LOCUS       NM_001369545            7282 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant u, mRNA.
ACCESSION   NM_001369545 XM_017014759
VERSION     NM_001369545.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7282)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 7282)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7282)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7282)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 7282)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 7282)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 7282)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 7282)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 7282)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 7282)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13.
            
            On Apr 10, 2019 this sequence version replaced XM_017014759.1.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (u), as well as variants b, o-t,
            v, and w, encodes isoform b.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.101448.1,
                                           SRR1803616.44364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL390777.13        29334-29597
            265-353             AL390777.13        30147-30235
            354-937             AL390777.13        31189-31772
            938-1012            AL390777.13        62971-63045
            1013-1084           AL390777.13        63160-63231
            1085-1153           AL390777.13        68656-68724
            1154-1308           AL390777.13        71449-71603
            1309-1445           AL390777.13        84385-84521
            1446-1578           AL390777.13        85036-85168
            1579-1884           AL390777.13        88466-88771
            1885-1920           AL390777.13        102704-102739
            1921-2021           AL390777.13        105785-105885
            2022-2121           AL390777.13        112798-112897
            2122-7282           AL390777.13        171354-176514
FEATURES             Location/Qualifiers
     source          1..7282
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..7282
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..264
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            265..353
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            354..937
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             726..2159
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform b precursor is encoded by transcript
                     variant u; BDNF/NT-3 growth factors receptor; tyrosine
                     kinase receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform b
                     precursor"
                     /protein_id="NP_001356474.1"
                     /db_xref="CCDS:CCDS35053.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNY
                     PDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM
                     LFLLKLARHSKFGMKGFVLFHKIPLDG"
     exon            938..1012
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1084
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1153
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1308
