LOCUS       NM_001369532            8931 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant k, mRNA.
ACCESSION   NM_001369532
VERSION     NM_001369532.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8931)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 8931)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8931)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8931)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 8931)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 8931)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 8931)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 8931)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 8931)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 8931)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13, AL596132.7 and
            AL445532.8.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (k), as well as variants c and l,
            encodes isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.12281.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL390777.13        29334-29597
            265-473             AL390777.13        30492-30700
            474-1057            AL390777.13        31189-31772
            1058-1132           AL390777.13        62971-63045
            1133-1204           AL390777.13        63160-63231
            1205-1273           AL390777.13        68656-68724
            1274-1428           AL390777.13        71449-71603
            1429-1565           AL390777.13        84385-84521
            1566-1698           AL390777.13        85036-85168
            1699-2004           AL390777.13        88466-88771
            2005-2040           AL390777.13        102704-102739
            2041-2141           AL390777.13        105785-105885
            2142-2241           AL390777.13        112798-112897
            2242-2430           AL596132.7         47141-47329
            2431-2561           AL596132.7         114060-114190
            2562-2734           AL445532.8         6204-6376
            2735-2969           AL445532.8         13025-13259
            2970-3128           AL445532.8         77948-78106
            3129-8931           AL445532.8         78994-84796
FEATURES             Location/Qualifiers
     source          1..8931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..8931
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..264
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            265..473
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            474..1057
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             846..3314
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform c precursor is encoded by transcript
                     variant k; BDNF/NT-3 growth factors receptor; tyrosine
                     kinase receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform c
                     precursor"
                     /protein_id="NP_001356461.1"
                     /db_xref="CCDS:CCDS35050.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNY
                     PDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM
                     LFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKI
                     PVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDK
                     ILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGD
                     LNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNC
                     LVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG
                     VVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRK
                     NIKGIHTLLQNLAKASPVYLDILG"
     exon            1058..1132
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1204
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1273
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1428
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1565
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1698
