LOCUS       NM_001291937            7485 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neurotrophic receptor tyrosine kinase 2 (NTRK2),
            transcript variant f, mRNA.
ACCESSION   NM_001291937
VERSION     NM_001291937.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7485)
  AUTHORS   Gupta,R., Dittmeier,M., Wohlleben,G., Nickl,V., Bischler,T.,
            Luzak,V., Wegat,V., Doll,D., Sodmann,A., Bady,E., Langlhofer,G.,
            Wachter,B., Havlicek,S., Gupta,J., Horn,E., Luningschror,P.,
            Villmann,C., Polat,B., Wischhusen,J., Monoranu,C.M., Kuper,J. and
            Blum,R.
  TITLE     Atypical cellular responses mediated by intracellular constitutive
            active TrkB (NTRK2) kinase domains and a solely intracellular
            NTRK2-fusion oncogene
  JOURNAL   Cancer Gene Ther 31 (9), 1357-1379 (2024)
   PUBMED   39039193
  REMARK    GeneRIF: Atypical cellular responses mediated by intracellular
            constitutive active TrkB (NTRK2) kinase domains and a solely
            intracellular NTRK2-fusion oncogene.
REFERENCE   2  (bases 1 to 7485)
  AUTHORS   Zhang,X., Zhang,Y., Yan,H., Yu,H., Zhang,D., Mattay,V.S., Tan,H.Y.
            and Yue,W.
  TITLE     Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2
  JOURNAL   BMC Med 22 (1), 146 (2024)
   PUBMED   38561734
  REMARK    GeneRIF: Childhood urbanicity is associated with emotional episodic
            memory-related striatal function and common variation in NTRK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7485)
  AUTHORS   Ikhlef,L., Yassine,M., Chandouri,B., Riviere,L., Naves,T.,
            Dmytruk,N., Gachard,N., Jauberteau,M.O. and Gallet,P.F.
  TITLE     Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic
            leukemia
  JOURNAL   Sci Rep 14 (1), 6084 (2024)
   PUBMED   38480783
  REMARK    GeneRIF: Targeting the NTSR2/TrkB oncogenic pathway in chronic
            lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7485)
  AUTHORS   Wang,Y., Liang,J., Xu,B., Yang,J., Wu,Z. and Cheng,L.
  TITLE     TrkB/BDNF signaling pathway and its small molecular agonists in CNS
            injury
  JOURNAL   Life Sci 336, 122282 (2024)
   PUBMED   38008209
  REMARK    GeneRIF: TrkB/BDNF signaling pathway and its small molecular
            agonists in CNS injury.
            Review article
REFERENCE   5  (bases 1 to 7485)
  AUTHORS   Luberg,K., Wong,J., Weickert,C.S. and Timmusk,T.
  TITLE     Human TrkB gene: novel alternative transcripts, protein isoforms
            and expression pattern in the prefrontal cerebral cortex during
            postnatal development
  JOURNAL   J Neurochem 113 (4), 952-964 (2010)
   PUBMED   20193039
  REMARK    GeneRIF: Identification of 36 potential TrkB protein isoforms
            suggests high complexity in the synthesis, regulation and function
            of this important neurotrophin receptor emphasizing the need for
            further study of these novel TrkB variants.
REFERENCE   6  (bases 1 to 7485)
  AUTHORS   Stoilov,P., Castren,E. and Stamm,S.
  TITLE     Analysis of the human TrkB gene genomic organization reveals novel
            TrkB isoforms, unusual gene length, and splicing mechanism
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1054-1065 (2002)
   PUBMED   11798182
  REMARK    GeneRIF: analysis of TrkB gene reveals novel gene length and
            splicing mechanism
REFERENCE   7  (bases 1 to 7485)
  AUTHORS   Haniu,M., Talvenheimo,J., Le,J., Katta,V., Welcher,A. and
            Rohde,M.F.
  TITLE     Extracellular domain of neurotrophin receptor trkB: disulfide
            structure, N-glycosylation sites, and ligand binding
  JOURNAL   Arch Biochem Biophys 322 (1), 256-264 (1995)
   PUBMED   7574684
REFERENCE   8  (bases 1 to 7485)
  AUTHORS   Nakagawara,A., Liu,X.G., Ikegaki,N., White,P.S., Yamashiro,D.J.,
            Nycum,L.M., Biegel,J.A. and Brodeur,G.M.