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1445
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1578
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1884
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1920
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2021
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2121
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..7282
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7264..7269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      7282
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaaacag attccgagcc gcaaaaggga agacggattc tcagacaagg cttgcaaatg
       61 ccccgcagcc atcatttaac tgcacccgca gaatagttac ggtttgtcac ccgaccctcc
      121 cggatcgcct aatttgtccc tagtgagacc ccgaggctct gcccgcgcct ggcttcttcg
      181 tagctggatg catatcgtgc tccgggcagc gcgggcgcag ggcacgcgtt cgcgcacacc
      241 ctagcacaca tgaacacgcg caagggagac agcctctacc gcgattgtag aagagactgt
      301 ggtgtgaatt agggaccggg aggcgtcgaa cggaggaacg gttcatctta gagcctcgag
      361 gtgcataccg gacccccatt cgcatctaac aaggaatctg cgccccagag agtcccggga
      421 gcgccgccgg tcggtgcccg gcgcgccggg ccatgcagcg acggccgccg cggagctccg
      481 agcagcggta gcgcccccct gtaaagcggt tcgctatgcc ggggccactg tgaaccctgc
      541 cgcctgccgg aacactcttc gctccggacc agctcagcct ctgataagct ggactcggca
      601 cgcccgcaac aagcaccgag gagttaagag agccgcaagc gcagggaagg cctccccgca
      661 cgggtggggg aaagcggccg gtgcagcgcg gggacaggca ctcgggctgg cactggctgc
      721 tagggatgtc gtcctggata aggtggcatg gacccgccat ggcgcggctc tggggcttct
      781 gctggctggt tgtgggcttc tggagggccg ctttcgcctg tcccacgtcc tgcaaatgca
      841 gtgcctctcg gatctggtgc agcgaccctt ctcctggcat cgtggcattt ccgagattgg
      901 agcctaacag tgtagatcct gagaacatca ccgaaatttt catcgcaaac cagaaaaggt
      961 tagaaatcat caacgaagat gatgttgaag cttatgtggg actgagaaat ctgacaattg
     1021 tggattctgg attaaaattt gtggctcata aagcatttct gaaaaacagc aacctgcagc
     1081 acatcaattt tacccgaaac aaactgacga gtttgtctag gaaacatttc cgtcaccttg
     1141 acttgtctga actgatcctg gtgggcaatc catttacatg ctcctgtgac attatgtgga
     1201 tcaagactct ccaagaggct aaatccagtc cagacactca ggatttgtac tgcctgaatg
     1261 aaagcagcaa gaatattccc ctggcaaacc tgcagatacc caattgtggt ttgccatctg
     1321 caaatctggc cgcacctaac ctcactgtgg aggaaggaaa gtctatcaca ttatcctgta
     1381 gtgtggcagg tgatccggtt cctaatatgt attgggatgt tggtaacctg gtttccaaac
     1441 atatgaatga aacaagccac acacagggct ccttaaggat aactaacatt tcatccgatg
     1501 acagtgggaa gcagatctct tgtgtggcgg aaaatcttgt aggagaagat caagattctg
     1561 tcaacctcac tgtgcatttt gcaccaacta tcacatttct cgaatctcca acctcagacc
     1621 accactggtg cattccattc actgtgaaag gcaaccccaa accagcgctt cagtggttct
     1681 ataacggggc aatattgaat gagtccaaat acatctgtac taaaatacat gttaccaatc
     1741 acacggagta ccacggctgc ctccagctgg ataatcccac tcacatgaac aatggggact
     1801 acactctaat agccaagaat gagtatggga aggatgagaa acagatttct gctcacttca
     1861 tgggctggcc tggaattgac gatggtgcaa acccaaatta tcctgatgta atttatgaag
     1921 attatggaac tgcagcgaat gacatcgggg acaccacgaa cagaagtaat gaaatccctt
     1981 ccacagacgt cactgataaa accggtcggg aacatctctc ggtctatgct gtggtggtga
     2041 ttgcgtctgt ggtgggattt tgccttttgg taatgctgtt tctgcttaag ttggcaagac
     2101 actccaagtt tggcatgaaa ggttttgttt tgtttcataa gatcccactg gatgggtagc
