LOCUS       NM_001369534            8582 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant g, mRNA.
ACCESSION   NM_001369534
VERSION     NM_001369534.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8582)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 8582)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8582)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8582)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 8582)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 8582)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 8582)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 8582)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 8582)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 8582)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13, AL596132.7 and
            AL445532.8.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.87530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL390777.13        30541-30700
            161-744             AL390777.13        31189-31772
            745-819             AL390777.13        62971-63045
            820-891             AL390777.13        63160-63231
            892-960             AL390777.13        68656-68724
            961-1115            AL390777.13        71449-71603
            1116-1252           AL390777.13        84385-84521
            1253-1385           AL390777.13        85036-85168
            1386-1691           AL390777.13        88466-88771
            1692-1792           AL390777.13        105785-105885
            1793-1892           AL390777.13        112798-112897
            1893-2081           AL596132.7         47141-47329
            2082-2212           AL596132.7         114060-114190
            2213-2385           AL445532.8         6204-6376
            2386-2620           AL445532.8         13025-13259
            2621-2779           AL445532.8         77948-78106
            2780-8582           AL445532.8         78994-84796
FEATURES             Location/Qualifiers
     source          1..8582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..8582
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..160
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            161..744
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..2965
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform g precursor is encoded by transcript
                     variant g; BDNF/NT-3 growth factors receptor; tyrosine
                     kinase receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform g
                     precursor"
                     /protein_id="NP_001356463.1"
                     /db_xref="CCDS:CCDS94427.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDDYGTAA
                     NDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKF
                     GMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGIT
                     NSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDAS
                     DNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA
                     VLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGD
                     FGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQ
                     PWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL
                     AKASPVYLDILG"
     exon            745..819
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            820..891
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            892..960
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1115
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1252
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1385
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1691
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1792
