LOCUS       NM_001369547            7100 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant j, mRNA.
ACCESSION   NM_001369547
VERSION     NM_001369547.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7100)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 7100)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7100)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7100)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 7100)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 7100)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 7100)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 7100)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 7100)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 7100)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.40653.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA1970526 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL390777.13        30118-30235
            119-702             AL390777.13        31189-31772
            703-777             AL390777.13        62971-63045
            778-849             AL390777.13        63160-63231
            850-918             AL390777.13        68656-68724
            919-1073            AL390777.13        71449-71603
            1074-1210           AL390777.13        84385-84521
            1211-1343           AL390777.13        85036-85168
            1344-1649           AL390777.13        88466-88771
            1650-1685           AL390777.13        102704-102739
            1686-1786           AL390777.13        105785-105885
            1787-1886           AL390777.13        112798-112897
            1887-1939           AL390777.13        122032-122084
            1940-7100           AL390777.13        171354-176514
FEATURES             Location/Qualifiers
     source          1..7100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..7100
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..118
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            119..702
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..1906
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform j precursor is encoded by transcript
                     variant j; BDNF/NT-3 growth factors receptor; tyrosine
                     kinase receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform j
                     precursor"
                     /protein_id="NP_001356476.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNY
                     PDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM
                     LFLLKLARHSKFGMKDINILD"
     exon            703..777
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            778..849
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            850..918
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1073
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1210
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1343
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1649
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1685
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1786
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1886
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1939
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..7100
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7082..7087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      7100
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 gaaccaagca cggtttccat ttcaaaaagg gagacagcct ctaccgcgat tgtagaagag
       61 actgtggtgt gaattaggga ccgggaggcg tcgaacggag gaacggttca tcttagagcc
      121 tcgaggtgca taccggaccc ccattcgcat ctaacaagga atctgcgccc cagagagtcc
      181 cgggagcgcc gccggtcggt gcccggcgcg ccgggccatg cagcgacggc cgccgcggag
      241 ctccgagcag cggtagcgcc cccctgtaaa gcggttcgct atgccggggc cactgtgaac
      301 cctgccgcct gccggaacac tcttcgctcc ggaccagctc agcctctgat aagctggact
      361 cggcacgccc gcaacaagca ccgaggagtt aagagagccg caagcgcagg gaaggcctcc
      421 ccgcacgggt gggggaaagc ggccggtgca gcgcggggac aggcactcgg gctggcactg
      481 gctgctaggg atgtcgtcct ggataaggtg gcatggaccc gccatggcgc ggctctgggg
