LOCUS       NM_001369537            8468 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant m, mRNA.
ACCESSION   NM_001369537 XM_017014756
VERSION     NM_001369537.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8468)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 8468)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8468)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8468)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 8468)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 8468)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 8468)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 8468)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 8468)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 8468)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13 and AL596132.7.
            
            On Apr 10, 2019 this sequence version replaced XM_017014756.1.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (m), as well as variant d, encodes
            isoform d.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.71586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL390777.13        29334-29597
            265-353             AL390777.13        30147-30235
            354-937             AL390777.13        31189-31772
            938-1012            AL390777.13        62971-63045
            1013-1084           AL390777.13        63160-63231
            1085-1153           AL390777.13        68656-68724
            1154-1308           AL390777.13        71449-71603
            1309-1445           AL390777.13        84385-84521
            1446-1578           AL390777.13        85036-85168
            1579-1884           AL390777.13        88466-88771
            1885-1920           AL390777.13        102704-102739
            1921-2021           AL390777.13        105785-105885
            2022-2121           AL390777.13        112798-112897
            2122-2169           AL596132.7         40938-40985
            2170-2358           AL596132.7         47141-47329
            2359-8468           AL596132.7         51687-57796
FEATURES             Location/Qualifiers
     source          1..8468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..8468
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..264
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            265..353
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            354..937
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             726..2387
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform d precursor is encoded by transcript
                     variant m; BDNF/NT-3 growth factors receptor; tyrosine
                     kinase receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform d
                     precursor"
                     /protein_id="NP_001356466.1"
                     /db_xref="CCDS:CCDS35051.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNY
                     PDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM
                     LFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPS
                     SSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTWPRGSPKTA"
     exon            938..1012
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1084
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1153
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1308
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1445
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1578
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1884
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1920
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2021