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..2004
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2040
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2141
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2241
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2430
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2561
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2734
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2969
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3128
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..8931
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8911..8916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      8931
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaaacag attccgagcc gcaaaaggga agacggattc tcagacaagg cttgcaaatg
       61 ccccgcagcc atcatttaac tgcacccgca gaatagttac ggtttgtcac ccgaccctcc
      121 cggatcgcct aatttgtccc tagtgagacc ccgaggctct gcccgcgcct ggcttcttcg
      181 tagctggatg catatcgtgc tccgggcagc gcgggcgcag ggcacgcgtt cgcgcacacc
      241 ctagcacaca tgaacacgcg caagactaat tttctggagt ttctgcccct gctctgcgtc
      301 agccctcacg tcacttcgcc agcagtagca gaggcggcgg cggcggctcc cggaattggg
      361 ttggagcagg agcctcgctg gctgcttcgc tcgcgctcta cgcgctcagt ccccggcggt
      421 agcaggagcc tggacccagg cgccgccggc gggcgtgagg cgccggagcc cggcctcgag
      481 gtgcataccg gacccccatt cgcatctaac aaggaatctg cgccccagag agtcccggga
      541 gcgccgccgg tcggtgcccg gcgcgccggg ccatgcagcg acggccgccg cggagctccg
      601 agcagcggta gcgcccccct gtaaagcggt tcgctatgcc ggggccactg tgaaccctgc
      661 cgcctgccgg aacactcttc gctccggacc agctcagcct ctgataagct ggactcggca
      721 cgcccgcaac aagcaccgag gagttaagag agccgcaagc gcagggaagg cctccccgca
      781 cgggtggggg aaagcggccg gtgcagcgcg gggacaggca ctcgggctgg cactggctgc
      841 tagggatgtc gtcctggata aggtggcatg gacccgccat ggcgcggctc tggggcttct
      901 gctggctggt tgtgggcttc tggagggccg ctttcgcctg tcccacgtcc tgcaaatgca
      961 gtgcctctcg gatctggtgc agcgaccctt ctcctggcat cgtggcattt ccgagattgg
     1021 agcctaacag tgtagatcct gagaacatca ccgaaatttt catcgcaaac cagaaaaggt
     1081 tagaaatcat caacgaagat gatgttgaag cttatgtggg actgagaaat ctgacaattg
     1141 tggattctgg attaaaattt gtggctcata aagcatttct gaaaaacagc aacctgcagc
     1201 acatcaattt tacccgaaac aaactgacga gtttgtctag gaaacatttc cgtcaccttg
     1261 acttgtctga actgatcctg gtgggcaatc catttacatg ctcctgtgac attatgtgga
     1321 tcaagactct ccaagaggct aaatccagtc cagacactca ggatttgtac tgcctgaatg
     1381 aaagcagcaa gaatattccc ctggcaaacc tgcagatacc caattgtggt ttgccatctg
     1441 caaatctggc cgcacctaac ctcactgtgg aggaaggaaa gtctatcaca ttatcctgta
     1501 gtgtggcagg tgatccggtt cctaatatgt attgggatgt tggtaacctg gtttccaaac
     1561 atatgaatga aacaagccac acacagggct ccttaaggat aactaacatt tcatccgatg
     1621 acagtgggaa gcagatctct tgtgtggcgg aaaatcttgt aggagaagat caagattctg
     1681 tcaacctcac tgtgcatttt gcaccaacta tcacatttct cgaatctcca acctcagacc
     1741 accactggtg cattccattc actgtgaaag gcaaccccaa accagcgctt cagtggttct
     1801 ataacggggc aatattgaat gagtccaaat acatctgtac taaaatacat gttaccaatc
     1861 acacggagta ccacggctgc ctccagctgg ataatcccac tcacatgaac aatggggact
     1921 acactctaat agccaagaat gagtatggga aggatgagaa acagatttct gctcacttca
     1981 tgggctggcc tggaattgac gatggtgcaa acccaaatta tcctgatgta atttatgaag
     2041 attatggaac tgcagcgaat gacatcgggg acaccacgaa cagaagtaat gaaatccctt
     2101 ccacagacgt cactgataaa accggtcggg aacatctctc ggtctatgct gtggtggtga
     2161 ttgcgtctgt ggtgggattt tgccttttgg taatgctgtt tctgcttaag ttggcaagac
     2221 actccaagtt tggcatgaaa ggcccagcct ccgttatcag caatgatgat gactctgcca
     2281 gcccactcca tcacatctcc aatgggagta acactccatc ttcttcggaa ggtggcccag
     2341 atgctgtcat tattggaatg accaagatcc ctgtcattga aaatccccag tactttggca
     2401 tcaccaacag tcagctcaag ccagacacat ttgttcagca catcaagcga cataacattg
     2461 ttctgaaaag ggagctaggc gaaggagcct ttggaaaagt gttcctagct gaatgctata
     2521 acctctgtcc tgagcaggac aagatcttgg tggcagtgaa gaccctgaag gatgccagtg