      541 cttctgctgg ctggttgtgg gcttctggag ggccgctttc gcctgtccca cgtcctgcaa
      601 atgcagtgcc tctcggatct ggtgcagcga cccttctcct ggcatcgtgg catttccgag
      661 attggagcct aacagtgtag atcctgagaa catcaccgaa attttcatcg caaaccagaa
      721 aaggttagaa atcatcaacg aagatgatgt tgaagcttat gtgggactga gaaatctgac
      781 aattgtggat tctggattaa aatttgtggc tcataaagca tttctgaaaa acagcaacct
      841 gcagcacatc aattttaccc gaaacaaact gacgagtttg tctaggaaac atttccgtca
      901 ccttgacttg tctgaactga tcctggtggg caatccattt acatgctcct gtgacattat
      961 gtggatcaag actctccaag aggctaaatc cagtccagac actcaggatt tgtactgcct
     1021 gaatgaaagc agcaagaata ttcccctggc aaacctgcag atacccaatt gtggtttgcc
     1081 atctgcaaat ctggccgcac ctaacctcac tgtggaggaa ggaaagtcta tcacattatc
     1141 ctgtagtgtg gcaggtgatc cggttcctaa tatgtattgg gatgttggta acctggtttc
     1201 caaacatatg aatgaaacaa gccacacaca gggctcctta aggataacta acatttcatc
     1261 cgatgacagt gggaagcaga tctcttgtgt ggcggaaaat cttgtaggag aagatcaaga
     1321 ttctgtcaac ctcactgtgc attttgcacc aactatcaca tttctcgaat ctccaacctc
     1381 agaccaccac tggtgcattc cattcactgt gaaaggcaac cccaaaccag cgcttcagtg
     1441 gttctataac ggggcaatat tgaatgagtc caaatacatc tgtactaaaa tacatgttac
     1501 caatcacacg gagtaccacg gctgcctcca gctggataat cccactcaca tgaacaatgg
     1561 ggactacact ctaatagcca agaatgagta tgggaaggat gagaaacaga tttctgctca
     1621 cttcatgggc tggcctggaa ttgacgatgg tgcaaaccca aattatcctg atgtaattta
     1681 tgaagattat ggaactgcag cgaatgacat cggggacacc acgaacagaa gtaatgaaat
     1741 cccttccaca gacgtcactg ataaaaccgg tcgggaacat ctctcggtct atgctgtggt
     1801 ggtgattgcg tctgtggtgg gattttgcct tttggtaatg ctgtttctgc ttaagttggc
     1861 aagacactcc aagtttggca tgaaagacat taatatcctg gattgaagca gaagagtcat
     1921 ctctgtcttc agcgacagtg ttttgttttg tttcataaga tcccactgga tgggtagctg
     1981 aaataaagga aaagacagag aaaggggctg tggtgcttgt tggttgatgc tgccatgtaa
     2041 gctggactcc tgggactgct gttggcttat cccgggaagt gctgcttatc tggggttttc
     2101 tggtagatgt gggcggtgtt tggaggctgt actatatgaa gcctgcatat actgtgagct
     2161 gtgattgggg aacaccaatg cagaggtaac tctcaggcag ctaagcagca cctcaagaaa
     2221 acatgttaaa ttaatgcttc tcttcttaca gtagttcaaa tacaaaactg aaatgaaatc
     2281 ccattggatt gtacttctct tctgaaaagt gtgctttttg accctactgg acatttattg
     2341 acttaattgc ttctgtttat taaaattgac ctgcaaagtt aaaaaaaaat taaagttgag
     2401 aacaggtata agtgcacact gaatagtcta atctacatgt aacacatatt ttagtgtgat
     2461 tttctatact ctaatcagca ctgaattcag agggtttgac tttttcatct ataacacagt
     2521 gactaaaaga gttaagggta tatataccat cactttggga cttggtagta ttattaaaag
     2581 gttatttcct tcactgtcaa taaaagtcca aatgtttagc ttaggtctga gagtcaaaca
     2641 atgttaagga ttgtcttaaa gttccttagc cagcaaaaca aaacaaaaca aaacaaacaa
     2701 atgaaaaacg tttaaaaaga agaagaagaa aaaaaacaag aacaagcagc aacagctgtt
     2761 ttgttggggc tatagattta agttaggcat agtcaatttc agaataacta agagtggaat
     2821 atatgcatat ggtgaaatta taaccttgcc cttttttatt tgccctctgc gatccacctg
     2881 ctttttagaa gtctgccgag tgagaaggcc acagtatctc atgctgtttg cattacagaa
     2941 ctgcagcttt tctactctga aaaggcctgg gagcagaatg gctggcctgc tgtgagcagg
     3001 agaggagatt ctaagaagga tagtcccccc tacaacatac tgtcatactg ctgggttttc
     3061 atgggtagga aagcttgtcc tgaccccagc agcaaagagg tggcaggtcg ctaatgaata
     3121 tatgctttat aatgtccttc ttcattgctg agagggcagc cttagagctg tggatttctg
     3181 catcccccct gagtctgacc catggacacc tgtttcattc actttagcat cacagtgacc
     3241 tttgtatgct ctgttcagtc tgtgtcaggc agtatgcttg tcctgaagag aggtttggct
     3301 atccccaccc caccccaccc caccctgttc cttttttatc aggaggactt cagagccagg
     3361 cctgcagcat tttgtttgaa aacacaatca gctctgacag ttagacatgc acacagacgc
     3421 catagctgga ttggaaacat tgatgtttta aaaatttatt ttttttggaa atagttgcac
     3481 aaatgctgca atttagcttt aaggttctat agatttttaa ctagtccaac acagtcagaa
     3541 acattgtttt gaatcctctg taaaccaagg cattaatctt aataaaccag gatccattta
     3601 ggtaccactt gatataaaaa ggatatccat aatgaatatt ttatactgca tcctttacat
     3661 tagccactaa atacgttatt gcttgatgaa gacctttcac agaatcctat ggattgcagc
     3721 atttcacttg gctacttcat acccatgcct taaagagggg cagtttctca aaagcagaaa
     3781 catgccgcca gttctcaagt tttcctccta actccatttg aatgtaaggg cagctggccc
