LOCUS       NM_001369536            8003 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant h, mRNA.
ACCESSION   NM_001369536
VERSION     NM_001369536.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8003)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 8003)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8003)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8003)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 8003)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 8003)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 8003)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 8003)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 8003)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 8003)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13, AL596132.7 and
            AL445532.8.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.170917.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL390777.13        32903-32983
            82-156              AL390777.13        62971-63045
            157-228             AL390777.13        63160-63231
            229-297             AL390777.13        68656-68724
            298-452             AL390777.13        71449-71603
            453-589             AL390777.13        84385-84521
            590-722             AL390777.13        85036-85168
            723-1028            AL390777.13        88466-88771
            1029-1064           AL390777.13        102704-102739
            1065-1165           AL390777.13        105785-105885
            1166-1265           AL390777.13        112798-112897
            1266-1313           AL596132.7         40938-40985
            1314-1502           AL596132.7         47141-47329
            1503-1633           AL596132.7         114060-114190
            1634-1806           AL445532.8         6204-6376
            1807-2041           AL445532.8         13025-13259
            2042-2200           AL445532.8         77948-78106
            2201-8003           AL445532.8         78994-84796
FEATURES             Location/Qualifiers
     source          1..8003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..8003
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..81
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            82..156
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            157..228
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            229..297
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            298..452
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..2386
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform h is encoded by transcript variant h;
                     BDNF/NT-3 growth factors receptor; tyrosine kinase
                     receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform h"
                     /protein_id="NP_001356465.1"
                     /db_xref="CCDS:CCDS94430.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSAN
                     LAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSD
                     DSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQ
                     WFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI
                     SAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLS
                     VYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISND
                     DDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQH
                     IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAE
                     LLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL
                     TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDY
                     YRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE
                     CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
                     "
     exon            453..589
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            590..722
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1028
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1064
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1165
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1265
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1313
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1502
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1633
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1806
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2041
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2200
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..8003
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7983..7988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      8003
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 gcgcatgcat ttttccttcc acagaaaaca tacaaccatg tttctgccaa cgtagttgac
       61 caagataacc tgttttttaa ttttcatcgc aaaccagaaa aggttagaaa tcatcaacga
      121 agatgatgtt gaagcttatg tgggactgag aaatctgaca attgtggatt ctggattaaa
      181 atttgtggct cataaagcat ttctgaaaaa cagcaacctg cagcacatca attttacccg
      241 aaacaaactg acgagtttgt ctaggaaaca tttccgtcac cttgacttgt ctgaactgat
      301 cctggtgggc aatccattta catgctcctg tgacattatg tggatcaaga ctctccaaga
      361 ggctaaatcc agtccagaca ctcaggattt gtactgcctg aatgaaagca gcaagaatat
      421 tcccctggca aacctgcaga tacccaattg tggtttgcca tctgcaaatc tggccgcacc
      481 taacctcact gtggaggaag gaaagtctat cacattatcc tgtagtgtgg caggtgatcc
      541 ggttcctaat atgtattggg atgttggtaa cctggtttcc aaacatatga atgaaacaag
      601 ccacacacag ggctccttaa ggataactaa catttcatcc gatgacagtg ggaagcagat
      661 ctcttgtgtg gcggaaaatc ttgtaggaga agatcaagat tctgtcaacc tcactgtgca
      721 ttttgcacca actatcacat ttctcgaatc tccaacctca gaccaccact ggtgcattcc
      781 attcactgtg aaaggcaacc ccaaaccagc gcttcagtgg ttctataacg gggcaatatt
      841 gaatgagtcc aaatacatct gtactaaaat acatgttacc aatcacacgg agtaccacgg
      901 ctgcctccag ctggataatc ccactcacat gaacaatggg gactacactc taatagccaa
      961 gaatgagtat gggaaggatg agaaacagat ttctgctcac ttcatgggct ggcctggaat
     1021 tgacgatggt gcaaacccaa attatcctga tgtaatttat gaagattatg gaactgcagc
     1081 gaatgacatc ggggacacca cgaacagaag taatgaaatc ccttccacag acgtcactga
     1141 taaaaccggt cgggaacatc tctcggtcta tgctgtggtg gtgattgcgt ctgtggtggg
     1201 attttgcctt ttggtaatgc tgtttctgct taagttggca agacactcca agtttggcat
     1261 gaaagatttc tcatggtttg gatttgggaa agtaaaatca agacaaggtg ttggcccagc
     1321 ctccgttatc agcaatgatg atgactctgc cagcccactc catcacatct ccaatgggag
     1381 taacactcca tcttcttcgg aaggtggccc agatgctgtc attattggaa tgaccaagat
     1441 ccctgtcatt gaaaatcccc agtactttgg catcaccaac agtcagctca agccagacac
     1501 atttgttcag cacatcaagc gacataacat tgttctgaaa agggagctag gcgaaggagc
     1561 ctttggaaaa gtgttcctag ctgaatgcta taacctctgt cctgagcagg acaagatctt
     1621 ggtggcagtg aagaccctga aggatgccag tgacaatgca cgcaaggact tccaccgtga
     1681 ggccgagctc ctgaccaacc tccagcatga gcacatcgtc aagttctatg gcgtctgcgt
     1741 ggagggcgac cccctcatca tggtctttga gtacatgaag catggggacc tcaacaagtt
     1801 cctcagggca cacggccctg atgccgtgct gatggctgag ggcaacccgc ccacggaact
     1861 gacgcagtcg cagatgctgc atatagccca gcagatcgcc gcgggcatgg tctacctggc
     1921 gtcccagcac ttcgtgcacc gcgatttggc caccaggaac tgcctggtcg gggagaactt
     1981 gctggtgaaa atcggggact ttgggatgtc ccgggacgtg tacagcactg actactacag
     2041 ggtcggtggc cacacaatgc tgcccattcg ctggatgcct ccagagagca tcatgtacag