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2121
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2169
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2358
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..8468
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8446..8451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      8468
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaaacag attccgagcc gcaaaaggga agacggattc tcagacaagg cttgcaaatg
       61 ccccgcagcc atcatttaac tgcacccgca gaatagttac ggtttgtcac ccgaccctcc
      121 cggatcgcct aatttgtccc tagtgagacc ccgaggctct gcccgcgcct ggcttcttcg
      181 tagctggatg catatcgtgc tccgggcagc gcgggcgcag ggcacgcgtt cgcgcacacc
      241 ctagcacaca tgaacacgcg caagggagac agcctctacc gcgattgtag aagagactgt
      301 ggtgtgaatt agggaccggg aggcgtcgaa cggaggaacg gttcatctta gagcctcgag
      361 gtgcataccg gacccccatt cgcatctaac aaggaatctg cgccccagag agtcccggga
      421 gcgccgccgg tcggtgcccg gcgcgccggg ccatgcagcg acggccgccg cggagctccg
      481 agcagcggta gcgcccccct gtaaagcggt tcgctatgcc ggggccactg tgaaccctgc
      541 cgcctgccgg aacactcttc gctccggacc agctcagcct ctgataagct ggactcggca
      601 cgcccgcaac aagcaccgag gagttaagag agccgcaagc gcagggaagg cctccccgca
      661 cgggtggggg aaagcggccg gtgcagcgcg gggacaggca ctcgggctgg cactggctgc
      721 tagggatgtc gtcctggata aggtggcatg gacccgccat ggcgcggctc tggggcttct
      781 gctggctggt tgtgggcttc tggagggccg ctttcgcctg tcccacgtcc tgcaaatgca
      841 gtgcctctcg gatctggtgc agcgaccctt ctcctggcat cgtggcattt ccgagattgg
      901 agcctaacag tgtagatcct gagaacatca ccgaaatttt catcgcaaac cagaaaaggt
      961 tagaaatcat caacgaagat gatgttgaag cttatgtggg actgagaaat ctgacaattg
     1021 tggattctgg attaaaattt gtggctcata aagcatttct gaaaaacagc aacctgcagc
     1081 acatcaattt tacccgaaac aaactgacga gtttgtctag gaaacatttc cgtcaccttg
     1141 acttgtctga actgatcctg gtgggcaatc catttacatg ctcctgtgac attatgtgga
     1201 tcaagactct ccaagaggct aaatccagtc cagacactca ggatttgtac tgcctgaatg
     1261 aaagcagcaa gaatattccc ctggcaaacc tgcagatacc caattgtggt ttgccatctg
     1321 caaatctggc cgcacctaac ctcactgtgg aggaaggaaa gtctatcaca ttatcctgta
     1381 gtgtggcagg tgatccggtt cctaatatgt attgggatgt tggtaacctg gtttccaaac
     1441 atatgaatga aacaagccac acacagggct ccttaaggat aactaacatt tcatccgatg
     1501 acagtgggaa gcagatctct tgtgtggcgg aaaatcttgt aggagaagat caagattctg
     1561 tcaacctcac tgtgcatttt gcaccaacta tcacatttct cgaatctcca acctcagacc
     1621 accactggtg cattccattc actgtgaaag gcaaccccaa accagcgctt cagtggttct
     1681 ataacggggc aatattgaat gagtccaaat acatctgtac taaaatacat gttaccaatc
     1741 acacggagta ccacggctgc ctccagctgg ataatcccac tcacatgaac aatggggact
     1801 acactctaat agccaagaat gagtatggga aggatgagaa acagatttct gctcacttca
     1861 tgggctggcc tggaattgac gatggtgcaa acccaaatta tcctgatgta atttatgaag
     1921 attatggaac tgcagcgaat gacatcgggg acaccacgaa cagaagtaat gaaatccctt
     1981 ccacagacgt cactgataaa accggtcggg aacatctctc ggtctatgct gtggtggtga
     2041 ttgcgtctgt ggtgggattt tgccttttgg taatgctgtt tctgcttaag ttggcaagac
     2101 actccaagtt tggcatgaaa gatttctcat ggtttggatt tgggaaagta aaatcaagac
     2161 aaggtgttgg cccagcctcc gttatcagca atgatgatga ctctgccagc ccactccatc
     2221 acatctccaa tgggagtaac actccatctt cttcggaagg tggcccagat gctgtcatta
     2281 ttggaatgac caagatccct gtcattgaaa atccccagta ctttggcatc accaacagtc
     2341 agctcaagcc agacacatgg cccagaggtt cccccaagac cgcctgataa taatttggta
     2401 tttggaggct cctgtgtcac tgcaggaact aaaggaggct aaatccatgc ctgatggagg
     2461 agaagagttc tatggttatc tgcaaattct ggccagacaa catcttgacg tcactcctta
     2521 gcttccataa cctagccaag caagaagttg cctttccaag acaaagcagt gtgctctaat
     2581 gactaacccc tcaaagtact atgccacttt aactatagac ccatctcctc gatcaatcag