     3841 ccaatgtggg gaggtccgaa cattttctga attcccattt tcttgttcgc ggctaaatga
     3901 cagtttctgt cattacttag attccgatct ttcccaaagg tgttgattta caaagaggcc
     3961 agctaatagc agaaatcatg accctgaaag agagatgaaa ttcaagctgt gagccaggca
     4021 ggagctcagt atggcaaagg ttcttgagaa tcagccattt ggtacaaaaa agatttttaa
     4081 agcttttatg ttataccatg gagccataga aaggctatgg attgtttaag aactatttta
     4141 aagtgttcca gacccaaaaa ggaaaaataa aaaaaaagga atatttgtac ccaacagcta
     4201 gaaggattgc aaggtagatt tttgttttaa aatggagaga agtggacaga taaggccatt
     4261 taatatatca aagatcagtt gacatctcct agggaatgat gaaaacagca ggctattaga
     4321 aaattatttc atatagttct cgtgttcttt tctttttttt aatccctgaa gggatgatca
     4381 gtaacatagc ttctcttttc tgtactctag accacccctt ttcatcattt tgctttttat
     4441 gtctcccata agaaatgtgc tttttagagc ttcctaatgc atgtgttgca ttattgcagc
     4501 attagaaaag gagaggtagc atttttgctg aaatcgggcc tgtcactctc caataaaggt
     4561 tctggcactt caatgccagg caggtctcct aaatgaacag aatgatctgt gtgagccgat
     4621 gcctgccctt ccagaggggc cactgtcccc agccgcagcc aactgtgtcc cacaggaatg
     4681 ggagcctagg tttccaaatc ttgtgattct ttaggagaaa catgaaacct ggatttcgtg
     4741 tgaaatgtcc cgattgttaa aaagttggct caattatttt taaaacattt tgtaagccaa
     4801 caaaagtctg tgggctgcca gtttattact tttgtcttaa aacatgatca ttgttctctc
     4861 acggtatcct tctgtcttcc cgttgcaaat tcacttttct ttcttcctga cattgccatt
     4921 gagggctttg ttaccacaag ctaagaaact gagtttaaca gcccagttat ctgcaacatg
     4981 tcaattacct ttgctcctct cctgtgattc ccaccatgct gtgaccctca gctgtctccc
     5041 tttgctggga attctgcacc aatgtctccc ctcaacccat tccctggttg gtcctactcc
     5101 cgtgtggcca gagacatcct agcaaatcct tcctcctatt atatctgaca ctaatttctt
     5161 ttcaacagcg ctcatgtctc ttggcccagt caggtgctgc caggtttaga taggaaagta
     5221 catgtcccat tttcatgggt gcccttaatg tggtccacgt cctatatctt attatattta
     5281 ctcatggctc aatgggggcc tccagagacc ctctcaggct gctgagctag actaaggaat
     5341 gcatccaccg tcatcacatg agacactgac tctgtgacga caaaagtaca aacagtctga
     5401 ggctaagaaa ggttcatctc acaacaggaa aaacaaatct caacacacat tagagataat
     5461 tgattcaggg gttttctctc ccagtctccc agcagggact gatttcattt ctgacccact
     5521 aggttttctt tccagaaata ggtagcaagg acaagaacta aacaatccca gccccaccca
     5581 gcaacacaga acacaggagt ttgcttttgg cttctcactc tccaagtaac cctgaattag
     5641 gcccagaatg gctgaggctt ggagcatctc ctcagacaga gcagaggcga cacctcttca
     5701 ggggtgtgtg gagtaaatag ctcgaagagc tgaagacaga aaaccagttt cacgccaggt
     5761 gcgagagaga gcataatgga gggaagcccg ctttctctct cctcttcttt tctctttatt
     5821 tctttagagc acttgacttt tttttctctc tctctctagt attctaaact gaccccatga
     5881 ccaactgaga atttattttt gtttcattgg ttgtttcaca gaattagaac acacacgact
     5941 ttttattcct ccattgcaaa atggaatcaa gatactacac aagacctgtg ctttcttcct
     6001 ttgcatgatt tacacctccg cctgttttgg tgctagctgt ctagaacttc tctcttggtt
     6061 tgaatctgat tccttcacac tacactagaa gtttatttca tcttgttttg tctagactcc
     6121 agatacagag ggacagctgg actgaggaca agcaattcca tctagcatag ggtctctcag
     6181 ggttggtgca tccagccaca tgggcagggc cagtcacatc tagtctatgt ccccagagcc
     6241 cttggagttg cgcagcttag ctgacttgac tccaaggaaa ttagtacaga agtaaccact
     6301 ctattaagtg tgttctgcta tgttcacatg cctgtagtac ctgcaaacca tgccaggttc
     6361 atctaaagac ataggggaag attaaggact cttttggaca gaccatgaat tgaatttgct
     6421 gccaggtgct gccagactga atttggctga cagaactccc agcccaggaa agttccatga
     6481 caatgactgt cgcagaagga aatttcccac taaagtcagt ccattttcaa gttttggtct
     6541 tcagagacaa aagaacgtcc cagccacctg attttgatgg tgaggtaact ctaagttgaa
     6601 ttcaggctag tgttgcagta tagctttggc atgttcatga gtgagcaccc agaatgtgtt
     6661 gaaccaaccc ccacccctaa ctactgacta tgactgcagt gggtttttat ggggaaaaaa
     6721 agtgtgaaaa gcaaaaagaa aggaacagag attttttatc acctttattg taagacagtc
     6781 catttatgaa ttgagtataa acacatacaa agtaacaaga gattcctaag aaacgcaaat
     6841 ccttgagttt cacgcacttc atgttcaacc atttgctgta atccagaggc agcctgtgaa
     6901 tcattctcat gccctgtttt tttttttttt ttcctataat gttctgggtt taaaagccat
     6961 cttttccaca ttttctgtaa ataatggata atcattttaa aaatttttat ttttagtgct
     7021 gttttaacaa tgtagataga tcataaatgt acttgctgaa ttcaatcatt tttaacaagc
     7081 caataaagtt tgataattca
//