     2581 acaatgcacg caaggacttc caccgtgagg ccgagctcct gaccaacctc cagcatgagc
     2641 acatcgtcaa gttctatggc gtctgcgtgg agggcgaccc cctcatcatg gtctttgagt
     2701 acatgaagca tggggacctc aacaagttcc tcagggcaca cggccctgat gccgtgctga
     2761 tggctgaggg caacccgccc acggaactga cgcagtcgca gatgctgcat atagcccagc
     2821 agatcgccgc gggcatggtc tacctggcgt cccagcactt cgtgcaccgc gatttggcca
     2881 ccaggaactg cctggtcggg gagaacttgc tggtgaaaat cggggacttt gggatgtccc
     2941 gggacgtgta cagcactgac tactacaggg tcggtggcca cacaatgctg cccattcgct
     3001 ggatgcctcc agagagcatc atgtacagga aattcacgac ggaaagcgac gtctggagcc
     3061 tgggggtcgt gttgtgggag attttcacct atggcaaaca gccctggtac cagctgtcaa
     3121 acaatgaggt gatagagtgt atcactcagg gccgagtcct gcagcgaccc cgcacgtgcc
     3181 cccaggaggt gtatgagctg atgctggggt gctggcagcg agagccccac atgaggaaga
     3241 acatcaaggg catccatacc ctccttcaga acttggccaa ggcatctccg gtctacctgg
     3301 acattctagg ctagggccct tttccccaga ccgatccttc ccaacgtact cctcagacgg
     3361 gctgagagga tgaacatctt ttaactgccg ctggaggcca ccaagctgct ctccttcact
     3421 ctgacagtat taacatcaaa gactccgaga agctctcgag ggaagcagtg tgtacttctt
     3481 catccataga cacagtattg acttcttttt ggcattatct ctttctctct ttccatctcc
     3541 cttggttgtt cctttttctt tttttaaatt ttctttttct tttttttttc gtcttccctg
     3601 cttcacgatt cttacccttt cttttgaatc aatctggctt ctgcattact attaactctg
     3661 catagacaaa ggccttaaca aacgtaattt gttatatcag cagacactcc agtttgccca
     3721 ccacaactaa caatgccttg ttgtattcct gcctttgatg tggatgaaaa aaagggaaaa
     3781 caaatatttc acttaaactt tgtcacttct gctgtacaga tatcgagagt ttctatggat
     3841 tcacttctat ttatttatta ttattactgt tcttattgtt tttggatggc ttaagcctgt
     3901 gtataaaaaa gaaaacttgt gttcaatctg tgaagccttt atctatggga gattaaaacc
     3961 agagagaaag aagatttatt atgaaccgca atatgggagg aacaaagaca accactggga
     4021 tcagctggtg tcagtcccta cttaggaaat actcagcaac tgttagctgg gaagaatgta
     4081 ttcggcacct tcccctgagg acctttctga ggagtaaaaa gactactggc ctctgtgcca
     4141 tggatgattc ttttcccatc accagaaatg atagcgtgca gtagagagca aagatggctt
     4201 ccgtgagaca caagatggcg catagtgtgc tcggacacag ttttgtcttc gtaggttgtg
     4261 atgatagcac tggtttgttt ctcaagcgct atccacagaa cctttgtcaa cttcagttga
     4321 aaagaggtgg attcatgtcc agagctcatt tcggggtcag gtgggaaagc caagaacttg
     4381 gaaaagataa gacaagctat aaattcggag gcaagtttct tttacaatga acttttcaga
     4441 tctcacttcc ctccgacccc taacttccat gcccacccgt ccttttaact gtgcaagcaa
     4501 aattgtgcat ggtcttcgtc gattaatacc ttgtgtgcag acactactgc tccagacgtc
     4561 gtttccctga taggtagagc agatccataa aaaggtatga cttatacaat taggggaagc
     4621 taatggagtt tattagctga gtatcaatgt ctctgcgttg tacggtggtg atgggtttta
     4681 atgaatatgg accctgaagc ctggaaatcc tcatccacgt cgaacccaca ggactgtggg
     4741 aagggcagaa tcaatcccta agggaaagga aacctcaccc tgagggcatc acatgcactc
     4801 atgttcagtg tacacaggtc aagtcccttg ctctgggctc tagttgggag agtggtttca
     4861 ttccaagtgt actccattgt cagtatgctg tttttgtttc cttcactcca ttcaaaaagt
     4921 caaaatacaa aatttggcac agcatgccaa cgggaggctg tgcccagacc aagcactgga
     4981 agtgtgcttc taggcatagt cattggtttt gcaaaaagag ggctcaaatt taaatagaaa
     5041 tttacagcta tttgaatggt cagatatacc aagaaagaaa aatatttctg ttcctcaaga
     5101 aaacttgcta ccctctgtga ggggaatttt gctaaacttg acatctttat aacatgagcc
     5161 agattgaaag ggagtgattt tcattcatct taggtcatgt tatttcatat ttgtttctga
     5221 aggtgcgata gctctgtttt aggttttgct tgcgcctgtt aattactgga acaccttatt
     5281 tttcattaaa ggctttgaaa gccaattctc aaaaattcaa aagtgcaaat taacagaaca
     5341 aaaggaaatc cagtagcaac tgcagtcaag cgagggagtt gacaagataa accttacgtc
     5401 cattcaagtt atatgctggc ctatgagaga tgagagttgg gtcgtttgtt ctctttgttg
     5461 atgattttaa aaaaaccctc tagaatacac ataataacat aatgaaagcc atatctccat
     5521 gatatatatg tgcacatata tatacataca tgtgcatgta tgtatcatat taaggaccca
     5581 tggtactctt aaaacactgt agaactctgt gacgcagtaa ggaaggggca gatttgtaca
     5641 aaaacttttc tagattccat cagcaaaaac caacacaggt ttgtcacgct gcatgtctgg
     5701 ccagctaatc tcgggggaaa agctacaagt tatttatttt attttaagag aataaagtag