     2101 gaaattcacg acggaaagcg acgtctggag cctgggggtc gtgttgtggg agattttcac
     2161 ctatggcaaa cagccctggt accagctgtc aaacaatgag gtgatagagt gtatcactca
     2221 gggccgagtc ctgcagcgac cccgcacgtg cccccaggag gtgtatgagc tgatgctggg
     2281 gtgctggcag cgagagcccc acatgaggaa gaacatcaag ggcatccata ccctccttca
     2341 gaacttggcc aaggcatctc cggtctacct ggacattcta ggctagggcc cttttcccca
     2401 gaccgatcct tcccaacgta ctcctcagac gggctgagag gatgaacatc ttttaactgc
     2461 cgctggaggc caccaagctg ctctccttca ctctgacagt attaacatca aagactccga
     2521 gaagctctcg agggaagcag tgtgtacttc ttcatccata gacacagtat tgacttcttt
     2581 ttggcattat ctctttctct ctttccatct cccttggttg ttcctttttc tttttttaaa
     2641 ttttcttttt cttttttttt tcgtcttccc tgcttcacga ttcttaccct ttcttttgaa
     2701 tcaatctggc ttctgcatta ctattaactc tgcatagaca aaggccttaa caaacgtaat
     2761 ttgttatatc agcagacact ccagtttgcc caccacaact aacaatgcct tgttgtattc
     2821 ctgcctttga tgtggatgaa aaaaagggaa aacaaatatt tcacttaaac tttgtcactt
     2881 ctgctgtaca gatatcgaga gtttctatgg attcacttct atttatttat tattattact
     2941 gttcttattg tttttggatg gcttaagcct gtgtataaaa aagaaaactt gtgttcaatc
     3001 tgtgaagcct ttatctatgg gagattaaaa ccagagagaa agaagattta ttatgaaccg
     3061 caatatggga ggaacaaaga caaccactgg gatcagctgg tgtcagtccc tacttaggaa
     3121 atactcagca actgttagct gggaagaatg tattcggcac cttcccctga ggacctttct
     3181 gaggagtaaa aagactactg gcctctgtgc catggatgat tcttttccca tcaccagaaa
     3241 tgatagcgtg cagtagagag caaagatggc ttccgtgaga cacaagatgg cgcatagtgt
     3301 gctcggacac agttttgtct tcgtaggttg tgatgatagc actggtttgt ttctcaagcg
     3361 ctatccacag aacctttgtc aacttcagtt gaaaagaggt ggattcatgt ccagagctca
     3421 tttcggggtc aggtgggaaa gccaagaact tggaaaagat aagacaagct ataaattcgg
     3481 aggcaagttt cttttacaat gaacttttca gatctcactt ccctccgacc cctaacttcc
     3541 atgcccaccc gtccttttaa ctgtgcaagc aaaattgtgc atggtcttcg tcgattaata
     3601 ccttgtgtgc agacactact gctccagacg tcgtttccct gataggtaga gcagatccat
     3661 aaaaaggtat gacttataca attaggggaa gctaatggag tttattagct gagtatcaat
     3721 gtctctgcgt tgtacggtgg tgatgggttt taatgaatat ggaccctgaa gcctggaaat
     3781 cctcatccac gtcgaaccca caggactgtg ggaagggcag aatcaatccc taagggaaag
     3841 gaaacctcac cctgagggca tcacatgcac tcatgttcag tgtacacagg tcaagtccct
     3901 tgctctgggc tctagttggg agagtggttt cattccaagt gtactccatt gtcagtatgc
     3961 tgtttttgtt tccttcactc cattcaaaaa gtcaaaatac aaaatttggc acagcatgcc
     4021 aacgggaggc tgtgcccaga ccaagcactg gaagtgtgct tctaggcata gtcattggtt
     4081 ttgcaaaaag agggctcaaa tttaaataga aatttacagc tatttgaatg gtcagatata
     4141 ccaagaaaga aaaatatttc tgttcctcaa gaaaacttgc taccctctgt gaggggaatt
     4201 ttgctaaact tgacatcttt ataacatgag ccagattgaa agggagtgat tttcattcat
     4261 cttaggtcat gttatttcat atttgtttct gaaggtgcga tagctctgtt ttaggttttg
     4321 cttgcgcctg ttaattactg gaacacctta tttttcatta aaggctttga aagccaattc
     4381 tcaaaaattc aaaagtgcaa attaacagaa caaaaggaaa tccagtagca actgcagtca
     4441 agcgagggag ttgacaagat aaaccttacg tccattcaag ttatatgctg gcctatgaga
     4501 gatgagagtt gggtcgtttg ttctctttgt tgatgatttt aaaaaaaccc tctagaatac
     4561 acataataac ataatgaaag ccatatctcc atgatatata tgtgcacata tatatacata
     4621 catgtgcatg tatgtatcat attaaggacc catggtactc ttaaaacact gtagaactct
     4681 gtgacgcagt aaggaagggg cagatttgta caaaaacttt tctagattcc atcagcaaaa
     4741 accaacacag gtttgtcacg ctgcatgtct ggccagctaa tctcggggga aaagctacaa
     4801 gttatttatt ttattttaag agaataaagt aggtaataat ttaagggatc aaattcaagg
     4861 aggaatgtgc aattttagag caaagatttg tttaaggcaa atgagacttt gggagcatcc
     4921 cattccagtt ttgtcttttt tttctctgaa agaaaaaagc aaaaaataaa ataaaattcc
     4981 acttatacct tctgacaagt ccctaaaggt cttgaaataa aaggttctat gcaagtgcaa