     2641 gatggcaaga tggagctgag gagctcagca acatcaagtc tggagttggt ctttaactca
     2701 actagctcgt ttagacgtgt ctgaacacca catcacctga cagcacgggg tggtttccca
     2761 gtaaaattta caaactcagc tcaagggcag ctgtgttgct ttcctttcct tgactgctga
     2821 gaaacttttt gacagggaac aatggaaaca caccttctga gctgaaacaa acaaacagaa
     2881 acaaaacata ctaaccagca aaatccccaa atcatcaatc ttgggttctc ttgaagggca
     2941 ggagtgtgtt ttatcttctc ccgtcggagc aaacactata gatgtcctcc ctaaaattct
     3001 gtcttcccta gagcagcctt gtaaattagc tagggtccta gggttgaggc ctaaatcaac
     3061 ttaaaattgt ctctaaatat gtacctggat gtgtttgtac ttgcagagca tgccctcttc
     3121 atgtgcctag ggctagtaac tccctgtggc agaggcatgt aaagtattct gacttttttt
     3181 ttttcaactt aattccattt ccaatgaaat ggatttttaa aaattttctc cagagtgtgc
     3241 catacttctc cagctattat agttaatgtg tgtgtatcct tgtgtatatg tgtgtttgtg
     3301 tgtgcatatg tgttttccta gtggttacat gcttactagg caattatgta aataagcaca
     3361 gattcatagg ccagctaggc ctgaggaaag aagacattat aaagggaggg agtattttaa
     3421 cattagctaa agctatcaca caaggcaccc attctgctcc cctcaacagc cacagcccac
     3481 ttcgtccttg tcttaccaat aaggggaaag gctggaggtg atatttttca cagaaccgca
     3541 gaggttttga acatatttgc aacattactt tgagtacaca tgagcaaaaa ttctgaatta
     3601 catccaggac cccagaagct cattagatca aagagtgcgg ggcccctcag agttaccaga
     3661 gattatctgc agacttcagt gcaatcgaat gaccatggtc cattttgatg gtcagaggta
     3721 ggactgaaaa acgggtagaa acaattgctt tagcgcttcc ttctgtactt tgcctattaa
     3781 tgttttgtct ttcaaaaata tattttctcc taattgttta attggccaaa taatggctgc
     3841 tttgggagtt gtttgtatgc cttggaaggc catggcctgc actttaaaaa taagctaagt
     3901 ccattctgcc cagcacgagc attaggacag agaatgcact tattttagga tccttaaaaa
     3961 ttgcttcttt tatggcacac tgggttgacg actcatctcg tgggagcctt catggcacat
     4021 tgctgctgtt ctgcaggtcc caatacaatt ccttccccct ctcagtgcca cggccccccc
     4081 attgctagct acaacaattt gatatcatat tcccttttca actccaaagg agatgataag
     4141 aagctatcaa ataatgcttt aaaaaagcaa cttgagtttc ttaaaagaaa ggaaatgaat
     4201 acatgctgca taattacatt taaaatgtaa gccatgttat tataagccgc actgagatga
     4261 agatttgtta gcaaaccagt ttcaagcaca ctcacagtga agtaaaatca tgtttttagc
     4321 atctgaccat tgggtaatat tattctttgt tatcaaaaga gaaatatcac ccaagtatag
     4381 tatacttaga cctcctagag gaaacactcc agtcctaagc ttggtgtctg aaaagaaaaa
     4441 caaaaataaa gattatggat ttaggtcagg gagacagagt gatattctga agactgtgtt
     4501 tactccctca tcatcggcca accaagatgg agttctgcat cctgcacata tcagacattt
     4561 cagtccaatt tcaccaaagc atcagtgatg ttctagaagc atcccagcag atggaggatc
     4621 ctaatgtatt tgttctgggt atttcccaag gcccagcctg actggagtgt gtgtaccaac
     4681 aggatgaatc caatcaagct acgcccccat tttggtttcg gattggccac tcttgcatgt
     4741 gctagtagat tgtggaccag gaccagctga gcaaacacag ttgcagagta gcctcctatg
     4801 ttgctaagaa gctcctgcta cccaggtgct ttgaacaatt gagtgctccc tctggttaag
     4861 tagagatggc accaccggag tttttcttgg atgtgaggct caatccttta cggcagctat
     4921 tataacaaag tgaaggtttt ctccctggga aatgcagctt ttctctgtct ttactaattc
     4981 tgccagcctg tgagagtaac caccgtagct gggcttcttc tcagattaat tgtcatgcca
     5041 ggtctccttc ctggggagct gtgatgctgc tctgaggttg attgctgagg ttgtagtggg
     5101 tttttgtttg tttttgttta gtttttcttg attgttcttc tttctcttga atggcaagag
     5161 aagaaacact ttctctaacc cacggccagg aaggaaatgg ggagagagct acttcttagt
     5221 tcaacctggt tgccacataa aggaatctct ctccttggac tcagccccta actggaagca
     5281 agagccactg ccctctgaga ctgagagagc agcccgagga ggagatgaat ccattctgcc
     5341 ctttgtttgg gtttgcttcc tgtcagtgag agaatgctga ggcagttcct gttatgtgaa
     5401 actttcattt ttaaaaccag gacagtccta aacagactgg aatgagttgg tcaatcccag
     5461 ttggtatagg cccaatgatt tttgctagta agataggatt gtcttcctca cccaaaatgc