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1892
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2081
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2212
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2385
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2620
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2779
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..8582
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8562..8567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      8582
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 cttcgccagc agtagcagag gcggcggcgg cggctcccgg aattgggttg gagcaggagc
       61 ctcgctggct gcttcgctcg cgctctacgc gctcagtccc cggcggtagc aggagcctgg
      121 acccaggcgc cgccggcggg cgtgaggcgc cggagcccgg cctcgaggtg cataccggac
      181 ccccattcgc atctaacaag gaatctgcgc cccagagagt cccgggagcg ccgccggtcg
      241 gtgcccggcg cgccgggcca tgcagcgacg gccgccgcgg agctccgagc agcggtagcg
      301 cccccctgta aagcggttcg ctatgccggg gccactgtga accctgccgc ctgccggaac
      361 actcttcgct ccggaccagc tcagcctctg ataagctgga ctcggcacgc ccgcaacaag
      421 caccgaggag ttaagagagc cgcaagcgca gggaaggcct ccccgcacgg gtgggggaaa
      481 gcggccggtg cagcgcgggg acaggcactc gggctggcac tggctgctag ggatgtcgtc
      541 ctggataagg tggcatggac ccgccatggc gcggctctgg ggcttctgct ggctggttgt
      601 gggcttctgg agggccgctt tcgcctgtcc cacgtcctgc aaatgcagtg cctctcggat
      661 ctggtgcagc gacccttctc ctggcatcgt ggcatttccg agattggagc ctaacagtgt
      721 agatcctgag aacatcaccg aaattttcat cgcaaaccag aaaaggttag aaatcatcaa
      781 cgaagatgat gttgaagctt atgtgggact gagaaatctg acaattgtgg attctggatt
      841 aaaatttgtg gctcataaag catttctgaa aaacagcaac ctgcagcaca tcaattttac
      901 ccgaaacaaa ctgacgagtt tgtctaggaa acatttccgt caccttgact tgtctgaact
      961 gatcctggtg ggcaatccat ttacatgctc ctgtgacatt atgtggatca agactctcca
     1021 agaggctaaa tccagtccag acactcagga tttgtactgc ctgaatgaaa gcagcaagaa
     1081 tattcccctg gcaaacctgc agatacccaa ttgtggtttg ccatctgcaa atctggccgc
     1141 acctaacctc actgtggagg aaggaaagtc tatcacatta tcctgtagtg tggcaggtga
     1201 tccggttcct aatatgtatt gggatgttgg taacctggtt tccaaacata tgaatgaaac
     1261 aagccacaca cagggctcct taaggataac taacatttca tccgatgaca gtgggaagca
     1321 gatctcttgt gtggcggaaa atcttgtagg agaagatcaa gattctgtca acctcactgt
     1381 gcattttgca ccaactatca catttctcga atctccaacc tcagaccacc actggtgcat
     1441 tccattcact gtgaaaggca accccaaacc agcgcttcag tggttctata acggggcaat
     1501 attgaatgag tccaaataca tctgtactaa aatacatgtt accaatcaca cggagtacca
     1561 cggctgcctc cagctggata atcccactca catgaacaat ggggactaca ctctaatagc
     1621 caagaatgag tatgggaagg atgagaaaca gatttctgct cacttcatgg gctggcctgg
     1681 aattgacgat gattatggaa ctgcagcgaa tgacatcggg gacaccacga acagaagtaa
     1741 tgaaatccct tccacagacg tcactgataa aaccggtcgg gaacatctct cggtctatgc
     1801 tgtggtggtg attgcgtctg tggtgggatt ttgccttttg gtaatgctgt ttctgcttaa
     1861 gttggcaaga cactccaagt ttggcatgaa aggcccagcc tccgttatca gcaatgatga
     1921 tgactctgcc agcccactcc atcacatctc caatgggagt aacactccat cttcttcgga
     1981 aggtggccca gatgctgtca ttattggaat gaccaagatc cctgtcattg aaaatcccca
     2041 gtactttggc atcaccaaca gtcagctcaa gccagacaca tttgttcagc acatcaagcg
     2101 acataacatt gttctgaaaa gggagctagg cgaaggagcc tttggaaaag tgttcctagc
     2161 tgaatgctat aacctctgtc ctgagcagga caagatcttg gtggcagtga agaccctgaa
     2221 ggatgccagt gacaatgcac gcaaggactt ccaccgtgag gccgagctcc tgaccaacct
     2281 ccagcatgag cacatcgtca agttctatgg cgtctgcgtg gagggcgacc ccctcatcat
     2341 ggtctttgag tacatgaagc atggggacct caacaagttc ctcagggcac acggccctga
     2401 tgccgtgctg atggctgagg gcaacccgcc cacggaactg acgcagtcgc agatgctgca
     2461 tatagcccag cagatcgccg cgggcatggt ctacctggcg tcccagcact tcgtgcaccg
     2521 cgatttggcc accaggaact gcctggtcgg ggagaacttg ctggtgaaaa tcggggactt