     5041 agttttatag ttatttttat tgctgattat tactattact atctctgttg tcttaagagt
     5101 atgtgctgat ttcagagaca tctcaaattg aaagaatatc agattgcttt taaagtagct
     5161 gaacgagcca cagaatatct gaaattattc attgttgttc ctccaccacc ccctttctca
     5221 tggtctgatt tttagaagag tggcatcctc gttctaaaat gtaatgatca ccaaatacgg
     5281 ccttccatca aatttgtgaa aactacaaca gtataacagt gacaaaccta attctctagc
     5341 ccaaacctgg tctgacaatc atttccattt agaagtcatt gaatagtttt ccaaacactt
     5401 tccatgtgtg ttagcaaatt attcctattt tgtgtagatg aggacgttga gactcagaga
     5461 cattcagagg cacgctagag gtctccagcc tagcttccag caccattggg actgaatcca
     5521 agtactctca ctctgaactt cgtggttctg tccactagag actctaatat gcaaacaagc
     5581 agttcaggaa agaaagcatg ctaacacatt catgaagcag tatatgaagt tagaagaaca
     5641 aaaggaaata caggagatga caagcaactg agatattgtg atatataatc atgctcttag
     5701 cttcagctaa attcagctaa attcttgtac actgaaccaa tgtcataatc aggcttattt
     5761 agaaaacact ttgaactatg ctataaaaga ttatatcaga attcatatta tacatgtgtt
     5821 cacatcagcg ctacctgtga tgttttcatg tatttatgta tgtgttataa atacttgatt
     5881 tatacatata caaatgcaca tacgtagtgt gtttgtgtgt ttatgtataa atttataggc
     5941 acacaataat agaggtaatt ataagtagga tgcggtatga ataatttgct taaaatatgc
     6001 taaataacca aaactgttta acgtcatgtt gctgttagtg cttccatact ccacgtgggt
     6061 aggactacat cacacttttc aactctgtgc agtactgcat gggtggaaga catatttaag
     6121 ataatgtgct tcccaaaaca actgaataaa agccatccca ctacattgag tgctttctct
     6181 ggctccttgc aaagaaagat actttttgta atggtccagg aaaggaacat tgctttcttt
     6241 ttgtctttca gcacatttgt attatgctca ccttgtctct gtctcactgt gaccccttta
     6301 cacttgagtt cagagttcaa gcattccaaa tataaattgg aatgttggca gcccagtggc
     6361 ttgaaggcca atgatgagca gtccaagacc ccacagcgag atgagcaact cttaggaatt
     6421 cccacatcct agagtgaatg caccaactaa cagtatagaa tgctgtcctt ttcaaagcgt
     6481 cctaacagca ggattacctg gtcaagtatg gactttcttt gaatctttct tttcacaaat
     6541 tggactgcct gtaataccaa taacattgtt gtatctaact aaataaatga ctgcatatac
     6601 acacataccc tcaattctct tgcttcccca ttttcttttt catcccctgt ctcaggactt
     6661 ttattttcaa tgttgacctt tggtttggcc atatatcact gttataggaa atctcatgag
     6721 aggaatggct agtgacccaa ctctccaaat gtctaagtta gtagttacag ctgatttttt
     6781 atgatgcata attggaatgt ggagcctctg aggttgtgat agcttgtaca tgaatttcaa
     6841 atgtcattct aaagaatgag gggtgggagg gatttatagt tagaaacgac agtgcaggaa
     6901 ggggtatttt cttgttgtca gggctggaat gaatcactgc tgctcaagtc aaaggttctt
     6961 gaatatcctt agtttttgca tttcccctcc ttttcctttg acctttattt atttaattat
     7021 gtatttattt atttatttat atacttttgc tccattcagc acaaacacaa agcaaagcaa
     7081 aaaaaaaaat atatatatat atatctgtat atgtgttgta ggcaaaacac tgtgaatttc
     7141 acaacaacca ccaccaagca actattttgc catcttaaca tacatctcag gagacgaaat
     7201 gagaaaagat ggggatgtca ttttttagtc tatgcgtttg aggccaggtc catgtttatt
     7261 tatttcttta gtctatgcat taatgaaaat gatcctgagt ggaggttagc tgaacgttca
     7321 atgtactgga gcaagcatca taaaagctgc tagtagccat gtgtttgaac aggaaaaata
     7381 ttacagaaaa tgaaatgtaa aggcctatat cttgcagctt gtatatctta ctattgctta
     7441 aaaaatgtat aaagcagctg gaaatgtttt aaatacaagg tctttgaatt aaatgtggat
     7501 tttaaatatg taatcccttg acaaatgacc aaattatggt gaactattgc tccctgcgtt
     7561 ctttgatcat tacctatgac ttacaaatct gcctggagat gtggacattc tgcatttgct
     7621 tctgtatctg gagagatgtt tgtatatatc caggccgtat acacacacat ttccatatct
     7681 ctctacagat atatttcccc ttcaatcgtg acctggtatt tggaactctc cttttcattt
     7741 ggcttatctt ccttttaatg tgatgtctct gtgctaatac ttaccagttc ttgttttgca
     7801 atctgttttg aggtccattg ctttactaag acccactgca tcttggctga tttcaaagtg
     7861 acacctgaat acagtgttta aaaaaaaaaa agttttgttt gtaaatcatg tgaccagctt
     7921 ctctcaacct gacatggaaa gtctcttgta ctacagtgta tttaataaaa atgatgtctt
     7981 acaataaata acatactcca aaa
//