  TITLE     Cloning and chromosomal localization of the human TRK-B tyrosine
            kinase receptor gene (NTRK2)
  JOURNAL   Genomics 25 (2), 538-546 (1995)
   PUBMED   7789988
REFERENCE   9  (bases 1 to 7485)
  AUTHORS   Squinto,S.P., Stitt,T.N., Aldrich,T.H., Davis,S., Blanco,S.M.,
            RadzieJewski,C., Glass,D.J., Masiakowski,P., Furth,M.E.,
            Valenzuela,D.M., Distefano,P.S. and Yancopoulos,G.D.
  TITLE     trkB encodes a functional receptor for brain-derived neurotrophic
            factor and neurotrophin-3 but not nerve growth factor
  JOURNAL   Cell 65 (5), 885-893 (1991)
   PUBMED   1710174
REFERENCE   10 (bases 1 to 7485)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390777.13.
            
            On Oct 11, 2019 this sequence version replaced NM_001291937.1.
            
            Summary: This gene encodes a member of the neurotrophic tyrosine
            receptor kinase (NTRK) family. This kinase is a membrane-bound
            receptor that, upon neurotrophin binding, phosphorylates itself and
            members of the MAPK pathway. Signalling through this kinase leads
            to cell differentiation. Mutations in this gene have been
            associated with obesity and mood disorders. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (f) uses an alternate in-frame
            splice site in the central coding region, and lacks several 3'
            exons but contains an alternate 3' terminal exon and it thus
            differs in the 3' coding region and 3' UTR, compared to variant a.
            The encoded isoform (f) has a distinct C-terminus and is shorter
            than isoform a. Variants f and x both encode the same isoform (f).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL390777.13        29334-29597
            265-386             AL390777.13        30114-30235
            387-595             AL390777.13        30492-30700
            596-1179            AL390777.13        31189-31772
            1180-1254           AL390777.13        62971-63045
            1255-1326           AL390777.13        63160-63231
            1327-1395           AL390777.13        68656-68724
            1396-1550           AL390777.13        71449-71603
            1551-1687           AL390777.13        84385-84521
            1688-1820           AL390777.13        85036-85168
            1821-2087           AL390777.13        88505-88771
            2088-2123           AL390777.13        102704-102739
            2124-2224           AL390777.13        105785-105885
            2225-2324           AL390777.13        112798-112897
            2325-7485           AL390777.13        171354-176514
FEATURES             Location/Qualifiers
     source          1..7485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..7485
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
     exon            1..264
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            265..386
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            387..595
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            596..1179
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             968..2362
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /EC_number="2.7.10.1"
                     /note="isoform f precursor is encoded by transcript
                     variant f; BDNF/NT-3 growth factors receptor; tyrosine
                     kinase receptor B; BDNF-tropomyosine receptor kinase B;
                     tropomyosin-related kinase B; neurotrophic tyrosine kinase
                     receptor type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform f
                     precursor"
                     /protein_id="NP_001278866.1"
