LOCUS       NM_001369542            7315 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant r, mRNA.
ACCESSION   NM_001369542 XM_005252007
VERSION     NM_001369542.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7315)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 7315)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7315)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7315)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 7315)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 7315)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 7315)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 7315)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 7315)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 7315)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13.
            
            On Apr 10, 2019 this sequence version replaced XM_005252007.4.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (r), as well as variants b, o-q,
            and s-w, encodes isoform b.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.7641.1,
                                           SRR1803611.99993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL390777.13        29334-29597
            265-386             AL390777.13        30114-30235
            387-970             AL390777.13        31189-31772
            971-1045            AL390777.13        62971-63045
            1046-1117           AL390777.13        63160-63231
            1118-1186           AL390777.13        68656-68724
            1187-1341           AL390777.13        71449-71603
            1342-1478           AL390777.13        84385-84521
            1479-1611           AL390777.13        85036-85168
            1612-1917           AL390777.13        88466-88771
            1918-1953           AL390777.13        102704-102739
            1954-2054           AL390777.13        105785-105885
            2055-2154           AL390777.13        112798-112897
            2155-7315           AL390777.13        171354-176514
FEATURES             Location/Qualifiers
     source          1..7315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..7315
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..264
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            265..386
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            387..970
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             759..2192
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform b precursor is encoded by transcript
                     variant r; BDNF/NT-3 growth factors receptor; tyrosine
                     kinase receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform b
                     precursor"
                     /protein_id="NP_001356471.1"
                     /db_xref="CCDS:CCDS35053.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNY
                     PDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM
                     LFLLKLARHSKFGMKGFVLFHKIPLDG"
     exon            971..1045
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1117
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1186
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1341