     5761 gtaataattt aagggatcaa attcaaggag gaatgtgcaa ttttagagca aagatttgtt
     5821 taaggcaaat gagactttgg gagcatccca ttccagtttt gtcttttttt tctctgaaag
     5881 aaaaaagcaa aaaataaaat aaaattccac ttataccttc tgacaagtcc ctaaaggtct
     5941 tgaaataaaa ggttctatgc aagtgcaaag ttttatagtt atttttattg ctgattatta
     6001 ctattactat ctctgttgtc ttaagagtat gtgctgattt cagagacatc tcaaattgaa
     6061 agaatatcag attgctttta aagtagctga acgagccaca gaatatctga aattattcat
     6121 tgttgttcct ccaccacccc ctttctcatg gtctgatttt tagaagagtg gcatcctcgt
     6181 tctaaaatgt aatgatcacc aaatacggcc ttccatcaaa tttgtgaaaa ctacaacagt
     6241 ataacagtga caaacctaat tctctagccc aaacctggtc tgacaatcat ttccatttag
     6301 aagtcattga atagttttcc aaacactttc catgtgtgtt agcaaattat tcctattttg
     6361 tgtagatgag gacgttgaga ctcagagaca ttcagaggca cgctagaggt ctccagccta
     6421 gcttccagca ccattgggac tgaatccaag tactctcact ctgaacttcg tggttctgtc
     6481 cactagagac tctaatatgc aaacaagcag ttcaggaaag aaagcatgct aacacattca
     6541 tgaagcagta tatgaagtta gaagaacaaa aggaaataca ggagatgaca agcaactgag
     6601 atattgtgat atataatcat gctcttagct tcagctaaat tcagctaaat tcttgtacac
     6661 tgaaccaatg tcataatcag gcttatttag aaaacacttt gaactatgct ataaaagatt
     6721 atatcagaat tcatattata catgtgttca catcagcgct acctgtgatg ttttcatgta
     6781 tttatgtatg tgttataaat acttgattta tacatataca aatgcacata cgtagtgtgt
     6841 ttgtgtgttt atgtataaat ttataggcac acaataatag aggtaattat aagtaggatg
     6901 cggtatgaat aatttgctta aaatatgcta aataaccaaa actgtttaac gtcatgttgc
     6961 tgttagtgct tccatactcc acgtgggtag gactacatca cacttttcaa ctctgtgcag
     7021 tactgcatgg gtggaagaca tatttaagat aatgtgcttc ccaaaacaac tgaataaaag
     7081 ccatcccact acattgagtg ctttctctgg ctccttgcaa agaaagatac tttttgtaat
     7141 ggtccaggaa aggaacattg ctttcttttt gtctttcagc acatttgtat tatgctcacc
     7201 ttgtctctgt ctcactgtga cccctttaca cttgagttca gagttcaagc attccaaata
     7261 taaattggaa tgttggcagc ccagtggctt gaaggccaat gatgagcagt ccaagacccc
     7321 acagcgagat gagcaactct taggaattcc cacatcctag agtgaatgca ccaactaaca
     7381 gtatagaatg ctgtcctttt caaagcgtcc taacagcagg attacctggt caagtatgga
     7441 ctttctttga atctttcttt tcacaaattg gactgcctgt aataccaata acattgttgt
     7501 atctaactaa ataaatgact gcatatacac acataccctc aattctcttg cttccccatt
     7561 ttctttttca tcccctgtct caggactttt attttcaatg ttgacctttg gtttggccat
     7621 atatcactgt tataggaaat ctcatgagag gaatggctag tgacccaact ctccaaatgt
     7681 ctaagttagt agttacagct gattttttat gatgcataat tggaatgtgg agcctctgag
     7741 gttgtgatag cttgtacatg aatttcaaat gtcattctaa agaatgaggg gtgggaggga
     7801 tttatagtta gaaacgacag tgcaggaagg ggtattttct tgttgtcagg gctggaatga
     7861 atcactgctg ctcaagtcaa aggttcttga atatccttag tttttgcatt tcccctcctt
     7921 ttcctttgac ctttatttat ttaattatgt atttatttat ttatttatat acttttgctc
     7981 cattcagcac aaacacaaag caaagcaaaa aaaaaaatat atatatatat atctgtatat
     8041 gtgttgtagg caaaacactg tgaatttcac aacaaccacc accaagcaac tattttgcca
     8101 tcttaacata catctcagga gacgaaatga gaaaagatgg ggatgtcatt ttttagtcta
     8161 tgcgtttgag gccaggtcca tgtttattta tttctttagt ctatgcatta atgaaaatga
     8221 tcctgagtgg aggttagctg aacgttcaat gtactggagc aagcatcata aaagctgcta
     8281 gtagccatgt gtttgaacag gaaaaatatt acagaaaatg aaatgtaaag gcctatatct
     8341 tgcagcttgt atatcttact attgcttaaa aaatgtataa agcagctgga aatgttttaa
     8401 atacaaggtc tttgaattaa atgtggattt taaatatgta atcccttgac aaatgaccaa
     8461 attatggtga actattgctc cctgcgttct ttgatcatta cctatgactt acaaatctgc
     8521 ctggagatgt ggacattctg catttgcttc tgtatctgga gagatgtttg tatatatcca
     8581 ggccgtatac acacacattt ccatatctct ctacagatat atttcccctt caatcgtgac
     8641 ctggtatttg gaactctcct tttcatttgg cttatcttcc ttttaatgtg atgtctctgt
     8701 gctaatactt accagttctt gttttgcaat ctgttttgag gtccattgct ttactaagac
     8761 ccactgcatc ttggctgatt tcaaagtgac acctgaatac agtgtttaaa aaaaaaaaag
     8821 ttttgtttgt aaatcatgtg accagcttct ctcaacctga catggaaagt ctcttgtact
     8881 acagtgtatt taataaaaat gatgtcttac aataaataac atactccaaa a
//