                     /db_xref="CCDS:CCDS94428.1"
                     /db_xref="GeneID:4915"
                     /db_xref="HGNC:HGNC:8032"
                     /db_xref="MIM:600456"
                     /translation="MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIW
                     CSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG
                     LKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIK
                     TLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC
                     SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHYHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQ
                     LDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAAN
                     DIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFG
                     MKGFVLFHKIPLDG"
     exon            1180..1254
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1326
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1395
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1550
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1687
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1820
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2087
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2123
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2224
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2324
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..7485
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7467..7472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="hexamer: AATAAA"
     polyA_site      7485
                     /gene="NTRK2"
                     /gene_synonym="DEE58; EIEE58; GP145-TrkB; OBHD; trk-B;
                     TRKB"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaaacag attccgagcc gcaaaaggga agacggattc tcagacaagg cttgcaaatg
       61 ccccgcagcc atcatttaac tgcacccgca gaatagttac ggtttgtcac ccgaccctcc
      121 cggatcgcct aatttgtccc tagtgagacc ccgaggctct gcccgcgcct ggcttcttcg
      181 tagctggatg catatcgtgc tccgggcagc gcgggcgcag ggcacgcgtt cgcgcacacc
      241 ctagcacaca tgaacacgcg caagagctga accaagcacg gtttccattt caaaaaggga
      301 gacagcctct accgcgattg tagaagagac tgtggtgtga attagggacc gggaggcgtc
      361 gaacggagga acggttcatc ttagagacta attttctgga gtttctgccc ctgctctgcg
      421 tcagccctca cgtcacttcg ccagcagtag cagaggcggc ggcggcggct cccggaattg
      481 ggttggagca ggagcctcgc tggctgcttc gctcgcgctc tacgcgctca gtccccggcg
      541 gtagcaggag cctggaccca ggcgccgccg gcgggcgtga ggcgccggag cccggcctcg
      601 aggtgcatac cggaccccca ttcgcatcta acaaggaatc tgcgccccag agagtcccgg
      661 gagcgccgcc ggtcggtgcc cggcgcgccg ggccatgcag cgacggccgc cgcggagctc
      721 cgagcagcgg tagcgccccc ctgtaaagcg gttcgctatg ccggggccac tgtgaaccct
      781 gccgcctgcc ggaacactct tcgctccgga ccagctcagc ctctgataag ctggactcgg
      841 cacgcccgca acaagcaccg aggagttaag agagccgcaa gcgcagggaa ggcctccccg
      901 cacgggtggg ggaaagcggc cggtgcagcg cggggacagg cactcgggct ggcactggct
      961 gctagggatg tcgtcctgga taaggtggca tggacccgcc atggcgcggc tctggggctt
     1021 ctgctggctg gttgtgggct tctggagggc cgctttcgcc tgtcccacgt cctgcaaatg
     1081 cagtgcctct cggatctggt gcagcgaccc ttctcctggc atcgtggcat ttccgagatt
     1141 ggagcctaac agtgtagatc ctgagaacat caccgaaatt ttcatcgcaa accagaaaag
     1201 gttagaaatc atcaacgaag atgatgttga agcttatgtg ggactgagaa atctgacaat
     1261 tgtggattct ggattaaaat ttgtggctca taaagcattt ctgaaaaaca gcaacctgca
     1321 gcacatcaat tttacccgaa acaaactgac gagtttgtct aggaaacatt tccgtcacct
     1381 tgacttgtct gaactgatcc tggtgggcaa tccatttaca tgctcctgtg acattatgtg
     1441 gatcaagact ctccaagagg ctaaatccag tccagacact caggatttgt actgcctgaa
     1501 tgaaagcagc aagaatattc ccctggcaaa cctgcagata cccaattgtg gtttgccatc