     2161 tgaaataaag gaaaagacag agaaaggggc tgtggtgctt gttggttgat gctgccatgt
     2221 aagctggact cctgggactg ctgttggctt atcccgggaa gtgctgctta tctggggttt
     2281 tctggtagat gtgggcggtg tttggaggct gtactatatg aagcctgcat atactgtgag
     2341 ctgtgattgg ggaacaccaa tgcagaggta actctcaggc agctaagcag cacctcaaga
     2401 aaacatgtta aattaatgct tctcttctta cagtagttca aatacaaaac tgaaatgaaa
     2461 tcccattgga ttgtacttct cttctgaaaa gtgtgctttt tgaccctact ggacatttat
     2521 tgacttaatt gcttctgttt attaaaattg acctgcaaag ttaaaaaaaa attaaagttg
     2581 agaacaggta taagtgcaca ctgaatagtc taatctacat gtaacacata ttttagtgtg
     2641 attttctata ctctaatcag cactgaattc agagggtttg actttttcat ctataacaca
     2701 gtgactaaaa gagttaaggg tatatatacc atcactttgg gacttggtag tattattaaa
     2761 aggttatttc cttcactgtc aataaaagtc caaatgttta gcttaggtct gagagtcaaa
     2821 caatgttaag gattgtctta aagttcctta gccagcaaaa caaaacaaaa caaaacaaac
     2881 aaatgaaaaa cgtttaaaaa gaagaagaag aaaaaaaaca agaacaagca gcaacagctg
     2941 ttttgttggg gctatagatt taagttaggc atagtcaatt tcagaataac taagagtgga
     3001 atatatgcat atggtgaaat tataaccttg ccctttttta tttgccctct gcgatccacc
     3061 tgctttttag aagtctgccg agtgagaagg ccacagtatc tcatgctgtt tgcattacag
     3121 aactgcagct tttctactct gaaaaggcct gggagcagaa tggctggcct gctgtgagca
     3181 ggagaggaga ttctaagaag gatagtcccc cctacaacat actgtcatac tgctgggttt
     3241 tcatgggtag gaaagcttgt cctgacccca gcagcaaaga ggtggcaggt cgctaatgaa
     3301 tatatgcttt ataatgtcct tcttcattgc tgagagggca gccttagagc tgtggatttc
     3361 tgcatccccc ctgagtctga cccatggaca cctgtttcat tcactttagc atcacagtga
     3421 cctttgtatg ctctgttcag tctgtgtcag gcagtatgct tgtcctgaag agaggtttgg
     3481 ctatccccac cccaccccac cccaccctgt tcctttttta tcaggaggac ttcagagcca
     3541 ggcctgcagc attttgtttg aaaacacaat cagctctgac agttagacat gcacacagac
     3601 gccatagctg gattggaaac attgatgttt taaaaattta ttttttttgg aaatagttgc
     3661 acaaatgctg caatttagct ttaaggttct atagattttt aactagtcca acacagtcag
     3721 aaacattgtt ttgaatcctc tgtaaaccaa ggcattaatc ttaataaacc aggatccatt
     3781 taggtaccac ttgatataaa aaggatatcc ataatgaata ttttatactg catcctttac
     3841 attagccact aaatacgtta ttgcttgatg aagacctttc acagaatcct atggattgca
     3901 gcatttcact tggctacttc atacccatgc cttaaagagg ggcagtttct caaaagcaga
     3961 aacatgccgc cagttctcaa gttttcctcc taactccatt tgaatgtaag ggcagctggc
     4021 ccccaatgtg gggaggtccg aacattttct gaattcccat tttcttgttc gcggctaaat
     4081 gacagtttct gtcattactt agattccgat ctttcccaaa ggtgttgatt tacaaagagg
     4141 ccagctaata gcagaaatca tgaccctgaa agagagatga aattcaagct gtgagccagg
     4201 caggagctca gtatggcaaa ggttcttgag aatcagccat ttggtacaaa aaagattttt
     4261 aaagctttta tgttatacca tggagccata gaaaggctat ggattgttta agaactattt
     4321 taaagtgttc cagacccaaa aaggaaaaat aaaaaaaaag gaatatttgt acccaacagc
     4381 tagaaggatt gcaaggtaga tttttgtttt aaaatggaga gaagtggaca gataaggcca
     4441 tttaatatat caaagatcag ttgacatctc ctagggaatg atgaaaacag caggctatta
     4501 gaaaattatt tcatatagtt ctcgtgttct tttctttttt ttaatccctg aagggatgat
     4561 cagtaacata gcttctcttt tctgtactct agaccacccc ttttcatcat tttgcttttt
     4621 atgtctccca taagaaatgt gctttttaga gcttcctaat gcatgtgttg cattattgca
     4681 gcattagaaa aggagaggta gcatttttgc tgaaatcggg cctgtcactc tccaataaag