     2581 tgggatgtcc cgggacgtgt acagcactga ctactacagg gtcggtggcc acacaatgct
     2641 gcccattcgc tggatgcctc cagagagcat catgtacagg aaattcacga cggaaagcga
     2701 cgtctggagc ctgggggtcg tgttgtggga gattttcacc tatggcaaac agccctggta
     2761 ccagctgtca aacaatgagg tgatagagtg tatcactcag ggccgagtcc tgcagcgacc
     2821 ccgcacgtgc ccccaggagg tgtatgagct gatgctgggg tgctggcagc gagagcccca
     2881 catgaggaag aacatcaagg gcatccatac cctccttcag aacttggcca aggcatctcc
     2941 ggtctacctg gacattctag gctagggccc ttttccccag accgatcctt cccaacgtac
     3001 tcctcagacg ggctgagagg atgaacatct tttaactgcc gctggaggcc accaagctgc
     3061 tctccttcac tctgacagta ttaacatcaa agactccgag aagctctcga gggaagcagt
     3121 gtgtacttct tcatccatag acacagtatt gacttctttt tggcattatc tctttctctc
     3181 tttccatctc ccttggttgt tcctttttct ttttttaaat tttctttttc tttttttttt
     3241 cgtcttccct gcttcacgat tcttaccctt tcttttgaat caatctggct tctgcattac
     3301 tattaactct gcatagacaa aggccttaac aaacgtaatt tgttatatca gcagacactc
     3361 cagtttgccc accacaacta acaatgcctt gttgtattcc tgcctttgat gtggatgaaa
     3421 aaaagggaaa acaaatattt cacttaaact ttgtcacttc tgctgtacag atatcgagag
     3481 tttctatgga ttcacttcta tttatttatt attattactg ttcttattgt ttttggatgg
     3541 cttaagcctg tgtataaaaa agaaaacttg tgttcaatct gtgaagcctt tatctatggg
     3601 agattaaaac cagagagaaa gaagatttat tatgaaccgc aatatgggag gaacaaagac
     3661 aaccactggg atcagctggt gtcagtccct acttaggaaa tactcagcaa ctgttagctg
     3721 ggaagaatgt attcggcacc ttcccctgag gacctttctg aggagtaaaa agactactgg
     3781 cctctgtgcc atggatgatt cttttcccat caccagaaat gatagcgtgc agtagagagc
     3841 aaagatggct tccgtgagac acaagatggc gcatagtgtg ctcggacaca gttttgtctt
     3901 cgtaggttgt gatgatagca ctggtttgtt tctcaagcgc tatccacaga acctttgtca
     3961 acttcagttg aaaagaggtg gattcatgtc cagagctcat ttcggggtca ggtgggaaag
     4021 ccaagaactt ggaaaagata agacaagcta taaattcgga ggcaagtttc ttttacaatg
     4081 aacttttcag atctcacttc cctccgaccc ctaacttcca tgcccacccg tccttttaac
     4141 tgtgcaagca aaattgtgca tggtcttcgt cgattaatac cttgtgtgca gacactactg
     4201 ctccagacgt cgtttccctg ataggtagag cagatccata aaaaggtatg acttatacaa
     4261 ttaggggaag ctaatggagt ttattagctg agtatcaatg tctctgcgtt gtacggtggt
     4321 gatgggtttt aatgaatatg gaccctgaag cctggaaatc ctcatccacg tcgaacccac
     4381 aggactgtgg gaagggcaga atcaatccct aagggaaagg aaacctcacc ctgagggcat
     4441 cacatgcact catgttcagt gtacacaggt caagtccctt gctctgggct ctagttggga
     4501 gagtggtttc attccaagtg tactccattg tcagtatgct gtttttgttt ccttcactcc
     4561 attcaaaaag tcaaaataca aaatttggca cagcatgcca acgggaggct gtgcccagac
     4621 caagcactgg aagtgtgctt ctaggcatag tcattggttt tgcaaaaaga gggctcaaat
     4681 ttaaatagaa atttacagct atttgaatgg tcagatatac caagaaagaa aaatatttct
     4741 gttcctcaag aaaacttgct accctctgtg aggggaattt tgctaaactt gacatcttta
     4801 taacatgagc cagattgaaa gggagtgatt ttcattcatc ttaggtcatg ttatttcata
     4861 tttgtttctg aaggtgcgat agctctgttt taggttttgc ttgcgcctgt taattactgg
     4921 aacaccttat ttttcattaa aggctttgaa agccaattct caaaaattca aaagtgcaaa
     4981 ttaacagaac aaaaggaaat ccagtagcaa ctgcagtcaa gcgagggagt tgacaagata
     5041 aaccttacgt ccattcaagt tatatgctgg cctatgagag atgagagttg ggtcgtttgt
     5101 tctctttgtt gatgatttta aaaaaaccct ctagaataca cataataaca taatgaaagc
     5161 catatctcca tgatatatat gtgcacatat atatacatac atgtgcatgt atgtatcata
     5221 ttaaggaccc atggtactct taaaacactg tagaactctg tgacgcagta aggaaggggc
     5281 agatttgtac aaaaactttt ctagattcca tcagcaaaaa ccaacacagg tttgtcacgc
     5341 tgcatgtctg gccagctaat ctcgggggaa aagctacaag ttatttattt tattttaaga
     5401 gaataaagta ggtaataatt taagggatca aattcaagga ggaatgtgca attttagagc
     5461 aaagatttgt ttaaggcaaa tgagactttg ggagcatccc attccagttt tgtctttttt
     5521 ttctctgaaa gaaaaaagca aaaaataaaa taaaattcca cttatacctt ctgacaagtc