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1478
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1611
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1917
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1953
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2054
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2154
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..7315
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7297..7302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      7315
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaaacag attccgagcc gcaaaaggga agacggattc tcagacaagg cttgcaaatg
       61 ccccgcagcc atcatttaac tgcacccgca gaatagttac ggtttgtcac ccgaccctcc
      121 cggatcgcct aatttgtccc tagtgagacc ccgaggctct gcccgcgcct ggcttcttcg
      181 tagctggatg catatcgtgc tccgggcagc gcgggcgcag ggcacgcgtt cgcgcacacc
      241 ctagcacaca tgaacacgcg caagagctga accaagcacg gtttccattt caaaaaggga
      301 gacagcctct accgcgattg tagaagagac tgtggtgtga attagggacc gggaggcgtc
      361 gaacggagga acggttcatc ttagagcctc gaggtgcata ccggaccccc attcgcatct
      421 aacaaggaat ctgcgcccca gagagtcccg ggagcgccgc cggtcggtgc ccggcgcgcc
      481 gggccatgca gcgacggccg ccgcggagct ccgagcagcg gtagcgcccc cctgtaaagc
      541 ggttcgctat gccggggcca ctgtgaaccc tgccgcctgc cggaacactc ttcgctccgg
      601 accagctcag cctctgataa gctggactcg gcacgcccgc aacaagcacc gaggagttaa
      661 gagagccgca agcgcaggga aggcctcccc gcacgggtgg gggaaagcgg ccggtgcagc
      721 gcggggacag gcactcgggc tggcactggc tgctagggat gtcgtcctgg ataaggtggc
      781 atggacccgc catggcgcgg ctctggggct tctgctggct ggttgtgggc ttctggaggg
      841 ccgctttcgc ctgtcccacg tcctgcaaat gcagtgcctc tcggatctgg tgcagcgacc
      901 cttctcctgg catcgtggca tttccgagat tggagcctaa cagtgtagat cctgagaaca
      961 tcaccgaaat tttcatcgca aaccagaaaa ggttagaaat catcaacgaa gatgatgttg
     1021 aagcttatgt gggactgaga aatctgacaa ttgtggattc tggattaaaa tttgtggctc
     1081 ataaagcatt tctgaaaaac agcaacctgc agcacatcaa ttttacccga aacaaactga
     1141 cgagtttgtc taggaaacat ttccgtcacc ttgacttgtc tgaactgatc ctggtgggca
     1201 atccatttac atgctcctgt gacattatgt ggatcaagac tctccaagag gctaaatcca
     1261 gtccagacac tcaggatttg tactgcctga atgaaagcag caagaatatt cccctggcaa
     1321 acctgcagat acccaattgt ggtttgccat ctgcaaatct ggccgcacct aacctcactg
     1381 tggaggaagg aaagtctatc acattatcct gtagtgtggc aggtgatccg gttcctaata
     1441 tgtattggga tgttggtaac ctggtttcca aacatatgaa tgaaacaagc cacacacagg
     1501 gctccttaag gataactaac atttcatccg atgacagtgg gaagcagatc tcttgtgtgg
     1561 cggaaaatct tgtaggagaa gatcaagatt ctgtcaacct cactgtgcat tttgcaccaa
     1621 ctatcacatt tctcgaatct ccaacctcag accaccactg gtgcattcca ttcactgtga
     1681 aaggcaaccc caaaccagcg cttcagtggt tctataacgg ggcaatattg aatgagtcca
     1741 aatacatctg tactaaaata catgttacca atcacacgga gtaccacggc tgcctccagc
     1801 tggataatcc cactcacatg aacaatgggg actacactct aatagccaag aatgagtatg
     1861 ggaaggatga gaaacagatt tctgctcact tcatgggctg gcctggaatt gacgatggtg
     1921 caaacccaaa ttatcctgat gtaatttatg aagattatgg aactgcagcg aatgacatcg
     1981 gggacaccac gaacagaagt aatgaaatcc cttccacaga cgtcactgat aaaaccggtc
     2041 gggaacatct ctcggtctat gctgtggtgg tgattgcgtc tgtggtggga ttttgccttt
     2101 tggtaatgct gtttctgctt aagttggcaa gacactccaa gtttggcatg aaaggttttg