     4741 gttctggcac ttcaatgcca ggcaggtctc ctaaatgaac agaatgatct gtgtgagccg
     4801 atgcctgccc ttccagaggg gccactgtcc ccagccgcag ccaactgtgt cccacaggaa
     4861 tgggagccta ggtttccaaa tcttgtgatt ctttaggaga aacatgaaac ctggatttcg
     4921 tgtgaaatgt cccgattgtt aaaaagttgg ctcaattatt tttaaaacat tttgtaagcc
     4981 aacaaaagtc tgtgggctgc cagtttatta cttttgtctt aaaacatgat cattgttctc
     5041 tcacggtatc cttctgtctt cccgttgcaa attcactttt ctttcttcct gacattgcca
     5101 ttgagggctt tgttaccaca agctaagaaa ctgagtttaa cagcccagtt atctgcaaca
     5161 tgtcaattac ctttgctcct ctcctgtgat tcccaccatg ctgtgaccct cagctgtctc
     5221 cctttgctgg gaattctgca ccaatgtctc ccctcaaccc attccctggt tggtcctact
     5281 cccgtgtggc cagagacatc ctagcaaatc cttcctccta ttatatctga cactaatttc
     5341 ttttcaacag cgctcatgtc tcttggccca gtcaggtgct gccaggttta gataggaaag
     5401 tacatgtccc attttcatgg gtgcccttaa tgtggtccac gtcctatatc ttattatatt
     5461 tactcatggc tcaatggggg cctccagaga ccctctcagg ctgctgagct agactaagga
     5521 atgcatccac cgtcatcaca tgagacactg actctgtgac gacaaaagta caaacagtct
     5581 gaggctaaga aaggttcatc tcacaacagg aaaaacaaat ctcaacacac attagagata
     5641 attgattcag gggttttctc tcccagtctc ccagcaggga ctgatttcat ttctgaccca
     5701 ctaggttttc tttccagaaa taggtagcaa ggacaagaac taaacaatcc cagccccacc
     5761 cagcaacaca gaacacagga gtttgctttt ggcttctcac tctccaagta accctgaatt
     5821 aggcccagaa tggctgaggc ttggagcatc tcctcagaca gagcagaggc gacacctctt
     5881 caggggtgtg tggagtaaat agctcgaaga gctgaagaca gaaaaccagt ttcacgccag
     5941 gtgcgagaga gagcataatg gagggaagcc cgctttctct ctcctcttct tttctcttta
     6001 tttctttaga gcacttgact tttttttctc tctctctcta gtattctaaa ctgaccccat
     6061 gaccaactga gaatttattt ttgtttcatt ggttgtttca cagaattaga acacacacga
     6121 ctttttattc ctccattgca aaatggaatc aagatactac acaagacctg tgctttcttc
     6181 ctttgcatga tttacacctc cgcctgtttt ggtgctagct gtctagaact tctctcttgg
     6241 tttgaatctg attccttcac actacactag aagtttattt catcttgttt tgtctagact
     6301 ccagatacag agggacagct ggactgagga caagcaattc catctagcat agggtctctc
     6361 agggttggtg catccagcca catgggcagg gccagtcaca tctagtctat gtccccagag
     6421 cccttggagt tgcgcagctt agctgacttg actccaagga aattagtaca gaagtaacca
     6481 ctctattaag tgtgttctgc tatgttcaca tgcctgtagt acctgcaaac catgccaggt
     6541 tcatctaaag acatagggga agattaagga ctcttttgga cagaccatga attgaatttg
     6601 ctgccaggtg ctgccagact gaatttggct gacagaactc ccagcccagg aaagttccat
     6661 gacaatgact gtcgcagaag gaaatttccc actaaagtca gtccattttc aagttttggt
     6721 cttcagagac aaaagaacgt cccagccacc tgattttgat ggtgaggtaa ctctaagttg
     6781 aattcaggct agtgttgcag tatagctttg gcatgttcat gagtgagcac ccagaatgtg
     6841 ttgaaccaac ccccacccct aactactgac tatgactgca gtgggttttt atggggaaaa
     6901 aaagtgtgaa aagcaaaaag aaaggaacag agatttttta tcacctttat tgtaagacag
     6961 tccatttatg aattgagtat aaacacatac aaagtaacaa gagattccta agaaacgcaa
     7021 atccttgagt ttcacgcact tcatgttcaa ccatttgctg taatccagag gcagcctgtg
     7081 aatcattctc atgccctgtt tttttttttt ttttcctata atgttctggg tttaaaagcc
     7141 atcttttcca cattttctgt aaataatgga taatcatttt aaaaattttt atttttagtg
     7201 ctgttttaac aatgtagata gatcataaat gtacttgctg aattcaatca tttttaacaa
     7261 gccaataaag tttgataatt ca
//