     5521 cttcaagtgc cctaaaatgg gtattttaaa ataagaataa ataatgtaga tttagtagaa
     5581 aacctggaaa acataagaaa caaagatgaa acgaaaagtc ccatgtaatt ccaccagtta
     5641 gagttaacca ctgatatcgt ttggatatat ggctttctag tcttgtggat atccttttaa
     5701 tctcttgtaa tataaagtct gaccatatgt gtccttgcat ttgtttgtac tggactctgt
     5761 taatatttct atagtaatgg ctcactttgg ggagattgtg ctgcacagtg tgtaggaagc
     5821 acattgggtg tattattccc agttttgtat tttgtatttc cttggagatg tgcaggggtt
     5881 aagagcgggg gtctggccat agctggccac gtcagactct catatggtaa gtatcacaga
     5941 gcacatgagg cctgtgttat gcgctggaaa gactcaggaa atgagaggct ctcttgttct
     6001 gacaaggcag gctgagagct ctcatttagg gtcatcactc cagataactc caaatgcagt
     6061 ttattgctca actgaagcag atgatcactt tttgcctcca agttcttcac cctagctagc
     6121 tcctttcaaa gagccgagta tgctggatct taaagggcca aactagttac atctcataca
     6181 tttcctgatg tttagggatg ccttcacttc catcaaggat accttggctg tgcaaggacc
     6241 tctgatagct ggagtctcct tttggtcact cccagctttg cttaaacttg atggagtttg
     6301 ctgtccagtg atccccggat ctttcatcat gaaagccttc cttcctctcc tgatgtctca
     6361 ggcctctaga cctagactgg ggttctggca aggaggcctc tatcaatagt atgacatcca
     6421 ataatatgtt agtgttgata ttttgcacag taatattaag tttaagagat tataaaaatg
     6481 agttcaaatg aataagttcc tgtgatgtaa gagattagat atgtgtgatt tcagaaccaa
     6541 aggcaggggg gaatcccaga aagaaaacaa taatataatc ctagtttcta tatattattt
     6601 ttattcatta ctgtatatgg gtagagatca atattctttc ttatgctgtt actattaatt
     6661 aacacatttt ttaaccatgc cattgaactt ttgggtgcat taaagtggaa cccaagctcc
     6721 tcattagata ataatggcat ttggactgag tgccatattc ctaaatttcc aataaagtgg
     6781 ttgatataga gaggacagga taaagcccta tagtgtgcag ttatatcaaa acagctagtc
     6841 tccactttag ggaatgcctt tactagagat tacatgaaat gtctgcttat aaaataagca
     6901 gagatggcac cactaagcag ccacctgaat tgttttccta caggaatgat tacttttcag
     6961 atccatttat gttttcatgc tcaatactta ctccccttcc ctgcaacacc caaagagttt
     7021 acttttgcaa gtcatttggt cttcagtcta ctactgagga atagagaggc actaactgct
     7081 ttacccagga tcagaactca tgttcttacc ttctattaat agagtacttg agccagatgg
     7141 actaactggt ctcacatttt ctctatcttg gttttacttc cataaacatc aatatcttta
     7201 cccacatgat ttttccatcc tcccattttt ttccatatgt attagggttc aggaactatg
     7261 atgctaatga tcacatttct tcctagttcc taatttcatt agtgccattt cctgatatct
     7321 acagaaacaa ttatcaatac atgtagctgc ttgagcctta tttagaaggc tagcctttct
     7381 tttccaagtg ctgtcagaat gtatacattt agtctgtctt tttccctttt aggagtcttt
     7441 gttctgggtt gatggcaaaa ttcctctttt tacatgtgag atttttgatt tcactgaatt
     7501 ctacctagat ttttatggac attggatttt aaagaggaaa acactcattt tcttagtaag
     7561 atattggtga tacatagcta tgccattgat ttccatactc ctgagctttg gggagggaga
     7621 cagtggccaa gtagcaggca gaataagatc atcactcatg tcctgaatca atcacacttt
     7681 ccttctcgga ttgtgtatat gctctgccac ttcctacata ttacatcctg agtttttaag
     7741 taaagtggat cttagccaga tttgagtcta atggctgatt catcggcata gttcttggcg
     7801 ttaacatctc agtgtcctct ttagttctct ttgaggattc atgtcattga gggcctttgt
     7861 gcctccactt gtctcagtat gaggaagaac tttggtgtga gggcggagct atgtgaaggg
     7921 ttgctgggtt gggggattag ttcatatggt ccccatgcca tctatttact tttggagaga
     7981 ggggactttg agtgggtggg tatggataga tgttcctcaa ggaaaccctg ctggctaatg
     8041 ggcactacat ctgtgtatta ctgtgattct ctctgtaagc tccccatgtg gccaaggacc
     8101 cccctcctac cagggcactt cctgccacct cattgcactg gtctcaacca ttcagcctgc
     8161 tgctgctgca ccatgttggg ctgcggtagg atagggaagg ggttctgttg attgctaaat
     8221 gttgcctaac tttatttccc tctcccacat ttcatgcaag ggagcggacc taacacatga
     8281 cttgcattct cttcctatgt tcagaaactc cagggcttgc ccacgtgtat gtatgagtga
     8341 ccaatggagc ttggaattct ttatctatat gatctgtccg aaaatgagat cttttgtact
     8401 ggaatttgtg atgtagttga tcattcagag ccaaacgcat ataccaataa agacaagact
     8461 gtcatata
//