     2161 ttttgtttca taagatccca ctggatgggt agctgaaata aaggaaaaga cagagaaagg
     2221 ggctgtggtg cttgttggtt gatgctgcca tgtaagctgg actcctggga ctgctgttgg
     2281 cttatcccgg gaagtgctgc ttatctgggg ttttctggta gatgtgggcg gtgtttggag
     2341 gctgtactat atgaagcctg catatactgt gagctgtgat tggggaacac caatgcagag
     2401 gtaactctca ggcagctaag cagcacctca agaaaacatg ttaaattaat gcttctcttc
     2461 ttacagtagt tcaaatacaa aactgaaatg aaatcccatt ggattgtact tctcttctga
     2521 aaagtgtgct ttttgaccct actggacatt tattgactta attgcttctg tttattaaaa
     2581 ttgacctgca aagttaaaaa aaaattaaag ttgagaacag gtataagtgc acactgaata
     2641 gtctaatcta catgtaacac atattttagt gtgattttct atactctaat cagcactgaa
     2701 ttcagagggt ttgacttttt catctataac acagtgacta aaagagttaa gggtatatat
     2761 accatcactt tgggacttgg tagtattatt aaaaggttat ttccttcact gtcaataaaa
     2821 gtccaaatgt ttagcttagg tctgagagtc aaacaatgtt aaggattgtc ttaaagttcc
     2881 ttagccagca aaacaaaaca aaacaaaaca aacaaatgaa aaacgtttaa aaagaagaag
     2941 aagaaaaaaa acaagaacaa gcagcaacag ctgttttgtt ggggctatag atttaagtta
     3001 ggcatagtca atttcagaat aactaagagt ggaatatatg catatggtga aattataacc
     3061 ttgccctttt ttatttgccc tctgcgatcc acctgctttt tagaagtctg ccgagtgaga
     3121 aggccacagt atctcatgct gtttgcatta cagaactgca gcttttctac tctgaaaagg
     3181 cctgggagca gaatggctgg cctgctgtga gcaggagagg agattctaag aaggatagtc
     3241 ccccctacaa catactgtca tactgctggg ttttcatggg taggaaagct tgtcctgacc
     3301 ccagcagcaa agaggtggca ggtcgctaat gaatatatgc tttataatgt ccttcttcat
     3361 tgctgagagg gcagccttag agctgtggat ttctgcatcc cccctgagtc tgacccatgg
     3421 acacctgttt cattcacttt agcatcacag tgacctttgt atgctctgtt cagtctgtgt
     3481 caggcagtat gcttgtcctg aagagaggtt tggctatccc caccccaccc caccccaccc
     3541 tgttcctttt ttatcaggag gacttcagag ccaggcctgc agcattttgt ttgaaaacac
     3601 aatcagctct gacagttaga catgcacaca gacgccatag ctggattgga aacattgatg
     3661 ttttaaaaat ttattttttt tggaaatagt tgcacaaatg ctgcaattta gctttaaggt
     3721 tctatagatt tttaactagt ccaacacagt cagaaacatt gttttgaatc ctctgtaaac
     3781 caaggcatta atcttaataa accaggatcc atttaggtac cacttgatat aaaaaggata
     3841 tccataatga atattttata ctgcatcctt tacattagcc actaaatacg ttattgcttg
     3901 atgaagacct ttcacagaat cctatggatt gcagcatttc acttggctac ttcataccca
     3961 tgccttaaag aggggcagtt tctcaaaagc agaaacatgc cgccagttct caagttttcc
     4021 tcctaactcc atttgaatgt aagggcagct ggcccccaat gtggggaggt ccgaacattt
     4081 tctgaattcc cattttcttg ttcgcggcta aatgacagtt tctgtcatta cttagattcc
     4141 gatctttccc aaaggtgttg atttacaaag aggccagcta atagcagaaa tcatgaccct
     4201 gaaagagaga tgaaattcaa gctgtgagcc aggcaggagc tcagtatggc aaaggttctt
     4261 gagaatcagc catttggtac aaaaaagatt tttaaagctt ttatgttata ccatggagcc
     4321 atagaaaggc tatggattgt ttaagaacta ttttaaagtg ttccagaccc aaaaaggaaa
     4381 aataaaaaaa aaggaatatt tgtacccaac agctagaagg attgcaaggt agatttttgt
     4441 tttaaaatgg agagaagtgg acagataagg ccatttaata tatcaaagat cagttgacat
     4501 ctcctaggga atgatgaaaa cagcaggcta ttagaaaatt atttcatata gttctcgtgt
     4561 tcttttcttt tttttaatcc ctgaagggat gatcagtaac atagcttctc ttttctgtac
     4621 tctagaccac cccttttcat cattttgctt tttatgtctc ccataagaaa tgtgcttttt
     4681 agagcttcct aatgcatgtg ttgcattatt gcagcattag aaaaggagag gtagcatttt