     5581 cctaaaggtc ttgaaataaa aggttctatg caagtgcaaa gttttatagt tatttttatt
     5641 gctgattatt actattacta tctctgttgt cttaagagta tgtgctgatt tcagagacat
     5701 ctcaaattga aagaatatca gattgctttt aaagtagctg aacgagccac agaatatctg
     5761 aaattattca ttgttgttcc tccaccaccc cctttctcat ggtctgattt ttagaagagt
     5821 ggcatcctcg ttctaaaatg taatgatcac caaatacggc cttccatcaa atttgtgaaa
     5881 actacaacag tataacagtg acaaacctaa ttctctagcc caaacctggt ctgacaatca
     5941 tttccattta gaagtcattg aatagttttc caaacacttt ccatgtgtgt tagcaaatta
     6001 ttcctatttt gtgtagatga ggacgttgag actcagagac attcagaggc acgctagagg
     6061 tctccagcct agcttccagc accattggga ctgaatccaa gtactctcac tctgaacttc
     6121 gtggttctgt ccactagaga ctctaatatg caaacaagca gttcaggaaa gaaagcatgc
     6181 taacacattc atgaagcagt atatgaagtt agaagaacaa aaggaaatac aggagatgac
     6241 aagcaactga gatattgtga tatataatca tgctcttagc ttcagctaaa ttcagctaaa
     6301 ttcttgtaca ctgaaccaat gtcataatca ggcttattta gaaaacactt tgaactatgc
     6361 tataaaagat tatatcagaa ttcatattat acatgtgttc acatcagcgc tacctgtgat
     6421 gttttcatgt atttatgtat gtgttataaa tacttgattt atacatatac aaatgcacat
     6481 acgtagtgtg tttgtgtgtt tatgtataaa tttataggca cacaataata gaggtaatta
     6541 taagtaggat gcggtatgaa taatttgctt aaaatatgct aaataaccaa aactgtttaa
     6601 cgtcatgttg ctgttagtgc ttccatactc cacgtgggta ggactacatc acacttttca
     6661 actctgtgca gtactgcatg ggtggaagac atatttaaga taatgtgctt cccaaaacaa
     6721 ctgaataaaa gccatcccac tacattgagt gctttctctg gctccttgca aagaaagata
     6781 ctttttgtaa tggtccagga aaggaacatt gctttctttt tgtctttcag cacatttgta
     6841 ttatgctcac cttgtctctg tctcactgtg acccctttac acttgagttc agagttcaag
     6901 cattccaaat ataaattgga atgttggcag cccagtggct tgaaggccaa tgatgagcag
     6961 tccaagaccc cacagcgaga tgagcaactc ttaggaattc ccacatccta gagtgaatgc
     7021 accaactaac agtatagaat gctgtccttt tcaaagcgtc ctaacagcag gattacctgg
     7081 tcaagtatgg actttctttg aatctttctt ttcacaaatt ggactgcctg taataccaat
     7141 aacattgttg tatctaacta aataaatgac tgcatataca cacataccct caattctctt
     7201 gcttccccat tttctttttc atcccctgtc tcaggacttt tattttcaat gttgaccttt
     7261 ggtttggcca tatatcactg ttataggaaa tctcatgaga ggaatggcta gtgacccaac
     7321 tctccaaatg tctaagttag tagttacagc tgatttttta tgatgcataa ttggaatgtg
     7381 gagcctctga ggttgtgata gcttgtacat gaatttcaaa tgtcattcta aagaatgagg
     7441 ggtgggaggg atttatagtt agaaacgaca gtgcaggaag gggtattttc ttgttgtcag
     7501 ggctggaatg aatcactgct gctcaagtca aaggttcttg aatatcctta gtttttgcat
     7561 ttcccctcct tttcctttga cctttattta tttaattatg tatttattta tttatttata
     7621 tacttttgct ccattcagca caaacacaaa gcaaagcaaa aaaaaaaata tatatatata
     7681 tatctgtata tgtgttgtag gcaaaacact gtgaatttca caacaaccac caccaagcaa
     7741 ctattttgcc atcttaacat acatctcagg agacgaaatg agaaaagatg gggatgtcat
     7801 tttttagtct atgcgtttga ggccaggtcc atgtttattt atttctttag tctatgcatt
     7861 aatgaaaatg atcctgagtg gaggttagct gaacgttcaa tgtactggag caagcatcat
     7921 aaaagctgct agtagccatg tgtttgaaca ggaaaaatat tacagaaaat gaaatgtaaa
     7981 ggcctatatc ttgcagcttg tatatcttac tattgcttaa aaaatgtata aagcagctgg
     8041 aaatgtttta aatacaaggt ctttgaatta aatgtggatt ttaaatatgt aatcccttga
     8101 caaatgacca aattatggtg aactattgct ccctgcgttc tttgatcatt acctatgact
     8161 tacaaatctg cctggagatg tggacattct gcatttgctt ctgtatctgg agagatgttt
     8221 gtatatatcc aggccgtata cacacacatt tccatatctc tctacagata tatttcccct
     8281 tcaatcgtga cctggtattt ggaactctcc ttttcatttg gcttatcttc cttttaatgt
     8341 gatgtctctg tgctaatact taccagttct tgttttgcaa tctgttttga ggtccattgc
     8401 tttactaaga cccactgcat cttggctgat ttcaaagtga cacctgaata cagtgtttaa
     8461 aaaaaaaaaa gttttgtttg taaatcatgt gaccagcttc tctcaacctg acatggaaag
     8521 tctcttgtac tacagtgtat ttaataaaaa tgatgtctta caataaataa catactccaa
     8581 aa
//
