactatt actatctctg ttgtcttaag
     5761 agtatgtgct gatttcagag acatctcaaa ttgaaagaat atcagattgc ttttaaagta
     5821 gctgaacgag ccacagaata tctgaaatta ttcattgttg ttcctccacc accccctttc
     5881 tcatggtctg atttttagaa gagtggcatc ctcgttctaa aatgtaatga tcaccaaata
     5941 cggccttcca tcaaatttgt gaaaactaca acagtataac agtgacaaac ctaattctct
     6001 agcccaaacc tggtctgaca atcatttcca tttagaagtc attgaatagt tttccaaaca
     6061 ctttccatgt gtgttagcaa attattccta ttttgtgtag atgaggacgt tgagactcag
     6121 agacattcag aggcacgcta gaggtctcca gcctagcttc cagcaccatt gggactgaat
     6181 ccaagtactc tcactctgaa cttcgtggtt ctgtccacta gagactctaa tatgcaaaca
     6241 agcagttcag gaaagaaagc atgctaacac attcatgaag cagtatatga agttagaaga
     6301 acaaaaggaa atacaggaga tgacaagcaa ctgagatatt gtgatatata atcatgctct
     6361 tagcttcagc taaattcagc taaattcttg tacactgaac caatgtcata atcaggctta
     6421 tttagaaaac actttgaact atgctataaa agattatatc agaattcata ttatacatgt
     6481 gttcacatca gcgctacctg tgatgttttc atgtatttat gtatgtgtta taaatacttg
     6541 atttatacat atacaaatgc acatacgtag tgtgtttgtg tgtttatgta taaatttata
     6601 ggcacacaat aatagaggta attataagta ggatgcggta tgaataattt gcttaaaata
     6661 tgctaaataa ccaaaactgt ttaacgtcat gttgctgtta gtgcttccat actccacgtg
     6721 ggtaggacta catcacactt ttcaactctg tgcagtactg catgggtgga agacatattt
     6781 aagataatgt gcttcccaaa acaactgaat aaaagccatc ccactacatt gagtgctttc
     6841 tctggctcct tgcaaagaaa gatacttttt gtaatggtcc aggaaaggaa cattgctttc
     6901 tttttgtctt tcagcacatt tgtattatgc tcaccttgtc tctgtctcac tgtgacccct
     6961 ttacacttga gttcagagtt caagcattcc aaatataaat tggaatgttg gcagcccagt
     7021 ggcttgaagg ccaatgatga gcagtccaag accccacagc gagatgagca actcttagga
     7081 attcccacat cctagagtga atgcaccaac taacagtata gaatgctgtc cttttcaaag
     7141 cgtcctaaca gcaggattac ctggtcaagt atggactttc tttgaatctt tcttttcaca
     7201 aattggactg cctgtaatac caataacatt gttgtatcta actaaataaa tgactgcata
     7261 tacacacata ccctcaattc tcttgcttcc ccattttctt tttcatcccc tgtctcagga
     7321 cttttatttt caatgttgac ctttggtttg gccatatatc actgttatag gaaatctcat
     7381 gagaggaatg gctagtgacc caactctcca aatgtctaag ttagtagtta cagctgattt
     7441 tttatgatgc ataattggaa tgtggagcct ctgaggttgt gatagcttgt acatgaattt
     7501 caaatgtcat tctaaagaat gaggggtggg agggatttat agttagaaac gacagtgcag
     7561 gaaggggtat tttcttgttg tcagggctgg aatgaatcac tgctgctcaa gtcaaaggtt
     7621 cttgaatatc cttagttttt gcatttcccc tccttttcct ttgaccttta tttatttaat
     7681 tatgtattta tttatttatt tatatacttt tgctccattc agcacaaaca caaagcaaag
     7741 caaaaaaaaa aatatatata tatatatctg tatatgtgtt gtaggcaaaa cactgtgaat
     7801 ttcacaacaa ccaccaccaa gcaactattt tgccatctta acatacatct caggagacga
     7861 aatgagaaaa gatggggatg tcatttttta gtctatgcgt ttgaggccag gtccatgttt
     7921 atttatttct ttagtctatg cattaatgaa aatgatcctg agtggaggtt agctgaacgt
     7981 tcaatgtact ggagcaagca tcataaaagc tgctagtagc catgtgtttg aacaggaaaa
     8041 atattacaga aaatgaaatg taaaggccta tatcttgcag cttgtatatc ttactattgc
     8101 ttaaaaaatg tataaagcag ctggaaatgt tttaaataca aggtctttga attaaatgtg
     8161 gattttaaat atgtaatccc ttgacaaatg accaaattat ggtgaactat tgctccctgc
     8221 gttctttgat cattacctat gacttacaaa tctgcctgga gatgtggaca ttctgcattt
     8281 gcttctgtat ctggagagat gtttgtatat atccaggccg tatacacaca catttccata
     8341 tctctctaca gatatatttc cccttcaatc gtgacctggt atttggaact ctccttttca
     8401 tttggcttat cttcctttta atgtgatgtc tctgtgctaa tacttaccag ttcttgtttt
     8461 gcaatctgtt ttgaggtcca ttgctttact aagacccact gcatcttggc tgatttcaaa
     8521 gtgacacctg aatacagtgt ttaaaaaaaa aaaagttttg tttgtaaatc atgtgaccag
     8581 cttctctcaa cctgacatgg aaagtctctt gtactacagt gtatttaata aaaatgatgt
     8641 cttacaataa ataacatact ccaaaa
//