     4741 tgctgaaatc gggcctgtca ctctccaata aaggttctgg cacttcaatg ccaggcaggt
     4801 ctcctaaatg aacagaatga tctgtgtgag ccgatgcctg cccttccaga ggggccactg
     4861 tccccagccg cagccaactg tgtcccacag gaatgggagc ctaggtttcc aaatcttgtg
     4921 attctttagg agaaacatga aacctggatt tcgtgtgaaa tgtcccgatt gttaaaaagt
     4981 tggctcaatt atttttaaaa cattttgtaa gccaacaaaa gtctgtgggc tgccagttta
     5041 ttacttttgt cttaaaacat gatcattgtt ctctcacggt atccttctgt cttcccgttg
     5101 caaattcact tttctttctt cctgacattg ccattgaggg ctttgttacc acaagctaag
     5161 aaactgagtt taacagccca gttatctgca acatgtcaat tacctttgct cctctcctgt
     5221 gattcccacc atgctgtgac cctcagctgt ctccctttgc tgggaattct gcaccaatgt
     5281 ctcccctcaa cccattccct ggttggtcct actcccgtgt ggccagagac atcctagcaa
     5341 atccttcctc ctattatatc tgacactaat ttcttttcaa cagcgctcat gtctcttggc
     5401 ccagtcaggt gctgccaggt ttagatagga aagtacatgt cccattttca tgggtgccct
     5461 taatgtggtc cacgtcctat atcttattat atttactcat ggctcaatgg gggcctccag
     5521 agaccctctc aggctgctga gctagactaa ggaatgcatc caccgtcatc acatgagaca
     5581 ctgactctgt gacgacaaaa gtacaaacag tctgaggcta agaaaggttc atctcacaac
     5641 aggaaaaaca aatctcaaca cacattagag ataattgatt caggggtttt ctctcccagt
     5701 ctcccagcag ggactgattt catttctgac ccactaggtt ttctttccag aaataggtag
     5761 caaggacaag aactaaacaa tcccagcccc acccagcaac acagaacaca ggagtttgct
     5821 tttggcttct cactctccaa gtaaccctga attaggccca gaatggctga ggcttggagc
     5881 atctcctcag acagagcaga ggcgacacct cttcaggggt gtgtggagta aatagctcga
     5941 agagctgaag acagaaaacc agtttcacgc caggtgcgag agagagcata atggagggaa
     6001 gcccgctttc tctctcctct tcttttctct ttatttcttt agagcacttg actttttttt
     6061 ctctctctct ctagtattct aaactgaccc catgaccaac tgagaattta tttttgtttc
     6121 attggttgtt tcacagaatt agaacacaca cgacttttta ttcctccatt gcaaaatgga
     6181 atcaagatac tacacaagac ctgtgctttc ttcctttgca tgatttacac ctccgcctgt
     6241 tttggtgcta gctgtctaga acttctctct tggtttgaat ctgattcctt cacactacac
     6301 tagaagttta tttcatcttg ttttgtctag actccagata cagagggaca gctggactga
     6361 ggacaagcaa ttccatctag catagggtct ctcagggttg gtgcatccag ccacatgggc
     6421 agggccagtc acatctagtc tatgtcccca gagcccttgg agttgcgcag cttagctgac
     6481 ttgactccaa ggaaattagt acagaagtaa ccactctatt aagtgtgttc tgctatgttc
     6541 acatgcctgt agtacctgca aaccatgcca ggttcatcta aagacatagg ggaagattaa
     6601 ggactctttt ggacagacca tgaattgaat ttgctgccag gtgctgccag actgaatttg
     6661 gctgacagaa ctcccagccc aggaaagttc catgacaatg actgtcgcag aaggaaattt
     6721 cccactaaag tcagtccatt ttcaagtttt ggtcttcaga gacaaaagaa cgtcccagcc
     6781 acctgatttt gatggtgagg taactctaag ttgaattcag gctagtgttg cagtatagct
     6841 ttggcatgtt catgagtgag cacccagaat gtgttgaacc aacccccacc cctaactact
     6901 gactatgact gcagtgggtt tttatgggga aaaaaagtgt gaaaagcaaa aagaaaggaa
     6961 cagagatttt ttatcacctt tattgtaaga cagtccattt atgaattgag tataaacaca
     7021 tacaaagtaa caagagattc ctaagaaacg caaatccttg agtttcacgc acttcatgtt
     7081 caaccatttg ctgtaatcca gaggcagcct gtgaatcatt ctcatgccct gttttttttt
     7141 tttttttcct ataatgttct gggtttaaaa gccatctttt ccacattttc tgtaaataat
     7201 ggataatcat tttaaaaatt tttattttta gtgctgtttt aacaatgtag atagatcata
     7261 aatgtacttg ctgaattcaa tcatttttaa caagccaata aagtttgata attca
//