     1561 tgcaaatctg gccgcaccta acctcactgt ggaggaagga aagtctatca cattatcctg
     1621 tagtgtggca ggtgatccgg ttcctaatat gtattgggat gttggtaacc tggtttccaa
     1681 acatatgaat gaaacaagcc acacacaggg ctccttaagg ataactaaca tttcatccga
     1741 tgacagtggg aagcagatct cttgtgtggc ggaaaatctt gtaggagaag atcaagattc
     1801 tgtcaacctc actgtgcatt accaccactg gtgcattcca ttcactgtga aaggcaaccc
     1861 caaaccagcg cttcagtggt tctataacgg ggcaatattg aatgagtcca aatacatctg
     1921 tactaaaata catgttacca atcacacgga gtaccacggc tgcctccagc tggataatcc
     1981 cactcacatg aacaatgggg actacactct aatagccaag aatgagtatg ggaaggatga
     2041 gaaacagatt tctgctcact tcatgggctg gcctggaatt gacgatggtg caaacccaaa
     2101 ttatcctgat gtaatttatg aagattatgg aactgcagcg aatgacatcg gggacaccac
     2161 gaacagaagt aatgaaatcc cttccacaga cgtcactgat aaaaccggtc gggaacatct
     2221 ctcggtctat gctgtggtgg tgattgcgtc tgtggtggga ttttgccttt tggtaatgct
     2281 gtttctgctt aagttggcaa gacactccaa gtttggcatg aaaggttttg ttttgtttca
     2341 taagatccca ctggatgggt agctgaaata aaggaaaaga cagagaaagg ggctgtggtg
     2401 cttgttggtt gatgctgcca tgtaagctgg actcctggga ctgctgttgg cttatcccgg
     2461 gaagtgctgc ttatctgggg ttttctggta gatgtgggcg gtgtttggag gctgtactat
     2521 atgaagcctg catatactgt gagctgtgat tggggaacac caatgcagag gtaactctca
     2581 ggcagctaag cagcacctca agaaaacatg ttaaattaat gcttctcttc ttacagtagt
     2641 tcaaatacaa aactgaaatg aaatcccatt ggattgtact tctcttctga aaagtgtgct
     2701 ttttgaccct actggacatt tattgactta attgcttctg tttattaaaa ttgacctgca
     2761 aagttaaaaa aaaattaaag ttgagaacag gtataagtgc acactgaata gtctaatcta
     2821 catgtaacac atattttagt gtgattttct atactctaat cagcactgaa ttcagagggt
     2881 ttgacttttt catctataac acagtgacta aaagagttaa gggtatatat accatcactt
     2941 tgggacttgg tagtattatt aaaaggttat ttccttcact gtcaataaaa gtccaaatgt
     3001 ttagcttagg tctgagagtc aaacaatgtt aaggattgtc ttaaagttcc ttagccagca
     3061 aaacaaaaca aaacaaaaca aacaaatgaa aaacgtttaa aaagaagaag aagaaaaaaa
     3121 acaagaacaa gcagcaacag ctgttttgtt ggggctatag atttaagtta ggcatagtca
     3181 atttcagaat aactaagagt ggaatatatg catatggtga aattataacc ttgccctttt
     3241 ttatttgccc tctgcgatcc acctgctttt tagaagtctg ccgagtgaga aggccacagt
     3301 atctcatgct gtttgcatta cagaactgca gcttttctac tctgaaaagg cctgggagca
     3361 gaatggctgg cctgctgtga gcaggagagg agattctaag aaggatagtc ccccctacaa
     3421 catactgtca tactgctggg ttttcatggg taggaaagct tgtcctgacc ccagcagcaa
     3481 agaggtggca ggtcgctaat gaatatatgc tttataatgt ccttcttcat tgctgagagg
     3541 gcagccttag agctgtggat ttctgcatcc cccctgagtc tgacccatgg acacctgttt
     3601 cattcacttt agcatcacag tgacctttgt atgctctgtt cagtctgtgt caggcagtat
     3661 gcttgtcctg aagagaggtt tggctatccc caccccaccc caccccaccc tgttcctttt
     3721 ttatcaggag gacttcagag ccaggcctgc agcattttgt ttgaaaacac aatcagctct
     3781 gacagttaga catgcacaca gacgccatag ctggattgga aacattgatg ttttaaaaat
     3841 ttattttttt tggaaatagt tgcacaaatg ctgcaattta gctttaaggt tctatagatt
     3901 tttaactagt ccaacacagt cagaaacatt gttttgaatc ctctgtaaac caaggcatta
     3961 atcttaataa accaggatcc atttaggtac cacttgatat aaaaaggata tccataatga
     4021 atattttata ctgcatcctt tacattagcc actaaatacg ttattgcttg atgaagacct
     4081 ttcacagaat cctatggatt gcagcatttc acttggctac ttcataccca tgccttaaag
     4141 aggggcagtt tctcaaaagc agaaacatgc cgccagttct caagttttcc tcctaactcc
     4201 atttgaatgt aagggcagct ggcccccaat gtggggaggt ccgaacattt tctgaattcc
     4261 cattttcttg ttcgcggcta aatgacagtt tctgtcatta cttagattcc gatctttccc
     4321 aaaggtgttg atttacaaag aggccagcta atagcagaaa tcatgaccct gaaagagaga
     4381 tgaaattcaa gctgtgagcc aggcaggagc tcagtatggc aaaggttctt gagaatcagc
     4441 catttggtac aaaaaagatt tttaaagctt ttatgttata ccatggagcc atagaaaggc
     4501 tatggattgt ttaagaacta ttttaaagtg ttccagaccc aaaaaggaaa aataaaaaaa
     4561 aaggaatatt tgtacccaac agctagaagg attgcaaggt agatttttgt tttaaaatgg
     4621 agagaagtgg acagataagg ccatttaata tatcaaagat cagttgacat ctcctaggga
     4681 atgatgaaaa cagcaggcta ttagaaaatt atttcatata gttctcgtgt tcttttcttt
     4741 tttttaatcc ctgaagggat gatcagtaac atagcttctc ttttctgtac tctagaccac
     4801 cccttttcat cattttgctt tttatgtctc ccataagaaa tgtgcttttt agagcttcct
     4861 aatgcatgtg ttgcattatt gcagcattag aaaaggagag gtagcatttt tgctgaaatc
     4921 gggcctgtca ctctccaata aaggttctgg cacttcaatg ccaggcaggt ctcctaaatg
     4981 aacagaatga tctgtgtgag ccgatgcctg cccttccaga ggggccactg tccccagccg
     5041 cagccaactg tgtcccacag gaatgggagc ctaggtttcc aaatcttgtg attctttagg
     5101 agaaacatga aacctggatt tcgtgtgaaa tgtcccgatt gttaaaaagt tggctcaatt
     5161 atttttaaaa cattttgtaa gccaacaaaa gtctgtgggc tgccagttta ttacttttgt
     5221 cttaaaacat gatcattgtt ctctcacggt atccttctgt cttcccgttg caaattcact
     5281 tttctttctt cctgacattg ccattgaggg ctttgttacc acaagctaag aaactgagtt
     5341 taacagccca gttatctgca acatgtcaat tacctttgct cctctcctgt gattcccacc
     5401 atgctgtgac cctcagctgt ctccctttgc tgggaattct gcaccaatgt ctcccctcaa
     5461 cccattccct ggttggtcct actcccgtgt ggccagagac atcctagcaa atccttcctc
     5521 ctattatatc tgacactaat ttcttttcaa cagcgctcat gtctcttggc ccagtcaggt
     5581 gctgccaggt ttagatagga aagtacatgt cccattttca tgggtgccct taatgtggtc
     5641 cacgtcctat atcttattat atttactcat ggctcaatgg gggcctccag agaccctctc
     5701 aggctgctga gctagactaa ggaatgcatc caccgtcatc acatgagaca ctgactctgt
     5761 gacgacaaaa gtacaaacag tctgaggcta agaaaggttc atctcacaac aggaaaaaca
     5821 aatctcaaca cacattagag ataattgatt caggggtttt ctctcccagt ctcccagcag
     5881 ggactgattt catttctgac ccactaggtt ttctttccag aaataggtag caaggacaag
     5941 aactaaacaa tcccagcccc acccagcaac acagaacaca ggagtttgct tttggcttct
     6001 cactctccaa gtaaccctga attaggccca gaatggctga ggcttggagc atctcctcag
     6061 acagagcaga ggcgacacct cttcaggggt gtgtggagta aatagctcga agagctgaag
     6121 acagaaaacc agtttcacgc caggtgcgag agagagcata atggagggaa gcccgctttc
     6181 tctctcctct tcttttctct ttatttcttt agagcacttg actttttttt ctctctctct
     6241 ctagtattct aaactgaccc catgaccaac tgagaattta tttttgtttc attggttgtt
     6301 tcacagaatt agaacacaca cgacttttta ttcctccatt gcaaaatgga atcaagatac
     6361 tacacaagac ctgtgctttc ttcctttgca tgatttacac ctccgcctgt tttggtgcta
     6421 gctgtctaga acttctctct tggtttgaat ctgattcctt cacactacac tagaagttta
     6481 tttcatcttg ttttgtctag actccagata cagagggaca gctggactga ggacaagcaa
     6541 ttccatctag catagggtct ctcagggttg gtgcatccag ccacatgggc agggccagtc
     6601 acatctagtc tatgtcccca gagcccttgg agttgcgcag cttagctgac ttgactccaa
     6661 ggaaattagt acagaagtaa ccactctatt aagtgtgttc tgctatgttc acatgcctgt
     6721 agtacctgca aaccatgcca ggttcatcta aagacatagg ggaagattaa ggactctttt
     6781 ggacagacca tgaattgaat ttgctgccag gtgctgccag actgaatttg gctgacagaa
     6841 ctcccagccc aggaaagttc catgacaatg actgtcgcag aaggaaattt cccactaaag
     6901 tcagtccatt ttcaagtttt ggtcttcaga gacaaaagaa cgtcccagcc acctgatttt
     6961 gatggtgagg taactctaag ttgaattcag gctagtgttg cagtatagct ttggcatgtt
     7021 catgagtgag cacccagaat gtgttgaacc aacccccacc cctaactact gactatgact
     7081 gcagtgggtt tttatgggga aaaaaagtgt gaaaagcaaa aagaaaggaa cagagatttt
     7141 ttatcacctt tattgtaaga cagtccattt atgaattgag tataaacaca tacaaagtaa
     7201 caagagattc ctaagaaacg caaatccttg agtttcacgc acttcatgtt caaccatttg
     7261 ctgtaatcca gaggcagcct gtgaatcatt ctcatgccct gttttttttt tttttttcct
     7321 ataatgttct gggtttaaaa gccatctttt ccacattttc tgtaaataat ggataatcat
     7381 tttaaaaatt tttattttta gtgctgtttt aacaatgtag atagatcata aatgtacttg
     7441 ctgaattcaa tcatttttaa caagccaata aagtttgata attca
//
